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Conserved domains on  [gi|1432775818|gb|RCQ98183|]
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HNH endonuclease [Escherichia coli]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
5-85 9.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 9.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432775818   5 KKQREKLRMKFGGRCAYCGCELPEKGWHADHVQAvlrkseqcmkaaekrifrlKSTGDvfrpeADCPENLVPACAPCNLL 84
Cdd:COG1403     8 PALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIP-------------------RSRGG-----TDTWENLVLLCRRCNRR 63


                  .
gi 1432775818  85 K 85
Cdd:COG1403    64 K 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
5-85 9.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 9.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432775818   5 KKQREKLRMKFGGRCAYCGCELPEKGWHADHVQAvlrkseqcmkaaekrifrlKSTGDvfrpeADCPENLVPACAPCNLL 84
Cdd:COG1403     8 PALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIP-------------------RSRGG-----TDTWENLVLLCRRCNRR 63


                  .
gi 1432775818  85 K 85
Cdd:COG1403    64 K 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 5-86 3.74e-07

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432775818   5 KKQREKLRmKFGGRCAYCGCELPEKGWHADHVQAvlrkseqcmkaaekrifrLKSTGdvfrpeADCPENLVPACAPCNLL 84
Cdd:cd00085     1 RSHRLVLL-ARDGLCPYCGKPGGTEGLEVDHIIP------------------LSDGG------NNDLDNLVLLCRKCHRK 55


                  ..
gi 1432775818  85 KT 86
Cdd:cd00085    56 KH 57
TIGR02646 TIGR02646
TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively ...
 8-37 5.94e-04

TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively in bacteria. Neighboring genes in various genomes are also uncharacterized or may annotated as similar to restriction system proteins. [Hypothetical proteins, Conserved]


Pssm-ID: 131694 [Multi-domain]  Cd Length: 144  Bit Score: 37.49  E-value: 5.94e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1432775818   8 REKLRMKFGGRCAYCGCELPEKGWHADHVQ 37
Cdd:TIGR02646  16 HNQLLQLQGGLCAYCEREIELLGSHIEHFR 45
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
5-85 9.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 9.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432775818   5 KKQREKLRMKFGGRCAYCGCELPEKGWHADHVQAvlrkseqcmkaaekrifrlKSTGDvfrpeADCPENLVPACAPCNLL 84
Cdd:COG1403     8 PALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIP-------------------RSRGG-----TDTWENLVLLCRRCNRR 63


                  .
gi 1432775818  85 K 85
Cdd:COG1403    64 K 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 5-86 3.74e-07

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432775818   5 KKQREKLRmKFGGRCAYCGCELPEKGWHADHVQAvlrkseqcmkaaekrifrLKSTGdvfrpeADCPENLVPACAPCNLL 84
Cdd:cd00085     1 RSHRLVLL-ARDGLCPYCGKPGGTEGLEVDHIIP------------------LSDGG------NNDLDNLVLLCRKCHRK 55


                  ..
gi 1432775818  85 KT 86
Cdd:cd00085    56 KH 57
TIGR02646 TIGR02646
TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively ...
 8-37 5.94e-04

TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively in bacteria. Neighboring genes in various genomes are also uncharacterized or may annotated as similar to restriction system proteins. [Hypothetical proteins, Conserved]


Pssm-ID: 131694 [Multi-domain]  Cd Length: 144  Bit Score: 37.49  E-value: 5.94e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1432775818   8 REKLRMKFGGRCAYCGCELPEKGWHADHVQ 37
Cdd:TIGR02646  16 HNQLLQLQGGLCAYCEREIELLGSHIEHFR 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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