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Conserved domains on  [gi|1955179186|gb|QQO64396|]
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glycosyltransferase family 2 protein [Providencia manganoxydans]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-177 9.05e-14

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd04186:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 166  Bit Score: 66.43  E-value: 9.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186   5 PNFHWIDDNYHCGFGHNNNIIynycynqLNMKTDDYFIILNPDVIIDYNVITHLIDNMLKNHDlIATVnlfkdidnhiyd 84
Cdd:cd04186    49 PEVRLIRNGENLGFGAGNNQG-------IREAKGDYVLLLNPDTVVEPGALLELLDAAEQDPD-VGIV------------ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186  85 nsirkfpslsdfiksflgfnnpsvvdkslltEPCsidwAAGSFLVIKASHYSNLKGFDENYFMYCEDIDICYRSALLNIP 164
Cdd:cd04186   109 -------------------------------GPK----VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYR 153

                         170
                  ....*....|...
gi 1955179186 165 VKYYPNFHALHLA 177
Cdd:cd04186   154 VLYVPQAVIYHHG 166
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-177 9.05e-14

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 66.43  E-value: 9.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186   5 PNFHWIDDNYHCGFGHNNNIIynycynqLNMKTDDYFIILNPDVIIDYNVITHLIDNMLKNHDlIATVnlfkdidnhiyd 84
Cdd:cd04186    49 PEVRLIRNGENLGFGAGNNQG-------IREAKGDYVLLLNPDTVVEPGALLELLDAAEQDPD-VGIV------------ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186  85 nsirkfpslsdfiksflgfnnpsvvdkslltEPCsidwAAGSFLVIKASHYSNLKGFDENYFMYCEDIDICYRSALLNIP 164
Cdd:cd04186   109 -------------------------------GPK----VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYR 153

                         170
                  ....*....|...
gi 1955179186 165 VKYYPNFHALHLA 177
Cdd:cd04186   154 VLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
3-197 6.14e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 62.32  E-value: 6.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186   3 DNPNFHWIDDNYHCGFGHNNNIIYNYCynqlnmkTDDYFIILNPDVIIDYNVITHLIDNmlknhdliatvnlfkdidnhi 82
Cdd:COG1216    54 AFPRVRVIRNPENLGFAAARNLGLRAA-------GGDYLLFLDDDTVVEPDWLERLLAA--------------------- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186  83 ydnsirkfpslsdfiksflgfnnpsvvdkslltepcsidwaagSFLVIKASHYSNLKGFDENYFMYCEDIDICYRSALLN 162
Cdd:COG1216   106 -------------------------------------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAG 142

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1955179186 163 IPVKYYPNFHALHLAkHANRNFLSKHFYWHISSVL 197
Cdd:COG1216   143 YRIVYVPDAVVYHLG-GASSGPLLRAYYLGRNRLL 176
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-177 9.05e-14

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 66.43  E-value: 9.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186   5 PNFHWIDDNYHCGFGHNNNIIynycynqLNMKTDDYFIILNPDVIIDYNVITHLIDNMLKNHDlIATVnlfkdidnhiyd 84
Cdd:cd04186    49 PEVRLIRNGENLGFGAGNNQG-------IREAKGDYVLLLNPDTVVEPGALLELLDAAEQDPD-VGIV------------ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186  85 nsirkfpslsdfiksflgfnnpsvvdkslltEPCsidwAAGSFLVIKASHYSNLKGFDENYFMYCEDIDICYRSALLNIP 164
Cdd:cd04186   109 -------------------------------GPK----VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYR 153

                         170
                  ....*....|...
gi 1955179186 165 VKYYPNFHALHLA 177
Cdd:cd04186   154 VLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
3-197 6.14e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 62.32  E-value: 6.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186   3 DNPNFHWIDDNYHCGFGHNNNIIYNYCynqlnmkTDDYFIILNPDVIIDYNVITHLIDNmlknhdliatvnlfkdidnhi 82
Cdd:COG1216    54 AFPRVRVIRNPENLGFAAARNLGLRAA-------GGDYLLFLDDDTVVEPDWLERLLAA--------------------- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955179186  83 ydnsirkfpslsdfiksflgfnnpsvvdkslltepcsidwaagSFLVIKASHYSNLKGFDENYFMYCEDIDICYRSALLN 162
Cdd:COG1216   106 -------------------------------------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAG 142

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1955179186 163 IPVKYYPNFHALHLAkHANRNFLSKHFYWHISSVL 197
Cdd:COG1216   143 YRIVYVPDAVVYHLG-GASSGPLLRAYYLGRNRLL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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