|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
395-1115 |
9.38e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 118.04 E-value: 9.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 395 KYAMIFIPVAQSnrllPLFHEWEDVELINELVEVVAM--DLGLE---------NELFNELLLTDVWLVSLGGTFVMASV- 462
Cdd:COG1033 160 KATLIVVTLDPD----PLSSDLDRKEVVAEIRAIIAKyeDPGVEvyltgfpvlRGDIAEAIQSDLAIFFPLALLLILLLl 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 463 WLYTGSAFITLM----SCVAICFSLGLAYFFYaivleFEFFPYMNLLAVVvIIGIGADdvflflkiwHCV-LTERFsnrc 537
Cdd:COG1033 236 FLFFRSLRGVLLpllvVLLAVIWTLGLMGLLG-----IPLSPLTILVPPL-LLAIGID---------YGIhLLNRY---- 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 538 tlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
Cdd:COG1033 297 ------------REERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTL 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 618 LPASVSIMERLFATRMSCHHPmsiklihackKSINRFCQMFEECITKsimnYAYLWLLIFGALgasSAVIVFWYPGLQ-- 695
Cdd:COG1033 365 LPALLSLLPRPKPKTRRLKKP----------PELGRLLAKLARFVLR----RPKVILVVALVL---AVVSLYGISRLKve 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 696 ------LPEKShfqlfvskhpfEVYSSLKqqfWFEkplqayENFKMHMHFVWGVQAVDDGDYTNPNsyghlhydnnfnvs 769
Cdd:COG1033 428 ydfedyLPEDS-----------PIRQDLD---FIE------ENFGGSDPLEVVVDTGEPDGLKDPE-------------- 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 770 srpAQLWILDFCQSVRQQPFYKETLGmllpncfienLIDYMKRRciddmdstrkdrspccdAQFPFEPHIFEYCLPQSIS 849
Cdd:COG1033 474 ---VLKEIDRLQDYLESLPEVGKVLS----------LADLVKEL-----------------NQALNEGDPKYYALPESRE 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 850 NMydttffrpGVAGPKFAEAPRLETEDYLgmsgnesaeySTNGSFTPLLVKALVIEFEsnvaystiyaNIRQFYESVEHW 929
Cdd:COG1033 524 LL--------AQLLLLLSSPPGDDLSRFV----------DEDYSAARVTVRLKDLDSE----------EIKALVEEVRAF 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 930 FQmqlKTAPPELQGGWFTSDLK-FYNVQDTLSHDTFVAICLAMAAsLAVLLCFTV-NILISIYAVLTVSLSIFNTVAVLI 1007
Cdd:COG1033 576 LA---ENFPPDGVEVTLTGSAVlFAAINESVIESQIRSLLLALLL-IFLLLLLAFrSLRLGLISLIPNLLPILLTFGLMG 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYI 1085
Cdd:COG1033 652 LLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
|
730 740 750
....*....|....*....|....*....|
gi 74870086 1086 QIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:COG1033 732 DFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
955-1147 |
8.92e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 79.52 E-value: 8.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 955 VQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLH 1034
Cdd:COG1033 212 IAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1035 YGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFL---MSL 1109
Cdd:COG1033 292 LLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLpalLSL 371
|
170 180 190
....*....|....*....|....*....|....*...
gi 74870086 1110 LRVAGPQHGFLElKWPLWSKRSSGSSKFYERKPSQVIA 1147
Cdd:COG1033 372 LPRPKPKTRRLK-KPPELGRLLAKLARFVLRRPKVILV 408
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
444-1111 |
5.77e-13 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 73.54 E-value: 5.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 444 LLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAicfSLGLAYFFYaivlefefFPYMNLLAVV--VIIGIGADDVFLF 521
Cdd:pfam02460 231 IIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVS---SFGLLFWMG--------FPFNSIVCVTpfLVLAIGVDDMFLM 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 522 LKIWHcvlterfsnrctlttqsqsalptleNSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGI 601
Cdd:pfam02460 300 VAAWQ-------------------------RTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCA 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 602 FAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHAC----------KKSINRFCQMFEECITKSIMN--- 668
Cdd:pfam02460 355 YTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRIdsegsepdksHNIEQLKSRFFLDIYCPFLLNpsv 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 669 --YAYLWLLIFgaLGASSAVIVFWYPGLQlPEKshfqLFVSKHPF-EVYSSLKQQFWFE-KPLQAYENfkmhmhfvwgvq 744
Cdd:pfam02460 435 rvCMLVLFVVY--IAIAIYGCVNIKEGLE-PDK----LVLEDSPLvEYLSLREKHFWPEgLQIQVAVN------------ 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 745 avDDGDYTNPNSYGHLHydnnfnvssrpaqLWILDFCQsvrqqpfYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKD 824
Cdd:pfam02460 496 --NPPNLTIPESRDRMN-------------EMVDEFEN-------TPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEKE 553
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 825 RspccdaqfpfephiFEYCLPQSIsnmyDTTFFRPGVAGPKFAEaprletedylgmsgnesaeysTNGSFTPLLVKALVi 904
Cdd:pfam02460 554 W--------------SYGNLPSFL----KAPGNSHWAGDLVWDD---------------------NTTMVTKFRFTLAG- 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 905 efeSNVAYSTIYANIRQFYESVEHWFqmqlktapPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN 984
Cdd:pfam02460 594 ---KGLSTWNDRTRALQEWRSIADQY--------PEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPN 662
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 985 ILISIYAVLTVsLSI-FNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHY---RMSPVKERLAATqfvLSRIIG 1060
Cdd:pfam02460 663 PPCVFVITLAI-ASIdIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFvrsRGDTPAERVVDA---LEALGW 738
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 74870086 1061 PTVMAATTTGLagGIMMASNILPYIqIGVF---LVVVMIVSWFYATFFLMSLLR 1111
Cdd:pfam02460 739 PVFQGGLSTIL--GVLVLLFVPSYM-VVVFfktVFLVVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
457-636 |
4.75e-11 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 62.22 E-value: 4.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 457 FVMASVWLYTGSAFITLMSCVAicfSLGLAYFF--YAIVLEFEFFPYmnllavvVIIGIGADDVFLFLKIWHcvlterfs 534
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVAS---SLGLCAYFglPLTLIISEVIPF-------LVLAIGVDNIFLLVKAVV-------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 535 nrctlttqsqsalptleNSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLM 614
Cdd:pfam12349 63 -----------------RTPRSLDVSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQ 125
|
170 180
....*....|....*....|....*.
gi 74870086 615 ITWLPASVSI----MERLFATRMSCH 636
Cdd:pfam12349 126 MTFFVAVLSLdirrLESNRLDVACCI 151
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
450-632 |
1.04e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 62.96 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 450 LVSLGGTFVMasVWLYTGSAFITLMSCVAICFSLGLAY-FFYAIVLEFEFfpyMNLLAVVVIIGIGADDVFLFLkiwhcv 528
Cdd:COG1033 612 LLALLLIFLL--LLLAFRSLRLGLISLIPNLLPILLTFgLMGLLGIPLNI---ATAVVASIALGIGVDYTIHFL------ 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 529 ltERFsnrctlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVV 608
Cdd:COG1033 681 --SRY----------------REERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLL 742
|
170 180
....*....|....*....|....
gi 74870086 609 TNYLLMITWLPASVSIMERLFATR 632
Cdd:COG1033 743 VALLAALLLLPALLLLLDPRIAKK 766
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
920-1117 |
3.74e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.39 E-value: 3.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 920 RQFYESVEHWFQmQLKTAPPELQ----GGWFTSDlkfYNvQDTLSHDTFVAICLAMAASLAVLLCFtvniLISIYAVLTV 995
Cdd:COG4258 209 QQLVAALRAAFA-ALNAAFPGAQllltGAGLFAV---AA-AQQIKHDISTIGLISLLGILLLLLLV----FRSLRPLLLG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 996 SLSI-----FNTVAVLILLGwQLNILeSIAVSTA-IGLAVDFSLHYGIHYRMSPVKERLAAtqfvLSRIIGPTVMAATTT 1069
Cdd:COG4258 280 LLPVavgalAGLAAVSLVFG-SVHGI-TLGFGSSlIGVAVDYSLHYLTHRRAAGEWDPRAA----LRRIWPTLLLGLLTT 353
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 74870086 1070 GLAGGIMMASNiLPYI-QIGVFLVVVMIVSWFYATFFLMSLLRVAGPQH 1117
Cdd:COG4258 354 VLGYLALLFSP-FPGLrQLGVFAAAGLLAAALTTLLWLPLLLPRAAPRP 401
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
958-1115 |
5.28e-06 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 51.04 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 958 TLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGI 1037
Cdd:TIGR00918 962 GLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIAL 1041
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1038 HYrMSPVKERLAATQFVLSRIIGPTVMAATTTGLaGGIMMASNILPYIQIGVF--LVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:TIGR00918 1042 GF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLL-GVLMLAGSEFDFIVRYFFavLAVLTCLGVLNGLVLLPVLLSMFGP 1119
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
958-1095 |
5.31e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.01 E-value: 5.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 958 TLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYgi 1037
Cdd:COG4258 636 RYRNDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFF-- 713
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74870086 1038 hYRMSPVKERLAATQFVLSriigptvMAATTTGLAGGIMMASNIlPYIQ-------IGVFLVVVM 1095
Cdd:COG4258 714 -TEGLLDKGELARTLLSIL-------LAALTTLLGFGLLAFSST-PALRsfgltvlLGILLALLL 769
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
435-690 |
5.53e-06 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 50.77 E-value: 5.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 435 LENELFnELLLTDVWlVSLGGTFVMASVWLYTG--------SAFITLMscVAICFSLGLAYFFyaiVLEFeffpymNLLA 506
Cdd:TIGR03480 259 LSDEEL-ATVSEGAT-VAGLLSFVLVLVLLWLAlrsprlvfAVLVTLI--VGLILTAAFATLA---VGHL------NLIS 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 507 V---VVIIGIGADdvflfLKIWHCV--LTERFSnrctlttqsqsalptleNSDHTESLENimalTMRHAAASMFVTSLTT 581
Cdd:TIGR03480 326 VafaVLFIGLGVD-----FAIQFSLryREERFR-----------------GGNHREALSV----AARRMGAALLLAALAT 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 582 AGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPAsvsIMeRLFATRMSCHHPMSIKLihackKSINRFcqmfeec 661
Cdd:TIGR03480 380 AAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPA---LL-RLLRPPRRRKPPGYATL-----APLDAF------- 443
|
250 260
....*....|....*....|....*....
gi 74870086 662 itksIMNYAYLWLLIFGALGASSAVIVFW 690
Cdd:TIGR03480 444 ----LRRHRRPVLGVTLILGIAALALLPQ 468
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
953-1110 |
1.11e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.84 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 953 YNVQDTLSHDTFVAICLAMAASLAVLLCFTVNIlisIYAVLTVSLSIFNTVAVLILLGWqLNILESIAVSTA----IGLA 1028
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRW---WRPLLPLVIILFGVAWVLGIMGW-LGIPLYATTLLAvpmlIGVG 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1029 VDFSLHygIHYRM-SPVKERLAATQFVLSRI--IGPTVMAATTTGLAGGIMMASNILPYI-QIGVFLVVVMIVSWFYATF 1104
Cdd:TIGR00921 261 IDYGIQ--TLNRYeEERDIGRAKGEAIVTAVrrTGRAVLIALLTTSAGFAALALSEFPMVsEFGLGLVAGLITAYLLTLL 338
|
....*.
gi 74870086 1105 FLMSLL 1110
Cdd:TIGR00921 339 VLPALL 344
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
955-1089 |
1.18e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 46.30 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 955 VQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNT--VAVLI------LLGWQLNILES----IAVS 1022
Cdd:COG2409 511 ISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAAlgVLVLVfqhgwlLLGFTPGPLDSfvplLLFV 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1023 TAIGLAVDfslhYGIhyrmspvkerlaatqFVLSRI-----IGPTVMAATTTGL---------AGGIM-------MASNI 1081
Cdd:COG2409 591 ILFGLGMD----YEV---------------FLVSRIreeydRGGGTREAVIRGLartgrvitsAALIMaavfaafATSPL 651
|
....*...
gi 74870086 1082 LPYIQIGV 1089
Cdd:COG2409 652 VFLKQIGF 659
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
959-1148 |
2.14e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 45.76 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 959 LSHDTFVAICLAMAASLAVLLCFTVNILI----SIYAVLTVSLSIFntVAVLILLGW------QLNILeSIAVSTA-IGL 1027
Cdd:TIGR03480 259 LSDEELATVSEGATVAGLLSFVLVLVLLWlalrSPRLVFAVLVTLI--VGLILTAAFatlavgHLNLI-SVAFAVLfIGL 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1028 AVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSwFYATF- 1104
Cdd:TIGR03480 336 GVDFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIA-LFVTLt 414
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 74870086 1105 FLMSLLRVAGPQHGflelKWPLWSKRSSGSSKFYERKPSQVIAS 1148
Cdd:TIGR03480 415 VLPALLRLLRPPRR----RKPPGYATLAPLDAFLRRHRRPVLGV 454
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
511-624 |
5.45e-04 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 44.49 E-value: 5.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 511 IGIGADDVFLflkiwhcvLTERFSNrctlttqsqsalpTLENSdhteSLENIMALTMRHAAASMFVTSLTTAGAFYASYS 590
Cdd:TIGR00918 468 LGVGVDDVFL--------LAHAFSE-------------TGQNI----PFEERTGECLKRTGASVVLTSISNVTAFFMAAL 522
|
90 100 110
....*....|....*....|....*....|....
gi 74870086 591 SSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI 624
Cdd:TIGR00918 523 IPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
935-1198 |
7.74e-04 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 43.81 E-value: 7.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 935 KTAPPELQGGWFTSDLKF-YNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQL 1013
Cdd:TIGR00833 146 QTNAPDGLTVHVTGPLATiADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPG 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1014 NILES-----IAVSTAIGLAVDFSLHYGIHYRMSPVK-ERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQ- 1086
Cdd:TIGR00833 226 LIGVNaqttvLLTALVIGAGTDYAVFLTGRYHEERRKgESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKt 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1087 IGVFLVVVMIVSWFYATFFLMSLLRVAGpqhgflelKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSE 1166
Cdd:TIGR00833 306 LGVSCAVGVLVALLNAVTLTPALLTLEG--------REGLMKPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLL 377
|
250 260 270
....*....|....*....|....*....|..
gi 74870086 1167 THELESLNSNSLIKTISGIESAHALSSLPRDF 1198
Cdd:TIGR00833 378 ALPLIRTGYDDEKMIPTDLESVQGYEAADRHF 409
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
954-1140 |
9.38e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 43.55 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 954 NVQDTLshdtFVAICLAMAaslaVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL 1033
Cdd:COG0841 332 EVVKTL----LEAILLVVL----VVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDAI 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1034 ------HYGIHYRMSPVKERLAATqfvlsRIIGPTVMAATTT------------GLAGGIMMasnilpyiQIGVFLVVVM 1095
Cdd:COG0841 404 vvveniERHMEEGLSPLEAAIKGA-----REVAGAVIASTLTlvavflplafmgGITGQLFR--------QFALTVAIAL 470
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 74870086 1096 IVSWFYATFFL--MS--LLRvagPQHGFLELKWPLWSKRS-SGSSKFYER 1140
Cdd:COG0841 471 LISLFVALTLTpaLCarLLK---PHPKGKKGRFFRAFNRGfDRLTRGYGR 517
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
969-1075 |
1.17e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 43.08 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 969 LAMAASLAVLLCFTvnILISIYAVL----TVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL------HYGIH 1038
Cdd:NF033617 336 LLEAVALVILVVFL--FLRNLRATLipavTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIvvveniHRHIE 413
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 74870086 1039 YRMSPVKERLAATqfvlsRIIGPTVMAATTT--------GLAGGI 1075
Cdd:NF033617 414 EGESPLEAALKGA-----REIGFTVIAMTLTlvavylpiLFMGGL 453
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
957-1120 |
2.37e-03 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 42.28 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 957 DTLSHDTFVAICLAmaaSLAVLLcFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL--- 1033
Cdd:pfam00873 331 EEVVKTLLEAIVLV---ILVMFL-FLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVDDAIvvv 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1034 ---HYGI-HYRMSPVKERLAATQFVLSRIIGPTVM-------AATTTGLAGGImmasnilpYIQIGVFLVVVMIVSWFYA 1102
Cdd:pfam00873 407 eniERVLeENGLKPLEAAYKSMGEIGGALVAIALVlsavflpILFLGGLTGRI--------FRQFAITIVLAILLSVLVA 478
|
170 180
....*....|....*....|....
gi 74870086 1103 TFF---LMSLL---RVAGPQHGFL 1120
Cdd:pfam00873 479 LTLtpaLCATLlkpRREPKHGGFF 502
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
467-620 |
4.88e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.98 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 467 GSAFITLMSCVAICFSLGLAYFF--------------YAIVLEFEFFPYM-------NLLAVVVIIGIGADDVFLFlkiw 525
Cdd:TIGR00921 192 GKDMGTTMAISGILVVLVLLLDFkrwwrpllplviilFGVAWVLGIMGWLgiplyatTLLAVPMLIGVGIDYGIQT---- 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 526 hcvlTERFSnrctlttqsqsalptlENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGT 605
Cdd:TIGR00921 268 ----LNRYE----------------EERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVA 327
|
170
....*....|....*
gi 74870086 606 VVVTNYLLMITWLPA 620
Cdd:TIGR00921 328 GLITAYLLTLLVLPA 342
|
|
|