|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
9-394 |
2.74e-157 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 448.57 E-value: 2.74e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 9 NPFQLNKRILSVVMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGL 88
Cdd:PRK05122 9 SGLRLTLRIVSIVMFTFISYLTIGLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 89 ACCGASGVFYALAFWFDALPWLSLLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLG 168
Cdd:PRK05122 89 CGCALSGLLYLLAGLLAAWPVLSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 169 VYLNQHWGLAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYADKGW 248
Cdd:PRK05122 169 VLLYHWGGLAGLGLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVLGRVWPYGMGLALASIGFGTIATFITLYYAARGW 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 249 SGAAFSLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAV 328
Cdd:PRK05122 249 DGAALALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAV 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1446899120 329 KQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLLQRGRA 394
Cdd:PRK05122 329 KRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLLYRRAPR 394
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
1-392 |
4.68e-103 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 310.07 E-value: 4.68e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 1 MTAIGAKENPFQLNKRILSVVMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGP 80
Cdd:PRK12382 1 MTAVSQTETRSSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 81 KKVVLFGLACCGASGVFYALAFWFDALPWLSLLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGA 160
Cdd:PRK12382 81 KRSALQGMLACGLAGLAYLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 161 MAAGAPLGVYLNQHWGLAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFIT 240
Cdd:PRK12382 161 LAAGAPLGLLLHSHFGFAALALTTMVLPLLAWAFNGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 241 LYYADKGWSGAAFSLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVF 320
Cdd:PRK12382 241 LYFASKGWAMAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIF 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1446899120 321 PALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLLQRG 392
Cdd:PRK12382 321 PALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRRG 392
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-389 |
1.13e-65 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 213.22 E-value: 1.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 20 VVMFTFVCYLTIGLPLAVLPGFVHnHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYA 99
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 100 LAFwfdalpwlSLLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWGLAG 179
Cdd:cd17489 80 LAT--------SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 180 VAALIALAVALSLLLASGKP-----SVSISAGRRIAFSAVF-GRIWAYGLGLALGTVGFGVIATFITLYYADKGWSGAAF 253
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKdpppvAAEEAEAGTRAFRRLVeKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 254 SLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQ 333
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1446899120 334 QNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLL 389
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-389 |
9.33e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.42 E-value: 9.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 24 TFVCYLTIGLPLAVLPGFVHnHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFW 103
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 104 FdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWGLAG---- 179
Cdd:cd17325 84 Y--------WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRApflv 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 180 -------VAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYADKGWSGAA 252
Cdd:cd17325 156 caalallALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 253 ---FSLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVK 329
Cdd:cd17325 236 qigLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 330 QVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLL 389
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-350 |
3.18e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.03 E-value: 3.18e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 17 ILSVVMFTFVCYLTIGLPLAVLPGFVHnHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGV 96
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 97 FYALAFWFdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWG 176
Cdd:COG2814 91 LCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 177 -----LAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYADK-GWSG 250
Cdd:COG2814 163 wrwvfLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 251 AAFSLTLFSCAFVGI--RLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAV 328
Cdd:COG2814 243 SAAGLLLALFGLGGVlgALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|..
gi 1446899120 329 KQVPQQNQGTALGTYSAFLDLA 350
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLG 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-393 |
7.39e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.80 E-value: 7.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 16 RILSVVMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASG 95
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 96 VFYALAfwfdalpwLSLLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHW 175
Cdd:COG2271 90 LLFGFA--------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 176 GLAGVAALIALavalslllasgkpsvsisagrrIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYAD-KGWS--GAA 252
Cdd:COG2271 162 GWRAAFLILGL----------------------PGLLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSlaQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 253 FSLTLFSCAFVGIRLIFSNSINRHG--GLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQ 330
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1446899120 331 VPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLLQRGR 393
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-353 |
1.25e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.27 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 24 TFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFW 103
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 104 FdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWG------- 176
Cdd:pfam07690 85 L--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwraafli 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 177 ---LAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGL-GLALGTVGFGVIATFITLYYADKGWSGAA 252
Cdd:pfam07690 157 laiLSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLlALLLFGFAFFGLLTYLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 253 FSLTLFSCAFVGIRL-----IFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEA 327
Cdd:pfam07690 237 AGLLLGLGGLLGAIGrlllgRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*.
gi 1446899120 328 VKQVPQQNQGTALGTYSAFLDLALGI 353
Cdd:pfam07690 317 SDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-394 |
9.23e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.70 E-value: 9.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 14 NKRILSVVMFTFVCYLTIGLPLAVLP---GFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLAC 90
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGpliPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 91 CGASGVFYALAFWFdalpwlslLLLCLGRVLLGIGESFASTGSTLWgIGLVGPLHTARVISWNGVATYGAMAAGAPLGVY 170
Cdd:COG0738 83 MALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPY-VAALGPETAASRLNLLHAFFSLGALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 171 L----------NQHWGLAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAV-FGRIWAYGLGLALGTVGFGVIATFI 239
Cdd:COG0738 154 LillglslswhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLkNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 240 TLYYAD-KGWSG--AAFSLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGF 316
Cdd:COG0738 234 PLYLKDvLGLSEatAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1446899120 317 SLVFPALGVEAVKQVPqQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRLLQRGRA 394
Cdd:COG0738 314 SLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-386 |
1.74e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 53 AGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFWFDALPWLSLLLLCLGRVLLGIGESFASTg 132
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 133 stlwgigLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWG-------LAGVAALIALAVALSLLLASGKPSVSISA 205
Cdd:cd17324 115 -------LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwraaflaIAVLALLAALLLWRLLPSLPPKKPGSLGL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 206 GRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYADKGW-SGAAFSLTLFSCAFVGI--RLIFSNSINRHGGLKVT 282
Cdd:cd17324 188 LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGfSSSAIIGLLLLFGVAGVvgSPLAGRLADRGGRRALL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 283 LASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVeAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMM 362
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT-RVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
|
330 340
....*....|....*....|....
gi 1446899120 363 SHMGVPSIYLAAALWVAMGALLTL 386
Cdd:cd17324 347 DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-179 |
5.93e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 13 LNKRILSVVMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCG 92
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 93 ASGVFYALAfwfdalpwLSLLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLN 172
Cdd:cd17325 277 VALLLLPLA--------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
....*..
gi 1446899120 173 QHWGLAG 179
Cdd:cd17325 349 DAFGFAT 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-394 |
7.52e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.65 E-value: 7.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 17 ILSVVMFtFVCYLTIGLpLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGV 96
Cdd:COG2223 8 LLATLAF-FLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 97 FYALAfwfdalPWLSLLLLCLGRVLLGIGESFASTGSTLwgIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWG 176
Cdd:COG2223 86 LLALA------VSYWLLLLLGLLLGIGGGGSFAVGIALV--SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 177 L------AGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFG--RIWAYGLGLALGTVGFGVIATFITLYYADK-G 247
Cdd:COG2223 158 WrnafliLGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRdpRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 248 WSGAAFSLTLFSCAFVGI--RLIFSNSINRHGGLKVTLASFLVEILG-LLLIWQAGDPLLAQAGALLAGAGFSLVFPALG 324
Cdd:COG2223 238 LSAATAGLLAALFALLGAlgRPLGGWLSDRIGGRRVLLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1446899120 325 VEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSI-YLAAALWVAMGALLTLRLLQRGRA 394
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAaFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
24-388 |
1.36e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.79 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 24 TFVCYLTIGLPLAVLPGfVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFW 103
Cdd:cd17474 8 TLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 104 FdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHW-----GLA 178
Cdd:cd17474 87 F--------ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISwrypfFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 179 GVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGL--ALGTVGFGVIATFI-----TLYYADKGWSGA 251
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVsaFLYFFLYFAFLTYLpflleLLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 252 AFSLTLFSCAFVGIRLIfSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQV 331
Cdd:cd17474 239 LFAGWSVLLALGSLFVG-RLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1446899120 332 PQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRL 388
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-386 |
4.88e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 4.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 20 VVMFTFVCYLTIGLPLAVLPGFVHnHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYA 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 100 LAFWFdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQH----- 174
Cdd:cd06174 80 FAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfgw 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 175 ----------WGLAGVAALIALAVALSLLLASGKPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYA 244
Cdd:cd06174 152 ravfliaaalALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 245 DKGWSGAAFS---LTLFSCAFVGIRLIFSNSINRHGGLKVTL-ASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVF 320
Cdd:cd06174 232 DLGGLSVAVAgllLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1446899120 321 PALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHM-GVPSIYLAAALWVAMGALLTL 386
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
230-389 |
8.63e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 8.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 230 VGFGVIATFITLYYADKGwsGAAFSLTLFSCAFVGIRLIFS-----NSINRHGGLKVTLASFLVEILGLLLIWQAGDPLL 304
Cdd:cd17490 209 ITFSTTFGFTPLIAKQLG--ASSFQLGLLSIIYLLPNALASllsgtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 305 AQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFldLALGIT-GP-LAGLMMSHMGVPSIYLAAALWVAMGA 382
Cdd:cd17490 287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI--YALGMFlGPvLVGIISEAFGLQTGFFVIGVIALLAA 364
|
....*..
gi 1446899120 383 LLTLRLL 389
Cdd:cd17490 365 ILSLAYY 371
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
21-94 |
1.54e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.54e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446899120 21 VMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGAS 94
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-394 |
2.22e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 218 IWAYGLGLALGTVGFGVIATFITLYYADKGWSGAAFSL--TLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLL 295
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLvvTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 296 IWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAA 375
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170
....*....|....*....
gi 1446899120 376 LWVAMGALLTLRLLQRGRA 394
Cdd:COG2814 172 VLALLALLLLLRLLPESRP 190
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
218-391 |
2.57e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.95 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 218 IWAYGLGLALGTVGFGVIATFITLYYADKGWSGAAFSLTLFSCAFVGI--RLIFSNSINRHGGLKVTLASFLVEILGLLL 295
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGAllRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 296 IWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAA 375
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170
....*....|....*.
gi 1446899120 376 LWVAMGALLTLRLLQR 391
Cdd:COG2223 167 ILLLVVAVLAWLFLRD 182
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-163 |
3.19e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 3.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 14 NKRILSVVMFTFVCYLTIGLPLAVLPGFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGA 93
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 94 SGVFYALAFWFdalpwlslLLLCLGRVLLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAA 163
Cdd:COG2814 286 GLLLLALAGSL--------WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
216-389 |
4.71e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 216 GRIWAYGLGLALGTVGFGVIATFITLYYADKGWSGAAFSLTLFSCAFVG---IRLIFSNSINRHGGLKVTLASFLVEILG 292
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAgaiGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 293 LLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAG-LMMSHMGVPSIY 371
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGpLVNLTGGLSGAF 356
|
170
....*....|....*...
gi 1446899120 372 LAAALWVAMGALLTLRLL 389
Cdd:cd17473 357 LILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
223-387 |
5.39e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 223 LGLALGTVGFGVIATFITLYYADKGWSGAAFSLTLFSCAFVGI---RLIFSNSINRHGGLKVTLASFLVEILGLLLIWQA 299
Cdd:cd17330 182 VYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGIlaqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 300 GDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVA 379
Cdd:cd17330 262 SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLL 341
|
....*...
gi 1446899120 380 MGALLTLR 387
Cdd:cd17330 342 IALFLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
223-393 |
8.96e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 8.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 223 LGLALGTVGFGVIATFITLYYADKGWSGAA--FSLTLFSCAFVGIRLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAG 300
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQigLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 301 DPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAM 380
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170
....*....|...
gi 1446899120 381 GALLTLRLLQRGR 393
Cdd:cd17325 163 ALVLALLLLPEPR 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-388 |
9.90e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 46 LGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFWFDalpWLSLLLLCLGRVLLGIG 125
Cdd:cd06173 29 LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLG---SLSLWLLLVLAFLLGIA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 126 ESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWGLAGVAALIALAVALSLLLASG-------- 197
Cdd:cd06173 106 SAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFirrpppaa 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 198 -KPSVSISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITL--YYADKGWSGAAFSLTLFSCAF-----VGIRLIF 269
Cdd:cd06173 186 pGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLlpLLAKEVLGGGAAGYGLLLAAFgvgalLGALLLG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 270 SNSINRHGGLKVTLASFLVEILGLLLIWqAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDL 349
Cdd:cd06173 266 RLSKRRRRGRLLLIGALLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSG 344
|
330 340 350
....*....|....*....|....*....|....*....
gi 1446899120 350 ALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTLRL 388
Cdd:cd06173 345 AMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
41-387 |
1.15e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 41 FVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFWFdalpwlslLLLCLGRV 120
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP--------WLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 121 LLGIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQH------WGLAGVAALIALAVALSLLL 194
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYsfrllfLAAAVLFLLAALVLLFLLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 195 ASGKPSVSISAGRRIAFSAVF--GRIWAYGLGLALGTVGFGVIATFITLYYADKGWSGA---AFSLTLFSCAFVGIRLIF 269
Cdd:cd17329 177 TRPKRRAAEKTEILRGYKIVLrdRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsllGLLLALNALLIVLLQFPV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 270 SNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDL 349
Cdd:cd17329 257 ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1446899120 350 AlGITGPLAGLMMSHM---GVPSIYLAAALWVAMGALLTLR 387
Cdd:cd17329 337 G-RAIGPLVGGLLLDLlgpGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-386 |
5.84e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 36 AVLPgFVHNHLGYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYALAFWFdalpwlslLLL 115
Cdd:cd17478 17 ALLP-LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY--------WLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 116 CLGRVLLGIGES-FASTGSTLwgIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWGLAGVAALIALAVALSLLL 194
Cdd:cd17478 88 LLLVALAGIGSAaFHPEGARL--ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 195 ASGKPSVSISAGRRIAFSAVFG---RIWAYGLGLALGTVGFGVIA-----TFITLYYADKGWSGAAFSLTLFSCAFVGI- 265
Cdd:cd17478 166 LLRLRPLKKPEAKKAAAKSSARstlKGVWRALLLLLIIVFLRSWVlssltTFLPFYLVQRGYSLVFAGLLLSLFLFAGAi 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 266 -RLIFSNSINRHGGLKVTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLvFPALGVEAVKQVPqQNQGTALGTYS 344
Cdd:cd17478 246 gTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFAS-FPVTVVLAQELLP-GNVGLASGLMM 323
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1446899120 345 AFLDLALGITGPLAGLMMSHMGVPSIYLAAALWVAMGALLTL 386
Cdd:cd17478 324 GLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
47-376 |
7.59e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 47 GYNSVLAGLIISAQYFATLFSRPHAGRYADQLGPKKVVLFGLACCGASGVFYAL----AFWFdalpwlsllllcLGRVLL 122
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALtdspWVWF------------LLRFVM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 123 GIGESFASTGSTLWGIGLVGPLHTARVISWNGVATYGAMAAGAPLGVYLNQHWGLAGVAALIALAVALSLLLASGKPSVS 202
Cdd:cd17477 95 GIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 203 ISAGRRIAFSAVFGRIWAYGLGLALGTVGFGVIATFITLYYADKGWSGAAFSLTLFSCAFVGIRL-----IFSNSINRHG 277
Cdd:cd17477 175 IEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLqwplgWLADRFDRRR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446899120 278 GLkvTLASFLVEILGLLLIWQAGDPLLAQAGALLAGAGFSLVFPALGVEAVKQVPQQNQGTALGTYSAFLDLALGITGPL 357
Cdd:cd17477 255 VL--LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLL 332
|
330
....*....|....*....
gi 1446899120 358 AGLMMSHMGVPSIYLAAAL 376
Cdd:cd17477 333 AGALMDAFGPHGLFLFLAA 351
|
|
| |
