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Conserved domains on  [gi|1491035360|gb|RLF43052|]
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MAG: hypothetical protein DRN18_01075 [Thermoplasmata archaeon]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 43-323 1.31e-37

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 143.13  E-value: 1.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  43 LMLAIFICGVLALVSATCKAETtdgrilyvggdgpgnytkIQDAIDNASDGDIIFVKSGVYKENVVLNKNVSIEGENReT 122
Cdd:COG3420     2 ALLLLLLLLAGAAAAATAPGDS------------------LQAAIDAAPPGDTIEVPPGTYEGNIVIDKPLTLIGEGG-A 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 123 TIleAASTERRTLELyKVSNCKISNITIRGAKGDKSN--------------------------LYLSECRNVTIQYCSIE 176
Cdd:COG3420    63 VI--DGGGKGTVITI-TADNVTVRGLTITGSGDSLTDddagiyvrgadnaviennriennlfgIYLEGSDNNVIRNNTIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 177 -----ESEEGDGIFLYRCSLISIRNNSILNNKQG---------------------------------------------- 205
Cdd:COG3420   140 gnrdlRADRGNGIHLWNSPGNVIEGNTISGGRDGiylefsdnnvirnntirnlrygihymysndnlvegntfrdngagia 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 206 -------------------NGILLAYSSYCIITNNKISGNQIGIFLqYQSCNNTIARNYIEDNlLVGVRipksgnFLINP 266
Cdd:COG3420   220 lmyskgntvrgntilgnsgYGILLKESSDSVIEGNTISGNGKGIFI-YNSNRNTIRGNLFAGN-GIGIH------LTAGS 291

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360 267 RNNTIFENVFKSNGQNAEdcvNVTEERNLWYnpETKRGNYWDDYQGKDANHDGIGDT 323
Cdd:COG3420   292 EGNRIYGNNFIGNRTQVK---YVGGRDNEWS--ADGRGNYWSDYTGFDLDGDGIGDV 343
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 353-435 1.97e-31

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


:

Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 116.99  E-value: 1.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 353 NQKPVADAGGDYYGTVNESIRFDASQSRDPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTT 432
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTAT 80


                  ...
gi 1491035360 433 LAH 435
Cdd:pfam18911  81 DTV 83
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 442-520 1.08e-19

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


:

Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 83.86  E-value: 1.08e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 442 NKKPVPVIESKDIAVIGEIIEFNASKSYDPDGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTK 520
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTA 79
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 543-596 6.93e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


:

Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 69.72  E-value: 6.93e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1491035360 543 LFVGAEIVFNASESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTV 596
Cdd:pfam00801   8 VAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTA 61
 
Name Accession Description Interval E-value
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 43-323 1.31e-37

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 143.13  E-value: 1.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  43 LMLAIFICGVLALVSATCKAETtdgrilyvggdgpgnytkIQDAIDNASDGDIIFVKSGVYKENVVLNKNVSIEGENReT 122
Cdd:COG3420     2 ALLLLLLLLAGAAAAATAPGDS------------------LQAAIDAAPPGDTIEVPPGTYEGNIVIDKPLTLIGEGG-A 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 123 TIleAASTERRTLELyKVSNCKISNITIRGAKGDKSN--------------------------LYLSECRNVTIQYCSIE 176
Cdd:COG3420    63 VI--DGGGKGTVITI-TADNVTVRGLTITGSGDSLTDddagiyvrgadnaviennriennlfgIYLEGSDNNVIRNNTIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 177 -----ESEEGDGIFLYRCSLISIRNNSILNNKQG---------------------------------------------- 205
Cdd:COG3420   140 gnrdlRADRGNGIHLWNSPGNVIEGNTISGGRDGiylefsdnnvirnntirnlrygihymysndnlvegntfrdngagia 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 206 -------------------NGILLAYSSYCIITNNKISGNQIGIFLqYQSCNNTIARNYIEDNlLVGVRipksgnFLINP 266
Cdd:COG3420   220 lmyskgntvrgntilgnsgYGILLKESSDSVIEGNTISGNGKGIFI-YNSNRNTIRGNLFAGN-GIGIH------LTAGS 291

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360 267 RNNTIFENVFKSNGQNAEdcvNVTEERNLWYnpETKRGNYWDDYQGKDANHDGIGDT 323
Cdd:COG3420   292 EGNRIYGNNFIGNRTQVK---YVGGRDNEWS--ADGRGNYWSDYTGFDLDGDGIGDV 343
NosD_copper_fam TIGR04247
nitrous oxide reductase family maturation protein NosD; Members of this family include NosD, a ...
 83-325 1.19e-34

nitrous oxide reductase family maturation protein NosD; Members of this family include NosD, a repetitive periplasmic protein required for the maturation of the copper-containing enzyme nitrous-oxide reductase. NosD appears to be part of a complex with NosF (an ABC transporter family ATP-binding protein) and NosY (a six-helix transmembrane protein in the ABC-2 permease family). However, NosDFY-like complexes appear to occur also in species whose copper requiring enzymes are something other than nitrous-oxide reductase.


Pssm-ID: 275079 [Multi-domain]  Cd Length: 377  Bit Score: 135.40  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  83 IQDAIDNASDGDIIFVKSGVYKENVVLNKNVS--------IEGENRETTILEAASteRRTLE------------------ 136
Cdd:TIGR04247   1 LQEAIDAARPGDTIRLAPGTYKGNIVIDKPLTligeggavIDGEGKGTVITIKAP--DVTIEgltvrnsgtslteddagi 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 137 -LYKVSNCKISNITIRGakgdksNL---YLSECRNVTIQYCSI------EESEEGDGIFLYRCSLISIRNNSIL------ 200
Cdd:TIGR04247  79 kVEKADRAVIENNRLED------NLfgiYLQEAHDSLIENNRItgkpdlRSNDRGNGIHLWNSPGNVIEGNTVRggrdgi 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 201 -----------NNK---------------------------------------------------QGNGILLAYSSYCII 218
Cdd:TIGR04247 153 yiefshhnlirNNTshnlryglhfmysndnlvednvfrgnsvgyalmyskrltvrgnvflnnwgdAGYGILLKEINDSEI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 219 TNNKISGNQIGIFLqYQSCNNTIARNYIEDNLlVGVRipksgnFLINPRNNTIFENVFKSNgqnAEDCVNVTEERNLWYn 298
Cdd:TIGR04247 233 EGNTVLGNTKGLFI-DNSPRNVFRDNDFEYNG-IGIH------FTAGSERNRFEGNAFIGN---REQVKYVGTRSLEWS- 300

                         330       340
                  ....*....|....*....|....*..
gi 1491035360 299 pETKRGNYWDDYQGKDANHDGIGDTPY 325
Cdd:TIGR04247 301 -ENGRGNYWSDYEGYDLDGDGIGDVPY 326
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 353-435 1.97e-31

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 116.99  E-value: 1.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 353 NQKPVADAGGDYYGTVNESIRFDASQSRDPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTT 432
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTAT 80


                  ...
gi 1491035360 433 LAH 435
Cdd:pfam18911  81 DTV 83
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 442-520 1.08e-19

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 83.86  E-value: 1.08e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 442 NKKPVPVIESKDIAVIGEIIEFNASKSYDPDGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTK 520
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTA 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 366-432 1.49e-17

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 77.49  E-value: 1.49e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360  366 GTVNESIRFDASQSrdPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAeDSDTT 432
Cdd:smart00089  11 GVAGESVTFTATSS--DDGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 135-283 1.83e-17

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 79.76  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 135 LELYKVSNCKISNITIRGAKGDksNLYLSECRNVTIQYCSIEESEeGDGIFLYRCSLISIRNNSILNNKQGnGILLAYSS 214
Cdd:pfam13229   3 ILLNGSSNATIKNNTISNNGGY--GIYLRGSSNATIENNTITNNG-GDGIEISGSSNNTISNNTISNNGGG-GIALRGSS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 215 YCIITNNKISGN-QIGIFLQYQScNNTIARNYIEDNLLVGVRIPKSGNflinprNNTIFENVFKSNGQNA 283
Cdd:pfam13229  79 NNLIENNTISNNgGAGIYLSDSS-NNTIENNIIHNNGGSGIVIEDSSN------NVTISNNTVTNNKGAG 141
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 356-432 6.02e-17

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 76.00  E-value: 6.02e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 356 PVADAGGDYYGTVNESIRFDASQSrdPDGEIVEYIWDFGDG--STGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTT 432
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDS--SGGSIVSYKWDFGDGevSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTT 77
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 543-596 6.93e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 69.72  E-value: 6.93e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1491035360 543 LFVGAEIVFNASESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTV 596
Cdd:pfam00801   8 VAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTA 61
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 540-612 3.07e-13

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 65.21  E-value: 3.07e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1491035360 540 TDLLFVGAEIVFNAS-ESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTVVGIDGEKDTKSLTIVI 612
Cdd:cd00146     8 PPVAELGASVTFSASdSSGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 448-525 7.02e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.39  E-value: 7.02e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491035360  448 VIESKDIAVIGEIIEFNASKSYDpdGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGyKNSTKKSIVI 525
Cdd:smart00089   4 VSASPTVGVAGESVTFTATSSDD--GSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVG-SASATVTVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 533-613 7.30e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.39  E-value: 7.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  533 NADFHVETDLLFVGAEIVFNA-SESSGAIVSYIWEFGDGENITTSSPvcNHTYTKPGIYVVNLTVVGIDGeKDTKSLTIV 611
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTAtSSDDGSIVSYTWDFGDGTSSTGPTV--THTYTKPGTYTVTLTVTNAVG-SASATVTVV 77


                   ..
gi 1491035360  612 IE 613
Cdd:smart00089  78 VQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 445-525 4.64e-10

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 56.35  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 445 PVPVIESKDIAVIGEIIEFNASKSydPDGEIVTYIWKFGDGKVD--YGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKKS 522
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDS--SGGSIVSYKWDFGDGEVSssGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTT 78


                  ...
gi 1491035360 523 IVI 525
Cdd:cd00146    79 VVV 81
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
536-624 5.67e-09

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.14  E-value: 5.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 536 FHVETDLLFVGAEIVFNASeSSGAIVSYIWEFGDGENITTSSPVcnHTYTKPGIYVVNLTVVGIDGEKDTKSLTIVIEGA 615
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDT-SSGNATSYEWDFGDGTTSTEANPS--HTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAP 77


                  ....*....
gi 1491035360 616 WKKETPGFG 624
Cdd:COG3291    78 NPGVTTVTT 86
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-485 3.49e-08

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 56.97  E-value: 3.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDyyGTVNE--SIRFDASQSrDPDGEIVEYIWDfgdgSTGKGKVVTHSYSTP----------GNYTVTLTV 420
Cdd:NF038112  1280 NRAPVAVAGAP--ATVDErsTVTLDGSGT-DADGDALTYAWT----QTSGPAVTLTGATTAtatftapevtADTQLTFTL 1352

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360  421 VDDDG-AEDSDT---TLAHIseytqNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIWKFGDG 485
Cdd:NF038112  1353 TVSDGtASATDTvtvTVRNV-----NRAPVANAGADQTVDERSTVTLSGSAT-DPDGDALTYAWTQTAG 1415
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-480 3.93e-08

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 56.97  E-value: 3.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDyyGTVNE--SIRFDASQSrDPDGEIVEYIWDFGDGST---GKGKVVTHSYSTP---GNYTVTLTVVDDD 424
Cdd:NF038112  1373 NRAPVANAGAD--QTVDErsTVTLSGSAT-DPDGDALTYAWTQTAGPTvtlTGADTATASFTAPevaADTELTFQLTVSA 1449

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1491035360  425 GAEDSDTTLAHISEYTQNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIW 480
Cdd:NF038112  1450 DGQASADVTVTVTVRNVNRAPVAHAGESITVDEGSTVTLDASAT-DPDGDTLTYAW 1504
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-480 1.04e-07

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 55.43  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDYygTVNE--SIRFDASQSRDPDGEIVEYIWDfgdgSTGkGKVVTHS---YSTPG--------NYTVTLT 419
Cdd:NF038112  1185 NRRPVANAGPDQ--TVLErtTVTLNGSGSFDPDGDPLTYAWT----QVS-GPAVTLTgadTATPSftapevtaDTVLTFQ 1257

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  420 VVDDDGAEDSDTTLAHISEYTQNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIW 480
Cdd:NF038112  1258 LVVSDGTKTSAPDTVTVLVRNVNRAPVAVAGAPATVDERSTVTLDGSGT-DADGDALTYAW 1317
PLN02314 PLN02314
pectinesterase
 70-127 1.04e-05

pectinesterase


Pssm-ID: 215179 [Multi-domain]  Cd Length: 586  Bit Score: 48.67  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1491035360  70 LYVGGDGPGNYTKIQDAID----NASDGDIIFVKSGVYKENVVLNK---NVSIEGENRETTILEA 127
Cdd:PLN02314  280 VTVAKDGSGDVKTINEAVAsipkKSKSRFVIYVKEGTYVENVLLDKskwNVMIYGDGKDKTIISG 344
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 368-416 1.21e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 1.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1491035360  368 VNESIRFDASQSrdPDGEIVEYIWDFGDGSTGK---GKVVTHSYSTPGNYTV 416
Cdd:TIGR00864 2056 TNKMAQFEAATS--PKPNFMACHWDFGDGSAGQdtdEPRAEHEYLHPGDYRV 2105
 
Name Accession Description Interval E-value
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 43-323 1.31e-37

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 143.13  E-value: 1.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  43 LMLAIFICGVLALVSATCKAETtdgrilyvggdgpgnytkIQDAIDNASDGDIIFVKSGVYKENVVLNKNVSIEGENReT 122
Cdd:COG3420     2 ALLLLLLLLAGAAAAATAPGDS------------------LQAAIDAAPPGDTIEVPPGTYEGNIVIDKPLTLIGEGG-A 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 123 TIleAASTERRTLELyKVSNCKISNITIRGAKGDKSN--------------------------LYLSECRNVTIQYCSIE 176
Cdd:COG3420    63 VI--DGGGKGTVITI-TADNVTVRGLTITGSGDSLTDddagiyvrgadnaviennriennlfgIYLEGSDNNVIRNNTIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 177 -----ESEEGDGIFLYRCSLISIRNNSILNNKQG---------------------------------------------- 205
Cdd:COG3420   140 gnrdlRADRGNGIHLWNSPGNVIEGNTISGGRDGiylefsdnnvirnntirnlrygihymysndnlvegntfrdngagia 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 206 -------------------NGILLAYSSYCIITNNKISGNQIGIFLqYQSCNNTIARNYIEDNlLVGVRipksgnFLINP 266
Cdd:COG3420   220 lmyskgntvrgntilgnsgYGILLKESSDSVIEGNTISGNGKGIFI-YNSNRNTIRGNLFAGN-GIGIH------LTAGS 291

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360 267 RNNTIFENVFKSNGQNAEdcvNVTEERNLWYnpETKRGNYWDDYQGKDANHDGIGDT 323
Cdd:COG3420   292 EGNRIYGNNFIGNRTQVK---YVGGRDNEWS--ADGRGNYWSDYTGFDLDGDGIGDV 343
NosD_copper_fam TIGR04247
nitrous oxide reductase family maturation protein NosD; Members of this family include NosD, a ...
 83-325 1.19e-34

nitrous oxide reductase family maturation protein NosD; Members of this family include NosD, a repetitive periplasmic protein required for the maturation of the copper-containing enzyme nitrous-oxide reductase. NosD appears to be part of a complex with NosF (an ABC transporter family ATP-binding protein) and NosY (a six-helix transmembrane protein in the ABC-2 permease family). However, NosDFY-like complexes appear to occur also in species whose copper requiring enzymes are something other than nitrous-oxide reductase.


Pssm-ID: 275079 [Multi-domain]  Cd Length: 377  Bit Score: 135.40  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  83 IQDAIDNASDGDIIFVKSGVYKENVVLNKNVS--------IEGENRETTILEAASteRRTLE------------------ 136
Cdd:TIGR04247   1 LQEAIDAARPGDTIRLAPGTYKGNIVIDKPLTligeggavIDGEGKGTVITIKAP--DVTIEgltvrnsgtslteddagi 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 137 -LYKVSNCKISNITIRGakgdksNL---YLSECRNVTIQYCSI------EESEEGDGIFLYRCSLISIRNNSIL------ 200
Cdd:TIGR04247  79 kVEKADRAVIENNRLED------NLfgiYLQEAHDSLIENNRItgkpdlRSNDRGNGIHLWNSPGNVIEGNTVRggrdgi 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 201 -----------NNK---------------------------------------------------QGNGILLAYSSYCII 218
Cdd:TIGR04247 153 yiefshhnlirNNTshnlryglhfmysndnlvednvfrgnsvgyalmyskrltvrgnvflnnwgdAGYGILLKEINDSEI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 219 TNNKISGNQIGIFLqYQSCNNTIARNYIEDNLlVGVRipksgnFLINPRNNTIFENVFKSNgqnAEDCVNVTEERNLWYn 298
Cdd:TIGR04247 233 EGNTVLGNTKGLFI-DNSPRNVFRDNDFEYNG-IGIH------FTAGSERNRFEGNAFIGN---REQVKYVGTRSLEWS- 300

                         330       340
                  ....*....|....*....|....*..
gi 1491035360 299 pETKRGNYWDDYQGKDANHDGIGDTPY 325
Cdd:TIGR04247 301 -ENGRGNYWSDYEGYDLDGDGIGDVPY 326
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 353-435 1.97e-31

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 116.99  E-value: 1.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 353 NQKPVADAGGDYYGTVNESIRFDASQSRDPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTT 432
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTAT 80


                  ...
gi 1491035360 433 LAH 435
Cdd:pfam18911  81 DTV 83
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 442-520 1.08e-19

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 83.86  E-value: 1.08e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 442 NKKPVPVIESKDIAVIGEIIEFNASKSYDPDGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTK 520
Cdd:pfam18911   1 NAAPVADAGGDRIVAEGETVTFDASASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTA 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 366-432 1.49e-17

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 77.49  E-value: 1.49e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360  366 GTVNESIRFDASQSrdPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAeDSDTT 432
Cdd:smart00089  11 GVAGESVTFTATSS--DDGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGS-ASATV 74
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 135-283 1.83e-17

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 79.76  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 135 LELYKVSNCKISNITIRGAKGDksNLYLSECRNVTIQYCSIEESEeGDGIFLYRCSLISIRNNSILNNKQGnGILLAYSS 214
Cdd:pfam13229   3 ILLNGSSNATIKNNTISNNGGY--GIYLRGSSNATIENNTITNNG-GDGIEISGSSNNTISNNTISNNGGG-GIALRGSS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 215 YCIITNNKISGN-QIGIFLQYQScNNTIARNYIEDNLLVGVRIPKSGNflinprNNTIFENVFKSNGQNA 283
Cdd:pfam13229  79 NNLIENNTISNNgGAGIYLSDSS-NNTIENNIIHNNGGSGIVIEDSSN------NVTISNNTVTNNKGAG 141
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 356-432 6.02e-17

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 76.00  E-value: 6.02e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 356 PVADAGGDYYGTVNESIRFDASQSrdPDGEIVEYIWDFGDG--STGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTT 432
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDS--SGGSIVSYKWDFGDGevSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTT 77
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 360-426 2.19e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 70.88  E-value: 2.19e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360 360 AGGDYYGTVNESIRFDASqsrDPDGEIVEYIWDFGDGSTGK--GKVVTHSYSTPGNYTVTLTVVDDDGA 426
Cdd:pfam00801   2 SASGTVVAAGQPVTFTAT---LADGSNVTYTWDFGDSPGTSgsGPTVTHTYLSPGTYTVTLTASNAVGS 67
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 543-596 6.93e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 69.72  E-value: 6.93e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1491035360 543 LFVGAEIVFNASESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTV 596
Cdd:pfam00801   8 VAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTA 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 404-595 1.74e-14

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 77.43  E-value: 1.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  404 VTHSYSTPGNYTVTLTVVDddgAEDSDTTLAHISEYTQNKKpVPVIESKDIAVIGEIIEFNASKSYDPDGeiVTYIWKFG 483
Cdd:TIGR00864 1052 VMHIYAAPGEYLATVLASN---AFENISQQINMSVRAILPR-VAIGTEDGLLLAGKPADFEAHPLPSPGG--IHYEWDFG 1125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  484 DGK---VDYGKVVEHSYSEPGTYEVTLEVvDNLGYKNSTKKSIVILAEGEKVNADFHVETDLlfvGAEIVFNASESSGAI 560
Cdd:TIGR00864 1126 DGSallQGRQPAAAHTFAKRGPFHVCLEV-NNTISGAAACADMFAFEEIEGLSADMSLATEL---GAATTVRAALQSGDN 1201

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1491035360  561 VSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLT 595
Cdd:TIGR00864 1202 ITWTFDMGDGKSLSGPEATVEHKYAKAGNCTVNIG 1236
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 540-612 3.07e-13

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 65.21  E-value: 3.07e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1491035360 540 TDLLFVGAEIVFNAS-ESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTVVGIDGEKDTKSLTIVI 612
Cdd:cd00146     8 PPVAELGASVTFSASdSSGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
366-611 4.98e-13

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 70.85  E-value: 4.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 366 GTVNESIRFDASQSrdpdGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSDTTLAHISEYTQNKKP 445
Cdd:COG3291     8 GCAPLTVQFTDTSS----GNATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 446 VPVIESKDIAVIGEIIEFNASKSYDPDGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKKSIVI 525
Cdd:COG3291    84 VTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 526 LAEGEKVNADFHVETDLLFVGAEIVFNASESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTVVGIDGEKDT 605
Cdd:COG3291   164 VTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDA 243


                  ....*.
gi 1491035360 606 KSLTIV 611
Cdd:COG3291   244 GTPGTN 249
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 448-525 7.02e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.39  E-value: 7.02e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491035360  448 VIESKDIAVIGEIIEFNASKSYDpdGEIVTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGyKNSTKKSIVI 525
Cdd:smart00089   4 VSASPTVGVAGESVTFTATSSDD--GSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVG-SASATVTVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 533-613 7.30e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.39  E-value: 7.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  533 NADFHVETDLLFVGAEIVFNA-SESSGAIVSYIWEFGDGENITTSSPvcNHTYTKPGIYVVNLTVVGIDGeKDTKSLTIV 611
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTAtSSDDGSIVSYTWDFGDGTSSTGPTV--THTYTKPGTYTVTLTVTNAVG-SASATVTVV 77


                   ..
gi 1491035360  612 IE 613
Cdd:smart00089  78 VQ 79
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 87-312 1.38e-12

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 67.44  E-value: 1.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  87 IDNASDGDIIFVKSGVYKENVVLNKNVSIEgenreTTILEAASTERRTLELYKVSNCKISNITIRGAKGdksNLYLSECR 166
Cdd:pfam05048   1 VNNAISGDTIGIYNGLSRGNGIQLWNTEGN-----VISNNDIINSRDGIYLDASNNNTITGNRISNLRY---GIHLMNSN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 167 NVTIQYCSIEESeeGDGIFLYRCSLISIRNNSILNNkQGNGILLAYSSYCIITNNKISG--------------------- 225
Cdd:pfam05048  73 DNTISDNVFSGN--TAGIALMSSSNNTLENNTISGN-TNYGILLSDSSNNTISNNTISNnngkgiflynsdyntitgnri 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 226 --NQIGIFLQYQSCNNTIARNYIEDNllvgvripksgnflinprnntiFENVFKSNGQNAEDCVNVTEERNLWYNPETkR 303
Cdd:pfam05048 150 tsNGIGIHFLAGSNGNTIYNNYFINN----------------------SENVKYVGTNDNYWNTTKTTGYNIIGGPYI-G 206


                  ....*....
gi 1491035360 304 GNYWDDYQG 312
Cdd:pfam05048 207 GNYWSDYDG 215
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 545-612 4.91e-12

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 61.90  E-value: 4.91e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491035360 545 VGAEIVFNASESS---GAIVSYIWEFGDGENITTSSPVcnHTYTKPGIYVVNLTVVGIDGEKD-TKSLTIVI 612
Cdd:pfam18911  16 EGETVTFDASASDdpdGDILSYRWDFGDGTTATGANVS--HTYAAPGTYTVTLTVTDDSGASNsTATDTVTV 85
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 182-294 1.04e-11

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 63.19  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 182 DGIFLYRCSLISIRNNSILNNkQGNGILLAYSSYCIITNNKISGNQIGIFLQYQSCNNTIARNYIEDNLLVGVRIPKSGN 261
Cdd:pfam13229   1 SGILLNGSSNATIKNNTISNN-GGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGGGIALRGSSN 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1491035360 262 FLInpRNNTIFENvfKSNGQNAEDCVNVTEERN 294
Cdd:pfam13229  80 NLI--ENNTISNN--GGAGIYLSDSSNNTIENN 108
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 455-514 3.13e-11

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 59.32  E-value: 3.13e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491035360 455 AVIGEIIEFNAsksYDPDGEIVTYIWKFGD--GKVDYGKVVEHSYSEPGTYEVTLEVVDNLG 514
Cdd:pfam00801   8 VAAGQPVTFTA---TLADGSNVTYTWDFGDspGTSGSGPTVTHTYLSPGTYTVTLTASNAVG 66
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 372-595 1.02e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 65.49  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  372 IRFDASQSRDPDGEIVEyiWDFGDGS---TGKG-KVVTHSYSTPGNYTVTLTVVDDDGAEDSDTTLAHISEYTQnkkpVP 447
Cdd:TIGR00864 1272 ANFRARVSGNAAHYLFD--WSFGDGSpneTHHGcPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPELGK----IS 1345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  448 VIESKDIAVIGEIIEFNASKsyDPDGEiVTYIWKFGdGKVDY-----GKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKKS 522
Cdd:TIGR00864 1346 LQAEKQFFALGDEAQFQACA--EPEFN-YRYEWDFG-GEEAAplpaaGAEVTFIYNDPGCYLVTVAASNNISAANDSALI 1421

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1491035360  523 IV---ILAEGEKVNADFHVETDLlfvGAEIVFNASeSSGAIVSYIWEFGDGENIttSSPVCNHTYTKPGIYVVNLT 595
Cdd:TIGR00864 1422 EVlepVGATSFKHNGSHGNNLEL---GQPYLFSAF-GRARNASYLWDFGDGGLL--EGPEILHAFNSPGDFNIRLA 1491
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 445-525 4.64e-10

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 56.35  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 445 PVPVIESKDIAVIGEIIEFNASKSydPDGEIVTYIWKFGDGKVD--YGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKKS 522
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDS--SGGSIVSYKWDFGDGEVSssGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTT 78


                  ...
gi 1491035360 523 IVI 525
Cdd:cd00146    79 VVV 81
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 384-595 6.01e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 6.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  384 GEIVEYIWDFGDGS--TGKGKVVTHSYSTPGNYTVTLTVVDddgAEDSDTTLAHISEYTqnkkpVPVIESKDIAVIGE-- 459
Cdd:TIGR00864 1199 GDNITWTFDMGDGKslSGPEATVEHKYAKAGNCTVNIGAAN---AAGHGARIIHVEVFV-----FEVAGIEPAACIGEha 1270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  460 IIEFNASKSYDPDGEIvtYIWKFGDGK----VDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKKsivILAEGEKVNAD 535
Cdd:TIGR00864 1271 DANFRARVSGNAAHYL--FDWSFGDGSpnetHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQ---ICVEPELGKIS 1345

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491035360  536 FHVETDLLFVGAEIVFNASESSGAIVSYIWEFGDGENITT--SSPVCNHTYTKPGIYVVNLT 595
Cdd:TIGR00864 1346 LQAEKQFFALGDEAQFQACAEPEFNYRYEWDFGGEEAAPLpaAGAEVTFIYNDPGCYLVTVA 1407
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
536-624 5.67e-09

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.14  E-value: 5.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 536 FHVETDLLFVGAEIVFNASeSSGAIVSYIWEFGDGENITTSSPVcnHTYTKPGIYVVNLTVVGIDGEKDTKSLTIVIEGA 615
Cdd:COG3291     1 FTATPTSGCAPLTVQFTDT-SSGNATSYEWDFGDGTTSTEANPS--HTYTTPGTYTVTLTVTDAAGCSDTTTKTITVGAP 77


                  ....*....
gi 1491035360 616 WKKETPGFG 624
Cdd:COG3291    78 NPGVTTVTT 86
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 476-596 1.65e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  476 VTYIWKFGDG-----------------------KVDYGKVVEHSYSEPGTYEVTLEVVDnlGYKNSTkKSIVILAEGEKV 532
Cdd:TIGR00864 1012 AAFLWSFGDGeqalfefkppynesfpcpdpspaQVLLEHNVMHIYAAPGEYLATVLASN--AFENIS-QQINMSVRAILP 1088

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491035360  533 NADFHVETDLLFVGAEIVFNAS--ESSGAIVsYIWEFGDGENITTSS-PVCNHTYTKPGIYVVNLTV 596
Cdd:TIGR00864 1089 RVAIGTEDGLLLAGKPADFEAHplPSPGGIH-YEWDFGDGSALLQGRqPAAAHTFAKRGPFHVCLEV 1154
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-485 3.49e-08

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 56.97  E-value: 3.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDyyGTVNE--SIRFDASQSrDPDGEIVEYIWDfgdgSTGKGKVVTHSYSTP----------GNYTVTLTV 420
Cdd:NF038112  1280 NRAPVAVAGAP--ATVDErsTVTLDGSGT-DADGDALTYAWT----QTSGPAVTLTGATTAtatftapevtADTQLTFTL 1352

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491035360  421 VDDDG-AEDSDT---TLAHIseytqNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIWKFGDG 485
Cdd:NF038112  1353 TVSDGtASATDTvtvTVRNV-----NRAPVANAGADQTVDERSTVTLSGSAT-DPDGDALTYAWTQTAG 1415
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-480 3.93e-08

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 56.97  E-value: 3.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDyyGTVNE--SIRFDASQSrDPDGEIVEYIWDFGDGST---GKGKVVTHSYSTP---GNYTVTLTVVDDD 424
Cdd:NF038112  1373 NRAPVANAGAD--QTVDErsTVTLSGSAT-DPDGDALTYAWTQTAGPTvtlTGADTATASFTAPevaADTELTFQLTVSA 1449

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1491035360  425 GAEDSDTTLAHISEYTQNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIW 480
Cdd:NF038112  1450 DGQASADVTVTVTVRNVNRAPVAHAGESITVDEGSTVTLDASAT-DPDGDTLTYAW 1504
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 384-614 6.07e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 6.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  384 GEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSD---TTLAHISEYTQNKK---------------- 444
Cdd:TIGR00864 1456 ARNASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGKNEATlnvAVKARVRGLTINASltnvplngsvhfeahl 1535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  445 -----------------PVP------------------VIESKDIA------------------VIGEIIEFNASKS--- 468
Cdd:TIGR00864 1536 dagddvrfswilcdhctPIFggntifytfrsvgtfniiVTAENDVGaaqasiflfvlqeieglqILGETAEGGGGGVqel 1615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  469 ---YDP------------DGEIVTYIWK-FGDGKVD------YGKVVEHSYSEPGTYEVTLEVVDNLGykNSTKKSIVIL 526
Cdd:TIGR00864 1616 dgcYFEtnhtvqfhagfkDGTNLSFSWNaILDNEPDgpafagSGKGAKLNPLEAGPCDIFLQAANLLG--QATADCTIDF 1693

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  527 AEGEKvNADFHVETDLLFVGAEIVFNASESSGAIVSYIWEFGDGENITTSSPVCNHTYTKPGIYVVNLTV---VGIDGEK 603
Cdd:TIGR00864 1694 LEPAG-NLMLAASDNPAAVNALINLSAELAEGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAfneLGSANAS 1772

                          330
                   ....*....|.
gi 1491035360  604 DTKSLTIVIEG 614
Cdd:TIGR00864 1773 EEVDVQEPISG 1783
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 353-480 1.04e-07

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 55.43  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  353 NQKPVADAGGDYygTVNE--SIRFDASQSRDPDGEIVEYIWDfgdgSTGkGKVVTHS---YSTPG--------NYTVTLT 419
Cdd:NF038112  1185 NRRPVANAGPDQ--TVLErtTVTLNGSGSFDPDGDPLTYAWT----QVS-GPAVTLTgadTATPSftapevtaDTVLTFQ 1257

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  420 VVDDDGAEDSDTTLAHISEYTQNKKPVPVIESKDIAVIGEIIEFNASKSyDPDGEIVTYIW 480
Cdd:NF038112  1258 LVVSDGTKTSAPDTVTVLVRNVNRAPVAVAGAPATVDERSTVTLDGSGT-DADGDALTYAW 1317
Pectinesterase pfam01095
Pectinesterase;
72-124 4.99e-07

Pectinesterase;


Pssm-ID: 395871 [Multi-domain]  Cd Length: 298  Bit Score: 51.88  E-value: 4.99e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  72 VGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVLNK---NVSIEGENRETTI 124
Cdd:pfam01095   4 VAKDGSGKFKTINEALAAAPKKSekrfVIYVKAGVYKENVEVPKkktNVMFVGDGKGKTI 63
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 368-595 1.05e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  368 VNESIRFDASQSrdpDGEIVEYIWDF--GDGSTGKGKVVTHSYSTPGNYTVTLTVVDDDGAEDSdttlahiSEYTQNKKP 445
Cdd:TIGR00864 1711 VNALINLSAELA---EGSGLQYRWFLeeGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANA-------SEEVDVQEP 1780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  446 VP--VIESKDiavIGEIIEFNASKSYDPDGEI-----VTYIWKFGDGKVDYGKVVEHSYSEPGTYEVTLEVVDNLGYKNS 518
Cdd:TIGR00864 1781 ISglKIRAAD---AGEQNFFAADSSVCFQGELatgtnVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASNAVSGKSA 1857

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491035360  519 TKKsivILAEGEKVNADFHVETDLLFVGAEIVFNASESSGAIVSYIWEFG-DGENITTSSPVCNHTYTKPGIYVVNLT 595
Cdd:TIGR00864 1858 SRE---FFAEEPIFGLELKASKKIAAIGEKVEFQILLAAGSAVNFRLQIGgAAPEVLQPGPRFSHSFPRVDDHMVNLR 1932
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 473-594 1.08e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  473 GEIVTYIWKF------GDGKVDY-GKVVEHSYSEPGTYEVTLEVVDNLGYKNSTKksiVILAEGEKVNADFHVETDLLFV 545
Cdd:TIGR00864 1980 GKPVAFAWTFdlhhlhGDSLVIHmGKDVSYTAEAAGLLEIQLGAFNALGAENITL---QLEAQDALMDAALQAGPQDCFT 2056

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  546 GAEIVFNASES-SGAIVSYIWEFGDGE-NITTSSPVCNHTYTKPGIYVVNL 594
Cdd:TIGR00864 2057 NKMAQFEAATSpKPNFMACHWDFGDGSaGQDTDEPRAEHEYLHPGDYRVQV 2107
para_beta_helix TIGR03804
parallel beta-helix repeat (two copies); This model represents a tandem pair of an ...
 207-249 1.88e-06

parallel beta-helix repeat (two copies); This model represents a tandem pair of an approximately 22-amino acid (each) repeat homologous to the beta-strand repeats that stack in a right-handed parallel beta-helix in the periplasmic C-5 mannuronan epimerase, AlgA, of Pseudomonas aeruginosa. A homology domain consisting of a longer tandem array of these repeats is described in the SMART database as CASH (SM00722), and is found in many carbohydrate-binding proteins and sugar hydrolases. A single repeat is represented by SM00710. This TIGRFAMs model represents a flavor of the parallel beta-helix-forming repeat based on prokaryotic sequences only in its seed alignment, although it also finds many eukaryotic sequences.


Pssm-ID: 274795 [Multi-domain]  Cd Length: 44  Bit Score: 44.81  E-value: 1.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1491035360 207 GILLAYSSYCIITNNKISGNQIGIFLQYQScNNTIARNYIEDN 249
Cdd:TIGR03804   1 GIYLESSSNNTLSNNTASNNSYGIYLYDSS-NNTLSNNTASNN 42
para_beta_helix TIGR03804
parallel beta-helix repeat (two copies); This model represents a tandem pair of an ...
 183-226 3.22e-06

parallel beta-helix repeat (two copies); This model represents a tandem pair of an approximately 22-amino acid (each) repeat homologous to the beta-strand repeats that stack in a right-handed parallel beta-helix in the periplasmic C-5 mannuronan epimerase, AlgA, of Pseudomonas aeruginosa. A homology domain consisting of a longer tandem array of these repeats is described in the SMART database as CASH (SM00722), and is found in many carbohydrate-binding proteins and sugar hydrolases. A single repeat is represented by SM00710. This TIGRFAMs model represents a flavor of the parallel beta-helix-forming repeat based on prokaryotic sequences only in its seed alignment, although it also finds many eukaryotic sequences.


Pssm-ID: 274795 [Multi-domain]  Cd Length: 44  Bit Score: 44.42  E-value: 3.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1491035360 183 GIFLYRCSLISIRNNSILNNKqgNGILLAYSSYCIITNNKISGN 226
Cdd:TIGR03804   1 GIYLESSSNNTLSNNTASNNS--YGIYLYDSSNNTLSNNTASNN 42
PLN02314 PLN02314
pectinesterase
 70-127 1.04e-05

pectinesterase


Pssm-ID: 215179 [Multi-domain]  Cd Length: 586  Bit Score: 48.67  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1491035360  70 LYVGGDGPGNYTKIQDAID----NASDGDIIFVKSGVYKENVVLNK---NVSIEGENRETTILEA 127
Cdd:PLN02314  280 VTVAKDGSGDVKTINEAVAsipkKSKSRFVIYVKEGTYVENVLLDKskwNVMIYGDGKDKTIISG 344
PLN02301 PLN02301
pectinesterase/pectinesterase inhibitor
 72-125 1.41e-05

pectinesterase/pectinesterase inhibitor


Pssm-ID: 215170 [Multi-domain]  Cd Length: 548  Bit Score: 47.95  E-value: 1.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  72 VGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVL---NKNVSIEGENRETTIL 125
Cdd:PLN02301  240 VAKDGSGKYKTVKEAVASAPDNSktryVIYVKKGTYKENVEIgkkKKNLMLVGDGMDSTII 300
PLN02201 PLN02201
probable pectinesterase/pectinesterase inhibitor
 72-125 4.01e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 177852 [Multi-domain]  Cd Length: 520  Bit Score: 46.80  E-value: 4.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  72 VGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVLNK---NVSIEGENRETTIL 125
Cdd:PLN02201  210 VAADGTGNFTTIMDAVLAAPDYStkryVIYIKKGVYLENVEIKKkkwNIMMVGDGIDATVI 270
PLN02480 PLN02480
Probable pectinesterase
 34-196 4.24e-05

Probable pectinesterase


Pssm-ID: 178098 [Multi-domain]  Cd Length: 343  Bit Score: 45.97  E-value: 4.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  34 MRRKRLLLGLMLAIFICGVLALVSATCKAETTD-------------GRILYVGGDGPGNYTKIQDAIDNASDGD----II 96
Cdd:PLN02480    1 MASPMLLPLRMAAVAAVVVSSPSGSKAAKKSQTvvdsplltekigtNRTIIVDINGKGDFTSVQSAIDAVPVGNsewiIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  97 FVKSGVYKENVVLNKN-----VSIEGENRETTILEAASTERRTLELYKVS--NCKISNITIRG-AKGDKSNlylsecrnv 168
Cdd:PLN02480   81 HLRKGVYREKVHIPENkpfifMRGNGKGRTSIVWSQSSSDNAASATFTVEapHFVAFGISIRNdAPTGMAF--------- 151

                         170       180
                  ....*....|....*....|....*...
gi 1491035360 169 TIQYCSIEESEEGDGIFLYRCSLISIRN 196
Cdd:PLN02480  152 TSENQSVAAFVGADKVAFYHCAFYSTHN 179
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 358-567 4.52e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 4.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  358 ADAGGDYYGTVNESIRFdasQSRDPDGEIVEYIWDFGDGSTGKGKVVTHSYSTPGNYTVTLTVVDDdgaedsdTTLAHIS 437
Cdd:TIGR00864 1789 ADAGEQNFFAADSSVCF---QGELATGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASNA-------VSGKSAS 1858

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  438 EYTQNKKPVPVIE---SKDIAVIGEIIEFNASKSYdpdGEIVTYIWKFGDGK---VDYGKVVEHSYSEPGTYEVTLEVVD 511
Cdd:TIGR00864 1859 REFFAEEPIFGLElkaSKKIAAIGEKVEFQILLAA---GSAVNFRLQIGGAApevLQPGPRFSHSFPRVDDHMVNLRAKN 1935

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1491035360  512 NLGYKNSTKKsIVILAEGEKVNADFHVETDLLfVGAEIVFNASESSGAIVSYIWEF 567
Cdd:TIGR00864 1936 EVSCAQANLH-IEVLEAVRGLQIPDCCAAGIA-TGEEKNFTANVQRGKPVAFAWTF 1989
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 137-223 8.47e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 43.16  E-value: 8.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360 137 LYKVSNCKISNITIRGAKGdkSNLYLSECRNVTIQYCSIEESEeGDGIFLYRCSL-ISIRNNSILNNKQGNGILLAYSSY 215
Cdd:pfam13229  74 LRGSSNNLIENNTISNNGG--AGIYLSDSSNNTIENNIIHNNG-GSGIVIEDSSNnVTISNNTVTNNKGAGILIVGGSSN 150


                  ....*...
gi 1491035360 216 CIITNNKI 223
Cdd:pfam13229 151 NTVENNTF 158
PLN02416 PLN02416
probable pectinesterase/pectinesterase inhibitor
 69-125 8.61e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 178037 [Multi-domain]  Cd Length: 541  Bit Score: 45.69  E-value: 8.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1491035360  69 ILYVGGDGPGNYTKIQDAI----DNASDGDIIFVKSGVYKENV---VLNKNVSIEGENRETTIL 125
Cdd:PLN02416  231 VLVVAADGTGNFSTITDAInfapNNSNDRIIIYVREGVYEENVeipIYKTNIVLIGDGSDVTFI 294
PLN02432 PLN02432
putative pectinesterase
 69-125 9.19e-05

putative pectinesterase


Pssm-ID: 178051 [Multi-domain]  Cd Length: 293  Bit Score: 44.83  E-value: 9.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1491035360  69 ILYVGGDGPGNYTKIQDAID----NASDGDIIFVKSGVYKENVVLNKN---VSIEGENRETTIL 125
Cdd:PLN02432   12 LIRVDQSGKGDFRKIQDAIDavpsNNSQLVFIWVKPGIYREKVVVPADkpfITLSGTQASNTII 75
PLN02773 PLN02773
pectinesterase
 68-133 9.63e-05

pectinesterase


Pssm-ID: 178372 [Multi-domain]  Cd Length: 317  Bit Score: 44.84  E-value: 9.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1491035360  68 RILYVGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVLNKN---VSIEGENRETTILEAASTERR 133
Cdd:PLN02773    5 RVLRVAQDGSGDYCTVQDAIDAVPLCNrcrtVIRVAPGVYRQPVYVPKTknlITLAGLSPEATVLTWNNTATK 77
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 368-416 1.21e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 1.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1491035360  368 VNESIRFDASQSrdPDGEIVEYIWDFGDGSTGK---GKVVTHSYSTPGNYTV 416
Cdd:TIGR00864 2056 TNKMAQFEAATS--PKPNFMACHWDFGDGSAGQdtdEPRAEHEYLHPGDYRV 2105
PLN02468 PLN02468
putative pectinesterase/pectinesterase inhibitor
 72-127 1.57e-04

putative pectinesterase/pectinesterase inhibitor


Pssm-ID: 178087 [Multi-domain]  Cd Length: 565  Bit Score: 44.87  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1491035360  72 VGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVLNK---NVSIEGENRETTILEA 127
Cdd:PLN02468  262 VAKDGSGKYKTISEALKDVPEKSekrtIIYVKKGVYFENVRVEKkkwNVVMVGDGMSKTIVSG 324
PLN02713 PLN02713
Probable pectinesterase/pectinesterase inhibitor
 69-112 2.83e-04

Probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215383 [Multi-domain]  Cd Length: 566  Bit Score: 44.01  E-value: 2.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  69 ILYVGGDGPGNYTKIQDAI---DNASDGD----IIFVKSGVYKENVVLNKN 112
Cdd:PLN02713  251 IVTVNQNGTGNFTTINDAVaaaPNNTDGSngyfVIYVTAGVYEEYVSIPKN 301
PLN02497 PLN02497
probable pectinesterase
 34-126 5.06e-04

probable pectinesterase


Pssm-ID: 178113 [Multi-domain]  Cd Length: 331  Bit Score: 42.56  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  34 MRRKRLLLGLMLAIFICGVLaLVSAtcKAETTDGRILYVGGDGPGNYTKIQDAID----NASDGDIIFVKSGVYKENVVL 109
Cdd:PLN02497    1 MGTHRIIIGLIALCCFCLPH-LIEA--KPFGVYQQQVFVDQSGHGNFTTIQSAIDsvpsNNKHWFCINVKAGLYREKVKI 77

                          90       100
                  ....*....|....*....|
gi 1491035360 110 NKN---VSIEGENRETTILE 126
Cdd:PLN02497   78 PYDkpfIVLVGAGKRRTRIE 97
PLN02506 PLN02506
putative pectinesterase/pectinesterase inhibitor
 72-125 1.07e-03

putative pectinesterase/pectinesterase inhibitor


Pssm-ID: 215280 [Multi-domain]  Cd Length: 537  Bit Score: 42.23  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  72 VGGDGPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVVLNK---NVSIEGENRETTIL 125
Cdd:PLN02506  236 VALDGSGHYRTITEAINEAPNHSnrryIIYVKKGVYKENIDMKKkktNIMLVGDGIGQTVV 296
PLN02995 PLN02995
Probable pectinesterase/pectinesterase inhibitor
 70-176 1.07e-03

Probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 178574 [Multi-domain]  Cd Length: 539  Bit Score: 41.97  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  70 LYVGGDGPGNYTKIQDAIDNA------SDGDIIFVKSGVYKENVVL---NKNVSIEGENRETTILEAASTERRTLELYKV 140
Cdd:PLN02995  225 LVVAKDGSGHFNTVQAAIDVAgrrkvtSGRFVIYVKRGIYQENINVrlnNDDIMLVGDGMRSTIITGGRSVKGGYTTYNS 304

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1491035360 141 SNCKIS-------NITIRGAKGDKSN--LYLSECRNVTIQY-CSIE 176
Cdd:PLN02995  305 ATAGIEglhfiakGITFRNTAGPAKGqaVALRSSSDLSIFYkCSIE 350
PLN02682 PLN02682
pectinesterase family protein
 68-130 2.21e-03

pectinesterase family protein


Pssm-ID: 215367 [Multi-domain]  Cd Length: 369  Bit Score: 40.91  E-value: 2.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  68 RILYVGGD-GPGNYTKIQDAIDNASDGD----IIFVKSGVYKENVV---LNKNVSIEGENRETTILEAAST 130
Cdd:PLN02682   69 YTIVVDKKpAAGDFTTIQAAIDSLPVINlvrvVIKVNAGTYREKVNippLKAYITLEGAGADKTIIQWGDT 139
PLN02313 PLN02313
Pectinesterase/pectinesterase inhibitor
 55-128 2.69e-03

Pectinesterase/pectinesterase inhibitor


Pssm-ID: 177947 [Multi-domain]  Cd Length: 587  Bit Score: 40.84  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491035360  55 LVSATCKAETTdgrilyVGGDGPGNYTKIQDAI----DNASDGDIIFVKSGVYKENVVLNK---NVSIEGENRETTILEA 127
Cdd:PLN02313  268 LQGSTIKADAT------VAADGSGDFTTVAAAVaaapEKSNKRFVIHIKAGVYRENVEVTKkkkNIMFLGDGRGKTIITG 341


                  .
gi 1491035360 128 A 128
Cdd:PLN02313  342 S 342
PLN02745 PLN02745
Putative pectinesterase/pectinesterase inhibitor
 72-125 3.40e-03

Putative pectinesterase/pectinesterase inhibitor


Pssm-ID: 178346 [Multi-domain]  Cd Length: 596  Bit Score: 40.61  E-value: 3.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491035360  72 VGGDGPGNYTKIQDAI----DNASDGDIIFVKSGVYKENVVLNK---NVSIEGENRETTIL 125
Cdd:PLN02745  289 VAKDGSGNFTTISDALaampAKYEGRYVIYVKQGIYDETVTVDKkmvNVTMYGDGSQKTIV 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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