|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-600 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1029.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 6 FFRSIQFKITLIYVLLIIIAMQIIGVYFVKQVENSLLKSYELSLNQRIDNLSYYIEQEY-KGDNDSTVIKDDVKRILNDF 84
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELsKEDEDDETLEEDIRTILNDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 85 TkNNEIREITFVDKSYEVVGSSRPYGEEIAGKQTTDPIFKRIFSTKQAYSKKYYDPKSKNRVLISAKPVVTENQEVVGAI 164
Cdd:NF033092 81 N-NNDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVVGAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 165 YVVASMEDTFNQMKTVNSILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTF 244
Cdd:NF033092 160 YIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 245 NHLTRELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLV 324
Cdd:NF033092 240 NNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 325 EQQDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAE 404
Cdd:NF033092 320 EEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 405 GAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRFEM-TKEQHVEFIRELPDRN 483
Cdd:NF033092 400 GAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPKRD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 484 LYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDvnEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGG 563
Cdd:NF033092 480 LWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL--ETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGG 557
|
570 580 590
....*....|....*....|....*....|....*..
gi 1913908798 564 TGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPY 600
Cdd:NF033092 558 TGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
190-610 |
9.24e-136 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 403.72 E-value: 9.24e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 190 LALVLTALLGIFLA---RTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLS 266
Cdd:NF033093 18 LLLLGFILYFILLAlrnRRDNKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 267 SVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQQDSMLLEIERD-DETTVLRV 345
Cdd:NF033093 98 SILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITKTPELTLDSRDEnGEFLSLRV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 346 NFSVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWeNKDIAPRFLMVTQNETE 425
Cdd:NF033093 178 RFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGAL-SEPVAPSFIKVSLDETN 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 426 RMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRFEMTKEQH------VEFIRELPDRNLYVEIDQDKVTQVLDN 499
Cdd:NF033093 257 RMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDtetgkkYEIVRDYPITSIWVEIDTDKMTQVIDN 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 500 IISNALKYSPEGGHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHG 579
Cdd:NF033093 337 ILNNAIKYSPDGGKITVSMKTTDTQ--LIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHK 414
|
410 420 430
....*....|....*....|....*....|...
gi 1913908798 580 GDIWADSVEGKGTKITFTLPYKEE--QEDDWDE 610
Cdd:NF033093 415 GFIWAKSEYGKGSTFTIVLPYDKDavKDDEWED 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
285-603 |
8.58e-107 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 327.28 E-value: 8.58e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 285 IILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQQDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAVL 364
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 365 YDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKD 444
Cdd:COG5002 153 RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 445 YQFNREWIHMIRFMSLIIDRFEMT-KEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEK 523
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDD 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 524 EelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:COG5002 313 Q--VRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
183-605 |
3.61e-85 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 272.22 E-value: 3.61e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 183 ILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEDAQAMTEGER 262
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 263 RKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENF-TFEDLVEQQDSMLLEIERDDETT 341
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAeLLREALERGWQEEIELTRDGRRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 342 VLrvnfsvIQREHGKIDGLIAVLYDVTEQekLDRER----REFVANVSHELRTPLTTMRSYLE----ALAEGAWENKDIA 413
Cdd:COG5000 170 LL------VRASPLRDDGYVIVFDDITEL--LRAERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDREDL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 414 PRFLMVTQNETERMIRLVNDLLQLSKFDskdyQFNREWIHMIRFMSLIIDRFEMT-KEQHVEFIRELPDRNLYVEIDQDK 492
Cdd:COG5000 242 ERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVLADRDQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALKYSPEGGHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAK 572
Cdd:COG5000 318 LEQVLINLLKNAIEAIEEGGEIEVSTRREDGR--VRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVK 389
|
410 420 430
....*....|....*....|....*....|...
gi 1913908798 573 EMVQAHGGDIWADSVEGKGTKITFTLPYKEEQE 605
Cdd:COG5000 390 KIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-603 |
2.88e-81 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 255.60 E-value: 2.88e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 369 EQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFN 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 449 REWIHMIRFMSLIIDRFEMT-KEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEELL 527
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTIT--ISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913908798 528 YISVKDEGIGIPKKDVEKVFDRFYRVDkaRTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
268-599 |
4.31e-74 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 240.20 E-value: 4.31e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 268 VIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQQDSMLLEIERDDETTVLRVNF 347
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 348 SVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWENkdiAPRFLMVTQNETERM 427
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 428 IRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRFE-MTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALK 506
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 507 YSPEGGHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRklGGTGLGLAIAKEMVQAHGGDIWADS 586
Cdd:COG0642 238 YTPEGGTVTVSVRREGDR--VRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|...
gi 1913908798 587 VEGKGTKITFTLP 599
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
263-598 |
7.11e-73 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 237.11 E-value: 7.11e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 263 RKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKEnftFEDLVEQQDS---MLLEIERDDE 339
Cdd:TIGR02966 6 SRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPE---FVEYLAAGRFsepLELPSPINSE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 340 TTVlrvnfsVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMV 419
Cdd:TIGR02966 83 RVL------EIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 420 TQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRFE-MTKEQHVEFIRELpDRNLYVEIDQDKVTQVLD 498
Cdd:TIGR02966 157 MLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEaLSQGKNHQITFEI-DGGVDVLGDEDELRSAFS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 499 NIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAH 578
Cdd:TIGR02966 236 NLVSNAIKYTPEGGTIT--VRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRH 313
|
330 340
....*....|....*....|
gi 1913908798 579 GGDIWADSVEGKGTKITFTL 598
Cdd:TIGR02966 314 HARLEIESELGKGSTFSFIF 333
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
5-603 |
2.11e-60 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 211.75 E-value: 2.11e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 5 GFFRSIQFKITLIYVLLIIIAMQIIGVYFVKQVENSLLKSYELSLN---QRID-----NLSYYIEQEYKGDNDstviKDD 76
Cdd:PRK11360 1 IYPRSFRNQLILLVILLVIVPTLLIGYILETEGRSAVLSEKEKKLSavvNLLDqalggRFDLYLASQGVADLP----REE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 77 VKRILN--------DFTKNNEIREITFVDKSYEVV---GSSRPYGEEIAGKQTTDPIFKRIFSTKQAYSkkYYDPKSKNR 145
Cdd:PRK11360 77 KIRALNaelapvteNITHAYPGIGAGYYSKELDAIityGPSALYQENVGVRIKADHPGREVMRTNTPLV--ESGGQVRGG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 146 VLISAKPVVtENQEVVGAIYVVASMEDTFNQMKTVNSILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKgNF 225
Cdd:PRK11360 155 ILNSMIPIE-RNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVDIIKDGLSTLEN-DL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 226 SRKVRKYgHDEIGQLATTFNHLTRELEDAQAMTEgerrklsSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALE 305
Cdd:PRK11360 233 STRLPPL-PGELGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVG 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 306 MPITSLLgiKENFTFEDLV-------EQQDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTE----QEKLD 374
Cdd:PRK11360 305 KPYSELF--PPNTPFASPLldtlehgTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTErkrlQRRVA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 375 RERR-----EFVANVSHELRTPLTTMRSYLEALAEGAweNKDIAPRFLMVTQNETERMIRLVNDLLQLSK-----FDSkd 444
Cdd:PRK11360 383 RQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpresqWQP-- 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 445 YQFNREWIHMIRFMSliidrfEMTKEQHVEFIRELpDRNL-YVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDvNEK 523
Cdd:PRK11360 459 VSLNALVEEVLQLFQ------TAGVQARVDFETEL-DNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTW-QYS 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 524 EELLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:PRK11360 531 DGQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
256-607 |
2.90e-60 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 204.70 E-value: 2.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 256 AMTEGERRkLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGikENFTFEDLVEQ-----QDSM 330
Cdd:COG3852 1 ALRESEEL-LRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFP--EDSPLRELLERalaegQPVT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 331 LLEIE---RDDETTVLRVNFSVIQREHGKiDGLIAVLYDVTEQEKLDRERR---------EFVANVSHELRTPLTTMRSY 398
Cdd:COG3852 78 EREVTlrrKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 399 LEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDskdyQFNREWIHMIRFMSLIIDRFEMTKEQHVEFIRE 478
Cdd:COG3852 157 AQLLERELPDDEL--REYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKNIRIVRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 479 LPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEEL--------LYISVKDEGIGIPKKDVEKVFDRF 550
Cdd:COG3852 231 YDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyVRIEVIDNGPGIPEEILDRIFEPF 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1913908798 551 YrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEEQEDD 607
Cdd:COG3852 311 F------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
249-601 |
2.92e-47 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 172.85 E-value: 2.92e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 249 RELEDAQAMTEGER---RKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVE 325
Cdd:COG5809 124 RDITERKRMEEALReseEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFIS 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 326 Q--QDSMLLEIE-----RDDETTVLRVNFSVIQREhGKIDGLIAVLYDVTEQEKLDRERR---------EFVANVSHELR 389
Cdd:COG5809 204 QllKDGGIAQGEvrfwtKDGRWRLLEASGAPIKKN-GEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIR 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 390 TPLTTMRSYLEALAEGAWENKDiapRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFnrewIHMIRFMSLIIDRFE--- 466
Cdd:COG5809 283 NPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----KDLNTLIEEVIPLLQpqa 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 467 -MTKEQ-HVEFIRELPDrnlyVEIDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEE-LLYISVKDEGIGIPKKDV 543
Cdd:COG5809 356 lLKNVQiELELEDDIPD----ILGDENQLKQVFINLLKNAIEAMPEGGNIT--IETKAEDDdKVVISVTDEGCGIPEERL 429
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1913908798 544 EKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYK 601
Cdd:COG5809 430 KKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
235-599 |
6.13e-47 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 172.66 E-value: 6.13e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 235 DEIGQLATTFNHLTRELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGI 314
Cdd:COG4251 133 ALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 315 KENFTFEDLVEQQDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAV------LYDVTEQ-EKLDRERREFVANVSHE 387
Cdd:COG4251 213 LEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELeeleeeLEERTAElERSNEELEQFAYVASHD 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 388 LRTPLTTMRSYLEALAEGAWENKD-IAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFnrEWIHMIRFMSLIIDRFE 466
Cdd:COG4251 293 LREPLRKISGFSQLLEEDYGDKLDeEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEVLEDLE 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 467 MT-KEQHVEF-IRELPDrnlyVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVE 544
Cdd:COG4251 371 PRiEERGAEIeVGPLPT----VRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAE 446
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1913908798 545 KVFDRFYRVDkaRTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:COG4251 447 KIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
262-599 |
9.88e-46 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 167.49 E-value: 9.88e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 262 RRKLSSVI-------AYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKEnftFEDLVEQQD-SMLLE 333
Cdd:PRK11006 90 RRELGNLIkrfrsgaESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPE---FTQYLKTRDfSRPLT 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 334 IERDDETTVlrvNFSVIQREHGKidgLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEAL----AEGAWEN 409
Cdd:PRK11006 167 LVLNNGRHL---EIRVMPYTEGQ---LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMqdqpLEGALRE 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 410 KDiaprfLMVTQNETERMIRLVNDLLQLSKFDSKDyQFNREWIHMIRFMSLIIDRFEMTKEQHVEFIRELPDRNLYVEID 489
Cdd:PRK11006 241 KA-----LHTMREQTQRMEGLVKQLLTLSKIEAAP-TIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGN 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 490 QDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLyiSVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLA 569
Cdd:PRK11006 315 EDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEF--SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLA 392
|
330 340 350
....*....|....*....|....*....|
gi 1913908798 570 IAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK11006 393 IVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
8-599 |
2.88e-44 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 165.20 E-value: 2.88e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 8 RSIQFKITLIYVLLIIIAMQIIGVYFVKQVENSLLKS----------------------YELSLNQRIDNLSYYIEQEYK 65
Cdd:NF040691 3 RSLQLRVVAITLLLSLVVILVLGVVLALQITNGLLDNrvdaalgdsrrartqaqsqlnaSDASTSDSAQQLLRTTLLSVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 66 GDNDSTVIK--DDVKRILNDFTKNNEIREITFVDKSYEVvgsSRPYGEEIAGKQTTDPIFK--RIFSTKQAYSkkyydpk 141
Cdd:NF040691 83 ASASGAMQGafDVVLLVPGDDPSGLGPRASGSVGLVSQI---PEELREAVAGGQVAQQYQSvaLPSGDGSSAP------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 142 sknrVLISAKPVVTENQEVVGaIYVVASMEDTFNQMKTVNSILASGtGLALVLTALLGIFL-ARTITHPLSDMRKQAMEL 220
Cdd:NF040691 153 ----ALVVGTPVTLPVAGNYE-LYLLFPLEDEQSTLALVRGTLLLG-GLALVVLLGLIAWLvTRQVVAPVRSAARTAERF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 221 AKGNFSRKVRKYGHDEIGQLATTFNhltreledaqAMTEgerrklssviaymtdgviatnrngaiillnspalellnvsr 300
Cdd:NF040691 227 AAGDLSERMPVKGEDDLARLARSFN----------QMAD----------------------------------------- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 301 etalempitsllgikenftfedlveqqdsmlleierddettvlrvnfsVIQREhgkidgliavlydVTEQEKLDRERREF 380
Cdd:NF040691 256 ------------------------------------------------SLQRQ-------------IRQLEELSRLQQRF 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 381 VANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSL 460
Cdd:NF040691 275 VSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRR 354
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 461 IIDRFEMTKEQH-VEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSpEGGHVTFSVDVNEKEelLYISVKDEGIGIP 539
Cdd:NF040691 355 VVDALRQLAERAgVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTA--VAVTVRDHGVGLK 431
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 540 KKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:NF040691 432 PGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
249-599 |
1.70e-40 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 151.10 E-value: 1.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 249 RELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQQD 328
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 329 SMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAvlyDVTEQEKLDRERR----------------EFVANVSHELRTPL 392
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELER---DITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 393 TTMRSYLEALAE--GAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDyqfnREWI---HMIRFMSLIIDRfeM 467
Cdd:COG4191 158 AAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVdlnELIDEALELLRP--R 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 468 TKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVF 547
Cdd:COG4191 232 LKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIF 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 548 DRFYRvdkarTRKLG-GTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:COG4191 312 EPFFT-----TKPVGkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
488-601 |
5.61e-40 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 141.63 E-value: 5.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 488 IDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKaRTRKLGGTGLG 567
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRIT--VTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 1913908798 568 LAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYK 601
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-598 |
6.11e-39 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 138.50 E-value: 6.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALKYSPEGGHVTFSVDvnEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRklGGTGLGLAIAK 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLR--QEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 1913908798 573 EMVQAHGGDIWADSVEGKGTKITFTL 598
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
149-599 |
7.21e-39 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 148.82 E-value: 7.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 149 SAKPVVTENQEVVGAIYV-VASMEDTF------NQMKTVNSILAsgtgLALVLTALLGIFLARTITHPLSDMRKQAMELA 221
Cdd:NF012163 128 TRRPILVNGQEVGALGASpVERLTRNTdinfdsQQKRASWLIVA----LALLLAALAAFLLARGLLAPVKRLVEATHRLA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 222 KGNFSRKVRKYGHDEIGQLATTFNHLTRELEDAQAMtegerrklssviaymtdgviatnrngaiillnspalellnvsre 301
Cdd:NF012163 204 AGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQM-------------------------------------------- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 302 talempitsllgikenftfedlveqqdsmlleierddettvlrvnfsviqrehgkidgliavlydvteqekldreRREFV 381
Cdd:NF012163 240 ---------------------------------------------------------------------------RRDFM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 382 ANVSHELRTPLTTMRSYLEALAEGAwenKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLI 461
Cdd:NF012163 245 ADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVE 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 462 IDRFEMTKEQH-VEFIRELPDRNLYVEiDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYisVKDEGIGIPK 540
Cdd:NF012163 322 GGAFRERFASAgLELEVSLPDSSLVFG-DRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLT--VADSAPGVSD 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1913908798 541 KDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:NF012163 399 EQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-599 |
1.12e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 135.31 E-value: 1.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGgHVTFSVDVNEKEE---LLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIA 571
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 1913908798 572 KEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-607 |
4.56e-37 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 144.01 E-value: 4.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 371 EKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAwenKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE 450
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 451 WIHMIRFMSLII----DRFEmTKEQHVEFirELPDrNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEEL 526
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA-SRGLTLQL--SLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 527 LYIsvKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEEQED 606
Cdd:PRK10549 387 LTF--ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 464
|
.
gi 1913908798 607 D 607
Cdd:PRK10549 465 E 465
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-602 |
3.32e-35 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 128.25 E-value: 3.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 489 DQDKVTQVLDNIISNALKYSPEGGHVTFSVdvnEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKartRKLGGTGLGL 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|....
gi 1913908798 569 AIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKE 602
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
369-599 |
1.80e-34 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 134.69 E-value: 1.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 369 EQEKLdRERREF----VANVSHELRTPLTTMRSYLEALAEGAWENKDIAP-----RFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:PRK09303 140 ENETL-LEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 440 FDSKDYQFNREWIHMIRFMSLIIDRFEMT-KEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSV 518
Cdd:PRK09303 219 TRWEALRFNPQKLDLGSLCQEVILELEKRwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 519 --DVNEKEEllyISVKDEGIGIPKKDVEKVFDRFYRVDkaRTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITF 596
Cdd:PRK09303 299 lhRTTQKVQ---VSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHF 373
|
...
gi 1913908798 597 TLP 599
Cdd:PRK09303 374 TLP 376
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
250-599 |
4.13e-33 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 132.93 E-value: 4.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 250 ELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLG------IKENFtfEDL 323
Cdd:COG5805 144 KKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHpcdkeeFKERI--ESI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 324 VEQQDSMLLE---IERDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTEQEKLDRERR---------EFVANVSHELRTP 391
Cdd:COG5805 222 TEVWQEFIIEreiITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQLAAGIAHEIRNP 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 392 LTTMRSYLEALAEGAWENKDIAPrfLMVTqnETERMIRLVNDLLQLSKFDSkdYQFNREWIHMI--RFMSLiidrfeMTK 469
Cdd:COG5805 302 LTSIKGFLQLLQPGIEDKEEYFD--IMLS--ELDRIESIISEFLALAKPQA--VNKEKENINELiqDVVTL------LET 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 470 E---QHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKV 546
Cdd:COG5805 370 EailHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNS--VIIRVIDEGIGIPEERLKKL 447
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 547 FDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:COG5805 448 GEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
1.57e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 120.89 E-value: 1.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGGHVTFSVDVNEkeelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEM 574
Cdd:cd16949 3 RALENVLRNALRYSPSKILLDISQDGDQ----WTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 1913908798 575 VQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
380-598 |
3.43e-32 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 129.81 E-value: 3.43e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 380 FVANVSHELRTPLTTM-----------RS---YLEALAEgawenkdiaprflmvTQNETERMIRLVNDLLQLSKFDSKDY 445
Cdd:TIGR01386 244 FSADLAHELRTPLTNLlgqtqvalsqpRTgeeYREVLES---------------NLEELERLSRMVSDMLFLARADNGQL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 446 QFNREWIHMIRFMSLIIDRFEMTKEQhvEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEE 525
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEE--RGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTIT--VRIERRSD 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 526 LLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGkgtKITFTL 598
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG---KTRFIL 454
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
381-599 |
3.48e-32 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 129.67 E-value: 3.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 381 VANVSHELRTPLTTMRSYLeALA---EGawENKDIApRFlmvtQNETERMIRLVNDLLQLSKFDSKDyQFNREWIHMIRF 457
Cdd:PRK09470 247 LSDISHELRTPLTRLQLAT-ALLrrrQG--ESKELE-RI----ETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 458 MSLIID--RFEMTKEQHVEFIRELPDRnLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEkeelLYISVKDEG 535
Cdd:PRK09470 318 WSEVLEdaKFEAEQMGKSLTVSAPPGP-WPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG----LTITVDDDG 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913908798 536 IGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK09470 393 PGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
307-599 |
1.82e-30 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 124.88 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 307 PITSLLGIKENFTFEDLVEQQDSMLLEIERddETTVLRVNFsviqrehgkidgLIAVLYDV-TEQEKldrerreFVANVS 385
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVRLDPQTVPIEL--EQLVLSFNH------------MIERIEDVfTRQSN-------FSADIA 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 386 HELRTPLTTMRSYLE-ALAEGAWEN--KDIaprfLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLII 462
Cdd:PRK09835 271 HEIRTPITNLITQTEiALSQSRSQKelEDV----LYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVF 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 463 DRFE-MTKEQHVEFirELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKK 541
Cdd:PRK09835 347 DFFEaWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAIT--VRCQEVDHQVQLVVENPGTPIAPE 422
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1913908798 542 DVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSvEGKGTKITFTLP 599
Cdd:PRK09835 423 HLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
355-599 |
1.20e-28 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 121.59 E-value: 1.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 355 GKIDGLIAVLYDVTE----QEKLDRERRE---FVANVSHELRTPLttmrsylealaegaweNKDIA-PRFLMVTQNETER 426
Cdd:PRK11091 254 GKRHGLMGFGRDITErkryQDALEKASRDkttFISTISHELRTPL----------------NGIVGlSRILLDTELTAEQ 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 427 M----------IRL---VNDLLQLSKFDSKDYQFNREWIHMIRFMS-------LIID----RFEMTKEQHvefireLPDr 482
Cdd:PRK11091 318 RkylktihvsaITLgniFNDIIDMDKMERRKLQLDNQPIDFTDFLAdlenlsgLQAEqkglRFDLEPLLP------LPH- 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 483 nlYVEIDQDKVTQVLDNIISNALKYSPEGGhVTFSVDVNEKEELLYiSVKDEGIGIPKKDVEKVFDRFYRV-DKARTRKL 561
Cdd:PRK11091 391 --KVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEGDMLTF-EVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPA 466
|
250 260 270
....*....|....*....|....*....|....*...
gi 1913908798 562 GGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK11091 467 TGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
359-606 |
1.92e-28 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 121.30 E-value: 1.92e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 359 GLIAV------LYDVTEQEKLDRERRE----FVANVSHELRTPLTTMRSYLEALA-EGAWENKDIAPRFLMVTQnETERM 427
Cdd:PRK10490 636 LLIANalerltLTASEEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQ-QVLNT 714
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 428 IRLVNDLLQLSKFDSKDYQFNREWIHM-------IRFMSLIIDRfemtkeQHVEFirELPDRNLYVEIDQDKVTQVLDNI 500
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLeevvgsaLQMLEPGLSG------HPINL--SLPEPLTLIHVDGPLFERVLINL 786
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 501 ISNALKYSpeGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrkLGGTGLGLAIAKEMVQAHGG 580
Cdd:PRK10490 787 LENAVKYA--GAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGG 862
|
250 260 270
....*....|....*....|....*....|..
gi 1913908798 581 DIWADSVEGKGTKITFTLPYK------EEQED 606
Cdd:PRK10490 863 TIWAENRPEGGACFRVTLPLEtppeleEFHED 894
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
315-599 |
1.99e-28 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 121.04 E-value: 1.99e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 315 KENFtfEDLVEQQDSMLleierddETTVLRVNFSVIQREHGKidgliavlydvTEQEKLDRERREFVANVSHELRTPLTT 394
Cdd:TIGR02956 422 KESL--EQLVAQRTQEL-------AETNERLNAEVKNHAKAR-----------AEAEEANRAKSAFLATMSHEIRTPLNG 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 395 MRSYLEALAEgawenKDIAP---RFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMirfMSLIIDRFEM---- 467
Cdd:TIGR02956 482 ILGTLELLGD-----TGLTSqqqQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDL---NALLDDVHHLmvsr 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 468 TKEQHVEFIRELPDR-NLYVEIDQDKVTQVLDNIISNALKYSPEgGHVTFSVDVNEKEELLyISVKDEGIGIPKKDVEKV 546
Cdd:TIGR02956 554 AQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSSLL-FEVEDTGCGIAEEEQATL 631
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 547 FDRFYRVDKarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:TIGR02956 632 FDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
380-599 |
8.35e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 116.87 E-value: 8.35e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 380 FVANVSHELRTPLTTMRSYLEALAEGAWEnkDIAPRFLMVTQNETERMIRLVNDLLQLSKFDskdyqfNREWIHM---IR 456
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPP--EDRARFTGNILTQSARLQQLIDRLLELARLE------QRQELEVlepVA 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 457 FMSLI---IDRFEMTKEQHVEFIRELPDrNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVneKEELLYISVKD 533
Cdd:PRK11100 331 LAALLeelVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEV--DGEQVALSVED 407
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1913908798 534 EGIGIPKKDVEKVFDRFY---RVDKARTrklgGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK11100 408 QGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-599 |
8.44e-28 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 116.24 E-value: 8.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 377 RREFVANVSHELRTPLTTMRSYLEAL-----AEGAWENKDIaprflmvTQNETermirLVNDLLQLSKFDSKDYQFNREW 451
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMSdnlsaAESQALNRDI-------GQLEA-----LIEELLTYARLDRPQNELHLSE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 452 IHMIRFMSLIIDRFEMTkEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSpeGGHVTFSVDVNEKEELLyiSV 531
Cdd:PRK10604 280 PDLPAWLSTHLADIQAV-TPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACL--IV 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1913908798 532 KDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK10604 355 EDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
237-603 |
1.90e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 114.56 E-value: 1.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 237 IGQLATTFNHLTRELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSretALEMPITSLLgike 316
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVL---- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 317 nftfedlveqqDSMLLEIERDDETT----VLRVNFSVIqREHGKIDGLIAVLYDVTEQEKLDRE---RREFVANV---SH 386
Cdd:COG3290 131 -----------AEVLETGERDEEILlngrVLVVNRVPI-RDDGRVVGAVATFRDRTELERLEEElegVKELAEALraqRH 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 387 ELRTPLTTMRSYLEalaegawenkdiaprflmvtQNETERMIRLVNDLLQLSKfdsKDYQFNREWIHMIRFMSLIIDRFE 466
Cdd:COG3290 199 DFRNHLHTISGLLQ--------------------LGEYDEALEYIDEISEELQ---ELIDSLLSRIGNPVLAALLLGKAA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 467 MTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKY--SPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVE 544
Cdd:COG3290 256 RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1913908798 545 KVFDRFYRvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:COG3290 336 KIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
382-607 |
3.76e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 114.88 E-value: 3.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 382 ANVSHELRTPLTTMRSYLEALAEGAWENKDiAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQ---FNREWIHMIRFM 458
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERAPAGGE-AHQLAQVMAKEADRLNRVVSELLELVKPTHLALQavdLNDLINHSLQLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 459 SliidRFEMTKEQHVEF-IRE-LPDrnlyVEIDQDKVTQVLDNIISNALKYSPEGGhvTFSVDVNEKEELLYISVKDEGI 536
Cdd:PRK10364 321 S----QDANSREIQLRFtANDtLPE----IQADPDRLTQVLLNLYLNAIQAIGQHG--VISVTASESGAGVKISVTDSGK 390
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1913908798 537 GIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEEQEDD 607
Cdd:PRK10364 391 GIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-599 |
2.04e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 103.70 E-value: 2.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 489 DQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYisVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGL 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLD--VEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1913908798 569 AIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-599 |
2.22e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 103.44 E-value: 2.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 499 NIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAH 578
Cdd:cd16952 7 NLVSNAVKYTPPSDTIT--VRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 1913908798 579 GGDIWADSVEGKGTKITFTLP 599
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
5.03e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 99.71 E-value: 5.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKarTRKLGGTGLGLAIAKEM 574
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1913908798 575 VQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
382-582 |
1.45e-24 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 105.46 E-value: 1.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 382 ANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMvtqNETERMIRLVNDLLQLSKFDSKDYQFNREWIHmirFMSLI 461
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEPDPALFKSLL---NQVEGLSHLVEDLRTLSLVENQQLRLNYESVD---LKDSI 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 462 IDRFEMTKE--QHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSpEGGHVTFSVDVNEKEELLYIsvKDEGIGIP 539
Cdd:NF012226 217 EKVLKMFEDrlEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQI--EDEGPGIA 293
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1913908798 540 KKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDI 582
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
377-605 |
1.83e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 109.05 E-value: 1.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 377 RREFVANVSHELRTPLTTMRSYLEALAeGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIR 456
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 457 FMSLIIDRF---EMTKEQHVEFIRELPDRNLyVEIDQDKVTQVLDNIISNALKYSPEGG-HVTFS-VDVNEKEELLYISV 531
Cdd:PRK09959 791 LVQNTCHSFgaiAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSlGHIDDNHAVIKMTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913908798 532 KDEGIGIPKKDVEKVFDRFYRVDKARTRKlgGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEEQE 605
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQ 941
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
361-599 |
1.55e-23 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 105.83 E-value: 1.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 361 IAVLYDVTEQEKLDRERRE--------------FVANVSHELRTPLTTMRSYLE-----ALAEGAwenkdiaPRFLMVTQ 421
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDllqtkELPKGV-------DRLVTAMN 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 422 NETERMIRLVNDLLQLSKFDSKDY-----QFN-REWI-HMI-RFMSLIIdRFEMTKEQHVEfirelPDRNLYVEIDQDKV 493
Cdd:PRK10841 490 NSSSLLLKIISDILDFSKIESEQLkieprEFSpREVInHITaNYLPLVV-KKRLGLYCFIE-----PDVPVALNGDPMRL 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 494 TQVLDNIISNALKYSPEGGhVTFSVDVneKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKE 573
Cdd:PRK10841 564 QQVISNLLSNAIKFTDTGC-IVLHVRV--DGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEK 640
|
250 260
....*....|....*....|....*.
gi 1913908798 574 MVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK10841 641 LINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-599 |
4.17e-23 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 94.48 E-value: 4.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 489 DQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLyISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGL 568
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1913908798 569 AIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
8.81e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 93.50 E-value: 8.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 496 VLDNIISNALKYSPEGGHVTFSVDVNEKEELLyiSVKDEGIGIPKKDVEKVFDRFYRVDKARtRKLGGTGLGLAIAKEMV 575
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVL--SIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 1913908798 576 QAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
379-601 |
9.30e-23 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 101.10 E-value: 9.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 379 EFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQ---FNREWIHMI 455
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLEkidVSEELEHVI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 456 RFMSliidrfEMTKEQHVEFIRELPDrNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELlyISVKDEG 535
Cdd:COG5806 282 DVLS------PYANMNNVEIQTELEP-GLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVI--ISIKDTG 352
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913908798 536 IGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYK 601
Cdd:COG5806 353 VGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-598 |
1.85e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 92.96 E-value: 1.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 478 ELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVdvNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKAR 557
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTL--REDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1913908798 558 TRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTL 598
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-580 |
3.07e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 98.50 E-value: 3.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 370 QEKLDRERrEFVANVSHELRTPLTTMRSYLEALAEGAweNKDIAPRFLMVTQneterMIRLVNDLLQLS----KFDSKDY 445
Cdd:PRK10755 131 TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQH--HIDVAPLIARLDQ-----MMHTVEQLLQLAragqSFSSGHY 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 446 QfNREWIHMIrFMSLIIDRFEMTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTfsVDVNEKEE 525
Cdd:PRK10755 203 Q-TVKLLEDV-ILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTIT--IKLSQEDG 278
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1913908798 526 LLYISVKDEGIGIPKKDVEKVFDRFYRVDkartRKLGGTGLGLAIAKEMVQAHGG 580
Cdd:PRK10755 279 GAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-596 |
5.26e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 90.98 E-value: 5.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 489 DQDKVTQVLDNIISNALKYSPEGGHVtfSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlGGTGLGL 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTV--SISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|....*...
gi 1913908798 569 AIAKEMVQAHGGDIWADSVEGKGTKITF 596
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-599 |
1.26e-21 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 99.43 E-value: 1.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 378 REFVANVSHELRTPLTTMRSYLEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRF 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQALEQEK--QKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 458 MSLIIDRFEMTKEQHVeFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELlyISVKDEGIG 537
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQR-FELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHAL--LTVSNEGPP 640
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 538 IPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSV-EGKGTKITFTLP 599
Cdd:TIGR03785 641 LPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-595 |
2.06e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 89.77 E-value: 2.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 482 RNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVtfSVDVNEKEELLyISVKDEGIGIPKKDVEKVFDRFYRVDKartRKL 561
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRV--EIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNY 76
|
90 100 110
....*....|....*....|....*....|....
gi 1913908798 562 GGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKIT 595
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
4.68e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 88.26 E-value: 4.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALKYSpeggHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAK 572
Cdd:cd16939 1 MARALDNLLRNALRYA----HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*..
gi 1913908798 573 EMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16939 77 RVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-605 |
5.13e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 97.79 E-value: 5.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 369 EQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIapRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFN 448
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 449 REWIHMIrfmsLIIDRfEMTKEQHVEFIREL-------PDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGhvtFSVDVN 521
Cdd:PRK15347 468 LEETALL----PLLDQ-AMLTIQGPAQSKSLtlrtfvgAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGG---IRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 522 EKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKartrKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYK 601
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
....
gi 1913908798 602 EEQE 605
Cdd:PRK15347 616 EYAP 619
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
8.33e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 87.45 E-value: 8.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALK----YSPEGGHVTFSVDVNEKEELLyISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGL 568
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVT-ISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 1913908798 569 AIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
373-602 |
4.49e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.05 E-value: 4.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 373 LDRERREFVANVSHELRTPLTTMR----------SYLealAEGAweNKDIaprflmvtqnetERMIRLVNDLLQLSKFDS 442
Cdd:PRK09467 225 LEDDRTLLMAGVSHDLRTPLTRIRlatemmseedGYL---AESI--NKDI------------EECNAIIEQFIDYLRTGQ 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 443 KDyQFNREWIHmirfmSLIID--RFEMTKEQHVEFirELPDRNLYVEIDQDKVTQVLDNIISNALKYSpeGGHVTFSVDV 520
Cdd:PRK09467 288 EM-PMEMADLN-----ALLGEviAAESGYEREIET--ALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGT 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 521 NEKeeLLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlgGTGLGLAIAKEMVQAHGGDI-WADSVEGkGTKITFTLP 599
Cdd:PRK09467 358 EGK--RAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLP 432
|
...
gi 1913908798 600 YKE 602
Cdd:PRK09467 433 LTT 435
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
4.80e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 85.55 E-value: 4.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGGhvTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLG-GTGLGLAIAKE 573
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 1913908798 574 MVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
8.03e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 84.75 E-value: 8.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 496 VLDNIISNALKYSPEGGHVtfSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKArtRKLGGTGLGLAIAKEMV 575
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRI--YITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 1913908798 576 QAHGGDIWAdSVEGKGTKITFTLP 599
Cdd:cd16923 80 ELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
1.13e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 81.34 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSpeGGHVTFSVDVNEKeeLLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrkLGGTGLGLAIAKEM 574
Cdd:cd16950 3 RVLSNLVDNALRYG--GGWVEVSSDGEGN--RTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 1913908798 575 VQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-601 |
1.16e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 90.35 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 369 EQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEgawenKDIAPR---FLMVTQNETERMIRLVNDLLQLSKFD--SK 443
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 444 DYQFNREWIHMIRFMSLIIDRFE-MTKEQHVEFIRELPDR-NLYVEIDQDKVTQVLDNIISNALKYSpEGGHVTFSVDVN 521
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQLMSgRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTD 589
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 522 EKEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARtrklGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYK 601
Cdd:PRK11466 590 GEQ--WLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
379-599 |
1.94e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 86.44 E-value: 1.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 379 EFVANVSHELRTPL----------------TTMRSYLealaegawenkdiaprflmvtqNETER----MIRLVNDLLQLS 438
Cdd:PRK11107 295 EFLANMSHELRTPLngvigftrqtlktpltPTQRDYL----------------------QTIERsannLLAIINDILDFS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 439 KFDS-----KDYQFN-R----EWIHMIRF--------MSLIIDRfemtkeqhvefirELPDrnlYVEIDQDKVTQVLDNI 500
Cdd:PRK11107 353 KLEAgklvlENIPFSlRetldEVVTLLAHsahekgleLTLNIDP-------------DVPD---NVIGDPLRLQQIITNL 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 501 ISNALKYSPEGghvtfSVDVN-EKEEL------LYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKE 573
Cdd:PRK11107 417 VGNAIKFTESG-----NIDILvELRALsntkvqLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQK 491
|
250 260
....*....|....*....|....*.
gi 1913908798 574 MVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:PRK11107 492 LVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
2.42e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.48 E-value: 2.42e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913908798 374 DRERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIApRFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
3.24e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.10 E-value: 3.24e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1913908798 376 ERREFVANVSHELRTPLTTMRSYLEALAEgaWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDS 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
370-579 |
7.28e-17 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 83.55 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 370 QEKLDRERReFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNR 449
Cdd:PRK10337 231 HAMMVRERR-FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDV 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 450 EWIHMIRFM-SLIIDRFEMTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEkeelly 528
Cdd:PRK10337 309 AEIPLEDLLqSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN------ 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1913908798 529 ISVKDEGIGIPKKDVEKVFDRFYR---VDKArtrklgGTGLGLAIAKEMVQAHG 579
Cdd:PRK10337 383 FTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHG 430
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
8.86e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 76.46 E-value: 8.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSP-EGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYrVDKARTRKLG-GTGLGLAIAK 572
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRIT--VSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 1913908798 573 EMVQAHGGDIWADSVE----GKGTKITFTLP 599
Cdd:cd16953 80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-582 |
1.83e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 75.19 E-value: 1.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGGHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlGGTGLGLAIAKEM 574
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEG--IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQEV 83
|
....*...
gi 1913908798 575 VQAHGGDI 582
Cdd:cd16945 84 AQLHGGRI 91
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
3.30e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.98 E-value: 3.30e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1913908798 376 ERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDS 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
369-605 |
2.01e-15 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 79.72 E-value: 2.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 369 EQEKLDRERR-----------EFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQL 437
Cdd:PRK13837 431 ETERDALERRleharrleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 438 S-KFDSKDYQFN-REWIHMIRfmSLIidrfEMTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVT 515
Cdd:PRK13837 510 GrKGERNTKPFDlSELVTEIA--PLL----RVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVD 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 516 FSVDVNE---KEELLY----------ISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDI 582
Cdd:PRK13837 584 ISLSRAKlraPKVLSHgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYI 657
|
250 260
....*....|....*....|...
gi 1913908798 583 WADSVEGKGTKITFTLPYKEEQE 605
Cdd:PRK13837 658 DVQSTVGRGTRFDVYLPPSSKVP 680
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
140-589 |
4.25e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 78.57 E-value: 4.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 140 PKSKNRVL---ISAKPVVTENQEVVGAI------YVVASMED--TFNQ-----MKTVNSILASGTGLALVLTALLGIFLA 203
Cdd:COG4192 268 PSLRRDELaaqATLEALAEENNSILEQLrtqisgLVGNSREQlvALNQetaqlVQQSGILLLAIALLSLLLAVLINYFYV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 204 -RTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLAttfnhltreledaqamtegerrklssviaymtdgviatnrn 282
Cdd:COG4192 348 rRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA----------------------------------------- 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 283 gaiillnspalELLNVSRETAlempitsllgikenftfedlVEQQDSMLLEIER--DDETTVLRVNFSVIQREHgkidgl 360
Cdd:COG4192 387 -----------RLLRVFRDQA--------------------IEKTQELETEIEErkRIEKNLRQTQDELIQAAK------ 429
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 361 IAVLYDVteqekldrerrefVANVSHELRTPLTTMRSYL-EALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:COG4192 430 MAVVGQT-------------MTSLAHELNQPLNAMSMYLfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 440 FDSKDYQFnrewihmIRFMSLIIDRFEMTKEQH--VEFIRELPDrNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVtfS 517
Cdd:COG4192 497 KSDTPLQP-------VDLRQVIEQAWELVESRAkpQQITLHIPD-DLMVQGDQVLLEQVLVNLLVNALDAVATQPQI--S 566
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 518 VDVNEKEELLYISVKDEGIGIPkkDVEKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIW-ADSVEG 589
Cdd:COG4192 567 VDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYlASTLER 631
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-582 |
9.09e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 68.43 E-value: 9.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 470 EQHVEFIRELPDrNLYVEIDQDKVTQVLDNIISNALKYSPEggHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDR 549
Cdd:cd16954 16 RKGVSISLDISP-ELRFPGERNDLMELLGNLLDNACKWCLE--FVE--VTARQTDGGLHLIVDDDGPGVPESQRSKIFQR 90
|
90 100 110
....*....|....*....|....*....|...
gi 1913908798 550 FYRVDKARTrklgGTGLGLAIAKEMVQAHGGDI 582
Cdd:cd16954 91 GQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
146-478 |
1.89e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 69.53 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 146 VLISAKPVVTENQEVVGAIYVVASMEDTFNQMKTVNSILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNF 225
Cdd:COG3850 82 LLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDF 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 226 SRKVRKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLssVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALE 305
Cdd:COG3850 162 DARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELE--AELELLALLDELLLLAALLLLLALLLALLLAALLAALL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 306 MPITSLLGIKENFTFEDLVEQQDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVS 385
Cdd:COG3850 240 LLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 386 HELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRF 465
Cdd:COG3850 320 LQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQ 399
|
330
....*....|...
gi 1913908798 466 EMTKEQHVEFIRE 478
Cdd:COG3850 400 GAGLVDVEGGVAG 412
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
378-601 |
3.37e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 68.18 E-value: 3.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 378 REFVANVSHELRTPLTTMRSYLEALAEGAWEnkdiaPRFLMVTQ---NETERMIRLVNDLLQLSKFDSKdyqfNREWIHM 454
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALPD-----PALTEYTKviiEQADRLRNLVDRLLGPQRPGTH----VTESIHK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 455 I--RFMSLIidrfEMTKEQHVEFIRE----LPDrnlyVEIDQDKVTQVLDNIISNALK-YSPEGGHVT------FSVDVN 521
Cdd:PRK11073 202 VaeRVVQLV----SLELPDNVRLIRDydpsLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITlrtrtaFQLTLH 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 522 EKEELLY--ISVKDEGIGIPKKDVEKVFdrfYRVDKARTrklGGTGLGLAIAKEMVQAHGGDIWADSVEGKgTKITFTLP 599
Cdd:PRK11073 274 GERYRLAarIDIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
..
gi 1913908798 600 YK 601
Cdd:PRK11073 347 IR 348
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
251-606 |
7.71e-12 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 68.02 E-value: 7.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 251 LEDAQAMtegerrkLSSVIaymtDGVIATNRNGAIILLNSPALELLNVsRETALEMPITSLL-GIKENFTFEDLVEQQds 329
Cdd:PRK11086 220 FEQRQAM-------LQSIK----EGVIAVDDRGEVTLINDEAKRLFNY-KKGLEDDPLGTDVeSWMPVSRLKEVLRTG-- 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 330 mllEIERDDETTV----LRVNfSVIQREHGKIDGLIAVLYDVTEQEKLDRErrefvanvshelrtpLTTMRSYLEALAEG 405
Cdd:PRK11086 286 ---TPRRDEEINIngrlLLTN-TVPVRVNGEIIGAIATFRDKTEVRQLAQR---------------LDGMVNYADALRAQ 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 406 AWE--NKdiaprflmvtqnetermIRLVNDLLQLSKFDS-KDY------QFNREWIHMIR------FMSLIIDRFEMTKE 470
Cdd:PRK11086 347 SHEfmNK-----------------LHVILGLLHLKSYDQlEDYilktanNYQEEIGSLLGkikspvIAGFLLGKISRARE 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 471 QHVEFI----RELPDRNlyveiDQDKVTQ---VLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDV 543
Cdd:PRK11086 410 LGITLIisedSQLPDSG-----DEDQVHElitILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEI 484
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 544 EKVFDRFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEEQED 606
Cdd:PRK11086 485 DAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
1.46e-11 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 59.56 E-value: 1.46e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 201 FLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELED 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
1.90e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 60.93 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLG-GTGLGLAIA 571
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 1913908798 572 KEMVQAHGGDIWADSVEGKGTKITFTL 598
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
495-599 |
2.02e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 61.24 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEGGHVTFS---VDVNEKEELLY----------ISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKL 561
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIEtsnQRVDADYALNYrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 1913908798 562 G-GTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
4.00e-11 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 58.22 E-value: 4.00e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1913908798 207 THPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTREL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-599 |
4.52e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 59.86 E-value: 4.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 489 DQDKVTQVLDNIISNALKySPEG-----GHVTFSVDVNeKEELLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGrpsdvGEVRIRVEAD-QDGRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKG 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 1913908798 564 TGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
7-479 |
5.14e-11 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 65.52 E-value: 5.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 7 FRSIQFKITLIYVLLIIIAMQIIGVYFVKQVENSLLKSYELSLNQRIDNLSYYIEQEYKGDNDSTVIKDDVKRILNDFTK 86
Cdd:COG2770 41 LLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 87 NNEIREITFVDKSYEVVGSSRPYGEEIAGKQTTDPIFKRIFSTKQAYSKKYYDPKSKNRVLISAKPVVTENQEVVGAIYV 166
Cdd:COG2770 121 LLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 167 VASMEDTFNQMKTVNSIlasgTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNH 246
Cdd:COG2770 201 VVLLEAALAALLLLLLL----ALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 247 LTRELEDAQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQ 326
Cdd:COG2770 277 MADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALAL 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 327 QDSMLLEIERDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTEQEKLDRERREFVANVSHELRTPLTTMRSYLEALAEGA 406
Cdd:COG2770 357 AALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAA 436
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 407 WENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMIRFMSLIIDRFEMTKEQHVEFIREL 479
Cdd:COG2770 437 ALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEEL 509
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
204-256 |
6.65e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 57.64 E-value: 6.65e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 204 RTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEDAQA 256
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
384-607 |
2.23e-10 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 63.54 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 384 VSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQN---ETERMIRLVNDLLQLS---KFDSKDYQFNrewiHMIRF 457
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENiraAAERAATLTQQLLAFArkqRLEGRVLNLN----GLVSG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 458 MSLIIDRfemTKEQHVEFIRELPDRNLYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFS---VDVNEKEELLY------ 528
Cdd:PRK13557 246 MGELAER---TLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRtrnVEIEDEDLAMYhglppg 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 529 ----ISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLG-GTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:PRK13557 323 ryvsIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQ 397
|
....
gi 1913908798 604 QEDD 607
Cdd:PRK13557 398 AENP 401
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
495-582 |
5.30e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 61.96 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 495 QVLDNIISNALKYSPEggHVTFSVDVNEKEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrklgGTGLGLAIAKEM 574
Cdd:PRK10815 381 EVMGNVLDNACKYCLE--FVEISARQTDEH--LHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREI 452
|
....*...
gi 1913908798 575 VQAHGGDI 582
Cdd:PRK10815 453 TEQYEGKI 460
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-599 |
6.89e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 56.02 E-value: 6.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 501 ISNALKYSPeGGHVTFSVDVNEKEELLYisVKDEGIGIPKKDVEkvfdrfyrvdkartrklGGTGLGLAIAKEMVQAHGG 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLT--VVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGG 68
|
90
....*....|....*....
gi 1913908798 581 DIWADSVEGKGTKITFTLP 599
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-253 |
1.02e-09 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 61.19 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 1 MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVKQVENSLLKSYELSLNQRIDNLSYYIEQEYKGDNDSTVIKDDVKRI 80
Cdd:COG0840 1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 81 LNDFTKNNEIREITFVDKSYEVVGSSRPYGEEIAGKQTTDPIFKRIFSTKQAYSKKYYDPKSKNRVLISAKPVVTENQEV 160
Cdd:COG0840 81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 161 VGAIYVVASMEDTFNQMKTVNSILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQL 240
Cdd:COG0840 161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240
|
250
....*....|...
gi 1913908798 241 ATTFNHLTRELED 253
Cdd:COG0840 241 ADAFNRMIENLRE 253
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
262-379 |
2.16e-09 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 59.78 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 262 RRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLgikENFTFEDLVEQQDSMLLEIER-DDET 340
Cdd:COG3829 10 EEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIQKtGGKG 86
|
90 100 110
....*....|....*....|....*....|....*....
gi 1913908798 341 TVLRVNFSVIqREHGKIDGLIAVLYDVTEQEKLDRERRE 379
Cdd:COG3829 87 KTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
4.34e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.33 E-value: 4.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVLDNIISNALK-YSPEGGHVTFSVDVNEKEEL--------LYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGG 563
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTQRQVTLghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 1913908798 564 TGLGLAIAKEMVQAHGGDIWADSVEGKgTKITFTLP 599
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-497 |
5.38e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 57.34 E-value: 5.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 254 AQAMTEGERRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTF----EDLVEQQDS 329
Cdd:COG2202 2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFlellRAALAGGGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 330 MLLEIE---RDDETTVLRVNFSVIQREHGKIDGLIAVLYDVTEQEKLDRERREfvanvSHELrtplttMRSYLEALAEGA 406
Cdd:COG2202 82 WRGELRnrrKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE-----SEER------LRLLVENAPDGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 407 WENkDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIHMI-RFMSLIIDRFEMTKE-QHVEFIRELPDRNL 484
Cdd:COG2202 151 FVL-DLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLrRLLEGGRESYELELRlKDGDGRWVWVEASA 229
|
250
....*....|...
gi 1913908798 485 YVEIDQDKVTQVL 497
Cdd:COG2202 230 VPLRDGGEVIGVL 242
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
497-603 |
5.53e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.49 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 497 LDNIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFyrvdkarTRKLGGTGLGLAIAKEMVQ 576
Cdd:COG2972 345 VENAIEHGIEPKEGGGTIR--ISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLK 415
|
90 100 110
....*....|....*....|....*....|
gi 1913908798 577 AHGGD---IWADSVEGKGTKITFTLPYKEE 603
Cdd:COG2972 416 LYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
392-603 |
6.45e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 56.94 E-value: 6.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 392 LTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVndllqlskfdskdyqfnREWIHMIR-----FMSLI----- 461
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAEL-----------------RRLVRGLRppaldDLGLAaalee 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 462 -IDRFEMTKEQHVEFIRELPDRNLYVEIDQDkVTQVLDNIISNALKYSPeGGHVTFSVDVNEKEelLYISVKDEGIGIPk 540
Cdd:COG4585 132 lAERLLRAAGIRVELDVDGDPDRLPPEVELA-LYRIVQEALTNALKHAG-ATRVTVTLEVDDGE--LTLTVRDDGVGFD- 206
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1913908798 541 kdvekvfdrfyrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPYKEE 603
Cdd:COG4585 207 -----------------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
1.23e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.06 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 496 VLDNIISNALKYSPE--GGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLGGTGLGLAIAKE 573
Cdd:cd16915 4 IVGNLIDNALDALAAtgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 1913908798 574 MVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
39-243 |
5.24e-07 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 51.18 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 39 NSLLKSYELSLNQRIDNLSYYIEQEYKGDNDSTVIKDDVKRILNDFTK----NNEIREITFVDKSYEVVGSSRPYGEEIA 114
Cdd:pfam02743 12 LSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESllrsNPGISSIYLVDADGRVLASSDESPSYPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 115 GKQTTDPIFKRIFSTKQA----YSKKYYDPKSKNRVLISAKPVVTENQEVVGAIYVVASMeDTFNQMktVNSILASGTGL 190
Cdd:pfam02743 92 LDVSERPWYKEALKGGGGiiwvFSSPYPSSESGEPVLTIARPIYDDDGEVIGVLVADLDL-DTLQEL--LSQIKLGEGGY 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1913908798 191 ALVLTAlLGIFLARTITHPLSDMRKQAMEL----AKGNFSRKVRKYGHDEIGQLATT 243
Cdd:pfam02743 169 VFIVDS-DGRILAHPLGKNLRSLLAPFLGKsladALPGSGITEIAVDLDGEDYLVAY 224
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-367 |
1.78e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 46.86 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 272 MTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQ----QDSMLLEIE---RDDETTVLR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENllsgGEPVTLEVRlrrKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 1913908798 345 VNFSVIQREHGKIDGLIAVLYDV 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
465-605 |
4.62e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 465 FEMTKEQHVEFIRELPDrnlyVEIDQDKVTQ---VLDNIISNALKY---SPEGGHVTfsVDVNEKEELLYISVKDEGIGI 538
Cdd:COG3920 373 RDSYGGRGIRIELDGPD----VELPADAAVPlglILNELVTNALKHaflSGEGGRIR--VSWRREDGRLRLTVSDNGVGL 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1913908798 539 PKkdvekvfdrfyRVDKARTRklggtGLGLAIAKEMVQAHGGDIwaDSVEGKGTKITFTLPYKEEQE 605
Cdd:COG3920 447 PE-----------DVDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAELAA 495
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
487-599 |
9.70e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 45.29 E-value: 9.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 487 EIDQDKVTQVLDNIISNALKYS-PEGGHVTFSVDVNEKEELLYISVKDEGIGIPKKDVEKVFDRfyrvdkartrkLGGTG 565
Cdd:COG2172 29 EDDADDLVLAVSEAVTNAVRHAyGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LAEGG 97
|
90 100 110
....*....|....*....|....*....|....*...
gi 1913908798 566 LGLAIAKEMvqahggdiwADSVE----GKGTKITFTLP 599
Cdd:COG2172 98 RGLFLIRRL---------MDEVEyesdPGGTTVRLVKR 126
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
479-598 |
1.75e-05 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 44.76 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 479 LPDrnlYVEIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVneKEELLYISVKDEGIGIPKKDVEKVFDRF-YRV---- 553
Cdd:cd16938 1 LPD---VVVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFL--EGGSEDRSDRDWGPWRPSMSDESVEIRFeVEIndsg 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1913908798 554 ----DKARTRK---------LGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTL 598
Cdd:cd16938 76 spsiESASMRNslnrrynlsELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
249-377 |
5.66e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 45.02 E-value: 5.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 249 RELEDAQAMTEgerRKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQ-- 326
Cdd:COG2202 126 KRAEEALRESE---ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRll 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1913908798 327 -QDSMLLEIE---RDDETTVLRVNFSVIQREHG-KIDGLIAVLYDVTEQEKLDRER 377
Cdd:COG2202 203 eGGRESYELElrlKDGDGRWVWVEASAVPLRDGgEVIGVLGIVRDITERKRAEEAL 258
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-312 |
1.06e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 40.46 E-value: 1.06e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1913908798 263 RKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLL 312
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
1.43e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 41.26 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 493 VTQVL-DNIISNALKYSPEGGHVTfsVDVNEKEELLYISVKDEGIGIPKkdvekvfDRFYRVDKARTRKLGGTGLGLA-I 570
Cdd:cd16957 5 ALQVLvENAIRHAFPKRKENNEVR--VVVKKDQHKVHVSVSDNGQGIPE-------ERLDLLGKTTVTSEKGTGTALEnL 75
|
90 100 110
....*....|....*....|....*....|.
gi 1913908798 571 AKEMVQAHG--GDIWADSVEGKGTKITFTLP 599
Cdd:cd16957 76 NRRLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
501-599 |
4.35e-04 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 43.07 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 501 ISNALKYSpEGGHVtfSVDVNEKEELLYISVKDEGIGIPkkdvekvfdrfyrvdkARTRKlggTGLGLAIAKEMVQAHGG 580
Cdd:COG3851 409 LTNILKHA-EASQI--RISLSQDKRLLSLEIRDDGIGLP----------------PELRA---KGFGLRGMRERVRALGG 466
|
90
....*....|....*....
gi 1913908798 581 DiWADSVEGKGTKITFTLP 599
Cdd:COG3851 467 D-FRLSSAPKGTRLSVLLP 484
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
263-367 |
6.16e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.71 E-value: 6.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 263 RKLSSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIKENFTFEDLVEQ-----QDSMLLEIER- 336
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQallqgEESRGFEVSFr 80
|
90 100 110
....*....|....*....|....*....|...
gi 1913908798 337 --DDETTVLRVNFSVIQREHGKIDGLIAVLYDV 367
Cdd:pfam00989 81 vpDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
487-595 |
6.70e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 39.66 E-value: 6.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 487 EIDQDKVTQVLDNIISNALKYSPEGGHVTFSVDVNEKEELLYISVkDEGIGIPkkDVEKVF-DRFyrvdkartRKLGGTG 565
Cdd:cd16934 20 EVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAV-DQGPGIA--DVDEALrDGF--------STGGGLG 88
|
90 100 110
....*....|....*....|....*....|
gi 1913908798 566 LGLAIAKEMvqAHGGDIwaDSVEGKGTKIT 595
Cdd:cd16934 89 LGLGGVRRL--ADEFDL--HSAPGRGTVVV 114
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-599 |
9.57e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 38.98 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 498 DNIISNALKYSPEGGHVTFSVDVNEKEELlYISVKDEGIGIPKKDVEKVfdrfyRVDKARTRKLG----------GTGLG 567
Cdd:cd16955 11 ENAIVHGIQEKKGKGVVKISVKKQLKNRL-HIAVEDNGIGISPKVIERV-----EQDEMPGNKIGllnvhqrlklGYGEG 84
|
90 100 110
....*....|....*....|....*....|..
gi 1913908798 568 LAIakemvqahggdiwaDSVEGKGTKITFTLP 599
Cdd:cd16955 85 LHI--------------RSRPDPGTLIAFYIP 102
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
488-607 |
1.05e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.13 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 488 IDQDKVTQVLDNIISNALKYS---PEGGHVTFSVDVNEKEELLyISVKDEGIGIPKKDVEKVFDRFYrvdKARTRKLGGT 564
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASlrsDEGNKIVELFLSDEGDDVV-IEVADQGCGVPESLRDKIFEQGV---STRADEPGEH 503
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1913908798 565 GLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLPyKEEQEDD 607
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP-KVKPNDS 545
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
518-592 |
1.21e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 40.02 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 518 VDVNEKEELLYISVKDEGIGIPKKDVEKVFDRFY-------------RVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWA 584
Cdd:cd16929 75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154
|
....*...
gi 1913908798 585 DSVEGKGT 592
Cdd:cd16929 155 QSMEGYGT 162
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
180-251 |
2.16e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 40.81 E-value: 2.16e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1913908798 180 VNSILASGTGLALVLTAllgIFLARTITHPLSDMRKQAMELAKGNFSRKVRKYGHDEIGQLATTFNHLTREL 251
Cdd:PRK10600 126 VHRVFAVFMALLLVFTI---IWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
505-599 |
3.20e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 40.55 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 505 LKYSPEGGHVtfsvdvnekeellYISVKDEGIGIpkkDVEKVfdrfyrVDKARTRKL---------------------G- 562
Cdd:COG0643 313 LSAYHEGGRV-------------VIEVSDDGRGL---DLEKI------RAKAIEKGLitaeeaaalsdeellelifapGf 370
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1913908798 563 ----------GTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:COG0643 371 staeevtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| spIIAB |
TIGR01925 |
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ... |
491-597 |
4.63e-03 |
|
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]
Pssm-ID: 130980 [Multi-domain] Cd Length: 137 Bit Score: 37.98 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 491 DKVTQVLDNIISNALKYSPE---GGHVTFSVDVNEKEelLYISVKDEGIGIpkKDVEKVFDRFYRVDKARTRklggTGLG 567
Cdd:TIGR01925 38 TDIKTAVSEAVTNAIIHGYEencEGVVYISATIEDHE--VYITVRDEGIGI--ENLEEAREPLYTSKPELER----SGMG 109
|
90 100 110
....*....|....*....|....*....|
gi 1913908798 568 LAIAKEMVQahggDIWADSVEGKGTKITFT 597
Cdd:TIGR01925 110 FTVMENFMD----DVSVDSEKEKGTKIIMK 135
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
561-599 |
5.08e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 38.33 E-value: 5.08e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1913908798 561 LGGTGLGLAIAKEMVQAHGGDIWADSVEGKGTKITFTLP 599
Cdd:cd16916 140 VSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
478-599 |
8.31e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 39.19 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913908798 478 ELPDRNLYVEIDQDKVTQVLDNI------------ISNALKYSpEGGHVTfsVDVNEKEELLYISVKDEGIGIPKKDVEK 545
Cdd:PRK11644 384 ELEDRGIVSHLDWRIDESALSETqrvtlfrvcqegLNNIVKHA-DASAVT--LQGWQQDERLMLVIEDDGSGLPPGSGQQ 460
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1913908798 546 vfdrfyrvdkartrklggtGLGLAIAKEMVQAHGGDIWADSVEgkGTKITFTLP 599
Cdd:PRK11644 461 -------------------GFGLRGMRERVTALGGTLTISCTH--GTRLSVSLP 493
|
|
| |
