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Conserved domains on  [gi|1825987552|gb|QIR00269|]
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YSIRK-type signal peptide-containing protein [Streptococcus mutans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4099 COG4099
Predicted peptidase [General function prediction only];
441-726 9.19e-46

Predicted peptidase [General function prediction only];


:

Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 163.21  E-value: 9.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 441 TTDRFSERGSYGNFNYAAYQPEAAIGGEKNPLIVWLHGIGEVGTDINIPLLASnVARLTEDPIQSHFtstgsggqkGAYV 520
Cdd:COG4099    20 EARTFTDPSDGDTLPYRLYLPKGYDPGKKYPLVLFLHGAGERGTDNEKQLTHG-APKFINPENQAKF---------PAIV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 521 LVPQ--SSTPWSQ-NQTASLMALIKAYVASHPdIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAAsysnqltdnQ 597
Cdd:COG4099    90 LAPQcpEDDYWSDtKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPICG---------G 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 598 ITAAALKALKGQPMWLIHTRTDKTISADSSVlPFYKELLQAGAqNKWLSYYETnvgkhhsgityNGHWSWVYFLNDQvtg 677
Cdd:COG4099   160 GDPANAANLKKVPVWIFHGAKDDVVPVEESR-AMVEALKAAGA-DVKYTEYPG-----------VGHNSWDPAYANP--- 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1825987552 678 vqntdnaknwsglsgmvatnptyggdakatvngrtysNVFDWLNGQRRR 726
Cdd:COG4099   224 -------------------------------------DLYDWLFAQKRP 235
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 161-223 1.03e-24

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


:

Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 97.59  E-value: 1.03e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1825987552 161 YYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFAQDSDGnKHYYDRDSGEMWTNRFVNDQGN 223
Cdd:TIGR04035   1 YYFDADGKAVTGAQTIDGVTYYFDENGKQVKGDFVTNGGG-TYYYDKDSGALVTNRFVTIKDG 62
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
157-294 1.04e-23

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


:

Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 105.34  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGafAQDSDGNKhYYDRDSGEMwTNRFVNDQGNWCYLNSDGVPVIG 236
Cdd:COG5263   352 DGKWYYLGSDGAMATGWQKIDGKWYYFDSNGAMATG--WVKVDGKW-YYFDSSGAM-ATGWLKIDGKWYYFDSDGAMATG 427

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1825987552 237 SITVNGQSLYFNSDGSQVKGnFVEEDGSlRYYDKNSGDLLRKTsRTINGVNYQFDNDG 294
Cdd:COG5263   428 WQKIGGKWYYFDSNGAMATG-WVKVDGK-WYYFDSDGAMATGW-QTIDGKTYYFDSNG 482
EstA_Ig_like pfam18435
Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain ...
 306-424 6.82e-19

Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain found in esterases such as EstA. Analysis of the EstA structure confirms that it is a member of the alpha/beta hydrolase family, with a conserved Ser-Asp-His catalytic triad. The Ig-like domain presumably plays a role in the multimerization of EstA into an unusual hexameric structure. Additionally, it may also participate in the catalysis of EstA by guiding the substrate to the active site.


:

Pssm-ID: 465765  Cd Length: 120  Bit Score: 82.75  E-value: 6.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 306 KTSLVVDSYEFGPSVSKIILEFNHKVTPAVVHAGAMVTTA-----GVQRKILNSYVSNASGHVVYFDSSHYVTLELDipy 380
Cdd:pfam18435   1 SVTAVTEVFGDGQKVSAVALEYDKPIDGSSLSADTFQVEVtrdaaKGPRTITKVYVNDAPGNAAKSKDGRYVILELD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1825987552 381 dpnDSSRNASPFIFDSA-AFRNNWVN-SYTVKVDNLQVQADGSNSS 424
Cdd:pfam18435  78 ---PDDPNASPFQYDPSkVSDNVWVDlKYTVTQTKDVKTADGTVYA 120
PspC_subgroup_1 super family cl41462
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 32-271 1.24e-08

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


The actual alignment was detected with superfamily member NF033838:

Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 58.49  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  32 KTAEAD-ETVITEQRQTSKINASSQKVENQTSNQVeAKTDSANKDPQEKTGSVATDAPSiNSANNTSQSDKQNTVNEisS 110
Cdd:NF033838  372 KQAKAKvESKKAEATRLEKIKTDRKKAEEEAKRKA-AEEDKVKEKPAEQPQPAPAPQPE-KPAPKPEKPAEQPKAEK--P 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 111 DSQQTKTDEQTDLPQ--NSFKQQSAHVKMTTEAEKTP------SHSINTFVN-DG---------NGNWYYLGADGRNVTG 172
Cdd:NF033838  448 ADQQAEEDYARRSEEeyNRLTQQQPPKTEKPAQPSTPktgwkqENGMWYFYNtDGsmatgwlqnNGSWYYLNANGAMATG 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 173 SHTIAGKTMYFAQDGKQVKGAFAQDSdgnKHYYDRDSGEMWTNRFVNDqGNWCYLNSDGVPVIGSITVNGQSLYFNSDGS 252
Cdd:NF033838  528 WLQNNGSWYYLNANGSMATGWLQNNG---SWYYLNANGAMATGWLQYN-GSWYYLNANGDMATGWLQYNGSWYYLNANGD 603

                         250
                  ....*....|....*....
gi 1825987552 253 QVKGnFVEEDGSLRYYDKN 271
Cdd:NF033838  604 MATG-WLQYNGSWYYLNAN 621
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-38 2.10e-06

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


:

Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 44.78  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1825987552   3 FEKQKHFSLRKLKFGLVSVAiIAFLFAVTKTAEADE 38
Cdd:TIGR01168   5 NEKQQKYSIRKLSVGVASVL-VASLFFGGGVAAAES 39
 
Name Accession Description Interval E-value
COG4099 COG4099
Predicted peptidase [General function prediction only];
441-726 9.19e-46

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 163.21  E-value: 9.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 441 TTDRFSERGSYGNFNYAAYQPEAAIGGEKNPLIVWLHGIGEVGTDINIPLLASnVARLTEDPIQSHFtstgsggqkGAYV 520
Cdd:COG4099    20 EARTFTDPSDGDTLPYRLYLPKGYDPGKKYPLVLFLHGAGERGTDNEKQLTHG-APKFINPENQAKF---------PAIV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 521 LVPQ--SSTPWSQ-NQTASLMALIKAYVASHPdIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAAsysnqltdnQ 597
Cdd:COG4099    90 LAPQcpEDDYWSDtKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPICG---------G 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 598 ITAAALKALKGQPMWLIHTRTDKTISADSSVlPFYKELLQAGAqNKWLSYYETnvgkhhsgityNGHWSWVYFLNDQvtg 677
Cdd:COG4099   160 GDPANAANLKKVPVWIFHGAKDDVVPVEESR-AMVEALKAAGA-DVKYTEYPG-----------VGHNSWDPAYANP--- 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1825987552 678 vqntdnaknwsglsgmvatnptyggdakatvngrtysNVFDWLNGQRRR 726
Cdd:COG4099   224 -------------------------------------DLYDWLFAQKRP 235
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 161-223 1.03e-24

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 97.59  E-value: 1.03e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1825987552 161 YYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFAQDSDGnKHYYDRDSGEMWTNRFVNDQGN 223
Cdd:TIGR04035   1 YYFDADGKAVTGAQTIDGVTYYFDENGKQVKGDFVTNGGG-TYYYDKDSGALVTNRFVTIKDG 62
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
157-294 1.04e-23

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 105.34  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGafAQDSDGNKhYYDRDSGEMwTNRFVNDQGNWCYLNSDGVPVIG 236
Cdd:COG5263   352 DGKWYYLGSDGAMATGWQKIDGKWYYFDSNGAMATG--WVKVDGKW-YYFDSSGAM-ATGWLKIDGKWYYFDSDGAMATG 427

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1825987552 237 SITVNGQSLYFNSDGSQVKGnFVEEDGSlRYYDKNSGDLLRKTsRTINGVNYQFDNDG 294
Cdd:COG5263   428 WQKIGGKWYYFDSNGAMATG-WVKVDGK-WYYFDSDGAMATGW-QTIDGKTYYFDSNG 482
EstA_Ig_like pfam18435
Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain ...
 306-424 6.82e-19

Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain found in esterases such as EstA. Analysis of the EstA structure confirms that it is a member of the alpha/beta hydrolase family, with a conserved Ser-Asp-His catalytic triad. The Ig-like domain presumably plays a role in the multimerization of EstA into an unusual hexameric structure. Additionally, it may also participate in the catalysis of EstA by guiding the substrate to the active site.


Pssm-ID: 465765  Cd Length: 120  Bit Score: 82.75  E-value: 6.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 306 KTSLVVDSYEFGPSVSKIILEFNHKVTPAVVHAGAMVTTA-----GVQRKILNSYVSNASGHVVYFDSSHYVTLELDipy 380
Cdd:pfam18435   1 SVTAVTEVFGDGQKVSAVALEYDKPIDGSSLSADTFQVEVtrdaaKGPRTITKVYVNDAPGNAAKSKDGRYVILELD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1825987552 381 dpnDSSRNASPFIFDSA-AFRNNWVN-SYTVKVDNLQVQADGSNSS 424
Cdd:pfam18435  78 ---PDDPNASPFQYDPSkVSDNVWVDlKYTVTQTKDVKTADGTVYA 120
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 226-285 8.85e-19

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 80.64  E-value: 8.85e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 226 YLNSDGVPVIGSITVNGQSLYFNSDGSQVKGNFVEEDGSLRYYDKNSGDLLRKTSRTING 285
Cdd:TIGR04035   2 YFDADGKAVTGAQTIDGVTYYFDENGKQVKGDFVTNGGGTYYYDKDSGALVTNRFVTIKD 61
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 170-217 2.65e-16

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 72.96  E-value: 2.65e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1825987552 170 VTGSHTIAGKTMYFAQDGKQVKGAFAQDsDGNKHYYDRDSGEMWTNRF 217
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVTI-DGKWYYFDADSGEMVTNRF 47
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
157-255 5.59e-15

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 77.99  E-value: 5.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFaqdSDGNKHYYDRDSGEMWTNrFVNDQGNWCYLNSDGVPVIG 236
Cdd:COG5263   392 DGKWYYFDSSGAMATGWLKIDGKWYYFDSDGAMATGWQ---KIGGKWYYFDSNGAMATG-WVKVDGKWYYFDSDGAMATG 467

                          90
                  ....*....|....*....
gi 1825987552 237 SITVNGQSLYFNSDGSQVK 255
Cdd:COG5263   468 WQTIDGKTYYFDSNGAWVG 486
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 234-279 1.01e-13

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 65.64  E-value: 1.01e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1825987552 234 VIGSITVNGQSLYFNSDGSQVKGNFVEEDGSLRYYDKNSGDLLRKT 279
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVTIDGKWYYFDADSGEMVTNR 46
Esterase_PHB pfam10503
Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), ...
 456-582 4.08e-12

Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.


Pssm-ID: 431322 [Multi-domain]  Cd Length: 222  Bit Score: 66.24  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 456 YAAY-QPEAAIGGEKNPLIVWLHGIGE------VGTDINipLLASNVARLTEDPIQSHFTStgsgGQKGAYVLVPQSSTP 528
Cdd:pfam10503   3 YALYlPPEAAGDGAPMPLVVMLHGCKQhaddfaAGTRIN--ALADELGFAVLYPEQSKHAH----AHKCWNWFDEQGAAR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1825987552 529 wSQNQTASLMALIKAYVASHpDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAAL 582
Cdd:pfam10503  77 -GGGEAASIAALAKAIAAAH-RLDGARVYLAGLSAGAALAALLAHCYPDVFAAV 128
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 157-294 2.50e-10

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 63.95  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGK------QVKGAFaqdsdgnkhYYDRDSGEMWTNrFVNDQGNWCYLNSD 230
Cdd:NF033840  516 NGMWYFYNTDGSMATGWVQVNGSWYYLNSNGSmatgwvQVNGSW---------YYLNSNGSMATG-WVQVDGSWYYLNDN 585

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1825987552 231 GVPVIGSITVNGQSLYFNSDGSqVKGNFVEEDGSLRYYDKNSGDLLRKTSrtINGvnYQFDNDG 294
Cdd:NF033840  586 GSMETGWLQNNGSWYYLNSNGS-MKANQWFQVGSKWYYVNASGELAVNTS--IDG--YRVNDNG 644
esterase_phb TIGR01840
esterase, PHB depolymerase family; This model describes a subfamily among lipases of the ...
 456-586 6.50e-09

esterase, PHB depolymerase family; This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation]


Pssm-ID: 273828 [Multi-domain]  Cd Length: 212  Bit Score: 56.73  E-value: 6.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 456 YAAYQPEAAIGgeKNPLIVWLHGIGEVGTDINIPLLASNVARltedpiqshftstgsggQKGAYVLVPQSSTPWSQN--- 532
Cdd:TIGR01840   1 MYVYVPAGLTG--PRALVLALHGCGQTASAYVIDWGWKAAAD-----------------RYGFVLVAPEQTSYNSSNncw 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1825987552 533 -------------QTASLMALIKAYVASHpDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIA 586
Cdd:TIGR01840  62 dwffthhrargtgEVESLHQLIDAVKANY-SIDPNRVYVTGLSAGGGMTAVLGCTYPDVFAGGASNA 127
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 32-271 1.24e-08

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 58.49  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  32 KTAEAD-ETVITEQRQTSKINASSQKVENQTSNQVeAKTDSANKDPQEKTGSVATDAPSiNSANNTSQSDKQNTVNEisS 110
Cdd:NF033838  372 KQAKAKvESKKAEATRLEKIKTDRKKAEEEAKRKA-AEEDKVKEKPAEQPQPAPAPQPE-KPAPKPEKPAEQPKAEK--P 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 111 DSQQTKTDEQTDLPQ--NSFKQQSAHVKMTTEAEKTP------SHSINTFVN-DG---------NGNWYYLGADGRNVTG 172
Cdd:NF033838  448 ADQQAEEDYARRSEEeyNRLTQQQPPKTEKPAQPSTPktgwkqENGMWYFYNtDGsmatgwlqnNGSWYYLNANGAMATG 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 173 SHTIAGKTMYFAQDGKQVKGAFAQDSdgnKHYYDRDSGEMWTNRFVNDqGNWCYLNSDGVPVIGSITVNGQSLYFNSDGS 252
Cdd:NF033838  528 WLQNNGSWYYLNANGSMATGWLQNNG---SWYYLNANGAMATGWLQYN-GSWYYLNANGDMATGWLQYNGSWYYLNANGD 603

                         250
                  ....*....|....*....
gi 1825987552 253 QVKGnFVEEDGSLRYYDKN 271
Cdd:NF033838  604 MATG-WLQYNGSWYYLNAN 621
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 157-273 3.26e-08

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 56.95  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFAQDSdgnKHYYDRDSGEMWTNRFVNDqGNWCYLNSDGVPVIG 236
Cdd:NF033838  532 NGSWYYLNANGSMATGWLQNNGSWYYLNANGAMATGWLQYNG---SWYYLNANGDMATGWLQYN-GSWYYLNANGDMATG 607

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1825987552 237 SITVNGQSLYFNSDGSQVKGnFVeEDGSLRYYDKNSG 273
Cdd:NF033838  608 WLQYNGSWYYLNANGSMATG-WV-KDGDTWYYLEASG 642
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-38 2.10e-06

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 44.78  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1825987552   3 FEKQKHFSLRKLKFGLVSVAiIAFLFAVTKTAEADE 38
Cdd:TIGR01168   5 NEKQQKYSIRKLSVGVASVL-VASLFFGGGVAAAES 39
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 196-298 3.43e-06

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 50.47  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 196 QDSDGNKHYYDRDsGEMWTNrFVNDQGNWCYLNSDGVPVIGSITVNGQSLYFNSDGSQVKGnFVEEDGSLRYYDKNSGdl 275
Cdd:NF033840  513 KQENGMWYFYNTD-GSMATG-WVQVNGSWYYLNSNGSMATGWVQVNGSWYYLNSNGSMATG-WVQVDGSWYYLNDNGS-- 587

                          90       100
                  ....*....|....*....|...
gi 1825987552 276 LRKTSRTINGVNYQFDNDGNARA 298
Cdd:NF033840  588 METGWLQNNGSWYYLNSNGSMKA 610
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 1-148 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552   1 MTFEKQKHFSLRKLKFGLVSV---AIIAFLFAVTKTAEADETVITEQRQTS---KINASSQ-----KVENQ-------TS 62
Cdd:NF033609    1 MNMKKKEKHAIRKKSIGVASVlvgTLIGFGLLSSKEADASENSVTQSDSASnesKSNDSSSvsaapKTDDTnvsdtktSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  63 NQVEAKTDSA-NKDPQEKTGSVATDA-------------PSINSANNTSQSDKQNT-----VNEISSD--SQQTKTDEQT 121
Cdd:NF033609   81 NTNNGETSVAqNPAQQETTQSASTNAtteetpvtgeattTATNQANTPATTQSSNTnaeelVNQTSNEttSNDTNTVSSV 160

                         170       180
                  ....*....|....*....|....*..
gi 1825987552 122 DLPQNSFKQQSAHVKMTTEAEKTPSHS 148
Cdd:NF033609  161 NSPQNSTNAENVSTTQDTSTEATPSNN 187
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 157-254 1.66e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 48.09  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFaqdSDGNKHYYDRDSGEMWTNRFVNDQGNWCYLNSDGVPVIG 236
Cdd:NF033838  592 NGSWYYLNANGDMATGWLQYNGSWYYLNANGSMATGWV---KDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVN 668

                          90
                  ....*....|....*...
gi 1825987552 237 SiTVNGQSLyfNSDGSQV 254
Cdd:NF033838  669 T-TVDGYGV--NANGEWV 683
YSIRK_signal pfam04650
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and ...
 4-28 1.95e-04

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 428049 [Multi-domain]  Cd Length: 26  Bit Score: 38.90  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1825987552   4 EKQKHFSLRKLKFGLVSVAIIAFLF 28
Cdd:pfam04650   1 EKKQRYSIRKLSVGVASVLIGTLLF 25
 
Name Accession Description Interval E-value
COG4099 COG4099
Predicted peptidase [General function prediction only];
441-726 9.19e-46

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 163.21  E-value: 9.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 441 TTDRFSERGSYGNFNYAAYQPEAAIGGEKNPLIVWLHGIGEVGTDINIPLLASnVARLTEDPIQSHFtstgsggqkGAYV 520
Cdd:COG4099    20 EARTFTDPSDGDTLPYRLYLPKGYDPGKKYPLVLFLHGAGERGTDNEKQLTHG-APKFINPENQAKF---------PAIV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 521 LVPQ--SSTPWSQ-NQTASLMALIKAYVASHPdIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAAsysnqltdnQ 597
Cdd:COG4099    90 LAPQcpEDDYWSDtKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPICG---------G 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 598 ITAAALKALKGQPMWLIHTRTDKTISADSSVlPFYKELLQAGAqNKWLSYYETnvgkhhsgityNGHWSWVYFLNDQvtg 677
Cdd:COG4099   160 GDPANAANLKKVPVWIFHGAKDDVVPVEESR-AMVEALKAAGA-DVKYTEYPG-----------VGHNSWDPAYANP--- 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1825987552 678 vqntdnaknwsglsgmvatnptyggdakatvngrtysNVFDWLNGQRRR 726
Cdd:COG4099   224 -------------------------------------DLYDWLFAQKRP 235
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 161-223 1.03e-24

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 97.59  E-value: 1.03e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1825987552 161 YYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFAQDSDGnKHYYDRDSGEMWTNRFVNDQGN 223
Cdd:TIGR04035   1 YYFDADGKAVTGAQTIDGVTYYFDENGKQVKGDFVTNGGG-TYYYDKDSGALVTNRFVTIKDG 62
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
157-294 1.04e-23

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 105.34  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGafAQDSDGNKhYYDRDSGEMwTNRFVNDQGNWCYLNSDGVPVIG 236
Cdd:COG5263   352 DGKWYYLGSDGAMATGWQKIDGKWYYFDSNGAMATG--WVKVDGKW-YYFDSSGAM-ATGWLKIDGKWYYFDSDGAMATG 427

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1825987552 237 SITVNGQSLYFNSDGSQVKGnFVEEDGSlRYYDKNSGDLLRKTsRTINGVNYQFDNDG 294
Cdd:COG5263   428 WQKIGGKWYYFDSNGAMATG-WVKVDGK-WYYFDSDGAMATGW-QTIDGKTYYFDSNG 482
EstA_Ig_like pfam18435
Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain ...
 306-424 6.82e-19

Esterase Ig-like N-terminal domain; This is an N-terminal immunoglobulin (Ig)-like domain found in esterases such as EstA. Analysis of the EstA structure confirms that it is a member of the alpha/beta hydrolase family, with a conserved Ser-Asp-His catalytic triad. The Ig-like domain presumably plays a role in the multimerization of EstA into an unusual hexameric structure. Additionally, it may also participate in the catalysis of EstA by guiding the substrate to the active site.


Pssm-ID: 465765  Cd Length: 120  Bit Score: 82.75  E-value: 6.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 306 KTSLVVDSYEFGPSVSKIILEFNHKVTPAVVHAGAMVTTA-----GVQRKILNSYVSNASGHVVYFDSSHYVTLELDipy 380
Cdd:pfam18435   1 SVTAVTEVFGDGQKVSAVALEYDKPIDGSSLSADTFQVEVtrdaaKGPRTITKVYVNDAPGNAAKSKDGRYVILELD--- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1825987552 381 dpnDSSRNASPFIFDSA-AFRNNWVN-SYTVKVDNLQVQADGSNSS 424
Cdd:pfam18435  78 ---PDDPNASPFQYDPSkVSDNVWVDlKYTVTQTKDVKTADGTVYA 120
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 226-285 8.85e-19

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 80.64  E-value: 8.85e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 226 YLNSDGVPVIGSITVNGQSLYFNSDGSQVKGNFVEEDGSLRYYDKNSGDLLRKTSRTING 285
Cdd:TIGR04035   2 YFDADGKAVTGAQTIDGVTYYFDENGKQVKGDFVTNGGGTYYYDKDSGALVTNRFVTIKD 61
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
51-294 8.84e-17

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 83.77  E-value: 8.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  51 NASSQKVENQTSNQVEAKTDSA-NKDPQEKTGSVATDAPSINSANNTSQSDKQNTVNEISSDSQQTKTDEQTDLPQNSFK 129
Cdd:COG5263   186 GSAADTYYGGASTYLTGDAGAYgALGLAAGSGAGAKKTGSTAGASGTAYGDSGGTAGSGLSSLGGSSNALESGGENNQSL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 130 QQSAHVKMTTEAEKTPSHSINTFVNDGNGNWYYLGAdGRNVTGSHTIAGKTMYFAQDGKQVKGafaQDSDGNKHYYDRDS 209
Cdd:COG5263   266 AGNGTSYDDAGAAGVDGTGTTGTVGWVDGKWYYFDA-GKMVTGWQTINGKWYYFDSDGAMATG---WQKINGKWYYFDED 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 210 GEMwTNRFVNDQGNWCYLNSDGVPVIGSITVNGQSLYFNSDGSQVKGnFVEEDGSlRYYDKNSGDlLRKTSRTINGVNYQ 289
Cdd:COG5263   342 GAM-ATGWVTDDGKWYYLGSDGAMATGWQKIDGKWYYFDSNGAMATG-WVKVDGK-WYYFDSSGA-MATGWLKIDGKWYY 417


                  ....*
gi 1825987552 290 FDNDG 294
Cdd:COG5263   418 FDSDG 422
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 452-622 2.04e-16

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 80.43  E-value: 2.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 452 GNFNYAAYQPEAAIGGEKNPLIVWLHGIGevGTdinipllASNVARLTedpiqsHFTSTGsgGQKGAYVLVPQ-----SS 526
Cdd:COG3509    35 GTRTYRLYVPAGYDGGAPLPLVVALHGCG--GS-------AADFAAGT------GLNALA--DREGFIVVYPEgtgraPG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 527 TPWSQNQT----------ASLMALIKAYVASHPdIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAASYSNQLTDN 596
Cdd:COG3509    98 RCWNWFDGrdqrrgrddvAFIAALVDDLAARYG-IDPKRVYVTGLSAGGAMAYRLACEYPDVFAAVAPVAGLPYGAASDA 176

                         170       180
                  ....*....|....*....|....*.
gi 1825987552 597 QITAAalkalKGQPMWLIHTRTDKTI 622
Cdd:COG3509   177 ACAPG-----RPVPVLVIHGTADPTV 197
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 170-217 2.65e-16

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 72.96  E-value: 2.65e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1825987552 170 VTGSHTIAGKTMYFAQDGKQVKGAFAQDsDGNKHYYDRDSGEMWTNRF 217
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVTI-DGKWYYFDADSGEMVTNRF 47
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
157-255 5.59e-15

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 77.99  E-value: 5.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFaqdSDGNKHYYDRDSGEMWTNrFVNDQGNWCYLNSDGVPVIG 236
Cdd:COG5263   392 DGKWYYFDSSGAMATGWLKIDGKWYYFDSDGAMATGWQ---KIGGKWYYFDSNGAMATG-WVKVDGKWYYFDSDGAMATG 467

                          90
                  ....*....|....*....
gi 1825987552 237 SITVNGQSLYFNSDGSQVK 255
Cdd:COG5263   468 WQTIDGKTYYFDSNGAWVG 486
YpfH COG0400
Predicted esterase [General function prediction only];
466-647 5.40e-14

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 71.09  E-value: 5.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 466 GGEKNPLIVWLHGIGEVGTDInIPLlasnVARLTEDpiqshftstgsggqkGAYVLVPQSSTPWS--------------- 530
Cdd:COG0400     1 GGPAAPLVVLLHGYGGDEEDL-LPL----APELALP---------------GAAVLAPRAPVPEGpggrawfdlsflegr 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 531 ------QNQTASLMALIKAyVASHPDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAASysnqLTDNQITAAALK 604
Cdd:COG0400    61 edeeglAAAAEALAAFIDE-LEARYGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGY----LPGEEALPAPEA 135

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1825987552 605 ALKGQPMWLIHTRTDKTISADSSVLpFYKELLQAGAQNKWLSY 647
Cdd:COG0400   136 ALAGTPVFLAHGTQDPVIPVERARE-AAEALEAAGADVTYREY 177
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 234-279 1.01e-13

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 65.64  E-value: 1.01e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1825987552 234 VIGSITVNGQSLYFNSDGSQVKGNFVEEDGSLRYYDKNSGDLLRKT 279
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVTIDGKWYYFDADSGEMVTNR 46
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
466-668 3.11e-13

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 69.66  E-value: 3.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 466 GGEKNPLIVWLHGIG---EVGTDINIPLLASNvarltedpiqshftstgsggqkGAYVLVP------QSSTPWSQNQTAS 536
Cdd:COG1506    19 DGKKYPVVVYVHGGPgsrDDSFLPLAQALASR----------------------GYAVLAPdyrgygESAGDWGGDEVDD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 537 LMALIKaYVASHPDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAAsYSNQLTDNQITAAALKALKGQPMW---- 612
Cdd:COG1506    77 VLAAID-YLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAG-VSDLRSYYGTTREYTERLMGGPWEdpea 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1825987552 613 ------------------LIHTRTDKTISADSSVLpFYKELLQAGAqNKWLSYYEtnvGKHHsGITYNGHWSWV 668
Cdd:COG1506   155 yaarsplayadklktpllLIHGEADDRVPPEQAER-LYEALKKAGK-PVELLVYP---GEGH-GFSGAGAPDYL 222
Esterase_PHB pfam10503
Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), ...
 456-582 4.08e-12

Esterase PHB depolymerase; This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.


Pssm-ID: 431322 [Multi-domain]  Cd Length: 222  Bit Score: 66.24  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 456 YAAY-QPEAAIGGEKNPLIVWLHGIGE------VGTDINipLLASNVARLTEDPIQSHFTStgsgGQKGAYVLVPQSSTP 528
Cdd:pfam10503   3 YALYlPPEAAGDGAPMPLVVMLHGCKQhaddfaAGTRIN--ALADELGFAVLYPEQSKHAH----AHKCWNWFDEQGAAR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1825987552 529 wSQNQTASLMALIKAYVASHpDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAAL 582
Cdd:pfam10503  77 -GGGEAASIAALAKAIAAAH-RLDGARVYLAGLSAGAALAALLAHCYPDVFAAV 128
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 157-294 2.50e-10

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 63.95  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGK------QVKGAFaqdsdgnkhYYDRDSGEMWTNrFVNDQGNWCYLNSD 230
Cdd:NF033840  516 NGMWYFYNTDGSMATGWVQVNGSWYYLNSNGSmatgwvQVNGSW---------YYLNSNGSMATG-WVQVDGSWYYLNDN 585

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1825987552 231 GVPVIGSITVNGQSLYFNSDGSqVKGNFVEEDGSLRYYDKNSGDLLRKTSrtINGvnYQFDNDG 294
Cdd:NF033840  586 GSMETGWLQNNGSWYYLNSNGS-MKANQWFQVGSKWYYVNASGELAVNTS--IDG--YRVNDNG 644
esterase_phb TIGR01840
esterase, PHB depolymerase family; This model describes a subfamily among lipases of the ...
 456-586 6.50e-09

esterase, PHB depolymerase family; This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation]


Pssm-ID: 273828 [Multi-domain]  Cd Length: 212  Bit Score: 56.73  E-value: 6.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 456 YAAYQPEAAIGgeKNPLIVWLHGIGEVGTDINIPLLASNVARltedpiqshftstgsggQKGAYVLVPQSSTPWSQN--- 532
Cdd:TIGR01840   1 MYVYVPAGLTG--PRALVLALHGCGQTASAYVIDWGWKAAAD-----------------RYGFVLVAPEQTSYNSSNncw 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1825987552 533 -------------QTASLMALIKAYVASHpDIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIA 586
Cdd:TIGR01840  62 dwffthhrargtgEVESLHQLIDAVKANY-SIDPNRVYVTGLSAGGGMTAVLGCTYPDVFAGGASNA 127
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 32-271 1.24e-08

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 58.49  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  32 KTAEAD-ETVITEQRQTSKINASSQKVENQTSNQVeAKTDSANKDPQEKTGSVATDAPSiNSANNTSQSDKQNTVNEisS 110
Cdd:NF033838  372 KQAKAKvESKKAEATRLEKIKTDRKKAEEEAKRKA-AEEDKVKEKPAEQPQPAPAPQPE-KPAPKPEKPAEQPKAEK--P 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 111 DSQQTKTDEQTDLPQ--NSFKQQSAHVKMTTEAEKTP------SHSINTFVN-DG---------NGNWYYLGADGRNVTG 172
Cdd:NF033838  448 ADQQAEEDYARRSEEeyNRLTQQQPPKTEKPAQPSTPktgwkqENGMWYFYNtDGsmatgwlqnNGSWYYLNANGAMATG 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 173 SHTIAGKTMYFAQDGKQVKGAFAQDSdgnKHYYDRDSGEMWTNRFVNDqGNWCYLNSDGVPVIGSITVNGQSLYFNSDGS 252
Cdd:NF033838  528 WLQNNGSWYYLNANGSMATGWLQNNG---SWYYLNANGAMATGWLQYN-GSWYYLNANGDMATGWLQYNGSWYYLNANGD 603

                         250
                  ....*....|....*....
gi 1825987552 253 QVKGnFVEEDGSLRYYDKN 271
Cdd:NF033838  604 MATG-WLQYNGSWYYLNAN 621
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 157-273 3.26e-08

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 56.95  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFAQDSdgnKHYYDRDSGEMWTNRFVNDqGNWCYLNSDGVPVIG 236
Cdd:NF033838  532 NGSWYYLNANGSMATGWLQNNGSWYYLNANGAMATGWLQYNG---SWYYLNANGDMATGWLQYN-GSWYYLNANGDMATG 607

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1825987552 237 SITVNGQSLYFNSDGSQVKGnFVeEDGSLRYYDKNSG 273
Cdd:NF033838  608 WLQYNGSWYYLNANGSMATG-WV-KDGDTWYYLEASG 642
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-38 2.10e-06

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 44.78  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1825987552   3 FEKQKHFSLRKLKFGLVSVAiIAFLFAVTKTAEADE 38
Cdd:TIGR01168   5 NEKQQKYSIRKLSVGVASVL-VASLFFGGGVAAAES 39
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 196-298 3.43e-06

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 50.47  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 196 QDSDGNKHYYDRDsGEMWTNrFVNDQGNWCYLNSDGVPVIGSITVNGQSLYFNSDGSQVKGnFVEEDGSLRYYDKNSGdl 275
Cdd:NF033840  513 KQENGMWYFYNTD-GSMATG-WVQVNGSWYYLNSNGSMATGWVQVNGSWYYLNSNGSMATG-WVQVDGSWYYLNDNGS-- 587

                          90       100
                  ....*....|....*....|...
gi 1825987552 276 LRKTSRTINGVNYQFDNDGNARA 298
Cdd:NF033840  588 METGWLQNNGSWYYLNSNGSMKA 610
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 1-148 1.15e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552   1 MTFEKQKHFSLRKLKFGLVSV---AIIAFLFAVTKTAEADETVITEQRQTS---KINASSQ-----KVENQ-------TS 62
Cdd:NF033609    1 MNMKKKEKHAIRKKSIGVASVlvgTLIGFGLLSSKEADASENSVTQSDSASnesKSNDSSSvsaapKTDDTnvsdtktSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552  63 NQVEAKTDSA-NKDPQEKTGSVATDA-------------PSINSANNTSQSDKQNT-----VNEISSD--SQQTKTDEQT 121
Cdd:NF033609   81 NTNNGETSVAqNPAQQETTQSASTNAtteetpvtgeattTATNQANTPATTQSSNTnaeelVNQTSNEttSNDTNTVSSV 160

                         170       180
                  ....*....|....*....|....*..
gi 1825987552 122 DLPQNSFKQQSAHVKMTTEAEKTPSHS 148
Cdd:NF033609  161 NSPQNSTNAENVSTTQDTSTEATPSNN 187
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 157-254 1.66e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 48.09  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 157 NGNWYYLGADGRNVTGSHTIAGKTMYFAQDGKQVKGAFaqdSDGNKHYYDRDSGEMWTNRFVNDQGNWCYLNSDGVPVIG 236
Cdd:NF033838  592 NGSWYYLNANGDMATGWLQYNGSWYYLNANGSMATGWV---KDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVN 668

                          90
                  ....*....|....*...
gi 1825987552 237 SiTVNGQSLyfNSDGSQV 254
Cdd:NF033838  669 T-TVDGYGV--NANGEWV 683
YSIRK_signal pfam04650
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and ...
 4-28 1.95e-04

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 428049 [Multi-domain]  Cd Length: 26  Bit Score: 38.90  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1825987552   4 EKQKHFSLRKLKFGLVSVAIIAFLF 28
Cdd:pfam04650   1 EKKQRYSIRKLSVGVASVLIGTLLF 25
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 459-643 2.78e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 43.36  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 459 YQPEAAigGEKNPLIVWLHGIGEV--GTDINIPLLAS---NVarLTEDPiqSHFtstG-SGGQkgayvlvP-QSSTPWSQ 531
Cdd:COG1073    28 YLPAGA--SKKYPAVVVAHGNGGVkeQRALYAQRLAElgfNV--LAFDY--RGY---GeSEGE-------PrEEGSPERR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 532 NqtasLMALIKaYVASHPDIDSRRIYLAGVSNGGGMTLDMGVAYPNY--------FAALVPIAA---------------- 587
Cdd:COG1073    92 D----ARAAVD-YLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVkavildspFTSLEDLAAqrakeargaylpgvpy 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 588 ----SYSNQLTDNQITAAALKALKgQPMWLIHTRTDKTISADssvlpFYKELLQAGAQNK 643
Cdd:COG1073   167 lpnvRLASLLNDEFDPLAKIEKIS-RPLLFIHGEKDEAVPFY-----MSEDLYEAAAEPK 220
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
459-647 5.66e-04

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 41.78  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 459 YQPEAAigGEKNPLIVWLHGIGEVGTDINipllasnvarlTEDPIQSHFTStgsggQKGA------YVLVPQSSTPWSQN 532
Cdd:COG0657     4 YRPAGA--KGPLPVVVYFHGGGWVSGSKD-----------THDPLARRLAA-----RAGAavvsvdYRLAPEHPFPAALE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 533 QTASLMALIKAYVASHpDIDSRRIYLAGVSNGGGMTLDMGVAYPNY----FAALVPIAASYSnqltdnqITAAALKA-LK 607
Cdd:COG0657    66 DAYAALRWLRANAAEL-GIDPDRIAVAGDSAGGHLAAALALRARDRggprPAAQVLIYPVLD-------LTASPLRAdLA 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1825987552 608 GQ-PMWLIHTRTDKTisADSSVLpFYKELLQAGAQNKWLSY 647
Cdd:COG0657   138 GLpPTLIVTGEADPL--VDESEA-LAAALRAAGVPVELHVY 175
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
552-655 5.70e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 42.53  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 552 DSRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAASYSNQLTDNQITA-----AALKALKGQPMWLIHTRTDKTISAds 626
Cdd:COG2382   194 DPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSGSFWWPPGDADRGGwaellAAGAPKKPLRFYLDVGTEDDLLEA-- 271

                          90       100
                  ....*....|....*....|....*....
gi 1825987552 627 sVLPFYKELLQAGAQNkwlSYYETNvGKH 655
Cdd:COG2382   272 -NRALAAALKAKGYDV---EYREFP-GGH 295
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 465-627 2.12e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 40.37  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 465 IGGEKNPLIVWLHGIGEVGTDIN--IPLLASnvarltedpiqsHFTstgsggqkgayVLVP------QSSTPWSQNQTAS 536
Cdd:COG0596    18 EAGPDGPPVVLLHGLPGSSYEWRplIPALAA------------GYR-----------VIAPdlrghgRSDKPAGGYTLDD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 537 LMALIKAYVAShpdIDSRRIYLAGVSNGGGMTLDMGVAYPNYFAALV-------PIAASYSNQLTDNQITAAALKALKG- 608
Cdd:COG0596    75 LADDLAALLDA---LGLERVVLVGHSMGGMVALELAARHPERVAGLVlvdevlaALAEPLRRPGLAPEALAALLRALARt 151

                         170       180
                  ....*....|....*....|....*....
gi 1825987552 609 ----------QPMWLIHTRTDKTISADSS 627
Cdd:COG0596   152 dlrerlaritVPTLVIWGEKDPIVPPALA 180
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
543-627 7.68e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 38.44  E-value: 7.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825987552 543 AYVASHPDidsRRIYLAGVSNGGGMTLDMGVAYPNYFAALVPIAASYSNQlTDNQITAAALKALK--------GQPMWLI 614
Cdd:COG2267    91 DALRARPG---LPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRAD-PLLGPSARWLRALRlaealariDVPVLVL 166

                          90
                  ....*....|...
gi 1825987552 615 HTRTDKTISADSS 627
Cdd:COG2267   167 HGGADRVVPPEAA 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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