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Conserved domains on  [gi|1478526383|gb|RIO35349|]
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urease accessory protein UreE [Staphylococcus saprophyticus]

Protein Classification

urease accessory protein UreE( domain architecture ID 11486498)

urease accessory protein UreE is involved in urease metallocenter assembly by assisting in the insertion of Ni(2+) ions in the active site of urease

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ureE PRK13261
urease accessory protein UreE; Provisional
 1-150 1.72e-58

urease accessory protein UreE; Provisional


:

Pssm-ID: 237322 [Multi-domain]  Cd Length: 159  Bit Score: 178.60  E-value: 1.72e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSDSekGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:PRK13261    2 MIITQILGNISDLPLA--AGAVETVTLEADERVKRRLRVTTDHGEEIGLRLPRGTVLRDGDVLFLDDGRVIVVRAAPEDV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLG-------IPYEHEDRKVNKAFRHIGHSHD 150
Cdd:PRK13261   80 LVVRPRDPLELARAAYHLGNRHVPLQIEGDELLVPYDHVLEDMLEGLGltvteveAPFEPERGAYGGAFRHHGHSHD 156
 
Name Accession Description Interval E-value
ureE PRK13261
urease accessory protein UreE; Provisional
 1-150 1.72e-58

urease accessory protein UreE; Provisional


Pssm-ID: 237322 [Multi-domain]  Cd Length: 159  Bit Score: 178.60  E-value: 1.72e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSDSekGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:PRK13261    2 MIITQILGNISDLPLA--AGAVETVTLEADERVKRRLRVTTDHGEEIGLRLPRGTVLRDGDVLFLDDGRVIVVRAAPEDV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLG-------IPYEHEDRKVNKAFRHIGHSHD 150
Cdd:PRK13261   80 LVVRPRDPLELARAAYHLGNRHVPLQIEGDELLVPYDHVLEDMLEGLGltvteveAPFEPERGAYGGAFRHHGHSHD 156
UreE cd00571
UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ...
 1-137 7.23e-46

UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-terminal region of UreE contains a histidine rich nickel binding site.


Pssm-ID: 238320 [Multi-domain]  Cd Length: 136  Bit Score: 145.83  E-value: 7.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSdsEKGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:cd00571     1 MIITRILGNIKDIA--LTDGQIDTVVLTWDDRQKRRLRLKSDHGEELGIRLPRGQVLRDGDVLFLDDGRLVVVRAAPEDV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIPYEHEDRK 137
Cdd:cd00571    79 LVITPKDMLELARLAYHLGNRHVPLQIEEDELYIPYDHVLEDMLRKLGVRYERVERP 135
UreE COG2371
Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];
1-130 1.01e-41

Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441938  Cd Length: 126  Bit Score: 134.95  E-value: 1.01e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSDsekgKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:COG2371     1 LRATEILGNGAALAA----AAVDTVTLDYDERQKRRLRLTTDDGREVGLDLPRGTVLRDGDVLVLEDGRLVVVRAAPEPV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIP 130
Cdd:COG2371    77 LVVRAADPLDLARLAYHLGNRHVPLQIEEDRLRIPPDHVLEDMLEGLGLT 126
UreE_N pfam02814
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
 18-71 1.33e-13

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 460708  Cd Length: 62  Bit Score: 61.48  E-value: 1.33e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1478526383  18 KGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMI 71
Cdd:pfam02814   9 DAATADTVVLDWDERQKRRLRLTTDDGREVGLRLPRGTVLRDGDILYADDGRLI 62
UreE_N smart00988
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
 6-71 8.52e-12

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 214958  Cd Length: 65  Bit Score: 56.85  E-value: 8.52e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1478526383    6 IVGNIANLSDSEKGkHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMI 71
Cdd:smart00988   1 MLTLTQRLDKPADA-AADTVTLTADERQKSRLRLTTDDGREVGLFLPRGTVLRDGDVLVADDGRLI 65
 
Name Accession Description Interval E-value
ureE PRK13261
urease accessory protein UreE; Provisional
 1-150 1.72e-58

urease accessory protein UreE; Provisional


Pssm-ID: 237322 [Multi-domain]  Cd Length: 159  Bit Score: 178.60  E-value: 1.72e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSDSekGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:PRK13261    2 MIITQILGNISDLPLA--AGAVETVTLEADERVKRRLRVTTDHGEEIGLRLPRGTVLRDGDVLFLDDGRVIVVRAAPEDV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLG-------IPYEHEDRKVNKAFRHIGHSHD 150
Cdd:PRK13261   80 LVVRPRDPLELARAAYHLGNRHVPLQIEGDELLVPYDHVLEDMLEGLGltvteveAPFEPERGAYGGAFRHHGHSHD 156
UreE cd00571
UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ...
 1-137 7.23e-46

UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-terminal region of UreE contains a histidine rich nickel binding site.


Pssm-ID: 238320 [Multi-domain]  Cd Length: 136  Bit Score: 145.83  E-value: 7.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSdsEKGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:cd00571     1 MIITRILGNIKDIA--LTDGQIDTVVLTWDDRQKRRLRLKSDHGEELGIRLPRGQVLRDGDVLFLDDGRLVVVRAAPEDV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIPYEHEDRK 137
Cdd:cd00571    79 LVITPKDMLELARLAYHLGNRHVPLQIEEDELYIPYDHVLEDMLRKLGVRYERVERP 135
UreE COG2371
Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];
1-130 1.01e-41

Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441938  Cd Length: 126  Bit Score: 134.95  E-value: 1.01e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIANLSDsekgKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDL 80
Cdd:COG2371     1 LRATEILGNGAALAA----AAVDTVTLDYDERQKRRLRLTTDDGREVGLDLPRGTVLRDGDVLVLEDGRLVVVRAAPEPV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1478526383  81 LVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIP 130
Cdd:COG2371    77 LVVRAADPLDLARLAYHLGNRHVPLQIEEDRLRIPPDHVLEDMLEGLGLT 126
PRK14112 PRK14112
urease accessory protein UreE; Provisional
 2-144 6.23e-36

urease accessory protein UreE; Provisional


Pssm-ID: 172602  Cd Length: 149  Bit Score: 121.30  E-value: 6.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   2 IIEEIVGNIANLSDSEKgKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDLL 81
Cdd:PRK14112    3 VFKEILDNIANIKNVES-YQIENIHLTSDDVLKRVIIISSDQNVEYGIRLEEDKKLMDGDILYKDDYKLVVIRLELSDVL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1478526383  82 VIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIPYEHEDRKVNKAFRH 144
Cdd:PRK14112   82 IITAHTIGEMAKIAHNLGNRHMPAQFTETQMIVPYDYLVEEYLQDNKALYERKKIKLKEAFKH 144
UreE_N pfam02814
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
 18-71 1.33e-13

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 460708  Cd Length: 62  Bit Score: 61.48  E-value: 1.33e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1478526383  18 KGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMI 71
Cdd:pfam02814   9 DAATADTVVLDWDERQKRRLRLTTDDGREVGLRLPRGTVLRDGDILYADDGRLI 62
UreE_N smart00988
UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease ...
 6-71 8.52e-12

UreE urease accessory protein, N-terminal domain; UreE is a urease accessory protein. Urease hydrolyses urea into ammonia and carbamic acid.


Pssm-ID: 214958  Cd Length: 65  Bit Score: 56.85  E-value: 8.52e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1478526383    6 IVGNIANLSDSEKGkHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMI 71
Cdd:smart00988   1 MLTLTQRLDKPADA-AADTVTLTADERQKSRLRLTTDDGREVGLFLPRGTVLRDGDVLVADDGRLI 65
UreE_C pfam05194
UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease ...
 78-149 1.23e-11

UreE urease accessory protein, C-terminal domain; UreE is a urease accessory protein. Urease pfam00449 hydrolyses urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.


Pssm-ID: 461580  Cd Length: 86  Bit Score: 56.87  E-value: 1.23e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1478526383  78 EDLLVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIPYEHEDRK---VNKAFRHIGHSH 149
Cdd:pfam05194   1 EPVLEVRAGDPPELARAAYHLGNRHVPLQIGEDRLRIPPDHVLEDMLRGLGATVEPVLAPfepEGGAYGGHGHGH 75
ureE PRK13263
urease accessory protein UreE; Provisional
 37-149 1.08e-07

urease accessory protein UreE; Provisional


Pssm-ID: 237323  Cd Length: 206  Bit Score: 49.02  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383  37 QRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDLLVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQY 116
Cdd:PRK13263   37 LAATLDTGREVAVVLPRGTVLRDGDVLVAEDGALVRVAAAPEAVLRVRAGDPLTLMRAAYHLGNRHTPVEVGADYLKLEY 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1478526383 117 DYLVESLLKDLGI-------PYEHEDRKVNKAFRHiGHSH 149
Cdd:PRK13263  117 DPVLADMLRRLGVtverasaPFEPEAGAYGGGHRH-GHDA 155
PRK14113 PRK14113
urease accessory protein UreE; Provisional
 38-149 7.91e-06

urease accessory protein UreE; Provisional


Pssm-ID: 237614  Cd Length: 152  Bit Score: 42.99  E-value: 7.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383  38 RVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDLLVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYD 117
Cdd:PRK14113   32 KSVTDNGEEIGVFLERGHPLLVGEILKTECGKIIQVKGKAEDVATASAEDWLAFSKACYHLGNRHTKLQIGERWVRFKPD 111

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1478526383 118 YLVESLLKDLGIPYEHED---RKVNKAF--RHIGHSH 149
Cdd:PRK14113  112 HVLEDLAENYGLSVNHEPavfEPESGAYgvRSHGHSH 148
ureE PRK14711
urease accessory protein UreE; Provisional
 1-114 1.19e-04

urease accessory protein UreE; Provisional


Pssm-ID: 173174  Cd Length: 191  Bit Score: 40.40  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIAN--LSDSEKGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILY--KDDKNMIVVDVN 76
Cdd:PRK14711    2 IIIEGIVGNSHDpqWRDRLADAKIDWLVLDQWEAQKSRLRKATSGDVELALSLDRNTHLHDGDILLwnEGDKCAVVARVH 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1478526383  77 SEDLLVIK------------PRTLQEMGdiaHQLGNRHLPAQFTETEMLV 114
Cdd:PRK14711   82 LKEVMVIDlasvigedgnaiVRTVFELG---HALGNQHWPAVVKETKVFV 128
ureE PRK13262
urease accessory protein UreE; Provisional
 1-114 3.78e-03

urease accessory protein UreE; Provisional


Pssm-ID: 183928  Cd Length: 231  Bit Score: 36.21  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1478526383   1 MIIEEIVGNIAN---LSDSEKGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKN--MIVVDV 75
Cdd:PRK13262    2 ILIEHILGNVKKdpvWREKLKDATFDLLILDQREAQKSRCRKSSTQGLDLGISLDRNVVLADGDVLAWDEETnvAVVVQI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1478526383  76 NSEDLLVI-----KPRTLQEM----GDIAHQLGNRHLPAQFTETEMLV 114
Cdd:PRK13262   82 NLRDVMVIdlselKSRSPDELiktcFELGHALGNQHWKAVTKHNEVYV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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