NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2035791155|gb|QVE47253|]
View 

NADH dehydrogenase subunit 6 (mitochondrion) [Megaloceros sp. Ari79]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.12e-89

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 259.35  E-value: 1.12e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   1 MMTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  81 EIWVSNKTVLGAFVTGLLMELMMVYYVLKDEEVEIV****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2035791155 161 LLIG*VVIMEI*RGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.12e-89

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 259.35  E-value: 1.12e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   1 MMTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  81 EIWVSNKTVLGAFVTGLLMELMMVYYVLKDEEVEIV****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2035791155 161 LLIG*VVIMEI*RGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 2.78e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 60.98  E-value: 2.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  18 VGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPEIWVSNKTVLGAFVTGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2035791155  98 LMELMMVYYVLKDEEVEIV****glgdwviyDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIG*VVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAA------------AAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 1.12e-89

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 259.35  E-value: 1.12e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   1 MMTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  81 EIWVSNKTVLGAFVTGLLMELMMVYYVLKDEEVEIV****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2035791155 161 LLIG*VVIMEI*RGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-174 4.76e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 112.93  E-value: 4.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   2 MTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPE 81
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  82 IWVSnktvlgafvtGLLMELMMVYYVLKDEEVEIV****GLGDWVI-YDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00138   81 SWGS----------WSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVvDELKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                         170
                  ....*....|....
gi 2035791155 161 LLIG*VVIMEI*RG 174
Cdd:MTH00138  151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-174 1.96e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 101.08  E-value: 1.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   2 MTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPE 81
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  82 IWvSNKTVLGaFVTGLLMELMMVYYVlkdeeveiV****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00065   81 AW-GSWSVLV-YVLFYLLLLIVGYIL--------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 2035791155 162 LIG*VVIMEI*RG 174
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-174 1.17e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 91.35  E-value: 1.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   2 MTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPE 81
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  82 IWVSNKTVLGAFVTGLLMELMMVYYVlkdeeveiV****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVG--------GLWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|...
gi 2035791155 162 LIG*VVIMEI*RG 174
Cdd:MTH00115  153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-174 8.11e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 68.09  E-value: 8.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   2 MTYIVFILSILFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPE 81
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  82 IWVSNKTVLGAFVTGLLMELMMVYYvlkdeeveiv****GLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYF--------------YGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|...
gi 2035791155 162 LIG*VVIMEI*RG 174
Cdd:MTH00214  147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 2.78e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 60.98  E-value: 2.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  18 VGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYPEIWVSNKTVLGAFVTGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2035791155  98 LMELMMVYYVLKDEEVEIV****glgdwviyDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIG*VVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAA------------AAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-175 1.21e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 56.84  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155   1 MMTYIVFILsILFVLGFVGFSSkpSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLG*MMVVFGYTTAM*TEQYP 80
Cdd:MTH00045    1 MVFYLFLIL-MLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035791155  81 EIWVSNKTVLGAFVTGLLmelmmvyyvlkdeeveIV****GLGDWVIYDTGDSGFFSEeaMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00045   78 SVSNLGEVLVLSLLLSLW----------------VFISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGGFI 139

                         170
                  ....*....|....*
gi 2035791155 161 LLIG*VVIMEI*RGN 175
Cdd:MTH00045  140 LLVALVVALVISFGH 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH