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Conserved domains on  [gi|9973298|sp|Q9Y625|]
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RecName: Full=Glypican-6; Contains: RecName: Full=Secreted glypican-6; Flags: Precursor

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-548 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 924.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298     22 GADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSR 101
Cdd:pfam01153  13 PASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    102 HKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYH 181
Cdd:pfam01153  93 HRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    182 FSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLP 261
Cdd:pfam01153 173 FSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLP 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    262 TVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGC 341
Cdd:pfam01153 253 SVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGC 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    342 GQPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNE 419
Cdd:pfam01153 333 GTPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNE 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    420 EECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGS 499
Cdd:pfam01153 412 DKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGD 491

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9973298    500 GCMDDVCPTEFEFVTTEA---------PAVDPDRREVDSSAAQRGHSLLS-----WSLTCIVL 548
Cdd:pfam01153 492 GCPSDLCKGDLPFVFELTdtpatpakpTTQQGTGSVDGSSTGGLPSSLLLatsmlLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-548 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 924.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298     22 GADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSR 101
Cdd:pfam01153  13 PASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    102 HKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYH 181
Cdd:pfam01153  93 HRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    182 FSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLP 261
Cdd:pfam01153 173 FSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLP 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    262 TVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGC 341
Cdd:pfam01153 253 SVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGC 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    342 GQPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNE 419
Cdd:pfam01153 333 GTPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNE 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    420 EECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGS 499
Cdd:pfam01153 412 DKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGD 491

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9973298    500 GCMDDVCPTEFEFVTTEA---------PAVDPDRREVDSSAAQRGHSLLS-----WSLTCIVL 548
Cdd:pfam01153 492 GCPSDLCKGDLPFVFELTdtpatpakpTTQQGTGSVDGSSTGGLPSSLLLatsmlLSLVTLLV 554
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
22-548 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 924.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298     22 GADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSR 101
Cdd:pfam01153  13 PASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    102 HKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYH 181
Cdd:pfam01153  93 HRKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    182 FSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLP 261
Cdd:pfam01153 173 FSDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLP 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    262 TVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGC 341
Cdd:pfam01153 253 SVKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGC 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    342 GQPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNE 419
Cdd:pfam01153 333 GTPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNE 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9973298    420 EECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGS 499
Cdd:pfam01153 412 DKCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGD 491

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9973298    500 GCMDDVCPTEFEFVTTEA---------PAVDPDRREVDSSAAQRGHSLLS-----WSLTCIVL 548
Cdd:pfam01153 492 GCPSDLCKGDLPFVFELTdtpatpakpTTQQGTGSVDGSSTGGLPSSLLLatsmlLSLVTLLV 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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