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Conserved domains on  [gi|75266171|sp|Q9SPL4|]
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RecName: Full=Vicilin-like antimicrobial peptides 2-2; AltName: Full=MiAMP2; Contains: RecName: Full=Antimicrobial peptide 2a; AltName: Full=Antimicrobial peptide Mac i 1; AltName: Full=MiAMP2a; AltName: Allergen=Mac i 1.0101 (28-76); Contains: RecName: Full=Antimicrobial peptide 2b; AltName: Full=MiAMP2b; Contains: RecName: Full=Antimicrobial peptide 2c-1; AltName: Full=MiAMP2c-1; Contains: RecName: Full=Antimicrobial peptide 2c-2; AltName: Full=MiAMP2c-2; Contains: RecName: Full=Antimicrobial peptide 2c-3; AltName: Full=MiAMP2c-3; Contains: RecName: Full=Antimicrobial peptide 2d; AltName: Full=MiAMP2d; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 262-437 6.94e-90

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380371  Cd Length: 178  Bit Score: 277.08  E-value: 6.94e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 262 RFRTEEGHISVLENFYGRSKLLRALKNYRLVLLEANPNAFVLPTHLDADAILLVTGGRGALKMIHRDNRESYNLECGDVI 341
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 342 RIPAGTTFYLINRDNNERLHIAKFLQTIS--TPGQYKEFFPAGGQNPEPYLSTFSKEILEAALNTQAERLRGVLGQQREG 419
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160

                       170
                ....*....|....*...
gi 75266171 420 VIISASQEQIRELTRDDS 437
Cdd:cd02244 161 PIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 462-634 4.85e-81

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380372  Cd Length: 166  Bit Score: 253.59  E-value: 4.85e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 462 PLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLSgrhggrRGGKRH 541
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS------SQSQQG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 542 EEEEDVHYEQVKARLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINAQNNHENFLAGRErNVLQQIEPQAMELAFAAPR 621
Cdd:cd02245  75 EEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKN-NVLRQLDREAKELAFNVPA 153

                       170
                ....*....|...
gi 75266171 622 KEVEELFNSQDES 634
Cdd:cd02245 154 EEVEEVLNAQDES 166
Vicilin_N pfam04702
Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to ...
 70-243 2.81e-18

Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to the Cupin domain (pfam00190). In Macadamia integrifolia, this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif. These peptides exhibit antimicrobial activity in vitro.


:

Pssm-ID: 252749 [Multi-domain]  Cd Length: 147  Bit Score: 82.07  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    70 SKYDNQDDPQTDCQQCQRRCRQQESGPRQQQYCQRRCKEICEEEEEYNRQR--DPQQQYEQCQERCQRHetEPRHMQTCQ 147
Cdd:pfam04702   1 PGRRNEDDPQQRYEQCQRRCEQETRGQREQQQCERRCKEQYKEEQQQQRQReeDPQRRYEQCQQRCQQH--EPRHRPTCQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   148 QRCERRYEKEKRKqqkryeeqqredeekyeermkeednkrdpQQREYEDCRRRCEQQE--PRQQYQCQRRCREQQRQHGR 225
Cdd:pfam04702  79 QRCERRYEKEQQQ-----------------------------QQRQYQECQQRCQQQEqrPRRQQQCQRECREQYQEHGR 129

                         170
                  ....*....|....*...
gi 75266171   226 GGDLINPQRGGSGRYEEG 243
Cdd:pfam04702 130 GEGENINQEGEEERSEEG 147
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 262-437 6.94e-90

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 277.08  E-value: 6.94e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 262 RFRTEEGHISVLENFYGRSKLLRALKNYRLVLLEANPNAFVLPTHLDADAILLVTGGRGALKMIHRDNRESYNLECGDVI 341
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 342 RIPAGTTFYLINRDNNERLHIAKFLQTIS--TPGQYKEFFPAGGQNPEPYLSTFSKEILEAALNTQAERLRGVLGQQREG 419
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160

                       170
                ....*....|....*...
gi 75266171 420 VIISASQEQIRELTRDDS 437
Cdd:cd02244 161 PIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 462-634 4.85e-81

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 253.59  E-value: 4.85e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 462 PLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLSgrhggrRGGKRH 541
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS------SQSQQG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 542 EEEEDVHYEQVKARLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINAQNNHENFLAGRErNVLQQIEPQAMELAFAAPR 621
Cdd:cd02245  75 EEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKN-NVLRQLDREAKELAFNVPA 153

                       170
                ....*....|...
gi 75266171 622 KEVEELFNSQDES 634
Cdd:cd02245 154 EEVEEVLNAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 458-625 2.33e-43

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 152.82  E-value: 2.33e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    458 FNKRPLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLsgrhggrrg 537
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNG--------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    538 gkrheeeedvhYEQVKARLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINAqNNHENFLAGRErNVLQQIEPQAMELAF 617
Cdd:smart00835  72 -----------NKVYDARLREGDVFVVPQGHPHFQVNSGDENLEFVAFNTND-PNRRFFLAGRN-SVLRGLPPEVLAAAF 138


                   ....*...
gi 75266171    618 AAPRKEVE 625
Cdd:smart00835 139 GVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 455-625 1.31e-20

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 88.93  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   455 YNLFNKRPLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHlsgrhgg 534
Cdd:pfam00190   1 LNLLEPGPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPG------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   535 rrggkrhEEEEDVHyeqvkARLSKREAIVVPVGHPVVFVSSGNENLLLF-AFGINAQNNHENFLAGreRNVLQQIEPQAM 613
Cdd:pfam00190  74 -------NGNRVFH-----KVLREGDVFVVPQGLPHFQYNIGDEPAVAFvAFDTNNPGNQSILAGG--FSSLPALPPEVL 139

                         170
                  ....*....|..
gi 75266171   614 ELAFAAPRKEVE 625
Cdd:pfam00190 140 AKAFQLAGEEVK 151
Vicilin_N pfam04702
Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to ...
 70-243 2.81e-18

Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to the Cupin domain (pfam00190). In Macadamia integrifolia, this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif. These peptides exhibit antimicrobial activity in vitro.


Pssm-ID: 252749 [Multi-domain]  Cd Length: 147  Bit Score: 82.07  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    70 SKYDNQDDPQTDCQQCQRRCRQQESGPRQQQYCQRRCKEICEEEEEYNRQR--DPQQQYEQCQERCQRHetEPRHMQTCQ 147
Cdd:pfam04702   1 PGRRNEDDPQQRYEQCQRRCEQETRGQREQQQCERRCKEQYKEEQQQQRQReeDPQRRYEQCQQRCQQH--EPRHRPTCQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   148 QRCERRYEKEKRKqqkryeeqqredeekyeermkeednkrdpQQREYEDCRRRCEQQE--PRQQYQCQRRCREQQRQHGR 225
Cdd:pfam04702  79 QRCERRYEKEQQQ-----------------------------QQRQYQECQQRCQQQEqrPRRQQQCQRECREQYQEHGR 129

                         170
                  ....*....|....*...
gi 75266171   226 GGDLINPQRGGSGRYEEG 243
Cdd:pfam04702 130 GEGENINQEGEEERSEEG 147
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 274-410 3.07e-14

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 70.39  E-value: 3.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    274 ENFYGRSKL-----LRALK--NYRLVLLEANPNAFVLP-THLDADAILLVTGGRGALKMIH-RDNRE-SYNLECGDVIRI 343
Cdd:smart00835   8 SNEGGRLREadptnFPALNglGISAARVNLEPGGMLPPhYHPRATELLYVVRGEGRVGVVDpNGNKVyDARLREGDVFVV 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75266171    344 PAGTTFYLINrDNNERLHIAKFlqtiSTPGQYKEFFPAGGQNpepYLSTFSKEILEAALNTQAERLR 410
Cdd:smart00835  88 PQGHPHFQVN-SGDENLEFVAF----NTNDPNRRFFLAGRNS---VLRGLPPEVLAAAFGVSAEEVR 146
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 116-209 1.53e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171  116 YNRQrdpQQQY-------EQCQERCQRHETEPRHMQTCQQRCERRYEKEKRKQQkryeEQQREDEEKYEERMKEEDNKRD 188
Cdd:PRK09510  64 YNRQ---QQQQksakraeEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQ----EQKKQAEEAAKQAALKQKQAEE 136

                         90       100
                 ....*....|....*....|.
gi 75266171  189 PQQREYEDCRRRCEQQEPRQQ 209
Cdd:PRK09510 137 AAAKAAAAAKAKAEAEAKRAA 157
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 289-403 6.55e-04

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 40.78  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   289 YRLVLleaNPNAFVLP-THLDADAILLVTGGRGALKMI--HRDNR-ESYNLECGDVIRIPAGTTFYLINRDNNERLHIAK 364
Cdd:pfam00190  36 ARVDL---APGGMNPPhWHPNATEILYVLQGRGRVGFVvpGNGNRvFHKVLREGDVFVVPQGLPHFQYNIGDEPAVAFVA 112

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 75266171   365 FlqtiSTPGQYKEFFPAGGQNPEPYLSTfskEILEAALN 403
Cdd:pfam00190 113 F----DTNNPGNQSILAGGFSSLPALPP---EVLAKAFQ 144
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 262-437 6.94e-90

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 277.08  E-value: 6.94e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 262 RFRTEEGHISVLENFYGRSKLLRALKNYRLVLLEANPNAFVLPTHLDADAILLVTGGRGALKMIHRDNRESYNLECGDVI 341
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 342 RIPAGTTFYLINRDNNERLHIAKFLQTIS--TPGQYKEFFPAGGQNPEPYLSTFSKEILEAALNTQAERLRGVLGQQREG 419
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNslTPGPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160

                       170
                ....*....|....*...
gi 75266171 420 VIISASQEQIRELTRDDS 437
Cdd:cd02244 161 PIVKASEEQIRALSRHAS 178
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 462-634 4.85e-81

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 253.59  E-value: 4.85e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 462 PLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLSgrhggrRGGKRH 541
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLS------SQSQQG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 542 EEEEDVHYEQVKARLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINAQNNHENFLAGRErNVLQQIEPQAMELAFAAPR 621
Cdd:cd02245  75 EEEGSGEYQKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKN-NVLRQLDREAKELAFNVPA 153

                       170
                ....*....|...
gi 75266171 622 KEVEELFNSQDES 634
Cdd:cd02245 154 EEVEEVLNAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 458-625 2.33e-43

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 152.82  E-value: 2.33e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    458 FNKRPLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHLsgrhggrrg 537
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNG--------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    538 gkrheeeedvhYEQVKARLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINAqNNHENFLAGRErNVLQQIEPQAMELAF 617
Cdd:smart00835  72 -----------NKVYDARLREGDVFVVPQGHPHFQVNSGDENLEFVAFNTND-PNRRFFLAGRN-SVLRGLPPEVLAAAF 138


                   ....*...
gi 75266171    618 AAPRKEVE 625
Cdd:smart00835 139 GVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 455-625 1.31e-20

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 88.93  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   455 YNLFNKRPLYSNKYGQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHlsgrhgg 534
Cdd:pfam00190   1 LNLLEPGPTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPG------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   535 rrggkrhEEEEDVHyeqvkARLSKREAIVVPVGHPVVFVSSGNENLLLF-AFGINAQNNHENFLAGreRNVLQQIEPQAM 613
Cdd:pfam00190  74 -------NGNRVFH-----KVLREGDVFVVPQGLPHFQYNIGDEPAVAFvAFDTNNPGNQSILAGG--FSSLPALPPEVL 139

                         170
                  ....*....|..
gi 75266171   614 ELAFAAPRKEVE 625
Cdd:pfam00190 140 AKAFQLAGEEVK 151
Vicilin_N pfam04702
Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to ...
 70-243 2.81e-18

Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to the Cupin domain (pfam00190). In Macadamia integrifolia, this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif. These peptides exhibit antimicrobial activity in vitro.


Pssm-ID: 252749 [Multi-domain]  Cd Length: 147  Bit Score: 82.07  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    70 SKYDNQDDPQTDCQQCQRRCRQQESGPRQQQYCQRRCKEICEEEEEYNRQR--DPQQQYEQCQERCQRHetEPRHMQTCQ 147
Cdd:pfam04702   1 PGRRNEDDPQQRYEQCQRRCEQETRGQREQQQCERRCKEQYKEEQQQQRQReeDPQRRYEQCQQRCQQH--EPRHRPTCQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   148 QRCERRYEKEKRKqqkryeeqqredeekyeermkeednkrdpQQREYEDCRRRCEQQE--PRQQYQCQRRCREQQRQHGR 225
Cdd:pfam04702  79 QRCERRYEKEQQQ-----------------------------QQRQYQECQQRCQQQEqrPRRQQQCQRECREQYQEHGR 129

                         170
                  ....*....|....*...
gi 75266171   226 GGDLINPQRGGSGRYEEG 243
Cdd:pfam04702 130 GEGENINQEGEEERSEEG 147
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 274-410 3.07e-14

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 70.39  E-value: 3.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    274 ENFYGRSKL-----LRALK--NYRLVLLEANPNAFVLP-THLDADAILLVTGGRGALKMIH-RDNRE-SYNLECGDVIRI 343
Cdd:smart00835   8 SNEGGRLREadptnFPALNglGISAARVNLEPGGMLPPhYHPRATELLYVVRGEGRVGVVDpNGNKVyDARLREGDVFVV 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75266171    344 PAGTTFYLINrDNNERLHIAKFlqtiSTPGQYKEFFPAGGQNpepYLSTFSKEILEAALNTQAERLR 410
Cdd:smart00835  88 PQGHPHFQVN-SGDENLEFVAF----NTNDPNRRFFLAGRNS---VLRGLPPEVLAAAFGVSAEEVR 146
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 260-422 2.39e-10

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 60.68  E-value: 2.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 260 STRFRTEEGHIsvlENFYGRSKLLR-----ALknyRLVLleaNPNAFVLPTHLDADAILLVTGGRGALKMI--------- 325
Cdd:cd02242  10 TRRIESEGGSY---EYWDPNNPQLQcagvaAG---RLTI---EPRGLLLPSYSNAPKLAYVLQGRGIVGVVfpgcpetfq 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 326 -----------HRDNRES-YNLECGDVIRIPAGTTFYLINrDNNERLhIAKFLQTIST-----PGQYKEFFPAGGQNPEP 388
Cdd:cd02242  81 ssqqsqgqgqrFRDQHQKvRRIRKGDVIAVPAGVVHWWYN-DGDSDL-VIVFLGDTSNnanqlDGNFRRFFLAGNPQQEQ 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 75266171 389 Y------------LSTFSKEILEAALNTQAERLRGVLGQQREGVII 422
Cdd:cd02242 159 QgqgqeqsgggniFSGFSTEFLAEAFGVDEETARKLQGSQDQRGLI 204
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 469-598 2.11e-08

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 52.61  E-value: 2.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 469 GQAYEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMACPHlsgrhggrrggkrheeeedvH 548
Cdd:cd20285   1 GNVTERTSNDFPILKSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGPK--------------------G 60

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 75266171 549 YEQVKARLSKREAIVVPVGHPVVFVSSGNeNLLLFAFGINAQNNHENFLA 598
Cdd:cd20285  61 YESYDAELSKGDVFVVPAAFPVAIKSTSH-NVEFTGFGTNANNNNRNLLA 109
Vicilin_N pfam04702
Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to ...
 33-178 1.58e-06

Vicilin N terminal region; This region is found in plant seed storage proteins, N-terminal to the Cupin domain (pfam00190). In Macadamia integrifolia, this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif. These peptides exhibit antimicrobial activity in vitro.


Pssm-ID: 252749 [Multi-domain]  Cd Length: 147  Bit Score: 48.17  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    33 RQEYEECKRQCMQLETSGQMRRCVSQCDKRFEEDIDWSKYDNQDDPQTDCQQCQRRCRQQEsgPRQQQYCQRRCKEicee 112
Cdd:pfam04702  10 QQRYEQCQRRCEQETRGQREQQQCERRCKEQYKEEQQQQRQREEDPQRRYEQCQQRCQQHE--PRHRPTCQQRCER---- 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75266171   113 eEEYNRQRDPQQQYEQCQERCQRHETEPRHMQTCQQRCERRYEKEKRKQQKryEEQQREDEEKYEE 178
Cdd:pfam04702  84 -RYEKEQQQQQRQYQECQQRCQQQEQRPRRQQQCQRECREQYQEHGRGEGE--NINQEGEEERSEE 146
cupin_11S_legumin_C cd02243
11S legumin seed storage globulin, C-terminal cupin domain; This family contains the ...
 482-638 5.06e-05

11S legumin seed storage globulin, C-terminal cupin domain; This family contains the C-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380370  Cd Length: 155  Bit Score: 44.00  E-value: 5.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 482 LQDMDVSVFIANITQGSMMGPFFNTRSTKVVVVASGEADVEMAcphlsgrhggrrggkrHEEEEDVHYEQVKA-RLskre 560
Cdd:cd02243  21 LRFVGLSAERVKLEPNAMFAPHWNANAHQVIYVTRGSGRVQVV----------------GDNGKRVLDGEVREgQL---- 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75266171 561 aIVVPVGHPVVfVSSGNENLLLFAFgINAQNNHENFLAGReRNVLQQIEPQAMELAFAAPRKEVEEL-FNSQDESIFFP 638
Cdd:cd02243  81 -LVVPQFFAVA-KIAGEEGFEWVSF-KTSDNPIFSELAGR-TSVLRALPPEVLANSYNISPEEAKQLkSNREKETVLFP 155
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 116-209 1.53e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171  116 YNRQrdpQQQY-------EQCQERCQRHETEPRHMQTCQQRCERRYEKEKRKQQkryeEQQREDEEKYEERMKEEDNKRD 188
Cdd:PRK09510  64 YNRQ---QQQQksakraeEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQ----EQKKQAEEAAKQAALKQKQAEE 136

                         90       100
                 ....*....|....*....|.
gi 75266171  189 PQQREYEDCRRRCEQQEPRQQ 209
Cdd:PRK09510 137 AAAKAAAAAKAKAEAEAKRAA 157
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 274-418 4.05e-04

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 41.35  E-value: 4.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 274 ENFYGRS-----KLLRALK--NYRLVLLEANPNAFVLPtHLD--ADAILLVTGGRGALKMI-----------HRDNRESY 333
Cdd:cd02245   4 SNQYGWLyeadpEDYKQLKdlDVGVSFVNITQGSMMAP-HYNsrATEIAVVVEGEGYVEMVcphlssqsqqgEEEGSGEY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 334 N-----LECGDVIRIPAGTTFYLINrDNNERLHIAKFlqTISTPGQYKEFFpAGGQNPepyLSTFSKEILEAALNTQAER 408
Cdd:cd02245  83 QkvrarLSEGDVFVVPAGHPVAQVA-SSNENLEFVGF--GINAQNNERQFL-AGKNNV---LRQLDREAKELAFNVPAEE 155

                       170
                ....*....|
gi 75266171 409 LRGVLGQQRE 418
Cdd:cd02245 156 VEEVLNAQDE 165
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 155-209 6.47e-04

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 41.18  E-value: 6.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 75266171   155 EKEKRKQQKRYEEQQREDEEKYEERMKEEDNKRDPQQREYEDCRRRCEQQEPRQQ 209
Cdd:pfam09756  13 LKEAKRQQREAEEEEREEREKLEEKREEEYKEREEREEEAEKEKEEEERKQEEEQ 67
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 289-403 6.55e-04

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 40.78  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   289 YRLVLleaNPNAFVLP-THLDADAILLVTGGRGALKMI--HRDNR-ESYNLECGDVIRIPAGTTFYLINRDNNERLHIAK 364
Cdd:pfam00190  36 ARVDL---APGGMNPPhWHPNATEILYVLQGRGRVGFVvpGNGNRvFHKVLREGDVFVVPQGLPHFQYNIGDEPAVAFVA 112

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 75266171   365 FlqtiSTPGQYKEFFPAGGQNPEPYLSTfskEILEAALN 403
Cdd:pfam00190 113 F----DTNNPGNQSILAGGFSSLPALPP---EVLAKAFQ 144
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 291-358 7.58e-04

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 38.62  E-value: 7.58e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75266171 291 LVLLEANPNAFVLP-THLDADAILLVTGGRGALKMihrDNRESYNLECGDVIRIPAGTTFYLINRDNNE 358
Cdd:cd02208   1 ISVVTLPPGTSSPPhWHPEQDEIFYVLSGEGELTL---DDGETVELKAGDIVLIPPGVPHSFVNTSDEP 66
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 103-209 1.92e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   103 QRRCKEICEEEEEYNRQRDPQQQYEQCQERCQRHEtEPRHMQTCQQRCERRYEKEKRKQQKRYEEQQREDEEKYEER--- 179
Cdd:pfam17380 429 QEEARQREVRRLEEERAREMERVRLEEQERQQQVE-RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERkqa 507

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 75266171   180 MKEEDNKRDPQQRE--------YEDCRRRCEQQEPRQQ 209
Cdd:pfam17380 508 MIEEERKRKLLEKEmeerqkaiYEEERRREAEEERRKQ 545
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 28-204 3.77e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.32  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171    28 ESEFDRQEYEECKR-QCMQLETSGQMRRCVSQCDKRFEEDIDWSKYDNQDDPQ----TDCQQCQRRCRQQESGPRQQQYC 102
Cdd:pfam15709 349 EVERKRREQEEQRRlQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQrqeeEERKQRLQLQAAQERARQQQEEF 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   103 QRRCKEIceeeeeynrqrdpqqQYEQCQERCQRHETEPRhmqtcqqrceRRYEKEKR--KQQKRYEEQQREDEEKYEERM 180
Cdd:pfam15709 429 RRKLQEL---------------QRKKQQEEAERAEAEKQ----------RQKELEMQlaEEQKRLMEMAEEERLEYQRQK 483

                         170       180
                  ....*....|....*....|....
gi 75266171   181 KEEDNKRdpqQREYEDCRRRCEQQ 204
Cdd:pfam15709 484 QEAEEKA---RLEAEERRQKEEEA 504
Caldesmon pfam02029
Caldesmon;
127-208 4.16e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 40.24  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171   127 EQCQERCQRHETEPRHMQTCQQRCERRYEKEKRKQQKR-----YEEQQREDEEKYEERMKEEDNKRDPQQREyedcRRRC 201
Cdd:pfam02029 252 ELRRRRQEKESEEFEKLRQKQQEAELELEELKKKREERrklleEEEQRRKQEEAERKLREEEEKRRMKEEIE----RRRA 327


                  ....*..
gi 75266171   202 EQQEPRQ 208
Cdd:pfam02029 328 EAAEKRQ 334
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 472-633 5.93e-03

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 38.72  E-value: 5.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 472 YEVKPEDYRQLQDMDVSVFIANITQGSMMGPFFnTRSTKVVVVASGEADVEMACP-----HLSGRHGGRRGGKRHEEEED 546
Cdd:cd02242  20 YEYWDPNNPQLQCAGVAAGRLTIEPRGLLLPSY-SNAPKLAYVLQGRGIVGVVFPgcpetFQSSQQSQGQGQRFRDQHQK 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75266171 547 VHyeqvkaRLSKREAIVVPVGHPVVFVSSGNENLLLFAFGINaqNNHEN---------FLAGR--------------ERN 603
Cdd:cd02242  99 VR------RIRKGDVIAVPAGVVHWWYNDGDSDLVIVFLGDT--SNNANqldgnfrrfFLAGNpqqeqqgqgqeqsgGGN 170

                       170       180       190
                ....*....|....*....|....*....|
gi 75266171 604 VLQQIEPQAMELAFAAPRKEVEELFNSQDE 633
Cdd:cd02242 171 IFSGFSTEFLAEAFGVDEETARKLQGSQDQ 200
cupin_Bh2720-like cd02223
Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, ...
 305-353 7.48e-03

Bacillus halodurans Bh2720 and related proteins, cupin domain; This family includes bacterial, archaeal, and eukaryotic proteins similar to Bh2720, a Bacillus halodurans protein of unknown function with a cupin beta-barrel fold.


Pssm-ID: 380352 [Multi-domain]  Cd Length: 98  Bit Score: 36.37  E-value: 7.48e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 75266171 305 THLDADAILLVTGGRGALKMihrdNRESYNLECGDVIRIPAGTTFYLIN 353
Cdd:cd02223  28 VHDDVDQFLRIEEGEGKAIM----GGFESEVKDGDAIIVPAGTWHNVIN 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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