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Conserved domains on  [gi|74870086|sp|Q9VNJ5|]
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RecName: Full=Protein dispatched

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
395-1115 9.38e-27

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.04  E-value: 9.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  395 KYAMIFIPVAQSnrllPLFHEWEDVELINELVEVVAM--DLGLE---------NELFNELLLTDVWLVSLGGTFVMASV- 462
Cdd:COG1033  160 KATLIVVTLDPD----PLSSDLDRKEVVAEIRAIIAKyeDPGVEvyltgfpvlRGDIAEAIQSDLAIFFPLALLLILLLl 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  463 WLYTGSAFITLM----SCVAICFSLGLAYFFYaivleFEFFPYMNLLAVVvIIGIGADdvflflkiwHCV-LTERFsnrc 537
Cdd:COG1033  236 FLFFRSLRGVLLpllvVLLAVIWTLGLMGLLG-----IPLSPLTILVPPL-LLAIGID---------YGIhLLNRY---- 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  538 tlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
Cdd:COG1033  297 ------------REERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTL 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  618 LPASVSIMERLFATRMSCHHPmsiklihackKSINRFCQMFEECITKsimnYAYLWLLIFGALgasSAVIVFWYPGLQ-- 695
Cdd:COG1033  365 LPALLSLLPRPKPKTRRLKKP----------PELGRLLAKLARFVLR----RPKVILVVALVL---AVVSLYGISRLKve 427
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  696 ------LPEKShfqlfvskhpfEVYSSLKqqfWFEkplqayENFKMHMHFVWGVQAVDDGDYTNPNsyghlhydnnfnvs 769
Cdd:COG1033  428 ydfedyLPEDS-----------PIRQDLD---FIE------ENFGGSDPLEVVVDTGEPDGLKDPE-------------- 473
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  770 srpAQLWILDFCQSVRQQPFYKETLGmllpncfienLIDYMKRRciddmdstrkdrspccdAQFPFEPHIFEYCLPQSIS 849
Cdd:COG1033  474 ---VLKEIDRLQDYLESLPEVGKVLS----------LADLVKEL-----------------NQALNEGDPKYYALPESRE 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  850 NMydttffrpGVAGPKFAEAPRLETEDYLgmsgnesaeySTNGSFTPLLVKALVIEFEsnvaystiyaNIRQFYESVEHW 929
Cdd:COG1033  524 LL--------AQLLLLLSSPPGDDLSRFV----------DEDYSAARVTVRLKDLDSE----------EIKALVEEVRAF 575
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  930 FQmqlKTAPPELQGGWFTSDLK-FYNVQDTLSHDTFVAICLAMAAsLAVLLCFTV-NILISIYAVLTVSLSIFNTVAVLI 1007
Cdd:COG1033  576 LA---ENFPPDGVEVTLTGSAVlFAAINESVIESQIRSLLLALLL-IFLLLLLAFrSLRLGLISLIPNLLPILLTFGLMG 651
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYI 1085
Cdd:COG1033  652 LLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
                        730       740       750
                 ....*....|....*....|....*....|
gi 74870086 1086 QIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:COG1033  732 DFGLLLALGLLVALLAALLLLPALLLLLDP 761
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
395-1115 9.38e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.04  E-value: 9.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  395 KYAMIFIPVAQSnrllPLFHEWEDVELINELVEVVAM--DLGLE---------NELFNELLLTDVWLVSLGGTFVMASV- 462
Cdd:COG1033  160 KATLIVVTLDPD----PLSSDLDRKEVVAEIRAIIAKyeDPGVEvyltgfpvlRGDIAEAIQSDLAIFFPLALLLILLLl 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  463 WLYTGSAFITLM----SCVAICFSLGLAYFFYaivleFEFFPYMNLLAVVvIIGIGADdvflflkiwHCV-LTERFsnrc 537
Cdd:COG1033  236 FLFFRSLRGVLLpllvVLLAVIWTLGLMGLLG-----IPLSPLTILVPPL-LLAIGID---------YGIhLLNRY---- 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  538 tlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
Cdd:COG1033  297 ------------REERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTL 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  618 LPASVSIMERLFATRMSCHHPmsiklihackKSINRFCQMFEECITKsimnYAYLWLLIFGALgasSAVIVFWYPGLQ-- 695
Cdd:COG1033  365 LPALLSLLPRPKPKTRRLKKP----------PELGRLLAKLARFVLR----RPKVILVVALVL---AVVSLYGISRLKve 427
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  696 ------LPEKShfqlfvskhpfEVYSSLKqqfWFEkplqayENFKMHMHFVWGVQAVDDGDYTNPNsyghlhydnnfnvs 769
Cdd:COG1033  428 ydfedyLPEDS-----------PIRQDLD---FIE------ENFGGSDPLEVVVDTGEPDGLKDPE-------------- 473
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  770 srpAQLWILDFCQSVRQQPFYKETLGmllpncfienLIDYMKRRciddmdstrkdrspccdAQFPFEPHIFEYCLPQSIS 849
Cdd:COG1033  474 ---VLKEIDRLQDYLESLPEVGKVLS----------LADLVKEL-----------------NQALNEGDPKYYALPESRE 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  850 NMydttffrpGVAGPKFAEAPRLETEDYLgmsgnesaeySTNGSFTPLLVKALVIEFEsnvaystiyaNIRQFYESVEHW 929
Cdd:COG1033  524 LL--------AQLLLLLSSPPGDDLSRFV----------DEDYSAARVTVRLKDLDSE----------EIKALVEEVRAF 575
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  930 FQmqlKTAPPELQGGWFTSDLK-FYNVQDTLSHDTFVAICLAMAAsLAVLLCFTV-NILISIYAVLTVSLSIFNTVAVLI 1007
Cdd:COG1033  576 LA---ENFPPDGVEVTLTGSAVlFAAINESVIESQIRSLLLALLL-IFLLLLLAFrSLRLGLISLIPNLLPILLTFGLMG 651
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYI 1085
Cdd:COG1033  652 LLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
                        730       740       750
                 ....*....|....*....|....*....|
gi 74870086 1086 QIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:COG1033  732 DFGLLLALGLLVALLAALLLLPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
444-1111 5.77e-13

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 73.54  E-value: 5.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    444 LLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAicfSLGLAYFFYaivlefefFPYMNLLAVV--VIIGIGADDVFLF 521
Cdd:pfam02460  231 IIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVS---SFGLLFWMG--------FPFNSIVCVTpfLVLAIGVDDMFLM 299
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    522 LKIWHcvlterfsnrctlttqsqsalptleNSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGI 601
Cdd:pfam02460  300 VAAWQ-------------------------RTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCA 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    602 FAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHAC----------KKSINRFCQMFEECITKSIMN--- 668
Cdd:pfam02460  355 YTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRIdsegsepdksHNIEQLKSRFFLDIYCPFLLNpsv 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    669 --YAYLWLLIFgaLGASSAVIVFWYPGLQlPEKshfqLFVSKHPF-EVYSSLKQQFWFE-KPLQAYENfkmhmhfvwgvq 744
Cdd:pfam02460  435 rvCMLVLFVVY--IAIAIYGCVNIKEGLE-PDK----LVLEDSPLvEYLSLREKHFWPEgLQIQVAVN------------ 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    745 avDDGDYTNPNSYGHLHydnnfnvssrpaqLWILDFCQsvrqqpfYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKD 824
Cdd:pfam02460  496 --NPPNLTIPESRDRMN-------------EMVDEFEN-------TPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEKE 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    825 RspccdaqfpfephiFEYCLPQSIsnmyDTTFFRPGVAGPKFAEaprletedylgmsgnesaeysTNGSFTPLLVKALVi 904
Cdd:pfam02460  554 W--------------SYGNLPSFL----KAPGNSHWAGDLVWDD---------------------NTTMVTKFRFTLAG- 593
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    905 efeSNVAYSTIYANIRQFYESVEHWFqmqlktapPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN 984
Cdd:pfam02460  594 ---KGLSTWNDRTRALQEWRSIADQY--------PEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPN 662
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    985 ILISIYAVLTVsLSI-FNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHY---RMSPVKERLAATqfvLSRIIG 1060
Cdd:pfam02460  663 PPCVFVITLAI-ASIdIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFvrsRGDTPAERVVDA---LEALGW 738
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....
gi 74870086   1061 PTVMAATTTGLagGIMMASNILPYIqIGVF---LVVVMIVSWFYATFFLMSLLR 1111
Cdd:pfam02460  739 PVFQGGLSTIL--GVLVLLFVPSYM-VVVFfktVFLVVAIGLLHGLFILPIILS 789
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
958-1115 5.28e-06

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 51.04  E-value: 5.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    958 TLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGI 1037
Cdd:TIGR00918  962 GLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIAL 1041
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1038 HYrMSPVKERLAATQFVLSRIIGPTVMAATTTGLaGGIMMASNILPYIQIGVF--LVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:TIGR00918 1042 GF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLL-GVLMLAGSEFDFIVRYFFavLAVLTCLGVLNGLVLLPVLLSMFGP 1119
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
969-1075 1.17e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 43.08  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   969 LAMAASLAVLLCFTvnILISIYAVL----TVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL------HYGIH 1038
Cdd:NF033617  336 LLEAVALVILVVFL--FLRNLRATLipavTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIvvveniHRHIE 413
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 74870086  1039 YRMSPVKERLAATqfvlsRIIGPTVMAATTT--------GLAGGI 1075
Cdd:NF033617  414 EGESPLEAALKGA-----REIGFTVIAMTLTlvavylpiLFMGGL 453
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
395-1115 9.38e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.04  E-value: 9.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  395 KYAMIFIPVAQSnrllPLFHEWEDVELINELVEVVAM--DLGLE---------NELFNELLLTDVWLVSLGGTFVMASV- 462
Cdd:COG1033  160 KATLIVVTLDPD----PLSSDLDRKEVVAEIRAIIAKyeDPGVEvyltgfpvlRGDIAEAIQSDLAIFFPLALLLILLLl 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  463 WLYTGSAFITLM----SCVAICFSLGLAYFFYaivleFEFFPYMNLLAVVvIIGIGADdvflflkiwHCV-LTERFsnrc 537
Cdd:COG1033  236 FLFFRSLRGVLLpllvVLLAVIWTLGLMGLLG-----IPLSPLTILVPPL-LLAIGID---------YGIhLLNRY---- 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  538 tlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITW 617
Cdd:COG1033  297 ------------REERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTL 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  618 LPASVSIMERLFATRMSCHHPmsiklihackKSINRFCQMFEECITKsimnYAYLWLLIFGALgasSAVIVFWYPGLQ-- 695
Cdd:COG1033  365 LPALLSLLPRPKPKTRRLKKP----------PELGRLLAKLARFVLR----RPKVILVVALVL---AVVSLYGISRLKve 427
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  696 ------LPEKShfqlfvskhpfEVYSSLKqqfWFEkplqayENFKMHMHFVWGVQAVDDGDYTNPNsyghlhydnnfnvs 769
Cdd:COG1033  428 ydfedyLPEDS-----------PIRQDLD---FIE------ENFGGSDPLEVVVDTGEPDGLKDPE-------------- 473
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  770 srpAQLWILDFCQSVRQQPFYKETLGmllpncfienLIDYMKRRciddmdstrkdrspccdAQFPFEPHIFEYCLPQSIS 849
Cdd:COG1033  474 ---VLKEIDRLQDYLESLPEVGKVLS----------LADLVKEL-----------------NQALNEGDPKYYALPESRE 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  850 NMydttffrpGVAGPKFAEAPRLETEDYLgmsgnesaeySTNGSFTPLLVKALVIEFEsnvaystiyaNIRQFYESVEHW 929
Cdd:COG1033  524 LL--------AQLLLLLSSPPGDDLSRFV----------DEDYSAARVTVRLKDLDSE----------EIKALVEEVRAF 575
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  930 FQmqlKTAPPELQGGWFTSDLK-FYNVQDTLSHDTFVAICLAMAAsLAVLLCFTV-NILISIYAVLTVSLSIFNTVAVLI 1007
Cdd:COG1033  576 LA---ENFPPDGVEVTLTGSAVlFAAINESVIESQIRSLLLALLL-IFLLLLLAFrSLRLGLISLIPNLLPILLTFGLMG 651
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1008 LLGWQLNILESIAVSTAIGLAVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYI 1085
Cdd:COG1033  652 LLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
                        730       740       750
                 ....*....|....*....|....*....|
gi 74870086 1086 QIGVFLVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:COG1033  732 DFGLLLALGLLVALLAALLLLPALLLLLDP 761
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
955-1147 8.92e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.52  E-value: 8.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  955 VQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLH 1034
Cdd:COG1033  212 IAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIH 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1035 YGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFL---MSL 1109
Cdd:COG1033  292 LLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLpalLSL 371
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 74870086 1110 LRVAGPQHGFLElKWPLWSKRSSGSSKFYERKPSQVIA 1147
Cdd:COG1033  372 LPRPKPKTRRLK-KPPELGRLLAKLARFVLRRPKVILV 408
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
444-1111 5.77e-13

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 73.54  E-value: 5.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    444 LLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAicfSLGLAYFFYaivlefefFPYMNLLAVV--VIIGIGADDVFLF 521
Cdd:pfam02460  231 IIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVS---SFGLLFWMG--------FPFNSIVCVTpfLVLAIGVDDMFLM 299
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    522 LKIWHcvlterfsnrctlttqsqsalptleNSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGI 601
Cdd:pfam02460  300 VAAWQ-------------------------RTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCA 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    602 FAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHAC----------KKSINRFCQMFEECITKSIMN--- 668
Cdd:pfam02460  355 YTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSSPQRIdsegsepdksHNIEQLKSRFFLDIYCPFLLNpsv 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    669 --YAYLWLLIFgaLGASSAVIVFWYPGLQlPEKshfqLFVSKHPF-EVYSSLKQQFWFE-KPLQAYENfkmhmhfvwgvq 744
Cdd:pfam02460  435 rvCMLVLFVVY--IAIAIYGCVNIKEGLE-PDK----LVLEDSPLvEYLSLREKHFWPEgLQIQVAVN------------ 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    745 avDDGDYTNPNSYGHLHydnnfnvssrpaqLWILDFCQsvrqqpfYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKD 824
Cdd:pfam02460  496 --NPPNLTIPESRDRMN-------------EMVDEFEN-------TPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEKE 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    825 RspccdaqfpfephiFEYCLPQSIsnmyDTTFFRPGVAGPKFAEaprletedylgmsgnesaeysTNGSFTPLLVKALVi 904
Cdd:pfam02460  554 W--------------SYGNLPSFL----KAPGNSHWAGDLVWDD---------------------NTTMVTKFRFTLAG- 593
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    905 efeSNVAYSTIYANIRQFYESVEHWFqmqlktapPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVN 984
Cdd:pfam02460  594 ---KGLSTWNDRTRALQEWRSIADQY--------PEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPN 662
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    985 ILISIYAVLTVsLSI-FNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHY---RMSPVKERLAATqfvLSRIIG 1060
Cdd:pfam02460  663 PPCVFVITLAI-ASIdIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFvrsRGDTPAERVVDA---LEALGW 738
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....
gi 74870086   1061 PTVMAATTTGLagGIMMASNILPYIqIGVF---LVVVMIVSWFYATFFLMSLLR 1111
Cdd:pfam02460  739 PVFQGGLSTIL--GVLVLLFVPSYM-VVVFfktVFLVVAIGLLHGLFILPIILS 789
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
457-636 4.75e-11

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 62.22  E-value: 4.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    457 FVMASVWLYTGSAFITLMSCVAicfSLGLAYFF--YAIVLEFEFFPYmnllavvVIIGIGADDVFLFLKIWHcvlterfs 534
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVAS---SLGLCAYFglPLTLIISEVIPF-------LVLAIGVDNIFLLVKAVV-------- 62
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    535 nrctlttqsqsalptleNSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLM 614
Cdd:pfam12349   63 -----------------RTPRSLDVSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQ 125
                          170       180
                   ....*....|....*....|....*.
gi 74870086    615 ITWLPASVSI----MERLFATRMSCH 636
Cdd:pfam12349  126 MTFFVAVLSLdirrLESNRLDVACCI 151
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
450-632 1.04e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 62.96  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  450 LVSLGGTFVMasVWLYTGSAFITLMSCVAICFSLGLAY-FFYAIVLEFEFfpyMNLLAVVVIIGIGADDVFLFLkiwhcv 528
Cdd:COG1033  612 LLALLLIFLL--LLLAFRSLRLGLISLIPNLLPILLTFgLMGLLGIPLNI---ATAVVASIALGIGVDYTIHFL------ 680
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  529 ltERFsnrctlttqsqsalptLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVV 608
Cdd:COG1033  681 --SRY----------------REERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLL 742
                        170       180
                 ....*....|....*....|....
gi 74870086  609 TNYLLMITWLPASVSIMERLFATR 632
Cdd:COG1033  743 VALLAALLLLPALLLLLDPRIAKK 766
COG4258 COG4258
Predicted exporter [General function prediction only];
920-1117 3.74e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 51.39  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  920 RQFYESVEHWFQmQLKTAPPELQ----GGWFTSDlkfYNvQDTLSHDTFVAICLAMAASLAVLLCFtvniLISIYAVLTV 995
Cdd:COG4258  209 QQLVAALRAAFA-ALNAAFPGAQllltGAGLFAV---AA-AQQIKHDISTIGLISLLGILLLLLLV----FRSLRPLLLG 279
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  996 SLSI-----FNTVAVLILLGwQLNILeSIAVSTA-IGLAVDFSLHYGIHYRMSPVKERLAAtqfvLSRIIGPTVMAATTT 1069
Cdd:COG4258  280 LLPVavgalAGLAAVSLVFG-SVHGI-TLGFGSSlIGVAVDYSLHYLTHRRAAGEWDPRAA----LRRIWPTLLLGLLTT 353
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 74870086 1070 GLAGGIMMASNiLPYI-QIGVFLVVVMIVSWFYATFFLMSLLRVAGPQH 1117
Cdd:COG4258  354 VLGYLALLFSP-FPGLrQLGVFAAAGLLAAALTTLLWLPLLLPRAAPRP 401
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
958-1115 5.28e-06

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 51.04  E-value: 5.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    958 TLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGI 1037
Cdd:TIGR00918  962 GLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIAL 1041
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1038 HYrMSPVKERLAATQFVLSRIIGPTVMAATTTGLaGGIMMASNILPYIQIGVF--LVVVMIVSWFYATFFLMSLLRVAGP 1115
Cdd:TIGR00918 1042 GF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLL-GVLMLAGSEFDFIVRYFFavLAVLTCLGVLNGLVLLPVLLSMFGP 1119
COG4258 COG4258
Predicted exporter [General function prediction only];
958-1095 5.31e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 51.01  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  958 TLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYgi 1037
Cdd:COG4258  636 RYRNDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFF-- 713
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74870086 1038 hYRMSPVKERLAATQFVLSriigptvMAATTTGLAGGIMMASNIlPYIQ-------IGVFLVVVM 1095
Cdd:COG4258  714 -TEGLLDKGELARTLLSIL-------LAALTTLLGFGLLAFSST-PALRsfgltvlLGILLALLL 769
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
435-690 5.53e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 50.77  E-value: 5.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    435 LENELFnELLLTDVWlVSLGGTFVMASVWLYTG--------SAFITLMscVAICFSLGLAYFFyaiVLEFeffpymNLLA 506
Cdd:TIGR03480  259 LSDEEL-ATVSEGAT-VAGLLSFVLVLVLLWLAlrsprlvfAVLVTLI--VGLILTAAFATLA---VGHL------NLIS 325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    507 V---VVIIGIGADdvflfLKIWHCV--LTERFSnrctlttqsqsalptleNSDHTESLENimalTMRHAAASMFVTSLTT 581
Cdd:TIGR03480  326 VafaVLFIGLGVD-----FAIQFSLryREERFR-----------------GGNHREALSV----AARRMGAALLLAALAT 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    582 AGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPAsvsIMeRLFATRMSCHHPMSIKLihackKSINRFcqmfeec 661
Cdd:TIGR03480  380 AAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPA---LL-RLLRPPRRRKPPGYATL-----APLDAF------- 443
                          250       260
                   ....*....|....*....|....*....
gi 74870086    662 itksIMNYAYLWLLIFGALGASSAVIVFW 690
Cdd:TIGR03480  444 ----LRRHRRPVLGVTLILGIAALALLPQ 468
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
953-1110 1.11e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.84  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    953 YNVQDTLSHDTFVAICLAMAASLAVLLCFTVNIlisIYAVLTVSLSIFNTVAVLILLGWqLNILESIAVSTA----IGLA 1028
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRW---WRPLLPLVIILFGVAWVLGIMGW-LGIPLYATTLLAvpmlIGVG 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1029 VDFSLHygIHYRM-SPVKERLAATQFVLSRI--IGPTVMAATTTGLAGGIMMASNILPYI-QIGVFLVVVMIVSWFYATF 1104
Cdd:TIGR00921  261 IDYGIQ--TLNRYeEERDIGRAKGEAIVTAVrrTGRAVLIALLTTSAGFAALALSEFPMVsEFGLGLVAGLITAYLLTLL 338

                   ....*.
gi 74870086   1105 FLMSLL 1110
Cdd:TIGR00921  339 VLPALL 344
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
955-1089 1.18e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 46.30  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  955 VQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNT--VAVLI------LLGWQLNILES----IAVS 1022
Cdd:COG2409  511 ISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAAlgVLVLVfqhgwlLLGFTPGPLDSfvplLLFV 590
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1023 TAIGLAVDfslhYGIhyrmspvkerlaatqFVLSRI-----IGPTVMAATTTGL---------AGGIM-------MASNI 1081
Cdd:COG2409  591 ILFGLGMD----YEV---------------FLVSRIreeydRGGGTREAVIRGLartgrvitsAALIMaavfaafATSPL 651

                 ....*...
gi 74870086 1082 LPYIQIGV 1089
Cdd:COG2409  652 VFLKQIGF 659
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
959-1148 2.14e-04

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 45.76  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    959 LSHDTFVAICLAMAASLAVLLCFTVNILI----SIYAVLTVSLSIFntVAVLILLGW------QLNILeSIAVSTA-IGL 1027
Cdd:TIGR03480  259 LSDEELATVSEGATVAGLLSFVLVLVLLWlalrSPRLVFAVLVTLI--VGLILTAAFatlavgHLNLI-SVAFAVLfIGL 335
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1028 AVDFSLHYGIHYR--MSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSwFYATF- 1104
Cdd:TIGR03480  336 GVDFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIA-LFVTLt 414
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 74870086   1105 FLMSLLRVAGPQHGflelKWPLWSKRSSGSSKFYERKPSQVIAS 1148
Cdd:TIGR03480  415 VLPALLRLLRPPRR----RKPPGYATLAPLDAFLRRHRRPVLGV 454
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
511-624 5.45e-04

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 44.49  E-value: 5.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    511 IGIGADDVFLflkiwhcvLTERFSNrctlttqsqsalpTLENSdhteSLENIMALTMRHAAASMFVTSLTTAGAFYASYS 590
Cdd:TIGR00918  468 LGVGVDDVFL--------LAHAFSE-------------TGQNI----PFEERTGECLKRTGASVVLTSISNVTAFFMAAL 522
                           90       100       110
                   ....*....|....*....|....*....|....
gi 74870086    591 SSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI 624
Cdd:TIGR00918  523 IPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
935-1198 7.74e-04

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 43.81  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    935 KTAPPELQGGWFTSDLKF-YNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQL 1013
Cdd:TIGR00833  146 QTNAPDGLTVHVTGPLATiADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPG 225
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1014 NILES-----IAVSTAIGLAVDFSLHYGIHYRMSPVK-ERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQ- 1086
Cdd:TIGR00833  226 LIGVNaqttvLLTALVIGAGTDYAVFLTGRYHEERRKgESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKt 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1087 IGVFLVVVMIVSWFYATFFLMSLLRVAGpqhgflelKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSE 1166
Cdd:TIGR00833  306 LGVSCAVGVLVALLNAVTLTPALLTLEG--------REGLMKPGRKSKIRFIWRRLGTAVVRRPWPILVTTLIISGVSLL 377
                          250       260       270
                   ....*....|....*....|....*....|..
gi 74870086   1167 THELESLNSNSLIKTISGIESAHALSSLPRDF 1198
Cdd:TIGR00833  378 ALPLIRTGYDDEKMIPTDLESVQGYEAADRHF 409
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
954-1140 9.38e-04

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 43.55  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086  954 NVQDTLshdtFVAICLAMAaslaVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL 1033
Cdd:COG0841  332 EVVKTL----LEAILLVVL----VVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDAI 403
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086 1034 ------HYGIHYRMSPVKERLAATqfvlsRIIGPTVMAATTT------------GLAGGIMMasnilpyiQIGVFLVVVM 1095
Cdd:COG0841  404 vvveniERHMEEGLSPLEAAIKGA-----REVAGAVIASTLTlvavflplafmgGITGQLFR--------QFALTVAIAL 470
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 74870086 1096 IVSWFYATFFL--MS--LLRvagPQHGFLELKWPLWSKRS-SGSSKFYER 1140
Cdd:COG0841  471 LISLFVALTLTpaLCarLLK---PHPKGKKGRFFRAFNRGfDRLTRGYGR 517
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
969-1075 1.17e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 43.08  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   969 LAMAASLAVLLCFTvnILISIYAVL----TVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL------HYGIH 1038
Cdd:NF033617  336 LLEAVALVILVVFL--FLRNLRATLipavTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIvvveniHRHIE 413
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 74870086  1039 YRMSPVKERLAATqfvlsRIIGPTVMAATTT--------GLAGGI 1075
Cdd:NF033617  414 EGESPLEAALKGA-----REIGFTVIAMTLTlvavylpiLFMGGL 453
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
957-1120 2.37e-03

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 42.28  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    957 DTLSHDTFVAICLAmaaSLAVLLcFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSL--- 1033
Cdd:pfam00873  331 EEVVKTLLEAIVLV---ILVMFL-FLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVDDAIvvv 406
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086   1034 ---HYGI-HYRMSPVKERLAATQFVLSRIIGPTVM-------AATTTGLAGGImmasnilpYIQIGVFLVVVMIVSWFYA 1102
Cdd:pfam00873  407 eniERVLeENGLKPLEAAYKSMGEIGGALVAIALVlsavflpILFLGGLTGRI--------FRQFAITIVLAILLSVLVA 478
                          170       180
                   ....*....|....*....|....
gi 74870086   1103 TFF---LMSLL---RVAGPQHGFL 1120
Cdd:pfam00873  479 LTLtpaLCATLlkpRREPKHGGFF 502
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
467-620 4.88e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 40.98  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    467 GSAFITLMSCVAICFSLGLAYFF--------------YAIVLEFEFFPYM-------NLLAVVVIIGIGADDVFLFlkiw 525
Cdd:TIGR00921  192 GKDMGTTMAISGILVVLVLLLDFkrwwrpllplviilFGVAWVLGIMGWLgiplyatTLLAVPMLIGVGIDYGIQT---- 267
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74870086    526 hcvlTERFSnrctlttqsqsalptlENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGT 605
Cdd:TIGR00921  268 ----LNRYE----------------EERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVA 327
                          170
                   ....*....|....*
gi 74870086    606 VVVTNYLLMITWLPA 620
Cdd:TIGR00921  328 GLITAYLLTLLVLPA 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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