RecName: Full=Macrophage-expressed gene 1 protein; Short=Macrophage gene 1 protein; Short=Mpg-1; AltName: Full=Perforin-2; Short=P-2; Contains: RecName: Full=Macrophage-expressed gene 1 protein, processed form; Flags: Precursor
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| MPEG1_P2 | cd22579 | P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; ... |
347-627 | 2.25e-158 | |||||
P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; Macrophage-expressed gene 1 protein (MPEG1), also called perforin-2 (P-2) or macrophage gene 1 protein (Mpg-1), is a pore-forming, antibacterial protein with broad-spectrum activity. It is a major antibacterial effector protein of the innate immune system in phagocytic as well as tissue forming cells. It plays an essential role in intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria by inserting into the bacterial surface to form pores. This model corresponds to a unique membrane bound P2 domain of MPEG1, which helps to stabilize the pre-pore state by swapping between monomers and enables MPEG1 to bind its targeted membrane. : Pssm-ID: 439345 Cd Length: 287 Bit Score: 459.04 E-value: 2.25e-158
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| MACPF | pfam01823 | MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ... |
125-341 | 5.96e-38 | |||||
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold. : Pssm-ID: 460349 Cd Length: 211 Bit Score: 140.23 E-value: 5.96e-38
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| Name | Accession | Description | Interval | E-value | |||||
| MPEG1_P2 | cd22579 | P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; ... |
347-627 | 2.25e-158 | |||||
P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; Macrophage-expressed gene 1 protein (MPEG1), also called perforin-2 (P-2) or macrophage gene 1 protein (Mpg-1), is a pore-forming, antibacterial protein with broad-spectrum activity. It is a major antibacterial effector protein of the innate immune system in phagocytic as well as tissue forming cells. It plays an essential role in intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria by inserting into the bacterial surface to form pores. This model corresponds to a unique membrane bound P2 domain of MPEG1, which helps to stabilize the pre-pore state by swapping between monomers and enables MPEG1 to bind its targeted membrane. Pssm-ID: 439345 Cd Length: 287 Bit Score: 459.04 E-value: 2.25e-158
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| MACPF | pfam01823 | MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ... |
125-341 | 5.96e-38 | |||||
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold. Pssm-ID: 460349 Cd Length: 211 Bit Score: 140.23 E-value: 5.96e-38
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| MACPF | smart00457 | membrane-attack complex / perforin; |
146-343 | 1.35e-35 | |||||
membrane-attack complex / perforin; Pssm-ID: 214671 Cd Length: 195 Bit Score: 133.33 E-value: 1.35e-35
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| Name | Accession | Description | Interval | E-value | |||||
| MPEG1_P2 | cd22579 | P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; ... |
347-627 | 2.25e-158 | |||||
P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins; Macrophage-expressed gene 1 protein (MPEG1), also called perforin-2 (P-2) or macrophage gene 1 protein (Mpg-1), is a pore-forming, antibacterial protein with broad-spectrum activity. It is a major antibacterial effector protein of the innate immune system in phagocytic as well as tissue forming cells. It plays an essential role in intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria by inserting into the bacterial surface to form pores. This model corresponds to a unique membrane bound P2 domain of MPEG1, which helps to stabilize the pre-pore state by swapping between monomers and enables MPEG1 to bind its targeted membrane. Pssm-ID: 439345 Cd Length: 287 Bit Score: 459.04 E-value: 2.25e-158
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| MACPF | pfam01823 | MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ... |
125-341 | 5.96e-38 | |||||
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold. Pssm-ID: 460349 Cd Length: 211 Bit Score: 140.23 E-value: 5.96e-38
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| MACPF | smart00457 | membrane-attack complex / perforin; |
146-343 | 1.35e-35 | |||||
membrane-attack complex / perforin; Pssm-ID: 214671 Cd Length: 195 Bit Score: 133.33 E-value: 1.35e-35
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