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Conserved domains on  [gi|1432804881|gb|RCR26372|]
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SOS response-associated peptidase [Escherichia coli]

Protein Classification

SOS response-associated peptidase( domain architecture ID 10013386)

SRAP (SOS response-associated peptidase) family protein similar to Bacillus subtilis putative SOS response-associated peptidases YoaM, YobE, and YoqW

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09951 PRK09951
hypothetical protein; Provisional
1-222 3.00e-171

hypothetical protein; Provisional


:

Pssm-ID: 182162  Cd Length: 222  Bit Score: 469.33  E-value: 3.00e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
Cdd:PRK09951    1 MCGRFAQSQTREDYLAYLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  81 AATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGSTPFERGDEAEGVLIVTAAADQGLVDIH 160
Cdd:PRK09951   81 AATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPYFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIH 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1432804881 161 DRRPLVLSPETAREWMRQDIGGKEASEIATRSCVPANQFIWHPVSRAVGNVKNQGAELIQPV 222
Cdd:PRK09951  161 DRRPLVLSPEAAREWMRQEISGKEASEIATSGCVPANQFTWHPVSRAVGNVKNQGAELIQPV 222
 
Name Accession Description Interval E-value
PRK09951 PRK09951
hypothetical protein; Provisional
1-222 3.00e-171

hypothetical protein; Provisional


Pssm-ID: 182162  Cd Length: 222  Bit Score: 469.33  E-value: 3.00e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
Cdd:PRK09951    1 MCGRFAQSQTREDYLAYLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  81 AATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGSTPFERGDEAEGVLIVTAAADQGLVDIH 160
Cdd:PRK09951   81 AATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPYFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIH 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1432804881 161 DRRPLVLSPETAREWMRQDIGGKEASEIATRSCVPANQFIWHPVSRAVGNVKNQGAELIQPV 222
Cdd:PRK09951  161 DRRPLVLSPEAAREWMRQEISGKEASEIATSGCVPANQFTWHPVSRAVGNVKNQGAELIQPV 222
SRAP COG2135
ssDNA abasic site-binding protein YedK/HMCES, SRAP family [Replication, recombination and ...
1-222 3.42e-78

ssDNA abasic site-binding protein YedK/HMCES, SRAP family [Replication, recombination and repair];


Pssm-ID: 441738  Cd Length: 222  Bit Score: 233.99  E-value: 3.42e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLaeDIERDIPYDPEPigRYNVAPGTKVLLLSERDE-HLHLDPVFWGYAPGWW----DKPPLIN 75
Cdd:COG2135     1 MCGRYALTATPEELAERF--GAEDAPGGDLEP--RYNIAPTQPVPVVRETDDgPRELRLARWGLVPSWAkdpkKGPRLIN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  76 ARVETAATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGST-PFERGDEAEGVLIVTAAADQ 154
Cdd:COG2135    77 ARAETVAEKPSFRAAFRRRRCLIPADGFYEWRKEGGKKQPYYIHRKDGEPFAFAGLWERwRDPDGEWLLTFTILTTEANG 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1432804881 155 GLVDIHDRRPLVLSPETAREWMRQDIGGKEASEIATRscVPANQFIWHPVSRAVGNVKNQGAELIQPV 222
Cdd:COG2135   157 LMAPIHDRMPVILPPEDWDAWLDPDLTDEELLALLRP--YPAEELEAYPVSRAVNSPRNDGPELIEPV 222
SRAP pfam02586
SOS response associated peptidase (SRAP); The SRAP family functions as a DNA-associated ...
1-211 3.71e-72

SOS response associated peptidase (SRAP); The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.


Pssm-ID: 460605  Cd Length: 213  Bit Score: 218.16  E-value: 3.71e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLAEDIERDIPYDPepigRYNVAPGTKVLLLSERDEH--LHLDPVFWGYAPGWWDKPP----LI 74
Cdd:pfam02586   1 MCGRYALTLDPEELAERFGAAEDEEDDYRP----RYNVAPTQPVPVVRARDPGgdRVLRLMRWGLVPSWAKDPKigprTI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  75 NARVETAATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGST-PFERGDEAEGVLIVTAAAD 153
Cdd:pfam02586  77 NARSETLAEKPSFRSAFRRRRCLVPADGFYEWKKGGKGKQPYYIHRKDGRPLAFAGLWEVwRDPDGEPLYTFTIITTEAN 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881 154 QGLVDIHDRRPLVLSPETAREWMrqDIGGKEASEIAT--RSCvPANQFIWHPVSRAVGNV 211
Cdd:pfam02586 157 GLLAPIHDRMPVILDPEDWDAWL--DPRTTDPDELLEllRPY-PGEELEAYPVSTAVNNV 213
 
Name Accession Description Interval E-value
PRK09951 PRK09951
hypothetical protein; Provisional
1-222 3.00e-171

hypothetical protein; Provisional


Pssm-ID: 182162  Cd Length: 222  Bit Score: 469.33  E-value: 3.00e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
Cdd:PRK09951    1 MCGRFAQSQTREDYLAYLAEDIERDIPYDPEPIGRYNVAPGTKVLLLSERDEHLHLDPVFWGYAPGWWDKPPLINARVET 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  81 AATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGSTPFERGDEAEGVLIVTAAADQGLVDIH 160
Cdd:PRK09951   81 AATSRMFKPLWQHGRAICFADGWFEWKKEGDKKQPYFIYRADGQPIFMAAIGSTPFERGDEAEGFLIVTAAADQGLVDIH 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1432804881 161 DRRPLVLSPETAREWMRQDIGGKEASEIATRSCVPANQFIWHPVSRAVGNVKNQGAELIQPV 222
Cdd:PRK09951  161 DRRPLVLSPEAAREWMRQEISGKEASEIATSGCVPANQFTWHPVSRAVGNVKNQGAELIQPV 222
SRAP COG2135
ssDNA abasic site-binding protein YedK/HMCES, SRAP family [Replication, recombination and ...
1-222 3.42e-78

ssDNA abasic site-binding protein YedK/HMCES, SRAP family [Replication, recombination and repair];


Pssm-ID: 441738  Cd Length: 222  Bit Score: 233.99  E-value: 3.42e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLaeDIERDIPYDPEPigRYNVAPGTKVLLLSERDE-HLHLDPVFWGYAPGWW----DKPPLIN 75
Cdd:COG2135     1 MCGRYALTATPEELAERF--GAEDAPGGDLEP--RYNIAPTQPVPVVRETDDgPRELRLARWGLVPSWAkdpkKGPRLIN 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  76 ARVETAATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGST-PFERGDEAEGVLIVTAAADQ 154
Cdd:COG2135    77 ARAETVAEKPSFRAAFRRRRCLIPADGFYEWRKEGGKKQPYYIHRKDGEPFAFAGLWERwRDPDGEWLLTFTILTTEANG 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1432804881 155 GLVDIHDRRPLVLSPETAREWMRQDIGGKEASEIATRscVPANQFIWHPVSRAVGNVKNQGAELIQPV 222
Cdd:COG2135   157 LMAPIHDRMPVILPPEDWDAWLDPDLTDEELLALLRP--YPAEELEAYPVSRAVNSPRNDGPELIEPV 222
SRAP pfam02586
SOS response associated peptidase (SRAP); The SRAP family functions as a DNA-associated ...
1-211 3.71e-72

SOS response associated peptidase (SRAP); The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.


Pssm-ID: 460605  Cd Length: 213  Bit Score: 218.16  E-value: 3.71e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881   1 MCGRFAQSQTREDYLAFLAEDIERDIPYDPepigRYNVAPGTKVLLLSERDEH--LHLDPVFWGYAPGWWDKPP----LI 74
Cdd:pfam02586   1 MCGRYALTLDPEELAERFGAAEDEEDDYRP----RYNVAPTQPVPVVRARDPGgdRVLRLMRWGLVPSWAKDPKigprTI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881  75 NARVETAATSRMFKPLWQHGRVICFADGWFEWKKEGDKKQPYFIYRADGQPVFIAAIGST-PFERGDEAEGVLIVTAAAD 153
Cdd:pfam02586  77 NARSETLAEKPSFRSAFRRRRCLVPADGFYEWKKGGKGKQPYYIHRKDGRPLAFAGLWEVwRDPDGEPLYTFTIITTEAN 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432804881 154 QGLVDIHDRRPLVLSPETAREWMrqDIGGKEASEIAT--RSCvPANQFIWHPVSRAVGNV 211
Cdd:pfam02586 157 GLLAPIHDRMPVILDPEDWDAWL--DPRTTDPDELLEllRPY-PGEELEAYPVSTAVNNV 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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