NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17433105|sp|Q9XFK7|]
View 

RecName: Full=Protein MOTHER of FT and TFL1

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 1002)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to Arabidopsis thaliana protein BROTHER of FT and TFL 1 that may form complexes with phosphorylated ligands by interfering with kinases and their effectors

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PEBP super family cl00227
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 6-173 2.26e-67

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


The actual alignment was detected with superfamily member PLN00169:

Pssm-ID: 469671  Cd Length: 175  Bit Score: 202.73  E-value: 2.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    6 DPLVVGRVIGDVLDMFIPTANMSVYFGPKHITNGCEIKPSTAVNPPKVNISGHS-DELYTLVMTDPDAPSPSEPNMREWV 84
Cdd:PLN00169   7 DPLVVGRVVGDVLDPFTRSISLRVTYGSREVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105   85 HWIVVDIPGGTNPSRGKEILPYMEPRPPVGIHRYILVLFRQnspVGLM-VQQPPSRANFSTRMFAGHFDLGLPVATVYFN 163
Cdd:PLN00169  87 HWLVTDIPATTGATFGQEVVCYESPRPTAGIHRFVFVLFRQ---LGRQtVYAPGWRQNFNTRDFAELYNLGSPVAAVYFN 163

                        170
                 ....*....|..
gi 17433105  164 AQKEPAS--RRR 173
Cdd:PLN00169 164 CQRESGSggRRP 175
 
Name Accession Description Interval E-value
PLN00169 PLN00169
CETS family protein; Provisional
 6-173 2.26e-67

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 202.73  E-value: 2.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    6 DPLVVGRVIGDVLDMFIPTANMSVYFGPKHITNGCEIKPSTAVNPPKVNISGHS-DELYTLVMTDPDAPSPSEPNMREWV 84
Cdd:PLN00169   7 DPLVVGRVVGDVLDPFTRSISLRVTYGSREVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105   85 HWIVVDIPGGTNPSRGKEILPYMEPRPPVGIHRYILVLFRQnspVGLM-VQQPPSRANFSTRMFAGHFDLGLPVATVYFN 163
Cdd:PLN00169  87 HWLVTDIPATTGATFGQEVVCYESPRPTAGIHRFVFVLFRQ---LGRQtVYAPGWRQNFNTRDFAELYNLGSPVAAVYFN 163

                        170
                 ....*....|..
gi 17433105  164 AQKEPAS--RRR 173
Cdd:PLN00169 164 CQRESGSggRRP 175
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 25-164 1.24e-43

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 141.74  E-value: 1.24e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105  25 ANMSVYFGPKH-ITNGCEIKPSTAVNPPKVNISG--HSDELYTLVMTDPDAPSPSEPNMREWVHWIVVDIPGGT----NP 97
Cdd:cd00866   1 VDLTVSYGSSGvVTPGNLLTPSETQKAPTVSFSSedPPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttgLV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17433105  98 SRGKEILPYMEPRPPV--GIHRYILVLFRQNSPVGLMVQQPP-----SRANFSTRMFAGHFDLGLPVATVYFNA 164
Cdd:cd00866  81 SKGEVLVPYLGPGPPKgtGPHRYVFLLFKQPGGLDFPESKLPptsglGRRGFDVREFAKKNGLGLPVAANFFQV 154
PBP pfam01161
Phosphatidylethanolamine-binding protein;
51-162 8.95e-18

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 75.07  E-value: 8.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    51 PKVNISGHSDE--LYTLVMTDPDAPSPSEPNmreWVHWIVVDIPGGTN------PSRGKE------ILPYMEPRPPVG-- 114
Cdd:pfam01161  15 PPLAWSGAPAGtkSFALVMIDPDAPKVGGSG---WLHWVVTNIPATVTelpegaPAGAVQglndfgGAGYGGPCPPAGdg 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17433105   115 IHRYILVLFRQNSPvGLMVQQPPSRANFSTRMfAGHfDLGLPVATVYF 162
Cdd:pfam01161  92 PHRYVFTLYALDVP-LLDRNWGFTKAELGVAF-AGH-VLALAVLAGNY 136
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 63-150 7.57e-10

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 54.39  E-value: 7.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105  63 YTLVMTDPDAPSPSEpnmreWVHWIVVDIPGGTN---PSRGKEILP--------------YMEPRPPVG--IHRYILVLF 123
Cdd:COG1881  41 FALIVEDPDAPTGGG-----FWHWVVYNIPADVTelpEGAGSADLPagavqgrndfgeagYGGPCPPPGdgPHRYVFTVY 115

                        90       100
                ....*....|....*....|....*..
gi 17433105 124 RQNSPVGLmvQQPPSRANFSTRMfAGH 150
Cdd:COG1881 116 ALDVELDL--PPGATRAELLFAM-EGH 139
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 51-123 1.58e-06

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 45.17  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    51 PKVNISGHSDELYTLVMT--DPDAPSPSEpnmreWVHWIVVDIPGGTN------PSRGKEI--------------LPYME 108
Cdd:TIGR00481  16 PPLSWDGVPEGAKSLALTciDPDAPTGCG-----WWHWVVVNIPADTTvlpenaSSDDKRLpqgvplqgrndfgkSGYIG 90

                          90
                  ....*....|....*
gi 17433105   109 PRPPVGIHRYILVLF 123
Cdd:TIGR00481  91 PCPPKGDHRYLFTVY 105
 
Name Accession Description Interval E-value
PLN00169 PLN00169
CETS family protein; Provisional
 6-173 2.26e-67

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 202.73  E-value: 2.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    6 DPLVVGRVIGDVLDMFIPTANMSVYFGPKHITNGCEIKPSTAVNPPKVNISGHS-DELYTLVMTDPDAPSPSEPNMREWV 84
Cdd:PLN00169   7 DPLVVGRVVGDVLDPFTRSISLRVTYGSREVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105   85 HWIVVDIPGGTNPSRGKEILPYMEPRPPVGIHRYILVLFRQnspVGLM-VQQPPSRANFSTRMFAGHFDLGLPVATVYFN 163
Cdd:PLN00169  87 HWLVTDIPATTGATFGQEVVCYESPRPTAGIHRFVFVLFRQ---LGRQtVYAPGWRQNFNTRDFAELYNLGSPVAAVYFN 163

                        170
                 ....*....|..
gi 17433105  164 AQKEPAS--RRR 173
Cdd:PLN00169 164 CQRESGSggRRP 175
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 25-164 1.24e-43

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 141.74  E-value: 1.24e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105  25 ANMSVYFGPKH-ITNGCEIKPSTAVNPPKVNISG--HSDELYTLVMTDPDAPSPSEPNMREWVHWIVVDIPGGT----NP 97
Cdd:cd00866   1 VDLTVSYGSSGvVTPGNLLTPSETQKAPTVSFSSedPPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttgLV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17433105  98 SRGKEILPYMEPRPPV--GIHRYILVLFRQNSPVGLMVQQPP-----SRANFSTRMFAGHFDLGLPVATVYFNA 164
Cdd:cd00866  81 SKGEVLVPYLGPGPPKgtGPHRYVFLLFKQPGGLDFPESKLPptsglGRRGFDVREFAKKNGLGLPVAANFFQV 154
PBP pfam01161
Phosphatidylethanolamine-binding protein;
51-162 8.95e-18

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 75.07  E-value: 8.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    51 PKVNISGHSDE--LYTLVMTDPDAPSPSEPNmreWVHWIVVDIPGGTN------PSRGKE------ILPYMEPRPPVG-- 114
Cdd:pfam01161  15 PPLAWSGAPAGtkSFALVMIDPDAPKVGGSG---WLHWVVTNIPATVTelpegaPAGAVQglndfgGAGYGGPCPPAGdg 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17433105   115 IHRYILVLFRQNSPvGLMVQQPPSRANFSTRMfAGHfDLGLPVATVYF 162
Cdd:pfam01161  92 PHRYVFTLYALDVP-LLDRNWGFTKAELGVAF-AGH-VLALAVLAGNY 136
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 30-164 1.94e-15

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 69.73  E-value: 1.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105  30 YFGPKHITNGCEIKPSTAVNPPKVNISghsdeLYTLVMTDPDAPSPsepnmREWVHWIVVDIPGGT------------NP 97
Cdd:cd00457  13 VLPPEYSFEGVGRFPSLSWDGPPPDVK-----EYVLVMEDPDAPLG-----RPIVHGLVYGIPANKtslsnddfvvtdNG 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17433105  98 SRGKEIL----------PYMEPRPPV--GIHRYILVLFRQNSPVgLMVQQPPSRANFSTRMFAGHFDLGlPVATVYFNA 164
Cdd:cd00457  83 KGGLQGGfkygknrggtVYIGPRPPLghGPHRYFFQVYALDEPL-DRSKLGDGRTKFEVARFAEGNVLG-AVGEWVGQF 159
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 63-150 7.57e-10

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 54.39  E-value: 7.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105  63 YTLVMTDPDAPSPSEpnmreWVHWIVVDIPGGTN---PSRGKEILP--------------YMEPRPPVG--IHRYILVLF 123
Cdd:COG1881  41 FALIVEDPDAPTGGG-----FWHWVVYNIPADVTelpEGAGSADLPagavqgrndfgeagYGGPCPPPGdgPHRYVFTVY 115

                        90       100
                ....*....|....*....|....*..
gi 17433105 124 RQNSPVGLmvQQPPSRANFSTRMfAGH 150
Cdd:COG1881 116 ALDVELDL--PPGATRAELLFAM-EGH 139
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 63-123 5.36e-08

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 49.52  E-value: 5.36e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17433105  63 YTLVMTDPDAPSPSEpnmreWVHWIVVDIPGGT-----NPSRGKEILPYME------------PRPPV-GIHRYILVLF 123
Cdd:cd00865  42 LALIVEDPDAPTGGG-----FVHWVVWNIPADTtelpeGASRGALPAGAVQgrndfgeagyggPCPPDgGPHRYVFTVY 115
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 51-123 1.58e-06

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 45.17  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17433105    51 PKVNISGHSDELYTLVMT--DPDAPSPSEpnmreWVHWIVVDIPGGTN------PSRGKEI--------------LPYME 108
Cdd:TIGR00481  16 PPLSWDGVPEGAKSLALTciDPDAPTGCG-----WWHWVVVNIPADTTvlpenaSSDDKRLpqgvplqgrndfgkSGYIG 90

                          90
                  ....*....|....*
gi 17433105   109 PRPPVGIHRYILVLF 123
Cdd:TIGR00481  91 PCPPKGDHRYLFTVY 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH