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Conserved domains on  [gi|2051290061|gb|QWO80166|]
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GNAT family N-acetyltransferase [Synechocystis sp. PCC 6803]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10024320)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

EC:  2.3.1.-
Gene Ontology:  GO:0016746

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MSMEG_0567_GNAT TIGR04045
putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family ...
 5-156 1.15e-102

putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family belong to the GNAT family (pfam00583), in which numerous characterized examples, though not all, are are shown to be N-acetyltransferases or to interact with acetyl-CoA. This family occurs in a sparsely distributed biosynthetic cluster that occurs in Actinobacteria, Cyanobacteria, and Proteobacteria.


:

Pssm-ID: 274941 [Multi-domain]  Cd Length: 153  Bit Score: 291.13  E-value: 1.15e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061   5 RFQFELAESAAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETPGKPTVVGAVRIYENEPNVWYGGRLGV 84
Cdd:TIGR04045   1 EFRVKLAESPWERRGYYALRRAVFCEEQGIFAGDDRDEIDAHAYPIVALSTEGGAPDRVVGTVRIHEEEPGLWYGGRLAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2051290061  85 HQNYRRVGRIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEIEICDRPHHLMEADLDFYPP 156
Cdd:TIGR04045  81 HAAFRRQGRIGKGLIRLAVSTAHALGCRRFLATVQSQNVPFFRRLHWQSLDELEIHGRPHHLMEADLAHYPP 152
 
Name Accession Description Interval E-value
MSMEG_0567_GNAT TIGR04045
putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family ...
 5-156 1.15e-102

putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family belong to the GNAT family (pfam00583), in which numerous characterized examples, though not all, are are shown to be N-acetyltransferases or to interact with acetyl-CoA. This family occurs in a sparsely distributed biosynthetic cluster that occurs in Actinobacteria, Cyanobacteria, and Proteobacteria.


Pssm-ID: 274941 [Multi-domain]  Cd Length: 153  Bit Score: 291.13  E-value: 1.15e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061   5 RFQFELAESAAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETPGKPTVVGAVRIYENEPNVWYGGRLGV 84
Cdd:TIGR04045   1 EFRVKLAESPWERRGYYALRRAVFCEEQGIFAGDDRDEIDAHAYPIVALSTEGGAPDRVVGTVRIHEEEPGLWYGGRLAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2051290061  85 HQNYRRVGRIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEIEICDRPHHLMEADLDFYPP 156
Cdd:TIGR04045  81 HAAFRRQGRIGKGLIRLAVSTAHALGCRRFLATVQSQNVPFFRRLHWQSLDELEIHGRPHHLMEADLAHYPP 152
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
14-152 7.32e-21

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 82.92  E-value: 7.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  14 AAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETPgkptvVGAVRIYENEPNVWYGGRLGVHQNYRRVGr 93
Cdd:COG2153     1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGEL-----VATARLLPPGDGEAKIGRVAVLPEYRGQG- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  94 IGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEI-EICDRPHHLMEADLD 152
Cdd:COG2153    75 LGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEfLEAGIPHIDMRKPLS 134
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 62-131 1.20e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 47.90  E-value: 1.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2051290061  62 TVVGAVRIYEN--EPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQN---VRFFQRQHW 131
Cdd:pfam00583  43 ELVGFASLSIIddEPPVGEIEGLAVAPEYRGKG-IGTALLQALLEWARERGCERIFLEVAADNlaaIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 62-117 2.34e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2051290061  62 TVVGAVRIY--ENEPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFAT 117
Cdd:cd04301     9 EIVGFASLSpdGSGGDTAYIGDLAVLPEYRGKG-IGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
MSMEG_0567_GNAT TIGR04045
putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family ...
 5-156 1.15e-102

putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Members of this family belong to the GNAT family (pfam00583), in which numerous characterized examples, though not all, are are shown to be N-acetyltransferases or to interact with acetyl-CoA. This family occurs in a sparsely distributed biosynthetic cluster that occurs in Actinobacteria, Cyanobacteria, and Proteobacteria.


Pssm-ID: 274941 [Multi-domain]  Cd Length: 153  Bit Score: 291.13  E-value: 1.15e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061   5 RFQFELAESAAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETPGKPTVVGAVRIYENEPNVWYGGRLGV 84
Cdd:TIGR04045   1 EFRVKLAESPWERRGYYALRRAVFCEEQGIFAGDDRDEIDAHAYPIVALSTEGGAPDRVVGTVRIHEEEPGLWYGGRLAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2051290061  85 HQNYRRVGRIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEIEICDRPHHLMEADLDFYPP 156
Cdd:TIGR04045  81 HAAFRRQGRIGKGLIRLAVSTAHALGCRRFLATVQSQNVPFFRRLHWQSLDELEIHGRPHHLMEADLAHYPP 152
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
14-152 7.32e-21

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 82.92  E-value: 7.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  14 AAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETPgkptvVGAVRIYENEPNVWYGGRLGVHQNYRRVGr 93
Cdd:COG2153     1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGEL-----VATARLLPPGDGEAKIGRVAVLPEYRGQG- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  94 IGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEI-EICDRPHHLMEADLD 152
Cdd:COG2153    75 LGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEfLEAGIPHIDMRKPLS 134
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
11-151 1.64e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 50.85  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  11 AESAAEIQGYFALRRAIFCEEQGIFAGHDFDETDQFAYPIVALDTETpgkptVVGAVRIY----ENEPNVWYGGRLGVHQ 86
Cdd:COG3153     3 PATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGLSLVAEDDGE-----IVGHVALSpvdiDGEGPALLLGPLAVDP 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2051290061  87 NYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWHSLQEIEICDRP-HHLMEADL 151
Cdd:COG3153    78 EYRGQG-IGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPdEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 62-131 1.20e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 47.90  E-value: 1.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2051290061  62 TVVGAVRIYEN--EPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQN---VRFFQRQHW 131
Cdd:pfam00583  43 ELVGFASLSIIddEPPVGEIEGLAVAPEYRGKG-IGTALLQALLEWARERGCERIFLEVAADNlaaIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 63-146 2.02e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 42.29  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  63 VVGAVRIYENEPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQHWhslQEIEICDR 142
Cdd:COG1246    39 IVGCAALHPLDEDLAELRSLAVHPDYRGRG-IGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGF---EEIDKEDL 114


                  ....
gi 2051290061 143 PHHL 146
Cdd:COG1246   115 PYAK 118
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 62-117 2.34e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2051290061  62 TVVGAVRIY--ENEPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFAT 117
Cdd:cd04301     9 EIVGFASLSpdGSGGDTAYIGDLAVLPEYRGKG-IGSALLEAAEEEARERGAKRLRLE 65
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 63-129 3.38e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 37.82  E-value: 3.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2051290061  63 VVGAVRIY-ENEPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQNVRFFQRQ 129
Cdd:pfam13508  14 IVGFAALLpLDDEGALAELRLAVHPEYRGQG-IGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 70-152 1.99e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 35.79  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2051290061  70 YENEPNVWYGGRLGVHQNYRRVGrIGKGLIYKAVTAAHGWGCTKFFATVQLQN---VRFFQRQHWHSLQEIEICDRPHHL 146
Cdd:COG0456     7 LVDGGDEAEIEDLAVDPEYRGRG-IGRALLEAALERARERGARRLRLEVREDNeaaIALYEKLGFEEVGERPNYYGDDAL 85


                  ....*..
gi 2051290061 147 -MEADLD 152
Cdd:COG0456    86 vMEKELA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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