|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1353.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 15 DYHALNAMLNLYDSAGRIQFDKDRQAVDAFIATHVRPNSVTFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFTHAHT 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 95 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADVAISQHYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 335 VADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASEYDENLDYTRTGHDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 415 CNLGSLNIAHTMDSPDFARTVETAVRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 495 NLYFYAITWHALRTSMLLARERGETFAGFKQSRYASGEYFSQYLQGNWQPKTAKVGELFtrSGITLPTREMWAQLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 655 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
67-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 756.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 67 VNEGYYDESVLNrysrDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKrYLEDFADRVTMVALTLAQGD----- 141
Cdd:COG0209 20 VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 142 ETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAK 301
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 302 ENAQMALFSPYDVERVYGKPFADvaISQHYDELVADERIRKKyLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPI--A 379
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 380 GRINMSNLCSEILQVNSASEydenldytrtghDISCNLGSLNIAHTM-----DSPDFARTVETAVRGLTAVSDMSHIrSV 454
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYESE------------DASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 455 PSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYF 534
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 535 -SQYLqgnwqpktakvgelftrSGITLPTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRK 613
Cdd:COG0209 477 fDKYL-----------------DDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRK 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 614 EGKTGRVYYPAPFM------------------------------TNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSL 663
Cdd:COG0209 540 VLDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISK 619
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1929625749 664 TLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTE 705
Cdd:COG0209 620 TLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
128-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 614.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 128 DRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 207
Cdd:cd01679 3 DRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGGGI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 208 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 287
Cdd:cd01679 82 GLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARDLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 288 LGVVIPDITFHLAKenaqmalfspydvervygkpfadvaisqhydelvaderirkkylnaRDFFQRLAEIQFESGYPYIM 367
Cdd:cd01679 162 YGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 368 YEDTVNRANP--IAGRINMSNLCSEILQVNSASEydenldyTRTGHDISCNLGSLNIAHTMDSPDFARTVETAVRGLTAV 445
Cdd:cd01679 196 FKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALDNV 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 446 SDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGetfagfkq 525
Cdd:cd01679 269 IDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 526 sryasgeyfsqylqgnwqpktakvgelftrsgitlptremwaqlrddvmryGIYNQNLQAVPPTGSISYINHATSSIHPI 605
Cdd:cd01679 340 ---------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPI 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 606 VAKVEIRKEGKtGRVYYPAPFMTNEN--LALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYA 683
Cdd:cd01679 369 TSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYFYA 447
|
570
....*....|..
gi 1929625749 684 WRKGIKTLYYIR 695
Cdd:cd01679 448 WKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 601.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPY---DVERVYGKPFADVaisqhYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEFEKE-----YY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 333 ELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVNSASEYdenldytrtg 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 411 hdISCNLGSLNIAHTMDSP------DFARTVETAVRGLTAVSDMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 485 YGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGE-YFSQYLQGNWQPKTAKvgelftrsgitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGIlQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 564 EMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKtgrvyypapfmtNENLALYQDAYEIGA 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1929625749 644 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-713 |
1.40e-115 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 365.20 E-value: 1.40e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 66 LVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKRYlEDFADRVTMVALTLAQGD-ETL 144
Cdd:PRK09209 122 LAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLMQNEpRER 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 145 ALQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAP 220
Cdd:PRK09209 201 RMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSD 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 221 IKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLA 300
Cdd:PRK09209 280 IRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAV 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 301 KENAQMALFSPYDVERVYGKPFADV--------AISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTV 372
Cdd:PRK09209 360 ERRGDWYLFDPHEVKKVMGWYLEDFydekkgdgSFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEV 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 373 NRANP--IAGRINMSNLCSEILQVNSAS----EY--DENLDYTRTGHD-ISCNLGSLNIAHTMDSPDFARTVETAVRGLT 443
Cdd:PRK09209 440 NRMNPnkHEGMIYSSNLCTEIMQNMSPTvmiqEIisGGQIVITKQPGDfVVCNLSSINLGRAVTADVLERLIPIQVRMLD 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 444 AVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGF 523
Cdd:PRK09209 520 NVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKG-AYPVF 597
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 524 KQSRYASGEYFS--QYlqgnwqpktakvgelftrsgitlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSS 601
Cdd:PRK09209 598 KGSDWQTGEYFErrGY------------------------NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTAS 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 602 IHPIVAKVEIrKEGKTGRVYYPAPFMTNENLALYQD-AYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQ 680
Cdd:PRK09209 654 IDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRASELLDLH 732
|
650 660 670
....*....|....*....|....*....|...
gi 1929625749 681 IYAWRKGIKTLYYIRLRQMalegtEIEGCVSCA 713
Cdd:PRK09209 733 MTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1353.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 15 DYHALNAMLNLYDSAGRIQFDKDRQAVDAFIATHVRPNSVTFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFTHAHT 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 95 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADVAISQHYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 335 VADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASEYDENLDYTRTGHDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 415 CNLGSLNIAHTMDSPDFARTVETAVRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 495 NLYFYAITWHALRTSMLLARERGETFAGFKQSRYASGEYFSQYLQGNWQPKTAKVGELFtrSGITLPTREMWAQLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 655 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
67-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 756.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 67 VNEGYYDESVLNrysrDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKrYLEDFADRVTMVALTLAQGD----- 141
Cdd:COG0209 20 VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 142 ETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAK 301
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 302 ENAQMALFSPYDVERVYGKPFADvaISQHYDELVADERIRKKyLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPI--A 379
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 380 GRINMSNLCSEILQVNSASEydenldytrtghDISCNLGSLNIAHTM-----DSPDFARTVETAVRGLTAVSDMSHIrSV 454
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYESE------------DASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 455 PSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYF 534
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 535 -SQYLqgnwqpktakvgelftrSGITLPTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRK 613
Cdd:COG0209 477 fDKYL-----------------DDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRK 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 614 EGKTGRVYYPAPFM------------------------------TNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSL 663
Cdd:COG0209 540 VLDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISK 619
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1929625749 664 TLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTE 705
Cdd:COG0209 620 TLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
128-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 614.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 128 DRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 207
Cdd:cd01679 3 DRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGGGI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 208 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 287
Cdd:cd01679 82 GLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARDLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 288 LGVVIPDITFHLAKenaqmalfspydvervygkpfadvaisqhydelvaderirkkylnaRDFFQRLAEIQFESGYPYIM 367
Cdd:cd01679 162 YGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 368 YEDTVNRANP--IAGRINMSNLCSEILQVNSASEydenldyTRTGHDISCNLGSLNIAHTMDSPDFARTVETAVRGLTAV 445
Cdd:cd01679 196 FKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALDNV 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 446 SDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGetfagfkq 525
Cdd:cd01679 269 IDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 526 sryasgeyfsqylqgnwqpktakvgelftrsgitlptremwaqlrddvmryGIYNQNLQAVPPTGSISYINHATSSIHPI 605
Cdd:cd01679 340 ---------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPI 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 606 VAKVEIRKEGKtGRVYYPAPFMTNEN--LALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYA 683
Cdd:cd01679 369 TSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYFYA 447
|
570
....*....|..
gi 1929625749 684 WRKGIKTLYYIR 695
Cdd:cd01679 448 WKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 601.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPY---DVERVYGKPFADVaisqhYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEFEKE-----YY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 333 ELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVNSASEYdenldytrtg 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 411 hdISCNLGSLNIAHTMDSP------DFARTVETAVRGLTAVSDMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 485 YGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGE-YFSQYLQGNWQPKTAKvgelftrsgitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGIlQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 564 EMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKtgrvyypapfmtNENLALYQDAYEIGA 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1929625749 644 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
102-697 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 548.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 102 FLGAWKFYTSYTLKTFDGKR---YLEDFADRVTMVALTLAQGDETLA-LQLTDEMLSG-RFQPATPTFLNCGKQqRGELV 176
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAiyeSPQEAYMRVAMGLASLEPKDTRLAdAIRFYDLLSRlKISPATPTLFNAGTP-RGQLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 177 SCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:TIGR02506 80 SCFLLDVtDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADvaISQHYDELV 335
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEE--FEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 336 ADERIRKKY--LNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA---GRINMSNLCSEILQVNSASEYdenldytrtG 410
Cdd:TIGR02506 238 KDVEARKKIrkVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTDDSHK---------G 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 411 HDISCNLGSLNIAH-----TMDSPDFARTVETAVRGLTAVSDMSHIRSVPSIEaGNAASHAIGLGQMNLHGYLAREGIAY 485
Cdd:TIGR02506 309 ETAVCNLASVNLANfvmedKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAK-SNQRRRSIGIGVMGLHDVLAKLGLPY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 486 GSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYFSQYLQGNWQPKTAKVgelftrsgitlPTREM 565
Cdd:TIGR02506 388 DSEEARDLNDRIFEAIYYYAIKASAELAKEKG-PFPGFSGSKYAKGWLHPDTWEKTIDPKTSMA-----------PTEED 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 566 WAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGK----------------------------T 617
Cdd:TIGR02506 456 WEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSgeflipnkylmkeleelglwdadrrgdiV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 618 GRVYYPAPFMT--NENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIR 695
Cdd:TIGR02506 536 ENVGSPQPIAAipETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEEVTAKDLLKLLLLAWKKGLKTMYYCR 615
|
..
gi 1929625749 696 LR 697
Cdd:TIGR02506 616 SR 617
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-713 |
1.40e-115 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 365.20 E-value: 1.40e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 66 LVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKRYlEDFADRVTMVALTLAQGD-ETL 144
Cdd:PRK09209 122 LAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLMQNEpRER 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 145 ALQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAP 220
Cdd:PRK09209 201 RMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSD 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 221 IKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLA 300
Cdd:PRK09209 280 IRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAV 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 301 KENAQMALFSPYDVERVYGKPFADV--------AISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTV 372
Cdd:PRK09209 360 ERRGDWYLFDPHEVKKVMGWYLEDFydekkgdgSFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEV 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 373 NRANP--IAGRINMSNLCSEILQVNSAS----EY--DENLDYTRTGHD-ISCNLGSLNIAHTMDSPDFARTVETAVRGLT 443
Cdd:PRK09209 440 NRMNPnkHEGMIYSSNLCTEIMQNMSPTvmiqEIisGGQIVITKQPGDfVVCNLSSINLGRAVTADVLERLIPIQVRMLD 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 444 AVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGF 523
Cdd:PRK09209 520 NVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKG-AYPVF 597
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 524 KQSRYASGEYFS--QYlqgnwqpktakvgelftrsgitlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSS 601
Cdd:PRK09209 598 KGSDWQTGEYFErrGY------------------------NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTAS 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 602 IHPIVAKVEIrKEGKTGRVYYPAPFMTNENLALYQD-AYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQ 680
Cdd:PRK09209 654 IDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRASELLDLH 732
|
650 660 670
....*....|....*....|....*....|...
gi 1929625749 681 IYAWRKGIKTLYYIRLRQMalegtEIEGCVSCA 713
Cdd:PRK09209 733 MTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
63-711 |
4.29e-97 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 316.75 E-value: 4.29e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 63 LNWLVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGKrYLEDFADRVTMVALTLA--QG 140
Cdd:PRK07088 121 VKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYEGLKLLADRYLVKGFNRE-ILELPQERFMGIAMHLAipEG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 141 DET---LALQLTDEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREA 217
Cdd:PRK07088 200 KEKrvyYAKKFYDLLSELKATVATPTLSNAGTPFY-QLSSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRAL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 218 GAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITF 297
Cdd:PRK07088 279 NSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFM 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 298 HLAKENAQMALFSPYDVERVYGKPFAD-------VAISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYED 370
Cdd:PRK07088 359 KRLEKRENWSLFDPHEIKKVKGYSLEDyydeedrKEFTKKYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRD 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 371 TVNRANPI--AGRINMSNLCSEILQVNSASEY------DENLDY-----TRTGHDISCNLGSLNIAHtMDSPDFARTVET 437
Cdd:PRK07088 439 TVNKANPNkhKGMIYSSNLCHEIAQNMSESELleeeiiDENGYYevvqkIKAGDMVTCNLNSIVLGN-VDDEELEEVIPT 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 438 AVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERG 517
Cdd:PRK07088 518 QIRMLDNVISLNYY-PVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKG 596
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 518 eTFAGFKQSRYASGEYfsqylqgnwqpktakvgelFTRSGItlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINH 597
Cdd:PRK07088 597 -SYPAFKGSEWETGKY-------------------FERRGY---NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIAN 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 598 ATSSIHPIVAKVEIrKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDIN 677
Cdd:PRK07088 654 TTAGIDPVFKRFFM-EEKKGSFTPKTAPDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYITPEYKAKQIL 732
|
650 660 670
....*....|....*....|....*....|....
gi 1929625749 678 KAQIYAWRKGIKTLYYIRLRqmALEGTEIEGCVS 711
Cdd:PRK07088 733 NLYIEAWKQGVKTIYYVRNK--SLEMDECTSCSS 764
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
61-713 |
1.39e-95 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 314.38 E-value: 1.39e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 61 QRLNWLVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFQTFLGAWKFYTSYTLKTFDGkRYLEDFADRVTMVALTLAQG 140
Cdd:PRK12364 197 DKIKYLTEEGLYGSYILEHYSREEIEEAAGFIDPERDKLFTYSGLDLLLKRYVIRTHSH-EPLESPQEMFLGIALHLAMP 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 141 DETLALQLTD---EMLSG-RFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLRE 216
Cdd:PRK12364 276 EKQDRMGWVKrfyDMLSKlKVTMATPTLSNARKPFH-QLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRA 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 217 AGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDIT 296
Cdd:PRK12364 355 VGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLF 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 297 FHLAKE--NAQMALFSPYDVERVYGKPFADV---AISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDT 371
Cdd:PRK12364 435 WKMVRDdiNQSWYLFCPHEILTVKGYALEDYygeEWEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDT 514
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 372 VNRANPIA--GRINMSNLCSEILQVNSASEY------DENLD-----YTRTGHDISCNLGSLNIAH--TMDSPDFARTVE 436
Cdd:PRK12364 515 VNRANPNKhkGMIYCSNLCTEIAQNMSAIETvsteieTEDGDtvvvtTTRPGDFVVCNLASLSLGNidLEDEEELEEVVR 594
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 437 TAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARER 516
Cdd:PRK12364 595 TVVRALDNVIDLNFY-PVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEK 673
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 517 GetfagfkqsRYasgeyfsQYLQG-NWQpktakVGELFTRSGItlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYI 595
Cdd:PRK12364 674 G---------AY-------GYFEGsDWQ-----TGAYFRKRGY---TSEEWQRLAREVAENGMRNAYLLAVAPTSSTSII 729
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 596 NHATSSIHPIVAK--VEIRKEGKTGRVyypAPFMTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATT 673
Cdd:PRK12364 730 AGTTAGVDPVMKRyfLEEKKGALMPRV---APELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITNEFTM 806
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1929625749 674 RDINKAQIYAWRKGIKTLYYIRLRQMalegtEIEGCVSCA 713
Cdd:PRK12364 807 RQVLDLYLLAWEEGVKTIYYVRSKSL-----EVEECESCS 841
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
148-692 |
1.62e-79 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 261.40 E-value: 1.62e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 148 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIED-NMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIEN 226
Cdd:cd02888 4 FFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDdSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 227 QSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKiRIKTLSLGVVIPDiTFHLAKENaqm 306
Cdd:cd02888 84 VASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTD-AFMEAVEN--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 307 alfspydvervyGKPFADVAISQHYDELVAderirkKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINM 384
Cdd:cd02888 159 ------------DEPWELRNPREPDTGKVY------RTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPglGRINA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 385 SNLCSEILQvnsaseydenLDYTrtghdiSCNLGSLNIA---------HTMDSPDFARTVETAVRGLTAVSDMSHIrSVP 455
Cdd:cd02888 221 TNPCGEQPL----------LPYE------SCNLGSINLSkfvknpfggASFDFERLREAVRLAVRFLDNVIDVNRY-PLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 456 SIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYFS 535
Cdd:cd02888 284 EIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERG-PFPLFDASRYLMLKVIV 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 536 QylqgnwqpktakvgelftrsgitlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIvakveirkeg 615
Cdd:cd02888 363 N-------------------------AKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI---------- 407
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1929625749 616 ktgrvyypapfmtnenlalyqdayeIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK--TLY 692
Cdd:cd02888 408 -------------------------FSPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKgiTVY 461
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
115-712 |
1.38e-77 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 260.28 E-value: 1.38e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 115 KTFDGKRYL---EDFADRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIG 191
Cdd:PRK09102 26 KATLRDRYLlegESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTD-RGLPISCFLNYVEDSLEGIV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 192 RAVNSALQLSKRGGGVAFLLSNLREAGAPIKRiENQSSGVIP---VMKMLEDAFSyanQLGARQGAGAVYLHAHHPDILR 268
Cdd:PRK09102 105 NTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPfikVMDSLTLAIS---QGSLRRGSFAVYLDIEHPEIEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 269 FLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVygkpfadvaisqhydelvaderirkKYLNAR 348
Cdd:PRK09102 181 FLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPKDKSVI-------------------------RTVKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 349 DFFQRLAEIQFESGYPYIMYEDTVNRANP----IAG-RINMSNLCSEILQVNSASEYDENldytRTghdISCNLGSLNIA 423
Cdd:PRK09102 236 DLWAKILETRIETGEPYLLFIDNVNRALPevykDLGlKVKASNLCSEITLPTGIDHLGED----RT---AVCCLSSLNLE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 424 HTMDSPDFARTVETAVRGLTAVsdMSHI--RSVPSIE-AGNAASH--AIGLGQMNLHGYLAREGIAYGSPEALDFTNLYF 498
Cdd:PRK09102 309 YYDEWKDTDAFIEDLMRFLDNV--LQDFidKAPDEMErAKYSAMRerSVGLGVMGFHSYLQSKMIPFESVMAKQWNKKIF 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 499 YAITWHALRTSMLLARERGETfagfkqsryasgeyfsqylqgnwqPKTAKVGelftrsgitlptremwaqlrddVMRygi 578
Cdd:PRK09102 387 KHIREQADKASKELAKEKGEC------------------------PDAAGYG----------------------VMR--- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 579 YNQNLQAVPPTGSISYINHATS-SIHPIVAKVEIRKeGKTGRVYYPAP-------------------------------F 626
Cdd:PRK09102 418 RFSTKMAIAPTASISIILGNTSpGIEPIAANYYTHK-TLKGSFTVKNKyleklleekgkdtdevwssiltnegsvqhldF 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 627 MTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIR----------- 695
Cdd:PRK09102 497 LSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLPANVPKRDLNKLHFEAWKKGVKSLYYQRsksvqradkvs 576
|
650 660
....*....|....*....|....
gi 1929625749 696 -------LRQMALEGTEIEGCVSC 712
Cdd:PRK09102 577 hdvlkkrLVEKSAFNRDYDECLAC 600
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
112-692 |
1.08e-75 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 254.56 E-value: 1.08e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 112 YTLKTFDGkRYLEDFADRVTMVALTLAQGD--------ETLALQLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRI 183
Cdd:TIGR02504 6 YLLKDEDG-NIIESPEDLFRRVARALAAAEdkynspvwKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFVLPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 184 EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHH 263
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 264 PDILRFLDTKRENadEKIRIKTLSLGVVipDITFHLAKENAQMALFSPYDVERvygkpfadvaisqhydelvaderirkK 343
Cdd:TIGR02504 165 PDIEEFIEAKAKE--GKLQNFNISVGVT--DEFMEAVENDEEYELRNPRTGEY--------------------------K 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 344 YLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQvnsaseydenLDYTrtghdiSCNLGSLN 421
Cdd:TIGR02504 215 EVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPygGRINATNPCGEQPL----------LPYE------SCNLGSIN 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 422 IA----------HTMDSPDFARTVETAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEAL 491
Cdd:TIGR02504 279 LAkfvkndfgdeASFDFERLREVVRLATRFLDNVIDINVF-PLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEAR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 492 DFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEyfsqylqgnwqpktakvgELFTRSGITLPTRemwaqLRD 571
Cdd:TIGR02504 358 ELAEEVMEFIADAAYRASAELAKERG-AFPLYDASKYPMGR------------------AMGARIPSALPAE-----IRE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 572 DVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTG---------------RVYYPAPFMT-------- 628
Cdd:TIGR02504 414 AIRKYGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGellevnplvelalreLGYYSDEIVKyvdekgtv 493
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1929625749 629 ------NENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK--TLY 692
Cdd:TIGR02504 494 egapgpEELPKVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGLKgiTVY 565
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-695 |
5.81e-74 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 255.04 E-value: 5.81e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 101 TFLGAWKFYTSYTLKTFDGKRYleDFADRVTM-VALTLAQGD---ETLALQLTDeMLSgRFQP--ATPTFLNcGKQQRGE 174
Cdd:PRK08447 138 NYLGIKTLYDRYLIKDRNNNPI--ELPQHMFMaIAMFLAQNEldpQKWAKKFYD-VIS-KFEVmlATPTLSN-ARTTRHQ 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:PRK08447 213 LSSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGA 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVE---RVYGKPFadvaiSQHY 331
Cdd:PRK08447 293 IAVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKdltELYGEEF-----EKRY 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 332 DELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSEILQVNSASEY--------- 400
Cdd:PRK08447 368 LEYEKDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAhaGIIRSSNLCTEIFQNTAPNHYkikiefedg 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 401 -----DENLD------YTRTGHDIS------------------------CNLGSLNIAHTMDSPDFARTVETAVRGLTAV 445
Cdd:PRK08447 448 sieffEEEELvtvdsgITKKAKKITsldslkgkkiyivekekkdgktavCNLASINLSKINTKEDIERVVPIAIRMLDNV 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 446 SDMSH--IRSVpsiEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGF 523
Cdd:PRK08447 528 IDLNFypNRKV---KATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKG-VYPDF 603
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 524 KQSRYASGeYFSQYLQGNWQPKTAKVGELFTRSgitlptrEMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIH 603
Cdd:PRK08447 604 EGSNWSKG-IFPIDKANEEAKKLVERGGLFDSA-------CDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIE 675
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 604 PiVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFP-DTATTRDINKAQIY 682
Cdd:PRK08447 676 P-VYKRKWFEENLSGLIPVVVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKYLNEIYTL 754
|
650
....*....|...
gi 1929625749 683 AWRKGIKTLYYIR 695
Cdd:PRK08447 755 AWKLGLKSTYYLR 767
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-707 |
1.96e-72 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 254.49 E-value: 1.96e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 101 TFLGAWKFYTSYtLKTFDGKRyLED---FADRVTM-VALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGkQQRGELV 176
Cdd:PRK12365 379 SYMGVQNLYDRY-FNHHEGRR-LETpqiFWMRVSMgLALNEGQDKTSWAITFYNLLSTFRYTPATPTLFNSG-MRHSQLS 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 177 SCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGA 256
Cdd:PRK12365 456 SCYLSTVQDDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVC 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 257 VYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDV---ERVYGKPFAdvAISQHYDE 333
Cdd:PRK12365 536 VYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVpglHEAYGEEFE--KLYEEYER 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 334 LVADERIR-KKYLNARDFFQRLAEIQFESGYPYIMYEDTVN--RANPIAGRINMSNLCSEILQVNSASEydenldytrtg 410
Cdd:PRK12365 614 KVDTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNirSAQDHKGVVRCSNLCTEILLNCSETE----------- 682
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 411 hDISCNLGSLNIAH-----TMDSPDFARTVETAVRGLTAVSDmshIRSVPSIEAGNA--ASHAIGLGQMNLHGYLAREGI 483
Cdd:PRK12365 683 -TAVCNLGSINLVEhivndGLDEEKLSETISIAIRILDNVID---INFYPTKEAKEAnlAHRAIGLGVMGFQDALYKLNI 758
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 484 AYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASG-------EYFSQYL-QGNWQPKTAkvgelftr 555
Cdd:PRK12365 759 SYASQEAVEFADYSSELIAYYAILASSLLAKERG-TYSSYKGSKWDRGylpidtiELLKEYRgEANLLMDTS-------- 829
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 556 sgitlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIrKEGKTGRVYYPAPFMTNE--NLA 633
Cdd:PRK12365 830 ------SRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFV-KSNLSGEFTIPNVYLIEKlkKLG 902
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 634 LYQD-----------------------------AYEIGAEKIIDTYAEATRHVDQGLSLTLFF--PDtatTRDINKAQIY 682
Cdd:PRK12365 903 IWDAdmlddlkyfdgslleieripdhlkkifltAFEIEPEWIIECASRRQKWIDMGQSLNLYLaePD---GKKLSNMYLT 979
|
650 660
....*....|....*....|....*
gi 1929625749 683 AWRKGIKTLYYIRlrqmALEGTEIE 707
Cdd:PRK12365 980 AWKKGLKTTYYLR----SSAATSVE 1000
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
67-714 |
6.32e-62 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 221.13 E-value: 6.32e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 67 VNEGYYDESVLNRYSRDFVITLFTHA-HTSGFRFqTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQgDETLA 145
Cdd:PHA02572 108 VNEGKYDPEILSKYSAEEITYLESFIdHDRDFEF-TYAGAMQLKEKYLVQDRSTGEIYETPQFAYMLIAMALHQ-DEPKE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 146 LQLT------DEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQ-LSKRGGgVAFLLSNLREAG 218
Cdd:PHA02572 186 DRLEhvirfyNAVSTRKISLPTPIMAGVRTPTR-QFSSCVVIESGDSLDSINKTAMAIVKyISKRAG-IGINAGMIRAEG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 219 APIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFH 298
Cdd:PHA02572 264 SKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYE 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 299 LAKENAQMALFSPYDV-ERVYGKPFADV-AISQHYDELVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRAN 376
Cdd:PHA02572 344 RFIKNDYITLFSPHDVgGELYDAYFADQdRFRELYEALEKDPSVRKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHS 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 377 PIAGRINMSNLCSEI-LQVNSASEYDENldytrtGHDISCNLGSLNIAHTMDSPDFARTVETAVRGLTAVSDMshiRSVP 455
Cdd:PHA02572 424 PFKDPIRQSNLCCEIaLPTKPLNHIDGE------GEIALCTLSAIVLGNFEDQDEIEELAEVAVRALDNLLDY---QDYP 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 456 SIEAGNA-ASHAIGLGQMNLHGYLAREGIAYGSPEAlDFTNLYFYAITWHALRTSMLLARERGETfAGFKQSRYASGEyf 534
Cdd:PHA02572 495 VPAALKAkKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEKGAC-EYFSDTKYSRGE-- 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 535 sqyLQGNWQPKTakVGElftrsgITLPTREM-WAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIrK 613
Cdd:PHA02572 571 ---LPIDWYKKK--VDE------LVAPKYNCdWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSI-K 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 614 EGKTGRVYYPAP-FMTNENL-ALYQDAYEIGAEKIIDTYAEATRHVDQGLSL-TLFFPDTATTRDINKAQI-----YAWR 685
Cdd:PHA02572 639 KSKEGPFNQVVPnVETLKDLyDLLWDLAKKGNKGYLTQVAIMQKFVDQAISAnTSYDPENYPNGKVPMSVMlddllYFYY 718
|
650 660 670
....*....|....*....|....*....|....*
gi 1929625749 686 KGIKTLYYIRLR------QMALEGTEIEGCVSCAL 714
Cdd:PHA02572 719 YGGKTLYYHNTRdgkgteDYEIETPKAEDCDSCKL 753
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-697 |
6.14e-55 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 202.08 E-value: 6.14e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 66 LVNEGYYDESVLNRYSRDFVITLFTHAHTSGFRFqtfLGAWKFYTSYTLKTFDGKRyLE---DFADRVTMvALTLAQGDE 142
Cdd:PRK06539 117 GVAEGLLDSRLGGLFDLERLAAALDPTRDELLKY---IGVVTLNNRYGIRARNGDA-LEvpqYFWMRIAM-GLSLNEDDP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 143 T-LALQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:PRK06539 192 TsSALAFYEKMSKLEYLAAGSTLVNAGTPY-PQLSNCFVMEMQDDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPI 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAK 301
Cdd:PRK06539 271 RSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQ 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 302 ENAQMALFSPY---DVERVYGKPFadvaiSQHYDELVADE---RIRK-KYLNARDFFQR-LAEIQFESgYPYIMYEDTVN 373
Cdd:PRK06539 351 NDEDWYLFDPLetpDLNELYGKAF-----SKRYAQYVEQAeagRIRMfKRITAREQFRAiLMSLQTTS-HPWLTWKDTIN 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 374 -RA-NPIAGRINMSNLCSEILqvnsaseYDENLDYTRTghdisCNLGSLNIAHTMDSP--DFARTVET---AVRGLTAVS 446
Cdd:PRK06539 425 nRAlNNNTGTIHLSNLCTEIC-------LPQDRDNVSV-----CNLASINLSRHLADGelDWAQLEEStrlAVRQLDNLI 492
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 447 DMShIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQS 526
Cdd:PRK06539 493 DIT-ASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERG-AYPNFEGS 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 527 RYASGEYFSQYLQGNWQPKTAKVgelftrsGITLPTREMWAQLRDDVmRYGIYNQNLQAVPPTGSISYINHATSSIHPIV 606
Cdd:PRK06539 571 RWSRGMVPVDSIALLEADRGVPV-------DVNRTTRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLDPQF 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 607 AKVEIR--KEGKTGRVyypapfmtNENL-----------------------------------ALYQDAYEIGAEKIIDT 649
Cdd:PRK06539 643 SQIFSRstSSGKFLEV--------NRNLvadlkelglwetvreeilrsqgdiqeiaaipdeikALYRTSFQLSPYAFLEV 714
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 1929625749 650 YAEATRHVDQGLSLTLFFpdtaTTRDI-NKAQIY--AWRKGIKTLYYIRLR 697
Cdd:PRK06539 715 AARAQKWVDQAISRNMYL----ESRDIgDMMDIYtaAWEMGVKTTYYLHMK 761
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-705 |
1.68e-53 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 199.03 E-value: 1.68e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 101 TFLGAWKFYTSYTLKTfDGKRYL--EDFADRVTMvALTLAQGD-ETLALQLTDEMLSGRFQPATPTFLNCGKQqRGELVS 177
Cdd:PRK07207 297 TYLGLQTLYDRYFLHV-DGTRIElpQAFFMRVAM-GLALNEIDrEARAIEFYNLLSSFDFMSSTPTLFNSGTL-RPQLSS 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 178 CFLLRIEDNMESIGRAV-NSALqLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGA 256
Cdd:PRK07207 374 CYLTTVPDDLDGIYEAIkDNAL-LSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVC 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 257 VYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDV---ERVYGKPFAdvAISQHYDE 333
Cdd:PRK07207 453 AYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVpdlHDLFGKAFE--EAYTAYEA 530
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 334 LVADERIRK-KYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPI--AGRINMSNLCSEILQVNSASEydenldytrtg 410
Cdd:PRK07207 531 KAARGEIKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQqhVGVVHSSNLCTEITLNTSDDE----------- 599
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 411 hdIS-CNLGSLNI-AHTMDSPD-----FARTVETAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGI 483
Cdd:PRK07207 600 --IAvCNLGSVNLvAHIKDGAKldhekLKRTVSTAMRMLDNVIDINYY-AVPKARNSNLRHRPVGLGIMGFQDALYLLRI 676
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 484 AYGSPEALDFTNLYFYAITWHALRTSMLLARERGetfagfkqsRYASGEyfsqylqgnwqpktakvGELFTRsGItLP-- 561
Cdd:PRK07207 677 PYASDEAVEFADRSMEAVSYYAIWASTELAEERG---------RYSSYE-----------------GSLWSR-GI-LPid 728
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 562 ------------------TREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP----------------IVA 607
Cdd:PRK07207 729 slkllaearggylevdrsSTLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPtyqnlyvksnlsgeftVVN 808
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 608 KVEIR--KE-------------------GKTGRVyyPApfmtnENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLF 666
Cdd:PRK07207 809 PYLVRdlKArglwdevmvndlkyfdgslQRIDRI--PA-----DLKALYATAFEVDPRWLVEAASRRQKWIDQAQSLNLY 881
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 1929625749 667 FpDTATTRDINkaQIY--AWRKGIKTLYYirLRQMALEGTE 705
Cdd:PRK07207 882 M-AGASGKKLD--ETYklAWLRGLKTTYY--LRTLGATHVE 917
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
79-700 |
1.73e-49 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 186.10 E-value: 1.73e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 79 RYSRDFVITLFthahtsGFRfqtflgawKFYTSYTLKTfDGKrYLEDFADRVTMVALTLAQGDETLALQlTDEMLSGR-F 157
Cdd:PLN02437 136 IYDRDFDYDYF------GFK--------TLERSYLLKV-NGK-VVERPQHMLMRVSVGIHKDDIESAIK-TYHLMSQRwF 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 158 QPATPTFLNCGKQqRGELVSCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMK 236
Cdd:PLN02437 199 THASPTLFNAGTP-RPQLSSCFLICMkDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLR 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 237 MLEDAFSYANQLGA-RQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPY--- 312
Cdd:PLN02437 278 VFNDTARYVDQGGGkRKGAFAIYLEPWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNeap 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 313 --------DVERVYGKpfadvaisqhYDElvadERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRI 382
Cdd:PLN02437 358 gladcwgeEFERLYTK----------YER----EGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQnlGTI 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 383 NMSNLCSEILQVNSASEydenldytrtghDISCNLGSL------------------NIAHTMDSP----DFARTVE---T 437
Cdd:PLN02437 424 KSSNLCTEIIEYTSPTE------------TAVCNLASIalprfvrekgvpleshpsKLVGSLGSKnryfDFEKLAEvtaV 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 438 AVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERG 517
Cdd:PLN02437 492 VTRNLNKIIDVNYY-PVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREG 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 518 --ETFAGFKQSryasgeyfsqylQGNWQPKTAkvgelftrsGITLPTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYI 595
Cdd:PLN02437 571 pyETYAGSPVS------------KGILQPDMW---------GVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQI 629
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 596 ---NHA----TSSIH---------------------------PIVAKVEIRKEGKTGRVyypaPFMTNENLALYQDAYEI 641
Cdd:PLN02437 630 lgnNECfepyTSNIYsrrvlsgefvvvnkhllhdltemglwtPTLKNKIIAENGSVQKI----PEIPDDLKAIYKTVWEI 705
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 642 GAEKIIDTYAEATRHVDQGLSLTLFFPDtATTRDINKAQIYAWRKGIKT-LYYIRLRQMA 700
Cdd:PLN02437 706 KQRTLVDMAADRGCYIDQSQSLNIHMDQ-PNFGKLTSLHFYAWSKGLKTgMYYLRSRAAA 764
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
112-692 |
2.82e-48 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 182.06 E-value: 2.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 112 YTLKTFDGKRyLEDFADRVTMVALTLAQGD---------ETLALQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLLR 182
Cdd:PRK08665 24 YLKKDEDGKP-IETPEDMFRRVARTIAAAEliydskadvEALADRFYDLMTSLEFLPNSPTLMNAGREL-GQLSACFVLP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 183 IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAH 262
Cdd:PRK08665 102 VGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRVD 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 263 HPDILRFLDTKRENADekirIKTLSLGVVIPDITFHLAKENAQMALFSPYDvERVYGKpfadvaisqhydelvaderirk 342
Cdd:PRK08665 182 HPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT-GEVVGR---------------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 343 kyLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNLCSE--ILqvnsasEYDenldytrtghdiSCNLG 418
Cdd:PRK08665 235 --LNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPhlGEIESTNPCGEqpLL------PYE------------SCNLG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 419 SLNIAHTMDSPDF-----ARTVETAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDF 493
Cdd:PRK08665 295 SINLSKMVKNGDVdweklREVVHLAVRFLDNVIDANKY-PLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVEL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 494 TNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYAsgeyfsqylqgnwQPKTAKvgelftrsgitlptremwaqlrddv 573
Cdd:PRK08665 374 AEKVMKFIQDEAHAASRELAEERG-PFPNYEGSIYD-------------KDGLGP------------------------- 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 574 MRygiyNQNLQAVPPTGSISYINHATSSIHPIVA------------KVEI--------RKEG-----------KTGRV-- 620
Cdd:PRK08665 415 MR----NATVTTIAPTGTISIIAGCSSGIEPLFAlsftrnvmdgerLVEVnpvfeaaaKEEGfyseelmekiaEKGSIqd 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 621 --YYPAP----FMTnenlalyqdAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK--TLY 692
Cdd:PRK08665 491 idEVPEDvrrvFVT---------AHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGCKgvTIY 561
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
150-692 |
3.56e-39 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 155.01 E-value: 3.56e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 150 DEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSS 229
Cdd:PRK06406 225 EVMSNLKFVPNSPTLMNAGTKL-GQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVAS 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 230 GVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKreNADEKIrIKTLSLGVVIPDITFHLAKENAQMALF 309
Cdd:PRK06406 304 GPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK--DSENKV-LSNFNISVAVTDEFFDKLDNDDYYPLR 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 310 SPYDVERVygkpfadvaisqhydelvadERIRkkylnARDFFQRLAEIQFESGYPYIMYEDTVNRANPIA--GRINMSNL 387
Cdd:PRK06406 381 NPRNGKEV--------------------KRIK-----ARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKnlGEIESTNP 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 388 CSEilqvnsaseyDENLDYTrtghdiSCNLGSLNIAH-----TMDSPDFARTVETAVRGLTAVSDMSHIrSVPSIEAGNA 462
Cdd:PRK06406 436 CGE----------QPLLPYE------SCNLGSINLSKfvengKIDWDRLRETVHIATRFLDNVIDANKF-PVPQIKEMTR 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 463 ASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSryasgeyfsqylqgNW 542
Cdd:PRK06406 499 MTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERG-VFPAWYGS--------------EW 563
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 543 QPKTAKvgelftrsgitlptremwaqlrddvMRygiyNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRK--------- 613
Cdd:PRK06406 564 EKKGIK-------------------------MR----NSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHvlngqelle 614
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 614 -----EGKTGRV-YYPAPFM-------------TNENLA-LYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATT 673
Cdd:PRK06406 615 vnplfEEITRKRgLYSEELMrkvaetgnlqnidVPEDIKrIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINLRYDATP 694
|
570 580
....*....|....*....|..
gi 1929625749 674 RDINKAQIYAWR---KGIkTLY 692
Cdd:PRK06406 695 EDIAKAYRLAKDlhcKGI-TVY 715
|
|
| RNR_N |
pfam08343 |
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ... |
16-97 |
1.88e-35 |
|
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyze the formation of deoxyribonucleotides. It occurs together with the RNR all-alpha domain (pfam00317) and the RNR barrel domain (pfam02867).
Pssm-ID: 429933 Cd Length: 82 Bit Score: 128.72 E-value: 1.88e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 16 YHALNAMLNLYDSAGRIQFDKDRQAVDAFIATHVRPNSVTFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFTHAHTS 95
Cdd:pfam08343 1 YIALNNELNLYDENGKIQFDKDKEALEAYFKEHVNPNTVFFHSLKEKLDYLVENDYYEEEFLNKYSFEFIEELYKYAYSY 80
|
..
gi 1929625749 96 GF 97
Cdd:pfam08343 81 KF 82
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-693 |
1.08e-33 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 138.20 E-value: 1.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 66 LVNEGYYDESVLNRYSRDFVITLfthahtsgfrfQTFLGAWK-FYTSYT-LKTFDGKrYLedFADRVT------------ 131
Cdd:PRK09103 106 MVEMGKYDKHLLEDYTEEEFDQM-----------DTFIDHWRdMNFSYAaVKQLEGK-YL--VQNRVTgeiyesaqflyi 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 132 MVALTLAQGDE----------------TLALQLTDEMLSG-RfqpaTPTflncgKQqrgeLVSCFLLRIEDNMESIGrAV 194
Cdd:PRK09103 172 LVAACLFSNYPketrldyvkrfydavsTFKISLPTPIMSGvR----TPT-----RQ----FSSCVLIECGDSLDSIN-AT 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 195 NSAL--QLSKRGG-GVAFllSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLD 271
Cdd:PRK09103 238 SSAIvkYVSQRAGiGINA--GRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLV 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 272 TKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADVA-ISQHYDELVADERIRKKYLNARDF 350
Cdd:PRK09103 316 LKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDeFERLYTKYEQDDSIRKKRVKAVEL 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 351 FQRLAEIQFESGYPYIMYEDTVNRA---NPIAGRINMSNLCSEI------LQ-VNsaseyDENldytrtGHDISCNLGSL 420
Cdd:PRK09103 396 FSLMMQERASTGRIYIQNVDHCNTHspfDPKVAPVRQSNLCLEIalptkpLNdVN-----DEN------GEIALCTLSAF 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 421 NIAHTMDSPDFARTVETAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYA 500
Cdd:PRK09103 465 NLGAINSLDELEELADLAVRALDALLDYQDY-PIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEA 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 501 ITWHALRTSMLLARERGETFAgFKQSRYASG----EYFSQYLQGNwqpktakvgelftrsgITLPTREMWAQLRDDVMRY 576
Cdd:PRK09103 544 IQYYLLKASNELAKEQGACPW-FNETTYAQGilpiDTYKKDLDAI----------------CNEPLHYDWETLREEIKTH 606
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 577 GIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIrKEGKTGRVYYPAPfmtneNLALYQDAYEIGAE-KIIDTYAEAT- 654
Cdd:PRK09103 607 GLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI-KASKDGILKQVVP-----DYERLKDAYELLWEmPNNDGYLQLVg 680
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 1929625749 655 ---RHVDQGLSL------TLFFPDTATTRDINKAQIYAWRKGIKTLYY 693
Cdd:PRK09103 681 imqKFVDQSISAntnydpSRFPSGKVPMKQLLKDLLTAYKFGVKTLYY 728
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
148-613 |
1.90e-24 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 109.29 E-value: 1.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 148 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIEDNMESIGR-AVNSALqLSKRGGGVAFLLSNLREAGapikriEN 226
Cdd:PRK06556 122 LTWLLLHQKFSFNSPVWFNVGTESPQQVSACFILSVDDSMESILNwYKEEGM-LFKGGSGTGTNLSRIRSSK------EL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 227 QSSGVI---PV--MKMLeDAFSYANQLGA--RQGAGAVYLHAHHPDILRFLDTKrenADEKIRIKTL-------SL-GVV 291
Cdd:PRK06556 195 LSGGGTasgPVsfMRGA-DASAGTIKSGGatRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALrdagydmDLgGEA 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 292 IPDITFHLAKENAQMALFSPYDVERvyGKPFADVAisqhydelVADERIRKKYlNARDFFQRLAEIQFESGYPYIMYEDT 371
Cdd:PRK06556 271 YSSVQYQNANNSVRVSDEFMRAVEN--DGEFGLRA--------RTDGEVIETV-DAKELFRKIAEAAWECADPGIQYDDT 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 372 VNR--ANPIAGRINMSNLCSEILqvnsaseydeNLDytrtghDISCNLGSLNIAH------TMDSPDFARTVETAVrglT 443
Cdd:PRK06556 340 INDwhTCPESGRINASNPCSEYM----------FLD------NSSCNLASLNLMKflrddgTFDVESFRHAVELVI---T 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 444 AVSDMSHIRSVPSiEAGNAASHA---IGLGQMNLHGYLAREGIAYGSPEALDF----TNLyfyaITWHALRTSMLLARER 516
Cdd:PRK06556 401 AMEISICFADFPT-EKIARNTRAfrqLGLGYANLGALLMATGLPYDSDGGRALaaaiTSL----MTGEAYRRSAELAGVV 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 517 GeTFAGFKQSRyasgEYFSQYLQgnwqpKTAKVGELFTRSGiTLPT------REMWaqlrDDVMRYGIYN--QNLQA--V 586
Cdd:PRK06556 476 G-PFEGYARNA----EPHLRVMR-----KHAAANDAIRPLG-EVDAalleaaKEAW----DDALELGEKNgyRNAQAsvL 540
|
490 500
....*....|....*....|....*...
gi 1929625749 587 PPTGSISY-INHATSSIHPIVAKVEIRK 613
Cdd:PRK06556 541 APTGTIGFmMDCDTTGIEPDFALVKYKK 568
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
166-695 |
6.32e-22 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 100.64 E-value: 6.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 166 NCGKQQRGELVSCFL--LRIEDNMESIGRAVNSALQLSKR----GGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLE 239
Cdd:PRK06948 76 NAGAAPDQTMVNCFVhpIRAPAALTAVHPNLDRALDDARLtllmGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 240 DAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENAdekiRIKTLSLGVVIPDITFHLAKENAQMALfspydverVYG 319
Cdd:PRK06948 156 RICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWAL--------RHR 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 320 KPFADVAISQHydeLVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIAG--RINMSNLCSEilqvNSA 397
Cdd:PRK06948 224 APPRRAAGGAL---RGADGAWTYATVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREheRIDATNPCGE----QPL 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 398 SEYDenldytrtghdiSCNLGSLNIAHTMDSP---------DFA---RTVETAVRGLTAVSDMS------HIRsvpsiEA 459
Cdd:PRK06948 297 PPYG------------SCVLGPIDLSRFVRHPfgvggeprfDFAalaTAVRIQVRMLDNALDLTrwplaaHAR-----EA 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 460 gnAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYFSQYLQ 539
Cdd:PRK06948 360 --RQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERG-AYPLCDPAAHLDALRAGPPLP 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 540 GNwqpktakvgelftrsgitlptremwaqLRDDVMRYGIYNQNLQAVPPTGSIS--YINHATSSIHPIVAKVEIRK-EGK 616
Cdd:PRK06948 437 HA---------------------------VCHAIARHGLRNSHLLSFAPVGSVSlaFGDNCSPGIEPARAWIEHRPvRAG 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 617 TGRVyypaPFMTNENLA--LYQD--------------AYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQ 680
Cdd:PRK06948 490 AGGA----RGMRAENHAyrLFRSlrgeraalpdyfvtAADVAPADHLAMRAALQPYVDAGISKTVTLPNHYSLAEVDALL 565
|
570
....*....|....*
gi 1929625749 681 IYAWRKGIKTLYYIR 695
Cdd:PRK06948 566 FQAWRAGLKGITIFR 580
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
147-692 |
1.89e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 99.92 E-value: 1.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 147 QLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLR-IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIE 225
Cdd:PRK08115 158 KFYQELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPfVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVN 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 226 NQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKREN-------------------ADEKIRIKTL 286
Cdd:PRK08115 238 GKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKMQNprilryllentedeqikrlVKEKLKFTPL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 287 SL-------GVV----IPD----------------------------------ITFHLAKE-------NAQMALFSPyDV 314
Cdd:PRK08115 318 SEveeamyqAIVnyknIEGqggfdtkvikeaenklrtggtytvnnpefltganISVCLTKEfmeavenDEEYELRFP-DV 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 315 E-------RVYGKPFADVAISQHYDELVADERIRKKyLNARDFFQRLAEIQFESGYPYIMYEDTVN---RANPIAGRINM 384
Cdd:PRK08115 397 EnyteeemEIYNEEWHEVGDVREWEKMGYPVRTYRK-IKAKELWNLINICATYSAEPGIFFIDNANemtNAKAYGQKVVA 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 385 SNLCSEilqvNSASEYDenldytrtghdiSCNLGSLNIAH-------TMDSPDFARTVETAVRGLTAVSDmshirSVPSI 457
Cdd:PRK08115 476 TNPCGE----QPLAPYS------------VCNLAAINLANmadketkTVDYEKLKRTVEVGVRMQDNVID-----ATPYF 534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 458 EAGNA----ASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAgfkqsryasgey 533
Cdd:PRK08115 535 LEENKkqalGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKG-SFP------------ 601
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 534 fsqYLQGNWQPKTAKVGELFTRSGItlpTREMWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP--------- 604
Cdd:PRK08115 602 ---FLVGQTEEETAKLREAFINTGY---MKKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPyfsfsyyrs 675
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 605 ------IVAKVEIRKEGKTGrvyYPAPfMTNENLALYQDAYEIGAEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINK 678
Cdd:PRK08115 676 grlgkfIEVKADIVQEYLDK---HPEA-DENHLPEWFISAMELKPEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQVQK 751
|
650
....*....|....*.
gi 1929625749 679 AQIYAWRKGIK--TLY 692
Cdd:PRK08115 752 VYERLYRGGAKggTVY 767
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
414-661 |
3.25e-19 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 92.91 E-value: 3.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 414 SCNLGSLNIAHTM----------DSPDFARTVETAVRGLTAVSDMSHIrSVPSIEAGNAASHAIGLGQMNLHGYLAREGI 483
Cdd:PRK08332 1307 SCNLASINLAKFVkydengkpyfDWDEYAYVIQKVAKYLDNAIDVNKF-PLPEIDYNTKLTRRIGVGMMGLADALFKLGI 1385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 484 AYGSPEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSRYASGEYfsqYLQGNWQPktakvgELFTrsgitLPtr 563
Cdd:PRK08332 1386 PYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRG-TFPLYEKTEYPKGEL---PVEGFYHP------EIWN-----LP-- 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 564 emWAQLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVeIRKEGKTGRVYYPAPFMTNE--NLALYQDayEI 641
Cdd:PRK08332 1449 --WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPVFEAElkKRGLYSE--EL 1523
|
250 260
....*....|....*....|
gi 1929625749 642 gAEKIIDTYAEAtrhvdQGL 661
Cdd:PRK08332 1524 -LKKISDNYGSV-----QGL 1537
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
101-169 |
6.41e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 67.26 E-value: 6.41e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1929625749 101 TFLGAWKFYTSYTLKTFDGKRYlEDFADRVTMVALTLAQ-----GDETLALQLTDEMLSGRFQPATPTFLNCGK 169
Cdd:pfam00317 2 TYLGAKVLEDRYLLKDEDGELL-ETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
343-527 |
1.04e-10 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 65.37 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 343 KYLNARDFFQRLAEIQFESGYPYIMYEDTVN--RANPIAGRINMSNLCSEILqvnsaseydeNLDytrtghDISCNLGSL 420
Cdd:PRK07562 429 KTLKARDLWEKIGYAAWASADPGLQFNTTINdwHTCPASGPIRASNPCSEYM----------FLD------DTACNLASL 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 421 NIAH-------TMDSPDFartvETAVRGLTAVSD----MSHIrsvPSIEAGNAAS--HAIGLGQMNLHGYLAREGIAYGS 487
Cdd:PRK07562 493 NLLTfrdedtkRFDVEAY----EHACRLWTVVLEisvlMAQF---PSKEIAELSYefRTLGLGYANIGGLLMTMGIPYDS 565
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1929625749 488 PEALDFTNLYFYAITWHALRTSMLLARERGeTFAGFKQSR 527
Cdd:PRK07562 566 DEGRAICGALSAIMTGVAYATSAEMAKELG-PFPGYEKNA 604
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
152-206 |
7.84e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 7.84e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1929625749 152 MLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGG 206
Cdd:PRK08332 248 MTNQIFMPNTPALINSGRPL-GMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGG 301
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
211-388 |
1.06e-05 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 48.99 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 211 LSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIrIKTLSLGV 290
Cdd:PRK08332 760 FSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-LSNFNISV 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1929625749 291 VIPDITFHLAKENAQMALFSPYDVERVygkpfadvaisqhydelvaderirkKYLNARDFFQRLAEIQFESGYPYIMYED 370
Cdd:PRK08332 839 GIWEDFWEALKEGKKYPLINPRTGEVV-------------------------KEIDPKSLFEELAYMAWAKADPGVIFFD 893
|
170 180
....*....|....*....|..
gi 1929625749 371 TVNRANPI----AGRINMSNLC 388
Cdd:PRK08332 894 VINRRNVLkeakGGPIRATNPC 915
|
|
| |
