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Conserved domains on  [gi|1843793707|gb|QJX15932|]
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L4 22 kDa encapsidation protein [Human mastadenovirus C]

Protein Classification

splicing factor family protein( domain architecture ID 10567434)

splicing factor family protein is a DUF2890 domain-containing protein; similar to Human adenovirus protein 33K and packaging protein 2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
15-176 2.99e-73

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


:

Pssm-ID: 314108  Cd Length: 168  Bit Score: 218.72  E-value: 2.99e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
Cdd:pfam11081  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPY 174
Cdd:pfam11081  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSKY 164

                  ..
gi 1843793707 175 CT 176
Cdd:pfam11081 165 CT 166
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
15-176 2.99e-73

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 218.72  E-value: 2.99e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
Cdd:pfam11081  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPY 174
Cdd:pfam11081  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSKY 164

                  ..
gi 1843793707 175 CT 176
Cdd:pfam11081 165 CT 166
PHA03269 PHA03269
envelope glycoprotein C; Provisional
46-160 4.82e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 37.02  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  46 SEAEEVSDETPSPSVAF-----PSPAPQKLATV---PSIATTSAPQAPPALPVrrpnrrwdtTGTRAGkSKQPPPLAQEQ 117
Cdd:PHA03269   76 PAASEKFDPAPAPHQAAsrapdPAVAPQLAAAPkpdAAEAFTSAAQAHEAPAD---------AGTSAA-SKKPDPAAHTQ 145
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1843793707 118 QQRQGYRSWRGHKNaiVACLQdcGGnisfaRRFLLYHHGVAFP 160
Cdd:PHA03269  146 HSPPPFAYTRSMEH--IACTH--GG-----IQFIPYFHKFILP 179
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
15-176 2.99e-73

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 218.72  E-value: 2.99e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
Cdd:pfam11081  15 TDEEEYWDSQAEEVLDEEEEMMEDWDSLDEASEAEEVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPN 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGHKNAIVACLQdcggnisfarRFLLYHHGVAFPRNILHYYRHLYSPY 174
Cdd:pfam11081  95 RRWDTTGTRAGKSKQPPPLAQEQQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSKY 164

                  ..
gi 1843793707 175 CT 176
Cdd:pfam11081 165 CT 166
PHA03269 PHA03269
envelope glycoprotein C; Provisional
46-160 4.82e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 37.02  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843793707  46 SEAEEVSDETPSPSVAF-----PSPAPQKLATV---PSIATTSAPQAPPALPVrrpnrrwdtTGTRAGkSKQPPPLAQEQ 117
Cdd:PHA03269   76 PAASEKFDPAPAPHQAAsrapdPAVAPQLAAAPkpdAAEAFTSAAQAHEAPAD---------AGTSAA-SKKPDPAAHTQ 145
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1843793707 118 QQRQGYRSWRGHKNaiVACLQdcGGnisfaRRFLLYHHGVAFP 160
Cdd:PHA03269  146 HSPPPFAYTRSMEH--IACTH--GG-----IQFIPYFHKFILP 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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