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Conserved domains on  [gi|1470072976|gb|RGU96202|]
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transcriptional regulator [Clostridium sp. AF15-17LB]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 1.71e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.34  E-value: 1.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976   6 PECPVEMTLKLIGDKWKVLIIRDLLSGTKRFSELMRSVTGISQKVLTGHLRAMEADGLLTRKVYPEVPPHVEYTLTETGY 85
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90
                  ....*....|....*.
gi 1470072976  86 SLEPILDAMTVWGSRY 101
Cdd:COG1733    88 SLLPVLDALAEWGEEH 103
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 1.71e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.34  E-value: 1.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976   6 PECPVEMTLKLIGDKWKVLIIRDLLSGTKRFSELMRSVTGISQKVLTGHLRAMEADGLLTRKVYPEVPPHVEYTLTETGY 85
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90
                  ....*....|....*.
gi 1470072976  86 SLEPILDAMTVWGSRY 101
Cdd:COG1733    88 SLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 16-101 4.35e-38

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 122.80  E-value: 4.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976  16 LIGDKWKVLIIRDLLSGTKRFSELMRSVTGISQKVLTGHLRAMEADGLLTRKVYPEVPPHVEYTLTETGYSLEPILDAMT 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 1470072976  96 VWGSRY 101
Cdd:pfam01638  81 DWGEEY 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-82 1.55e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 1.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1470072976  14 LKLIGDKWKVLIIRDLLSGTKRFSELMRSVtGISQKVLTGHLRAMEADGLLTRKvypEVPPHVEYTLTE 82
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-83 1.08e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1470072976   25 IIRDLLSGTKRFSELMRSvTGISQKVLTGHLRAMEADGLLTRKvypEVPPHVEYTLTET 83
Cdd:smart00418   2 ILKLLAEGELCVCELAEI-LGLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTDE 56
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
6-101 1.71e-51

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 157.34  E-value: 1.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976   6 PECPVEMTLKLIGDKWKVLIIRDLLSGTKRFSELMRSVTGISQKVLTGHLRAMEADGLLTRKVYPEVPPHVEYTLTETGY 85
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90
                  ....*....|....*.
gi 1470072976  86 SLEPILDAMTVWGSRY 101
Cdd:COG1733    88 SLLPVLDALAEWGEEH 103
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 16-101 4.35e-38

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 122.80  E-value: 4.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976  16 LIGDKWKVLIIRDLLSGTKRFSELMRSVTGISQKVLTGHLRAMEADGLLTRKVYPEVPPHVEYTLTETGYSLEPILDAMT 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*.
gi 1470072976  96 VWGSRY 101
Cdd:pfam01638  81 DWGEEY 86
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-82 1.55e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 1.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1470072976  14 LKLIGDKWKVLIIRDLLSGTKRFSELMRSVtGISQKVLTGHLRAMEADGLLTRKvypEVPPHVEYTLTE 82
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTD 65
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
14-82 5.29e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 36.55  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1470072976  14 LKLIGDKWKVLIIRDLLSGTKRFSELMRSVtGISQKVLTGHLRAMEADGLLT-----------RKVYPEVPPHVEYTLTE 82
Cdd:COG1777    11 LDALGNPTRRRILALLSEEPAYVSELAREL-GVSRQAVYKHLRKLEEAGLVEsyregredgraRKYYRLSAFRLEVTLTP 89
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-66 7.47e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 35.64  E-value: 7.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1470072976   1 MLNDIPECPVEMTLKLIGDKWKVLIIRDLLSGTKRFSELMRsVTGISQKVLTGHLRAMEADGLLTR 66
Cdd:COG0640     1 MSETKELEELAELFKALADPTRLRILRLLAEGELCVGELAE-ALGLSQSTVSHHLKVLREAGLVTS 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-83 1.08e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1470072976   25 IIRDLLSGTKRFSELMRSvTGISQKVLTGHLRAMEADGLLTRKvypEVPPHVEYTLTET 83
Cdd:smart00418   2 ILKLLAEGELCVCELAEI-LGLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 19-64 4.93e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 32.42  E-value: 4.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1470072976  19 DKWKVLIIRDLLSGTKRFSELMRsVTGISQKVLTGHLRAMEADGLL 64
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAE-ELGLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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