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Conserved domains on  [gi|1472785096|gb|RHV35318|]
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insulinase family protein [Ruminococcus sp. OM05-10BH]

Protein Classification

insulinase family protein( domain architecture ID 11437013)

insulinase family protein (peptidase M16) is a zinc-dependent peptidase that cleaves small peptides close to a terminus, often including bonds on the amino side of basic residues such as arginine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cym1 COG1026
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
1-974 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 1389.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096   1 MDSKKLQ---AYELIQERDLSGIKAKGTLLRHKKSGARIALIENDDDNKVFSIAFRTPPEDSTGLPHILEHSVLCGSKEF 77
Cdd:COG1026     1 MTLKVGKthhGFELLREEYIEELNSTAYLFRHEKTGARLLHLANDDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  78 PAKDPFVELVKGSLNTFLNAMTYPDKTVYPIASCNDQDFQNLMHVYMDAVFYPNIYESDktFRQEGWSYELEDPDGELKY 157
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLI--FAQEGWRYELEEPDSPLTY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 158 NGVVYNEMKGAFSSPDGVLDRMILNSLFPDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDMDMEEKLQ 237
Cdd:COG1026   159 KGVVYNEMKGAMSSPDSVLWRALQKSLFPDTTYGYNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEEHLA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 238 WLDEKYLSRFEKAEIDSEIRLQKPFDEPVEWKRYYSIAANESEEMNTYLSYNKVIGTSLDEKLYLAFSILDYALLSAPGA 317
Cdd:COG1026   239 FLDEEYLSRFERLEVDSEVPDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTDLEESLALQLLSYVLLGNSAS 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 318 PLKKALTDAGIGHDILGSYDNGIYQPTFSVIAKNAEESQKEEFVRVIESTLEKIVKEGIDPDALTAGINYHEFRYREADF 397
Cdd:COG1026   319 PLKKALLDSGLGKDVSGGLEDSLRQPVFSIGLKGSEPEKAEAFEKLILETLEKLVEEGIDKELLEAALNQLEFSLREIDG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 398 GSYPKGLMYGLQMFDSWLYDeESPFLHIEALDTFAFLKEQI-STSYYEDLIQKYLLDNTHASIVMICPKKGLTAEADQKL 476
Cdd:COG1026   399 GSYPYGLQLILRALDSWLYG-GDPLALLRYEPALEKLREKIkDPGYFENLIRKYLLDNPHRVLLTLKPDPGLAERKEAAE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 477 HQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPTPPEILEKIPVLKVSDISEDIAPIYNEEQKAGDVPCICHPIDTNGIG 556
Cdd:COG1026   478 KEKLAAIKASLSEEEKQAIIEQTKALKERQEQEDSPEALATLPKLTLEDIPKEVKEIPLEEEELGGVPVLFHDLFTNGIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 557 YLTLIFDLRTLSEKEIPYAGLLQAVLGIIDTEHYEYGKLFNEINRRTGGIETSLEMYTDVTKVkeKEFRPTFEIKTKAMY 636
Cdd:COG1026   558 YLDLYFDLPALPEELLPYLPLLTDLLGELGTGKYDYLELSNEIAAYTGGISASTSVYTNIDDV--QEYRPYFVVSGKALA 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 637 GQLPFALSMMEEILMRSVLTDEKRIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTNGIEYYETVSRIAD 716
Cdd:COG1026   636 RNLDKLFELLKEILLNTRFDDKKRLRELVAQIKARLEQSLTGSGHSLAMSRASSYFSPAAAYSEQLSGLSYYRFLKDLEE 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 717 HFEEEKDRLMEMLQTISRKVFRKDRMIVSYTGEPESKEPVLQEIEKFSGCLHTEEVEESGFQLTCAKKNEGFQTSSKVQY 796
Cdd:COG1026   716 NLDEKLEELAEKLQELADKLFNRPNLLISVTGEEEELEAFKKALEAFIASLPAGTAAPFKYPFDAEPKNEGWITSSQVNY 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 797 VAMAGNFIDAGAEYHGALQILKVIMGYEYLWQNIRVKGGAYGCMSSFNKL-GEGYFVSYRDPHLKNTLEIYQGVTEYLRN 875
Cdd:COG1026   796 VAKAYNFVPLGHEYAGALLVLAGILRNGYLWNKIRVQGGAYGGGASFDSLsGNFRFYSYRDPNLKETLDVYDEAPDWLRN 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 876 FDVSDRDMTKFIIGTISNMDQPMTPATKGDRSMNLYMNHVTEEMIRKERLEVLRATQQDIRNLADIVEKVLQADQICVIG 955
Cdd:COG1026   876 FDLSERELEKAIIGTISSLDKPLSPAGKGKRAFHRYLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIG 955
                         970
                  ....*....|....*....
gi 1472785096 956 NEDKIEQEKEIFTEVKALF 974
Cdd:COG1026   956 NEEKIEEAKDLFDEIIKLL 974
 
Name Accession Description Interval E-value
Cym1 COG1026
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
1-974 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 1389.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096   1 MDSKKLQ---AYELIQERDLSGIKAKGTLLRHKKSGARIALIENDDDNKVFSIAFRTPPEDSTGLPHILEHSVLCGSKEF 77
Cdd:COG1026     1 MTLKVGKthhGFELLREEYIEELNSTAYLFRHEKTGARLLHLANDDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  78 PAKDPFVELVKGSLNTFLNAMTYPDKTVYPIASCNDQDFQNLMHVYMDAVFYPNIYESDktFRQEGWSYELEDPDGELKY 157
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLI--FAQEGWRYELEEPDSPLTY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 158 NGVVYNEMKGAFSSPDGVLDRMILNSLFPDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDMDMEEKLQ 237
Cdd:COG1026   159 KGVVYNEMKGAMSSPDSVLWRALQKSLFPDTTYGYNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEEHLA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 238 WLDEKYLSRFEKAEIDSEIRLQKPFDEPVEWKRYYSIAANESEEMNTYLSYNKVIGTSLDEKLYLAFSILDYALLSAPGA 317
Cdd:COG1026   239 FLDEEYLSRFERLEVDSEVPDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTDLEESLALQLLSYVLLGNSAS 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 318 PLKKALTDAGIGHDILGSYDNGIYQPTFSVIAKNAEESQKEEFVRVIESTLEKIVKEGIDPDALTAGINYHEFRYREADF 397
Cdd:COG1026   319 PLKKALLDSGLGKDVSGGLEDSLRQPVFSIGLKGSEPEKAEAFEKLILETLEKLVEEGIDKELLEAALNQLEFSLREIDG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 398 GSYPKGLMYGLQMFDSWLYDeESPFLHIEALDTFAFLKEQI-STSYYEDLIQKYLLDNTHASIVMICPKKGLTAEADQKL 476
Cdd:COG1026   399 GSYPYGLQLILRALDSWLYG-GDPLALLRYEPALEKLREKIkDPGYFENLIRKYLLDNPHRVLLTLKPDPGLAERKEAAE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 477 HQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPTPPEILEKIPVLKVSDISEDIAPIYNEEQKAGDVPCICHPIDTNGIG 556
Cdd:COG1026   478 KEKLAAIKASLSEEEKQAIIEQTKALKERQEQEDSPEALATLPKLTLEDIPKEVKEIPLEEEELGGVPVLFHDLFTNGIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 557 YLTLIFDLRTLSEKEIPYAGLLQAVLGIIDTEHYEYGKLFNEINRRTGGIETSLEMYTDVTKVkeKEFRPTFEIKTKAMY 636
Cdd:COG1026   558 YLDLYFDLPALPEELLPYLPLLTDLLGELGTGKYDYLELSNEIAAYTGGISASTSVYTNIDDV--QEYRPYFVVSGKALA 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 637 GQLPFALSMMEEILMRSVLTDEKRIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTNGIEYYETVSRIAD 716
Cdd:COG1026   636 RNLDKLFELLKEILLNTRFDDKKRLRELVAQIKARLEQSLTGSGHSLAMSRASSYFSPAAAYSEQLSGLSYYRFLKDLEE 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 717 HFEEEKDRLMEMLQTISRKVFRKDRMIVSYTGEPESKEPVLQEIEKFSGCLHTEEVEESGFQLTCAKKNEGFQTSSKVQY 796
Cdd:COG1026   716 NLDEKLEELAEKLQELADKLFNRPNLLISVTGEEEELEAFKKALEAFIASLPAGTAAPFKYPFDAEPKNEGWITSSQVNY 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 797 VAMAGNFIDAGAEYHGALQILKVIMGYEYLWQNIRVKGGAYGCMSSFNKL-GEGYFVSYRDPHLKNTLEIYQGVTEYLRN 875
Cdd:COG1026   796 VAKAYNFVPLGHEYAGALLVLAGILRNGYLWNKIRVQGGAYGGGASFDSLsGNFRFYSYRDPNLKETLDVYDEAPDWLRN 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 876 FDVSDRDMTKFIIGTISNMDQPMTPATKGDRSMNLYMNHVTEEMIRKERLEVLRATQQDIRNLADIVEKVLQADQICVIG 955
Cdd:COG1026   876 FDLSERELEKAIIGTISSLDKPLSPAGKGKRAFHRYLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIG 955
                         970
                  ....*....|....*....
gi 1472785096 956 NEDKIEQEKEIFTEVKALF 974
Cdd:COG1026   956 NEEKIEEAKDLFDEIIKLL 974
PTZ00432 PTZ00432
falcilysin; Provisional
8-956 4.76e-156

falcilysin; Provisional


Pssm-ID: 240416 [Multi-domain]  Cd Length: 1119  Bit Score: 489.70  E-value: 4.76e-156
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096    8 AYELIQERDLSGIKAKGTLLRHKKSGAR-IALIENDDDNK--VFSIAFRTPPEDSTGLPHILEHSVLCGSKEFPAKDPFV 84
Cdd:PTZ00432    75 AYEKIEKRYLPDFGMVATVYSHKKTGLQvISLKTNDSSGKemCFDFYVPTPPHNDKGIPHILEHSVLSGSKKYNYKDSFS 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096   85 ELVKGSLNTFLNAMTYPDKTVYPIASCNDQDFQNLMHVYMDAVFYPNIYESDKTFRQEGWSYELEDPDGELK-------- 156
Cdd:PTZ00432   155 LLVQGGFNSFLNAYTFKDRTSYLFASTNEKDFYNTADVYMDSVFQPNILEDKDIFKQEGWHYKVTKLKDDEKnadelgnv 234
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  157 ------YNGVVYNEMKGAFSSPDGVLDRMILNSLFpDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDM 230
Cdd:PTZ00432   235 hdrhvsYSGIVYSEMKKRFSDPLSFGYSVIYQNLF-SNVYKYDSGGDPKDIVELTYEELVEFYKTYYGPKTATVYFYGPN 313
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  231 DMEEKLQWLDeKYLSRFEKAE----------IDSEIRLQKPFDEPVEWKRYYSIAANESEEM-----------NTYLSYN 289
Cdd:PTZ00432   314 DVTERLEFVD-NYLTKHPKTGqlshtayredADENLLYEEYKDKPKHVKKKFSSHSEEEENLmsvswllnpkhNGSKDYD 392
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  290 KVIGTSLDeklYLAFSILDYALLSAPGAPLKKALTDAGIGHDILGS-YDNGIYQPTFSVIAKNAEESQKE-------EFV 361
Cdd:PTZ00432   393 KSLIDPVD---YLALLVLNYLLLGTPESVLYKALIDSGLGKKVVGSgLDDYFKQSIFSIGLKGIKETNEKrkdkvhyTFE 469
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  362 RVIESTLEKIVKEGIDPDALTAGINYHEFRYREADFGSYPKGLMYGLQMfDSWLYDEESPFLHIEALDTFAFLKEQI--S 439
Cdd:PTZ00432   470 KVVLNALTKVVTEGFNKSAVEASLNNIEFVMKELNLGTYPKGLMLIFLM-QSRLQYGKDPFEILRFEKLLNELKLRIdnE 548
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  440 TSYYEDLIQKYLLDNTHASIVMI--CPKKGLTAEADQKLHQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPTPPEILEK 517
Cdd:PTZ00432   549 SKYLEKLIEKHLLNNNHRVTVHLeaVESSKYEKEFNKLVKDELKERLSHLTKEQVDEMEKAYEKFKKEREADDDPEHLDS 628
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  518 IPVLKVSDISEDIAPIYNEEQKA---------------GDVPCICHPIDTNGIGYLTLIFDLRTLSEKEIPYAGLLQAVL 582
Cdd:PTZ00432   629 FPILSLSDLNKETEEIPTKLYKLssdslkenmdldsdgGSVTVLVHPIESRGILYLDFAFSLDSLTVDELKYLNLFKALL 708
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  583 GIIDTEHYEYGKLFNEINRRTGGIETSLEMYT--DVTKVKEKE-FRPTFEIKTKAMYGQLPFALSMMEEILMRSVLTDEK 659
Cdd:PTZ00432   709 KENGTDKLSSEEFTYKREKNLGGLSASTAFYSetNNLTYDDPYnGVGYLNVRAKVLKHKVNEMVDIVLEALKDADFSNSK 788
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  660 RIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTNGIEYY----ETVSRIAdhfeeEKD--RLMEMLQTIS 733
Cdd:PTZ00432   789 KGVEILKRKINGMKTVFSSKGHKFALKRMKSKFSVSDYADELVNGYSQLlflkETLVPLA-----EKDwsKVESKLNEIR 863
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  734 RKVFRKDRMIVSYTGEPESKEPVLQEIEKFSGCLHT---------------EEVEESGFQLTcAKKNEGFQTSSKVQYVA 798
Cdd:PTZ00432   864 NKLLSMKNLTVNVTGDSELLDSLLDDSTTFLKKLSStfkendnkssdkvwvKEVLDKKLMES-VDKNEFIVLPTRVNFVG 942
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  799 MAGNFIDAGAEYHGALQILKVIMGYEYLWQNIRVKGGAYGCMSSFNKLGEGYFVSYRDPHLKNTLEIYQGVTEYLRNF-- 876
Cdd:PTZ00432   943 MGGKLFDKSDKVDGSFQVIVHYLKNSYLWKTVRMSLGAYGVFADLLYTGHVIFMSYADPNFEKTLEVYKEVASALREAae 1022
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  877 DVSDRDMTKFIIGTISNMDQPMTPATKGDRSMNLYMNHVTEEMIRKERLEVLRATQQDIRNLADIVEKVLQADQICVIGN 956
Cdd:PTZ00432  1023 TLTDKDLLRYKIGKISNIDKPLHVDELSKLALLRIIRNESDEDRQKFRKDILETTKEDFYRLADLMEKSKEWEKVIAVVN 1102
M16C_assoc pfam08367
Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to ...
464-714 1.39e-79

Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (pfam05193).


Pssm-ID: 462447 [Multi-domain]  Cd Length: 248  Bit Score: 259.00  E-value: 1.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 464 PKKGLTAEADQKLHQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPtPPEILEKIPVLKVSDISEDIAPIynEEQKAGDV 543
Cdd:pfam08367   3 PDEGLSEELEEEEKERLAAKKASLSEEEKEKIVERTLELKERQEAP-DSEDLSCLPTLTLSDIPREIEVE--PEEEIGGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 544 PCICHPIDTNGIGYLTLIFDLRTLSEKEIPYAGLLQAVLGIIDTEHYEYGKLFNEINRRTGGIETSLEMYTDVTKVKEke 623
Cdd:pfam08367  80 PVLHHDVPTNGIVYFRAIFDLSDLPEELLPYLPLFTSVLTELGTKKYDYEELEQEINLKTGGISASPSVSSDPDDLDK-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 624 FRPTFEIKTKAMYGQLPFALSMMEEILMRSVLTDEKRIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTN 703
Cdd:pfam08367 158 YEPGFVVSGKALDRNVPKMFDLLREILLETKFDDKERLKELVQESKSRLENSIASSGHSYAMSRAASYLSPAGALSEQLS 237
                         250
                  ....*....|.
gi 1472785096 704 GIEYYETVSRI 714
Cdd:pfam08367 238 GLSQYKFLKDL 248
 
Name Accession Description Interval E-value
Cym1 COG1026
Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein ...
1-974 0e+00

Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440649 [Multi-domain]  Cd Length: 974  Bit Score: 1389.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096   1 MDSKKLQ---AYELIQERDLSGIKAKGTLLRHKKSGARIALIENDDDNKVFSIAFRTPPEDSTGLPHILEHSVLCGSKEF 77
Cdd:COG1026     1 MTLKVGKthhGFELLREEYIEELNSTAYLFRHEKTGARLLHLANDDDNKVFSIAFRTPPEDSTGVAHILEHSVLCGSRKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  78 PAKDPFVELVKGSLNTFLNAMTYPDKTVYPIASCNDQDFQNLMHVYMDAVFYPNIYESDktFRQEGWSYELEDPDGELKY 157
Cdd:COG1026    81 PVKDPFFELLKGSLNTFLNAMTYSDKTAYPVASRNEKDFYNLMDVYLDAVFFPNLDPLI--FAQEGWRYELEEPDSPLTY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 158 NGVVYNEMKGAFSSPDGVLDRMILNSLFPDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDMDMEEKLQ 237
Cdd:COG1026   159 KGVVYNEMKGAMSSPDSVLWRALQKSLFPDTTYGYNSGGDPEVIPDLTYEQFLAFHKKYYHPSNAYIYLYGDIDAEEHLA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 238 WLDEKYLSRFEKAEIDSEIRLQKPFDEPVEWKRYYSIAANESEEMNTYLSYNKVIGTSLDEKLYLAFSILDYALLSAPGA 317
Cdd:COG1026   239 FLDEEYLSRFERLEVDSEVPDQKRFSAPREVEETYPVAEEEDTENKTYLSLNWLLGESTDLEESLALQLLSYVLLGNSAS 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 318 PLKKALTDAGIGHDILGSYDNGIYQPTFSVIAKNAEESQKEEFVRVIESTLEKIVKEGIDPDALTAGINYHEFRYREADF 397
Cdd:COG1026   319 PLKKALLDSGLGKDVSGGLEDSLRQPVFSIGLKGSEPEKAEAFEKLILETLEKLVEEGIDKELLEAALNQLEFSLREIDG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 398 GSYPKGLMYGLQMFDSWLYDeESPFLHIEALDTFAFLKEQI-STSYYEDLIQKYLLDNTHASIVMICPKKGLTAEADQKL 476
Cdd:COG1026   399 GSYPYGLQLILRALDSWLYG-GDPLALLRYEPALEKLREKIkDPGYFENLIRKYLLDNPHRVLLTLKPDPGLAERKEAAE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 477 HQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPTPPEILEKIPVLKVSDISEDIAPIYNEEQKAGDVPCICHPIDTNGIG 556
Cdd:COG1026   478 KEKLAAIKASLSEEEKQAIIEQTKALKERQEQEDSPEALATLPKLTLEDIPKEVKEIPLEEEELGGVPVLFHDLFTNGIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 557 YLTLIFDLRTLSEKEIPYAGLLQAVLGIIDTEHYEYGKLFNEINRRTGGIETSLEMYTDVTKVkeKEFRPTFEIKTKAMY 636
Cdd:COG1026   558 YLDLYFDLPALPEELLPYLPLLTDLLGELGTGKYDYLELSNEIAAYTGGISASTSVYTNIDDV--QEYRPYFVVSGKALA 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 637 GQLPFALSMMEEILMRSVLTDEKRIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTNGIEYYETVSRIAD 716
Cdd:COG1026   636 RNLDKLFELLKEILLNTRFDDKKRLRELVAQIKARLEQSLTGSGHSLAMSRASSYFSPAAAYSEQLSGLSYYRFLKDLEE 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 717 HFEEEKDRLMEMLQTISRKVFRKDRMIVSYTGEPESKEPVLQEIEKFSGCLHTEEVEESGFQLTCAKKNEGFQTSSKVQY 796
Cdd:COG1026   716 NLDEKLEELAEKLQELADKLFNRPNLLISVTGEEEELEAFKKALEAFIASLPAGTAAPFKYPFDAEPKNEGWITSSQVNY 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 797 VAMAGNFIDAGAEYHGALQILKVIMGYEYLWQNIRVKGGAYGCMSSFNKL-GEGYFVSYRDPHLKNTLEIYQGVTEYLRN 875
Cdd:COG1026   796 VAKAYNFVPLGHEYAGALLVLAGILRNGYLWNKIRVQGGAYGGGASFDSLsGNFRFYSYRDPNLKETLDVYDEAPDWLRN 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 876 FDVSDRDMTKFIIGTISNMDQPMTPATKGDRSMNLYMNHVTEEMIRKERLEVLRATQQDIRNLADIVEKVLQADQICVIG 955
Cdd:COG1026   876 FDLSERELEKAIIGTISSLDKPLSPAGKGKRAFHRYLSGRTPEDRQKFRDEILSTTLEDLRRVAELYLDVLKEASIAVIG 955
                         970
                  ....*....|....*....
gi 1472785096 956 NEDKIEQEKEIFTEVKALF 974
Cdd:COG1026   956 NEEKIEEAKDLFDEIIKLL 974
PTZ00432 PTZ00432
falcilysin; Provisional
8-956 4.76e-156

falcilysin; Provisional


Pssm-ID: 240416 [Multi-domain]  Cd Length: 1119  Bit Score: 489.70  E-value: 4.76e-156
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096    8 AYELIQERDLSGIKAKGTLLRHKKSGAR-IALIENDDDNK--VFSIAFRTPPEDSTGLPHILEHSVLCGSKEFPAKDPFV 84
Cdd:PTZ00432    75 AYEKIEKRYLPDFGMVATVYSHKKTGLQvISLKTNDSSGKemCFDFYVPTPPHNDKGIPHILEHSVLSGSKKYNYKDSFS 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096   85 ELVKGSLNTFLNAMTYPDKTVYPIASCNDQDFQNLMHVYMDAVFYPNIYESDKTFRQEGWSYELEDPDGELK-------- 156
Cdd:PTZ00432   155 LLVQGGFNSFLNAYTFKDRTSYLFASTNEKDFYNTADVYMDSVFQPNILEDKDIFKQEGWHYKVTKLKDDEKnadelgnv 234
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  157 ------YNGVVYNEMKGAFSSPDGVLDRMILNSLFpDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDM 230
Cdd:PTZ00432   235 hdrhvsYSGIVYSEMKKRFSDPLSFGYSVIYQNLF-SNVYKYDSGGDPKDIVELTYEELVEFYKTYYGPKTATVYFYGPN 313
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  231 DMEEKLQWLDeKYLSRFEKAE----------IDSEIRLQKPFDEPVEWKRYYSIAANESEEM-----------NTYLSYN 289
Cdd:PTZ00432   314 DVTERLEFVD-NYLTKHPKTGqlshtayredADENLLYEEYKDKPKHVKKKFSSHSEEEENLmsvswllnpkhNGSKDYD 392
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  290 KVIGTSLDeklYLAFSILDYALLSAPGAPLKKALTDAGIGHDILGS-YDNGIYQPTFSVIAKNAEESQKE-------EFV 361
Cdd:PTZ00432   393 KSLIDPVD---YLALLVLNYLLLGTPESVLYKALIDSGLGKKVVGSgLDDYFKQSIFSIGLKGIKETNEKrkdkvhyTFE 469
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  362 RVIESTLEKIVKEGIDPDALTAGINYHEFRYREADFGSYPKGLMYGLQMfDSWLYDEESPFLHIEALDTFAFLKEQI--S 439
Cdd:PTZ00432   470 KVVLNALTKVVTEGFNKSAVEASLNNIEFVMKELNLGTYPKGLMLIFLM-QSRLQYGKDPFEILRFEKLLNELKLRIdnE 548
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  440 TSYYEDLIQKYLLDNTHASIVMI--CPKKGLTAEADQKLHQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPTPPEILEK 517
Cdd:PTZ00432   549 SKYLEKLIEKHLLNNNHRVTVHLeaVESSKYEKEFNKLVKDELKERLSHLTKEQVDEMEKAYEKFKKEREADDDPEHLDS 628
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  518 IPVLKVSDISEDIAPIYNEEQKA---------------GDVPCICHPIDTNGIGYLTLIFDLRTLSEKEIPYAGLLQAVL 582
Cdd:PTZ00432   629 FPILSLSDLNKETEEIPTKLYKLssdslkenmdldsdgGSVTVLVHPIESRGILYLDFAFSLDSLTVDELKYLNLFKALL 708
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  583 GIIDTEHYEYGKLFNEINRRTGGIETSLEMYT--DVTKVKEKE-FRPTFEIKTKAMYGQLPFALSMMEEILMRSVLTDEK 659
Cdd:PTZ00432   709 KENGTDKLSSEEFTYKREKNLGGLSASTAFYSetNNLTYDDPYnGVGYLNVRAKVLKHKVNEMVDIVLEALKDADFSNSK 788
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  660 RIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTNGIEYY----ETVSRIAdhfeeEKD--RLMEMLQTIS 733
Cdd:PTZ00432   789 KGVEILKRKINGMKTVFSSKGHKFALKRMKSKFSVSDYADELVNGYSQLlflkETLVPLA-----EKDwsKVESKLNEIR 863
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  734 RKVFRKDRMIVSYTGEPESKEPVLQEIEKFSGCLHT---------------EEVEESGFQLTcAKKNEGFQTSSKVQYVA 798
Cdd:PTZ00432   864 NKLLSMKNLTVNVTGDSELLDSLLDDSTTFLKKLSStfkendnkssdkvwvKEVLDKKLMES-VDKNEFIVLPTRVNFVG 942
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  799 MAGNFIDAGAEYHGALQILKVIMGYEYLWQNIRVKGGAYGCMSSFNKLGEGYFVSYRDPHLKNTLEIYQGVTEYLRNF-- 876
Cdd:PTZ00432   943 MGGKLFDKSDKVDGSFQVIVHYLKNSYLWKTVRMSLGAYGVFADLLYTGHVIFMSYADPNFEKTLEVYKEVASALREAae 1022
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  877 DVSDRDMTKFIIGTISNMDQPMTPATKGDRSMNLYMNHVTEEMIRKERLEVLRATQQDIRNLADIVEKVLQADQICVIGN 956
Cdd:PTZ00432  1023 TLTDKDLLRYKIGKISNIDKPLHVDELSKLALLRIIRNESDEDRQKFRKDILETTKEDFYRLADLMEKSKEWEKVIAVVN 1102
M16C_assoc pfam08367
Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to ...
464-714 1.39e-79

Peptidase M16C associated; This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (pfam05193).


Pssm-ID: 462447 [Multi-domain]  Cd Length: 248  Bit Score: 259.00  E-value: 1.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 464 PKKGLTAEADQKLHQKLQDYKAGLSREEVEKLVQDTKDLRAYQEEPtPPEILEKIPVLKVSDISEDIAPIynEEQKAGDV 543
Cdd:pfam08367   3 PDEGLSEELEEEEKERLAAKKASLSEEEKEKIVERTLELKERQEAP-DSEDLSCLPTLTLSDIPREIEVE--PEEEIGGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 544 PCICHPIDTNGIGYLTLIFDLRTLSEKEIPYAGLLQAVLGIIDTEHYEYGKLFNEINRRTGGIETSLEMYTDVTKVKEke 623
Cdd:pfam08367  80 PVLHHDVPTNGIVYFRAIFDLSDLPEELLPYLPLFTSVLTELGTKKYDYEELEQEINLKTGGISASPSVSSDPDDLDK-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 624 FRPTFEIKTKAMYGQLPFALSMMEEILMRSVLTDEKRIKEILDMLKSRLQMKFLSAGHSSAVLRAMSYSSPLARFKDMTN 703
Cdd:pfam08367 158 YEPGFVVSGKALDRNVPKMFDLLREILLETKFDDKERLKELVQESKSRLENSIASSGHSYAMSRAASYLSPAGALSEQLS 237
                         250
                  ....*....|.
gi 1472785096 704 GIEYYETVSRI 714
Cdd:pfam08367 238 GLSQYKFLKDL 248
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
31-468 1.69e-35

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 140.44  E-value: 1.69e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  31 KSGARIALIENDDDNKV-FSIAFRTP----PEDSTGLPHILEHSVLCGSKEFPAKD--PFVELVKGSLNTFlnamTYPDK 103
Cdd:COG0612    21 PNGLRVILVPDPEAPVVsVRLWVRVGsrdePPGKTGLAHFLEHMLFKGTKKRSAGEiaEELEALGGSLNAF----TSFDY 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 104 TVYpIASCNDQDFQNLMHVYMDAVFYPniyesdkTFRQEgwsyELEdpdgelKYNGVVYNEMKGAFSSPDGVLDRMILNS 183
Cdd:COG0612    97 TVY-YLSVLSEDLELALELLADRLLNP-------TFDEE----ELE------RERGVVLEEIRRYEDDPDGLAFEALLAA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 184 LFPDTSYSNESGGDPDAIPSLTYEDFLNFHRKYYHPSNSYIYLYGDMDMEEKLQWLdEKYLSRFEKAEIDSEIRLQKPFD 263
Cdd:COG0612   159 LYGDHPYGRPIIGTEESIEAITREDLRAFYKRYYRPNNAVLVVVGDVDPEEVLALV-EKYFGDLPAGPAPPRPDPAEPPQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 264 EPvewKRYYSIAANESEEMNTYLSYnkvIGTSLDEKLYLAFSILDYALLSAPGAPL------KKALTDaGIGHDILGSYD 337
Cdd:COG0612   238 TG---PRRVVVDDPDAEQAHILLGY---PGPARDDPDYYALDVLNEILGGGFSSRLfqelreKKGLAY-SVGSSFSPYRD 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 338 NGIYQPTFSVIAKNAEESqkeefVRVIESTLEKIVKEGIDPDALTAGINY----HEFRYREADfgsypkGLMYGLQMFDS 413
Cdd:COG0612   311 AGLFTIYAGTAPDKLEEA-----LAAILEELERLAKEGVTEEELERAKNQllgsLALSLESNS------GLASQLGRYEL 379
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1472785096 414 WLYDEESPFLHIEALDtfAFLKEQIstsyyEDLIQKYlLDNTHASIVMICPKKGL 468
Cdd:COG0612   380 YGGDLDYLEEYLERIE--AVTAEDV-----QAVARKY-LDPDNLVVVVVGPKKKA 426
Peptidase_M16_C pfam05193
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
203-386 8.07e-18

Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.


Pssm-ID: 428362 [Multi-domain]  Cd Length: 181  Bit Score: 82.06  E-value: 8.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 203 SLTYEDFLNFHRKYYHPSNSYIYLYGDMDMEEKLQWLdEKYLSRFEKAEiDSEIRLQKPFDEPVEWKRYYSIAANESeem 282
Cdd:pfam05193   1 SLTREDLRDFYKKHYSPDNMVLVIVGDVDHEELLDLA-EKYFGDLPASP-KGKPRPPPLEPAKLKGREVVVPKKDEP--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096 283 NTYLSYNKVIGTSLDEKLYLAFSILDYALLSAPGAPLKKAL-TDAGIGHDILGSYDNGIYQPTFSVIAKNAEEsQKEEFV 361
Cdd:pfam05193  76 QAHLALAFPGPPLNNDEDSLALDVLNELLGGGMSSRLFQELrEKEGLAYSVSSFNDSYSDSGLFGIYATVDPE-NVDEVI 154
                         170       180
                  ....*....|....*....|....*
gi 1472785096 362 RVIESTLEKIVKEGIDPDALTAGIN 386
Cdd:pfam05193 155 ELILEELEKLAQEGVTEEELERAKN 179
PRK15101 PRK15101
protease3; Provisional
56-106 1.24e-04

protease3; Provisional


Pssm-ID: 185056 [Multi-domain]  Cd Length: 961  Bit Score: 46.12  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1472785096  56 PEDSTGLPHILEHSVLCGSKEFPAKDPFVELVK---GSlntfLNAMTYPDKTVY 106
Cdd:PRK15101   80 PDAQQGLAHYLEHMVLMGSKKYPQPDSLAEFLKkhgGS----HNASTASYRTAF 129
Peptidase_M16 pfam00675
Insulinase (Peptidase family M16);
56-154 1.81e-03

Insulinase (Peptidase family M16);


Pssm-ID: 425812 [Multi-domain]  Cd Length: 149  Bit Score: 39.98  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472785096  56 PEDSTGLPHILEHSVLCGSKEFPAkDPFVELVKgSLNTFLNAMTYPDKTVYpIASCNDQDFQNLMHVYMDAVFYPNIYES 135
Cdd:pfam00675  27 PDNNNGLAHFLEHMAFKGTKKYPS-NELEEELE-KLGGSLNAFTSRENTVY-YAEVLNDDLPKAVDRLADFFRNPLFTES 103
                          90
                  ....*....|....*....
gi 1472785096 136 DKTFRQEGWSYELEDPDGE 154
Cdd:pfam00675 104 EIERERLVVLYEVEAVDSE 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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