NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1821441125|gb|QIM31507|]
View 

iron ABC transporter permease [Streptococcus agalactiae]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821441125 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821441125 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-337 4.91e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  27 LFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGI 106
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 107 NAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYF--KL 184
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 185 NRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALI 264
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821441125 265 GTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
58-337 2.16e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.65  E-value: 2.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSM--HYSTILIVCLl 135
Cdd:PRK11228   40 PTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPfaGYSLAFIAAC- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 136 GSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILG 214
Cdd:PRK11228  119 GGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHaYGIFYWLAGGVSHARWQEVWQLLPFVVTA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK11228  199 VPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSM 278

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1821441125 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK11228  279 LLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-335 4.98e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 4.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  73 IIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQ 152
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 153 KGYHqlRLILAGAMISTLFTSVGQVVTLYF-KLNRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLN 231
Cdd:cd06550    81 LSPS--KLILIGIVLSAFFSAGVILISLLSdDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 232 ESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRII 311
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|....
gi 1821441125 312 NpPSETPISSIISIVGLPCFLWLI 335
Cdd:cd06550   239 L-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-339 1.00e-81

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 250.37  E-value: 1.00e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  35 SLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLAL 114
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 115 VVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN--RTVIGWQ 192
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEqlRSIVFWL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 193 AGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGL 272
Cdd:COG0609   160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821441125 273 IIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRKGK 339
Cdd:COG0609   240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 27-337 4.91e-72

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 225.87  E-value: 4.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  27 LFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGI 106
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGD-DSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 107 NAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYF--KL 184
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 185 NRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALI 264
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821441125 265 GTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
58-337 2.16e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.65  E-value: 2.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSM--HYSTILIVCLl 135
Cdd:PRK11228   40 PTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPfaGYSLAFIAAC- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 136 GSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILG 214
Cdd:PRK11228  119 GGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHaYGIFYWLAGGVSHARWQEVWQLLPFVVTA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK11228  199 VPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSM 278

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1821441125 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK11228  279 LLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
19-340 6.68e-47

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 168.09  E-value: 6.68e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  19 LVFFITLILFLIGCYASLRFGAINFKTSDLITVLKNPLKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAI 98
Cdd:PRK10577   12 LPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  99 ADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYtkQKGYHQLRLILAGAMISTLFTSVGQVV 178
Cdd:PRK10577   92 ASPTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAG--GKRLSPLRLVLAGMVVSLYLGALTTLL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 179 TLYF--KLNRTVIgWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFL 256
Cdd:PRK10577  170 LLFNeqYLQGLFL-WGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 257 SASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISS--IISIVGLPCFLWL 334
Cdd:PRK10577  249 SAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGELLPTgaVTALIGAPLLLWL 328


                  ....*.
gi 1821441125 335 IRKGKN 340
Cdd:PRK10577  329 LPRLRS 334
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-338 8.59e-45

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 162.32  E-value: 8.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  16 HFWLVFFITLILFLIGCYASLRFGainfKTSDLITVLknplkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTR 95
Cdd:PRK10577  353 RVLAWLLALGLLLLLALVVALSFG----RDAHGWNWL-----SGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTR 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  96 NAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSytKQKGYHQLRLILAGAMISTLFTSVG 175
Cdd:PRK10577  424 NPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLA--RRGGFAPERLLLTGIALSALFTALI 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 176 QVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVL 254
Cdd:PRK10577  502 QLLLASGDPRaAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAA 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 255 FLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWL 334
Cdd:PRK10577  582 LLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWL 661


                  ....
gi 1821441125 335 IRKG 338
Cdd:PRK10577  662 LRRS 665
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 9-341 6.66e-40

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 143.07  E-value: 6.66e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125   9 VQKNKSNHFWLVFFITLILFLIGCYASLRFGAINFKTSDLITvlknplknSNAQDVIFDIRLPRIIAAILVGAAMSQAGA 88
Cdd:COG4139     3 LPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLS--------EAWQLFVWQLRLPRTLAAVLVGASLAVSGA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  89 IMQGVTRNAIADPGLLGINAGAGLALVVA-YAFLGSMHYSTILIVCLLGSVISCLLVFTLSytkQKGYHQLRLILAGAMI 167
Cdd:COG4139    75 VMQALFENPLAEPGLLGISNGAGVGLVLVvLLGGGLLPPWLLSLAAIAGALLVTLLLLAFA---RRRLSNARLLLIGVAL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 168 STLFTSVgQVVTLYFKLN---RTVIGWQAGGLSQINWKmLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQL 244
Cdd:COG4139   152 GIICSAI-MTWAVYFSSSldlRQLMYWMMGSFGGVDWR-QLWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHR 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 245 MTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIIS 324
Cdd:COG4139   230 WRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTA 309

                         330
                  ....*....|....*..
gi 1821441125 325 IVGLPCFLWLIRKGKNL 341
Cdd:COG4139   310 TLGAPVFIWLLLRRRKI 326
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-335 4.98e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 4.98e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  73 IIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQ 152
Cdd:cd06550     1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 153 KGYHqlRLILAGAMISTLFTSVGQVVTLYF-KLNRTVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLN 231
Cdd:cd06550    81 LSPS--KLILIGIVLSAFFSAGVILISLLSdDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 232 ESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRII 311
Cdd:cd06550   159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                         250       260
                  ....*....|....*....|....
gi 1821441125 312 NpPSETPISSIISIVGLPCFLWLI 335
Cdd:cd06550   239 L-PSELPVGPVTALLGAPYFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
19-335 7.73e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 140.18  E-value: 7.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  19 LVFFITLILFLIGCY-ASLRFGAINFKTSDLITVLKNPLKNsnaQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNA 97
Cdd:PRK09777    3 IALVIFITLALAGCAlLSLRMGVIPLPWRALLTDWQAGDEH---YYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  98 IADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSytkqkGYHQ-LRLILAGAMISTLFTSVgq 176
Cdd:PRK09777   80 LASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLA-----GTHQpMKLALTGVALSALWASL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 177 vvTLYFKLNR-----TVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLL 251
Cdd:PRK09777  153 --TDYLMLSRpqdinNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 252 IVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCF 331
Cdd:PRK09777  231 LAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWF 310


                  ....
gi 1821441125 332 LWLI 335
Cdd:PRK09777  311 FWLL 314
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 61-337 4.38e-38

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 138.55  E-value: 4.38e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  61 AQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYSTILIVC-LLGSVI 139
Cdd:PRK03784   50 GELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCaIAGALL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 140 SCLLVFTLSYTKQKGyhQLRLILAGAMISTLFtsvGQVVT--LYFKLN---RTVIGWQAGGLSQINWKmLIIIAPIIILG 214
Cdd:PRK03784  130 ITLILLRFARRHRLS--TSRLLLAGVALGIIC---SALMTwaVYFSTSldlRQLMYWMMGGFGGVDWR-QSWLMLALLPV 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 215 LLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIG 294
Cdd:PRK03784  204 LIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCA 283

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1821441125 295 FSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK03784  284 LAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLR 326
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
25-337 1.41e-36

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 134.45  E-value: 1.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  25 LILFLIGCYASLRFGAINFKTSDLITVLKNPLKNSNAQdVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLL 104
Cdd:PRK10441   17 LLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCT-IVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 105 GINAGAGLALVVAYAFLGSMHYSTILIVCLLGSVISCLLVFTLSYTKQKGYHQLRLILAGAMISTLFTSVGQVVTLyfkL 184
Cdd:PRK10441   96 GVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIAL---L 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 185 NRTVIG----WQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASS 260
Cdd:PRK10441  173 NPDVYDqlrfWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSA 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821441125 261 VALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINpPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK10441  253 TAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRR 328
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 18-335 3.91e-35

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 130.63  E-value: 3.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  18 WLVFFITLILFLIGCYASLRFGAINFKTSDLITVLKNPLkNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNA 97
Cdd:COG4779    23 LLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEG-DPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  98 IADPGLLGINAGAGLALVVAYAFLGSmHYSTILIVCLLGSVISCLLVFTLSYTkqKGYHQLRLILAGAMISTLFTSVGQV 177
Cdd:COG4779   102 LASPDIIGITAGASAGAVAAIVVLGG-SGLAVALGALAGGLATALLVYLLAWR--GGVSGYRLILVGIGVSAMLTAVNSY 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 178 VTLYFKLNR--TVIGWQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLF 255
Cdd:COG4779   179 LLTRADLEDaqSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVA 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 256 LSASSVALIGTVSFIGLIIPHfIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSIISIVGLPCFLWLI 335
Cdd:COG4779   259 LAAVATAAAGPIAFVALAAPQ-IARRLTRSPGPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLL 337
btuC PRK09535
cobalamin ABC transporter permease BtuC;
58-337 1.82e-33

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 126.79  E-value: 1.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  58 NSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAIADPGLLGINAGAGLALVVAYAFLGSMHYStILIVCLLGS 137
Cdd:PRK09535   84 PETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFG-LQAAAFAGA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 138 VISCLLVFTLSyTKQKGYHQLRLILAGAMISTLFTSVGQVVTLYFKLN-RTVIGWQAGGLSQINWKMLIIIAPIIILGLL 216
Cdd:PRK09535  163 LVAAFGVYAIA-TENGRTPVATLLLAGVAVQTFLGAVISYLLLHSGESlRRAVYWLMGHLHGSTWSDVEVALPVVVVGFV 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 217 ISQLLAHQLTILSLNESVAKALGQKTQLMTAFLLLIVLFLSASSVALIGTVSFIGLIIPHFIKLFIPKDYRLLLPLIGFS 296
Cdd:PRK09535  242 VLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALA 321

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1821441125 297 GATFMIWVDLSSRiiNPPSETPISSIISIVGLPCFLWLIRK 337
Cdd:PRK09535  322 GASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
23-336 3.43e-23

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 98.24  E-value: 3.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  23 ITLILFLIGCYA----SLRFGAINFKTSDLITVLKNPlKNSNAQDVIFDIRLPRIIAAILVGAAMSQAGAIMQGVTRNAI 98
Cdd:PRK10440   10 ITCLLLLAACVAaglwGLRSGAVTLETSQVFAALMGD-APRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125  99 ADPGLLGINAGAGLALVVAYAFLGSmHYSTILIVCLLGSVISCLLVFTLSYtkQKGYHQLRLILAGAMISTLFTSVGQVV 178
Cdd:PRK10440   89 GSPDVMGFNTGAWSGVLVAMVLFGQ-DLTAIALAAMAGGIVTSLLVWLLAW--RNGIDTFRLIIIGIGVRAMLVAFNTWL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 179 TLYFKLNRTVIG--WQAGGLSQINWKMLIIIAPIIILGLLISQLLAHQLTILSLNESVAKALG---QKTQLMtafLLLIV 253
Cdd:PRK10440  166 LLKASLETALTAglWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGvsvERSRLL---LMLVA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821441125 254 LFLSASSVALIGTVSFIGLIIPHfIKLFIPKDYRLLLPLIGFSGATFMIWVDLSSRIINPPSETPISSI-ISIVGLPCFL 332
Cdd:PRK10440  243 VVLTAAATALAGPISFIALVAPH-IARRLSGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVtVSLGGIYLIV 321


                  ....
gi 1821441125 333 WLIR 336
Cdd:PRK10440  322 LLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH