|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
6-521 |
7.94e-177 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 507.38 E-value: 7.94e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 6 LKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKTREF 85
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 86 IAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQ 165
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF---------DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 166 FGVAAFSPVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPA 245
Cdd:COG0728 152 FAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 246 LFGVSVSQINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEgetvsERFSQTMDWGV 325
Cdd:COG0728 232 LLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL-----EEFRRTLSRGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 326 RMIFLLGIPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISM 405
Cdd:COG0728 307 RLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAV 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 406 ISNMGFNLLAI-PFSYVGLAMASAMSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGKVALAGLAMAAAVSYCMPALSLWQA 484
Cdd:COG0728 387 VVNIVLNLLLVpPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLG 466
|
490 500 510
....*....|....*....|....*....|....*..
gi 1913910128 485 QHNGMRMLWLAGLIGLAAVVYFAALLLLGVRPRHLRA 521
Cdd:COG0728 467 GGLLGRLLALALLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-442 |
1.53e-152 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 442.28 E-value: 1.53e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 13 SSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKTREFIAKVSGT 92
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 93 LGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAAFS 172
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF---------SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 173 PVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPALFGVSVS 252
Cdd:cd13123 152 PVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 253 QINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEgetvsERFSQTMDWGVRMIFLLG 332
Cdd:cd13123 232 QINLLVDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDL-----DEFRRTLSRGLRLVLFLL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 333 IPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISMISNMGFN 412
Cdd:cd13123 307 LPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLN 386
|
410 420 430
....*....|....*....|....*....|.
gi 1913910128 413 LLAI-PFSYVGLAMASAMSGTLNAWLLYRGL 442
Cdd:cd13123 387 LLLIkPLGHVGLALATSLSAWVNALLLLVLL 417
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
30-460 |
6.71e-127 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 378.17 E-value: 6.71e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 30 IANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYqKDGDLSKTREFIAKVSGTLGGLVTIVTLLAMIGSP 109
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAEL-KAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 110 VVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAAFSPVLLNVAMIGAAIWIAP 189
Cdd:pfam03023 80 WLIRLLAPGF---------DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLAN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 190 HTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPALFGVSVSQINLLLDTFIASFLMTG 269
Cdd:pfam03023 151 YLGNAIYALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 270 SISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEGEtvserFSQTMDWGVRMIFLLGIPAMFGIMVLAKPMMMV 349
Cdd:pfam03023 231 SVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDE-----FRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 350 LFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISMISNMGFN-LLAIPFSYVGLAMASA 428
Cdd:pfam03023 306 LFERGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSlLLLPPLGVAGLALATS 385
|
410 420 430
....*....|....*....|....*....|..
gi 1913910128 429 MSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGK 460
Cdd:pfam03023 386 LSSLIGLVFLYYILRKRLGGFDLRGIKTFLAS 417
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
5-514 |
1.66e-111 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 340.46 E-value: 1.66e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 5 LLKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKtRE 84
Cdd:TIGR01695 2 LLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEAR-RA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 85 FIAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIG 164
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGF---------ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 165 QFGVAAFSPVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIP 244
Cdd:TIGR01695 152 RFFIPSFSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 245 ALFGVSVSQINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEGEtvserFSQTMDWG 324
Cdd:TIGR01695 232 TTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE-----LRDLLNQG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 325 VRMIFLLGIPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIIS 404
Cdd:TIGR01695 307 IRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVIS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 405 MISNMGFNLLAI-PFSYVGLAMASAMSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGKVALAGLAMAAAVSYCMpALSLWQ 483
Cdd:TIGR01695 387 VVLNALLSLLLIfPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIV-SVSLGG 465
|
490 500 510
....*....|....*....|....*....|.
gi 1913910128 484 AQHNgmRMLWLAGLIGLAAVVYFAALLLLGV 514
Cdd:TIGR01695 466 VLVK--NLLGLLAIGLIGLLVYFLGLALLKI 494
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
6-521 |
7.94e-177 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 507.38 E-value: 7.94e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 6 LKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKTREF 85
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 86 IAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQ 165
Cdd:COG0728 81 ASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGF---------DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 166 FGVAAFSPVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPA 245
Cdd:COG0728 152 FAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 246 LFGVSVSQINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEgetvsERFSQTMDWGV 325
Cdd:COG0728 232 LLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDL-----EEFRRTLSRGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 326 RMIFLLGIPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISM 405
Cdd:COG0728 307 RLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAV 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 406 ISNMGFNLLAI-PFSYVGLAMASAMSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGKVALAGLAMAAAVSYCMPALSLWQA 484
Cdd:COG0728 387 VVNIVLNLLLVpPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLG 466
|
490 500 510
....*....|....*....|....*....|....*..
gi 1913910128 485 QHNGMRMLWLAGLIGLAAVVYFAALLLLGVRPRHLRA 521
Cdd:COG0728 467 GGLLGRLLALALLILVGAAVYFALLLLLGVRLRDLLR 503
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
13-442 |
1.53e-152 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 442.28 E-value: 1.53e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 13 SSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKTREFIAKVSGT 92
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 93 LGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAAFS 172
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF---------SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 173 PVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPALFGVSVS 252
Cdd:cd13123 152 PVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 253 QINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEgetvsERFSQTMDWGVRMIFLLG 332
Cdd:cd13123 232 QINLLVDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDL-----DEFRRTLSRGLRLVLFLL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 333 IPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISMISNMGFN 412
Cdd:cd13123 307 LPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLN 386
|
410 420 430
....*....|....*....|....*....|.
gi 1913910128 413 LLAI-PFSYVGLAMASAMSGTLNAWLLYRGL 442
Cdd:cd13123 387 LLLIkPLGHVGLALATSLSAWVNALLLLVLL 417
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
30-460 |
6.71e-127 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 378.17 E-value: 6.71e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 30 IANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYqKDGDLSKTREFIAKVSGTLGGLVTIVTLLAMIGSP 109
Cdd:pfam03023 1 IAAYFGAGLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAEL-KAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 110 VVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAAFSPVLLNVAMIGAAIWIAP 189
Cdd:pfam03023 80 WLIRLLAPGF---------DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLAN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 190 HTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIPALFGVSVSQINLLLDTFIASFLMTG 269
Cdd:pfam03023 151 YLGNAIYALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 270 SISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEGEtvserFSQTMDWGVRMIFLLGIPAMFGIMVLAKPMMMV 349
Cdd:pfam03023 231 SVSYLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDE-----FRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 350 LFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISMISNMGFN-LLAIPFSYVGLAMASA 428
Cdd:pfam03023 306 LFERGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSlLLLPPLGVAGLALATS 385
|
410 420 430
....*....|....*....|....*....|..
gi 1913910128 429 MSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGK 460
Cdd:pfam03023 386 LSSLIGLVFLYYILRKRLGGFDLRGIKTFLAS 417
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
5-514 |
1.66e-111 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 340.46 E-value: 1.66e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 5 LLKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLTEYQKDGDLSKtRE 84
Cdd:TIGR01695 2 LLKSTLIVSLGTLFSRITGFVRDAIIASAFGAGLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEAR-RA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 85 FIAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGTGWfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNTIG 164
Cdd:TIGR01695 81 FANTVTTLLILSLLLVVLIGIFFAPFVISLLAPGF---------ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 165 QFGVAAFSPVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLMIP 244
Cdd:TIGR01695 152 RFFIPSFSPILFNIGVILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 245 ALFGVSVSQINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEEGEtvserFSQTMDWG 324
Cdd:TIGR01695 232 TTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNE-----LRDLLNQG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 325 VRMIFLLGIPAMFGIMVLAKPMMMVLFMRGEFTFSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIIS 404
Cdd:TIGR01695 307 IRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVIS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 405 MISNMGFNLLAI-PFSYVGLAMASAMSGTLNAWLLYRGLAVSGVYRIQRNSAIFIGKVALAGLAMAAAVSYCMpALSLWQ 483
Cdd:TIGR01695 387 VVLNALLSLLLIfPLGLVGIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYLIV-SVSLGG 465
|
490 500 510
....*....|....*....|....*....|.
gi 1913910128 484 AQHNgmRMLWLAGLIGLAAVVYFAALLLLGV 514
Cdd:TIGR01695 466 VLVK--NLLGLLAIGLIGLLVYFLGLALLKI 494
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-514 |
1.48e-15 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 79.44 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 1 MSKRLLKSGLVVSSMTLLSRVLGLVRDVVIANMIGA------GAAADVFLFanripnFLrrlfaegAFSQAFVPV----- 69
Cdd:COG5841 2 KKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDegfglyQMAYPIYGL------FL-------TLATAGIPVaiskl 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 70 LTEYQKDGDlSKTREFIAKVSGTLGGLVTIVTLLAMigspvvaaIFGTGWFLDWLNGGPDagkyelASFLLRITFPYLWF 149
Cdd:COG5841 69 VAEYNALGD-YKGARRIFRVSLLLLLILGLVFFLLL--------FFGAPFIARLLLGDPR------AYYSLRALAPALLI 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 150 VTLVALSGAVLNTIGQFGVAAFSPV---LLNVA-MIGAAIWIAPHTQYPEVGLA-IGIFLGGLLQFLFQLPYMKKAGLLV 224
Cdd:COG5841 134 VPVMSVLRGYFQGLQNMTPTAVSQVieqIVRVIfILLLAYLLLPYGLEYAAAGAtFGAVIGALAGLLVLLYYYRKRKKKL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 225 KPKWAWHDPG--------VKKIRTLMIPALFGVSVSQINLLLDTF-IASFLMTGSIS-------YLYYSDR---LLEFPL 285
Cdd:COG5841 214 KRLLEKSKTKskesskdiLKELLRIAIPITLSSLVLPLFQLIDSFtVPRRLQAAGLSaseatslYGILSGMaqpLVNLPT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 286 gLFGIAIATVILPALSRRHSEKEEGEtVSERFSQTMdwgvRMIFLLGIPAMFGIMVLAKPMMMVLFMrgeftfSDVNAAS 365
Cdd:COG5841 294 -VLATALATSLVPAISEAFAKKDRKL-VRRRINQAL----RLTLLIGLPAAVGLAVLAEPINTLLFG------NPEGGGI 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 366 LSLLAFNAGLVSFMLikVLAPGYYARQDTKTPVRYGIISMISNMGFNLLAIP-FSYVGLAMASAMSGTLNAWLLYRglAV 444
Cdd:COG5841 362 LAILAPSAIFLSLQQ--VTTGILQGLGKQKIPVINLLIGLLVKIILNYLLVPlFGIYGAALATVIGYLVAAILNLA--AL 437
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 445 SGVYRIQRNSAIFIGKVALAGLAMAAAVSYCMPALSLWQAQHNGMRMLWLAGLIGLAAVVYFAALLLLGV 514
Cdd:COG5841 438 KKYTGFKLDLRRRLLKPLLASLIMGIVVLLLYRLLSLFLPESRLGALLATLIAVLVGAIVYLLLLLKLGL 507
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-430 |
2.39e-13 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 71.80 E-value: 2.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 5 LLKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAADVFLFANRIPNFLrrLFAEGAFSQAFVPVLTEYQKDgdlsKTRE 84
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFS--IFADLGLPTALVREIARYRKE----KIRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 85 FIAKVsgtlgglVTIVTLLAMIGSPVVAAIFGTGWFLDWLnggpdagkyelASFLLRITFPYLWFVTLVALSGAVLNTIG 164
Cdd:cd13128 75 IISTS-------LVLKLILGILALLLLFLFAFLIAFYDPE-----------LVLLLYILALSLPFSALNSLFRGIFQGFE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 165 QFGVAAFSPVLLNVAMIGAAIwIAPHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKAGLLVKpKWAWHDPGVKKIRTLMIP 244
Cdd:cd13128 137 KMKYIVIARIIESVLSLILAL-ILVLLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPK-FFSFDLKLAKELLRFSIP 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 245 ALFGVSVSQINLLLDTFIASFLMTGSISYLY-YSDRLLEFpLGLFGIAIATVILPALSRRHSEKEEgetvseRFSQTMDW 323
Cdd:cd13128 215 LALSGIFSLIYTRIDTIMLGYFLGDAAVGIYnAAYRIAEL-LLFIPSAISTALFPRISELYKNDKD------ELKKLLKK 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 324 GVRMIFLLGIPAMFGIMVLAKPMMMVLFmrGEFTFSDVNAasLSLLAFnaGLVSFMLIKVLAPGYYARQDTKTPVRYGII 403
Cdd:cd13128 288 SFKYLFLISLPIAIGLFLFAEPIITLLF--GEEYLPAALV--LQILAW--GFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
410 420
....*....|....*....|....*...
gi 1913910128 404 SMISNMGFNLLAIP-FSYVGLAMASAMS 430
Cdd:cd13128 362 GALLNVILNLLLIPkYGIIGAAIATLIS 389
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
16-442 |
3.27e-11 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 65.18 E-value: 3.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 16 TLLSRVLGLVRDVVIANMIGAGAAAdVFLFANRIPNFLRrlfaegAFSQAFVPV-----LTEYQKDGDLSKTREFIAKVS 90
Cdd:cd13124 7 GLISKILGAIYRIPLQNIIGDEGMG-LYQMAYPIYGIFL------TLATAGIPVaisklVAEYNALGDYKGARRIFRVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 91 GTLGGLVTIVTLLAMIGSPVVAAifgtgwfldWLNGGPDAgkyelaSFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAA 170
Cdd:cd13124 80 ILLLILGLVFFLLLFFGAPFLAQ---------LLLGDPRL------APVIRALAPAILIVPLLSVLRGYFQGLQNMTPTA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 171 FSPVL---LNVA-MIGAAIWIAPHTQYPEVGLAI---GIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLM- 242
Cdd:cd13124 145 VSQVIeqiVRVIvILVLAYLLLPVGGGLYYAAAGatfGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILk 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 243 ------IPALFGVSVSQINLLLD--TFIASFLMTG------SISYLYYSDR---LLEFPLgLFGIAIATVILPALSRRHS 305
Cdd:cd13124 225 ellsyaIPITLSSLILPLLQLIDsfTVPRRLQAAGlseseaTALYGILTGRaqpLVQLPT-VIATALSTSLVPAISEAYA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 306 EKEEgETVSERFSQTMdwgvRMIFLLGIPAMFGIMVLAKPMMMVLFMRGEftfsdvnaASLSLLAFNAGLVSFMLIKVLA 385
Cdd:cd13124 304 KGDK-KELRRRINQAL----RLTLLIGLPAAVGLAVLAEPINTLLFGDSE--------GGLILQILAPSILFLSLQQVTA 370
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1913910128 386 PGYYARQDTKTPVRYGIISMISNMGFNLLAIP-FSYVGLAMASAMSGTLNAWLLYRGL 442
Cdd:cd13124 371 AILQGLGKVKIPVINLLIGLLVKIVLNYVLIPiFGIYGAAIATVIGFLVAALLNLRAL 428
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
3-439 |
1.84e-07 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 53.41 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 3 KRLLKSGLVVSSMTLLSRVLGLVRDVVIANMIGAgAAADVFLFANRIPNFLRrLFAEGAFSQAFVPVLTEYQKDgdlsKT 82
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGP-EEYGLFALALSIVALLS-VLADLGLSTALVRFIAEYREE----EL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 83 REFIAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGtgwfldwlnggpdagkYELASFLLRITFPYLWFVTLVALSGAVLNT 162
Cdd:COG2244 76 RRLLSTALLLRLLLSLLLALLLLLLAPFIAALLG----------------EPELALLLLLLALALLLSALSAVLLALLRG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 163 IGQFGVAAFSPVLLNVAMIGAAIWIAphtqypevglaigIFLGGLLQFLFQLpymkkagllvkpkwawhdpgvkkirtlM 242
Cdd:COG2244 140 LERFKLLALINILSSLLSLLLALLLA-------------LLGLGLWGLVLKY---------------------------S 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 243 IPALFGVSVSQINLLLDTFIASFLMT-GSISYLYYSDRLLEFPLgLFGIAIATVILPALSRRHSEKEEgetvsERFSQTM 321
Cdd:COG2244 180 LPLLLSGLLGLLLTNLDRLLLGALLGpAAVGIYSAAYRLASLLL-LLITALSQVLFPRLSRLLAEGDR-----EELRRLY 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 322 DWGVRMIFLLGIPAMFGIMVLAKPMMMVLFMrgeftfSDVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYG 401
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLFG------PEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIIS 327
|
410 420 430
....*....|....*....|....*....|....*....
gi 1913910128 402 IISMISNMGFNLLAIP-FSYVGLAMASAMSGTLNAWLLY 439
Cdd:COG2244 328 LIGAVLNLVLNLLLIPrYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
5-439 |
1.13e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 50.95 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 5 LLKSGLVVSSMTLLSRVLGLVRDVVIANMIG------AGAAADVFLFANripnflrrLFAEGAFSQAFVpvlteyQKDGD 78
Cdd:cd13127 1 AVSGAFWSAISQVVVQLLQFVVTIILARLLTpedfglVAMATVFIAFAQ--------LFSDLGLSSALI------QRKDL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 79 LSKTREFIAKVSGTLGGLVTIVTLLAmigSPVVAAIFGTgwfldwlnggpdagkyELASFLLRITFPYLWFVTLVALSGA 158
Cdd:cd13127 67 TEEDLSTVFWLNLLLGLLLYLLLFLL---APLIAAFYNE----------------PELIPLLRVLSLSFLLSGLGSVPRA 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 159 VLNTIGQFGVAAFSPVLLNVAMIGAAIWIApHTQYPEVGLAIGIFLGGLLQFLFQLPYMKKagllvKPKWAWHDPGVKKI 238
Cdd:cd13127 128 LLQRELRFKKLAIIELISTLVSGVVAIVLA-LLGFGVWALVAQQLVGALVSTVLLWILSRW-----RPRLSFSLASLKEL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 239 RTLMIPALFGVSVSQINLLLDTF-IASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRRHSEKEegetvseRF 317
Cdd:cd13127 202 LSFGSKLLGSNLLNYFSRNLDNLiIGKFLGAAALGYYSRAYRLALLPVQNITGPITRVLFPALSRLQDDPE-------RL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 318 SQTMDWGVRMIFLLGIPAMFGIMVLAKPMMMVLFmrGEftfSDVNAAS-LSLLAFNAGLvsFMLIKVLAPGYYARQDTKT 396
Cdd:cd13127 275 RRAYLKALRLLALITFPLMVGLALLAEPLVLLLL--GE---KWLPAVPiLQILALAGLF--QPLSSLNGSLLLALGRTDL 347
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1913910128 397 PVRYGIISMISNMGFNLLAIPFSYVGLAMASAMSGTLNAWLLY 439
Cdd:cd13127 348 LLKLGLIKAVLTVLALLIGIPYGIIGVAIAYVIASLLSFPLNL 390
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
3-216 |
1.25e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 47.70 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 3 KRLLKSGLVVSSMTLLSRVLGLVRDVVIANMIGAGAAAdVFLFANRIPNFLRRLFaeGAFSQAFVPVLTEYQKDGDLSKT 82
Cdd:cd12082 219 RRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALA-AYTVAFRIASLAFMPA--LGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 83 REFIAKVSGTLGGLVTIVTLLAMIGSPVVAAIFGTgwfldwlnggpDAGKYELASFLLRITFPYLWFVTLVALSGAVLNT 162
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTN-----------DPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQA 364
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1913910128 163 IGQFGVAAFSPVLLNVAMIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPY 216
Cdd:cd12082 365 AGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLF 418
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
16-447 |
5.75e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 45.39 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 16 TLLSRVLGLVRDVVIANMIG---AGAAADVFLFANRIPNFLRRLFAEGAFSQAFVPVLteyqkdgdlsKTREFIAKVSGT 92
Cdd:cd12082 4 LLLSMLLQTLYNLVDTFFLGrllGDALAAVGLAFPLIALLIALGVGLSVGTSALISQA----------IGAGDEEKARRV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 93 LGGLVTIVTLLAMIGSPVVaaIFGTGWFLDWLNGGPDAgkYELASFLLRITFPYLWFVTLVALSGAVLNTIGQFGVAAFS 172
Cdd:cd12082 74 LVQSIVLAILLGLLLAALL--LFFSPLILSLLGAEEEV--IELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMII 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 173 PVLLNVAMIGAAIWIAPHTQYPE---VGLAIGIFLGGLLQFLFQLPYMKKAGLLVKPKWAWHDPGVKKIRTLM---IPAL 246
Cdd:cd12082 150 SVLSNLLNILLDPLLIFGLGPPElgiAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLrigLPSA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 247 FGVSVSQINLLLDTFIAS-FLMTGSISYLYYSDRLLEFPLgLFGIAIATVILPALSRRHSEKEEgetvsERFSQTMDWGV 325
Cdd:cd12082 230 IQNSLLSLGLLIIVAIVAaFGGAAALAAYTVAFRIASLAF-MPALGLAQAALPVVGQNLGAGNF-----DRARRITWVAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 326 RMIFLLGIPAMFGIMVLAKPMMMVLFMRGEFtfsdVNAASLSLLAFNAGLVSFMLIKVLAPGYYARQDTKTPVRYGIISM 405
Cdd:cd12082 304 LIGLLIGAVLGLLILLFPEPILSLFTNDPEF----LELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSY 379
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1913910128 406 IsnmgfnLLAIPFSYVGLAMasamsgTLNAWLLYRGLAVSGV 447
Cdd:cd12082 380 W------VVRLPLAYVLAYL------GLGLYGIWLALVISLI 409
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
57-426 |
1.87e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 44.07 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 57 FAEGAFSQAFVPVLTEYQKDgdlsktrefIAKVSGTLGGLVTIVTLLAMIGSPVVaaIFGTGWFLDWLNGGPDagkYELA 136
Cdd:cd13125 49 IAGGGINNGVVKYTAEYKDD---------EEKLARVWSTAFRITLILSILGGLLL--LLFSKPLSSLLFGDID---YSWV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 137 SFLLRITfpyLWFVTLVALSGAVLNTIGQFGVAAFSPVLLNVamIGAAIWIAPHTQYPEVGLAIGIFLGGLLQFLFQLPY 216
Cdd:cd13125 115 FILLGLA---LPLFALNNLLLAILNGLKEIKRYALINIISSL--IGLLVSVLLVYFYGLKGALLALVLNQSLIFLVTLIY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 217 MKKAG--LLVKPKWAWHDPGVKKIRTLMIPALF-GVSVSQINLLLDTFIASFLMTGSISYLYYSDRLLEFPLGLFGIAIA 293
Cdd:cd13125 190 SRKQPwfKLKYLWGRLDKDIIKKLLKFSLMALVsALSLPLSQIIVRNILIRQLGWEAAGYWQAVWKISDVYLGFITTALS 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 294 TVILPALSRRHSEKEEGETVSErfsqtmdwGVRMIFLLGIPAMFGIMVLAKPMMMVLFMRgEFTfsdvnAASLSLLAFNA 373
Cdd:cd13125 270 TYYLPRLSAIKDNKELKREVNK--------QLKVILPLVAIGALLIYLLRDLIIQILFSE-EFL-----PARELFLWQLI 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1913910128 374 GlvsfMLIKVLA--PGYY--ARQDTKTPVRYGIISMISNMGFNLLAIP-FSYVGLAMA 426
Cdd:cd13125 336 G----DFFKIASwlLGYIllAKGMTKLFIITEILFALLFVLLSLLFIPlFGLEGAGIA 389
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
225-351 |
3.23e-03 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 39.50 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913910128 225 KPKWAWHDPGVKKIRTLMIPALFGVSVSQINLLLDTF-IASFLMTGSISYLYYSDRLLEFPLGLFGIAIATVILPALSRR 303
Cdd:pfam13440 164 RPRLTFSLKVIKELFSFGSWLLLSNLLNYLARNLDNLiIGKVLGTAALGLYSVAYRLALLPTANITSVITKVLFPALSRI 243
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1913910128 304 HSEKEEGETVSERFsqtmdwgVRMIFLLGIPAMFGIMVLAKPMMMVLF 351
Cdd:pfam13440 244 QDDKAKLRELYLRV-------LRLIAFIVFPIMAGLAVVAEPLVLVLL 284
|
|
| |
