NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|77416385|sp|Q9R0Z3|]
View 

RecName: Full=Cyclin-dependent kinase inhibitor 2A; AltName: Full=Cyclin-dependent kinase 4 inhibitor A; Short=CDK4I; AltName: Full=p16-INK4a; Short=p16; Short=p16-INK4

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-122 9.46e-24

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  15 GREHEVRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAG 93
Cdd:COG0666  98 GDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAG 176

                        90       100
                ....*....|....*....|....*....
gi 77416385  94 ARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:COG0666 177 ADVNARDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-122 9.46e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  15 GREHEVRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAG 93
Cdd:COG0666  98 GDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAG 176

                        90       100
                ....*....|....*....|....*....
gi 77416385  94 ARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:COG0666 177 ADVNARDNDGETPLHLAAENGHLEIVKLL 205
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 20-122 1.09e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQ-VMMMGNVKVAALLLSYGADSNCEDPTTlSRPVHDAAREGFLDTLVVLHQAGARLDV 98
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHyAIKKGDLESIKMLFEYGADVNIEDDNG-CYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         90       100
                 ....*....|....*....|....
gi 77416385   99 RDAWGRLPLDLALERGHHDVVRYL 122
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLL 209
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-122 2.44e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 2.44e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 77416385    71 SRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-122 9.46e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  15 GREHEVRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAG 93
Cdd:COG0666  98 GDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAG 176

                        90       100
                ....*....|....*....|....*....
gi 77416385  94 ARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:COG0666 177 ADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-123 2.13e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.13e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  20 VRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAGARLDV 98
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIVKLLLEAGADVNA 214

                        90       100
                ....*....|....*....|....*
gi 77416385  99 RDAWGRLPLDLALERGHHDVVRYLR 123
Cdd:COG0666 215 KDNDGKTALDLAAENGNLEIVKLLL 239
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-122 2.65e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  15 GREHEVRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGA 94
Cdd:COG0666  32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA 111

                        90       100
                ....*....|....*....|....*...
gi 77416385  95 RLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:COG0666 112 DVNARDKDGETPLHLAAYNGNLEIVKLL 139
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 20-122 1.09e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQ-VMMMGNVKVAALLLSYGADSNCEDPTTlSRPVHDAAREGFLDTLVVLHQAGARLDV 98
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHyAIKKGDLESIKMLFEYGADVNIEDDNG-CYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         90       100
                 ....*....|....*....|....
gi 77416385   99 RDAWGRLPLDLALERGHHDVVRYL 122
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLL 209
PHA03095 PHA03095
ankyrin-like protein; Provisional
 20-140 1.52e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.33  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQVMMMGN--VKVAALLLSYGADSNCEDptTLSR-PVHDAAREGFLDTLVV--LHQAGA 94
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKD--KVGRtPLHVYLSGFNINPKVIrlLLRKGA 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 77416385   95 RLDVRDAWGRLPLDLALERghHDV-VRYLRYLLSSAGNVSRVTDRHN 140
Cdd:PHA03095 144 DVNALDLYGMTPLAVLLKS--RNAnVELLRLLIDAGADVYAVDDRFR 188
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-122 2.44e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 2.44e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 77416385    71 SRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
20-100 7.63e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385    20 VRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYG-ADSNCEDPTtlsrPVHDAAREGFLDTLVVLHQAGARLD 97
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEHAdVNLKDNGRT----ALHYAARSGHLEIVKLLLEKGADIN 88


                  ...
gi 77416385    98 VRD 100
Cdd:pfam12796  89 VKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-122 1.18e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 1.18e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77416385    47 GNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQaGARLDVRDAwGRLPLDLALERGHHDVVRYL 122
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-122 1.82e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 77416385    75 HDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA03095 PHA03095
ankyrin-like protein; Provisional
 20-120 2.22e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAALLLSY---GADSNCEDPTTLSrPVHDAAreGFLDTLVVLH--QAGA 94
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLliaGISINARNRYGQT-PLHYAA--VFNNPRACRRliALGA 281

                         90       100
                 ....*....|....*....|....*.
gi 77416385   95 RLDVRDAWGRLPLDLALERGHHDVVR 120
Cdd:PHA03095 282 DINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-113 7.86e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 7.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAAL--LLSYGADSNCEDPTTLSrPVHDAAR-EGFLDTLVVLHQAGARL 96
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIrtLIMLGADVNAADRLYIT-PLHQASTlDRNKDIVITLLELGANV 368

                         90
                 ....*....|....*..
gi 77416385   97 DVRDAWGRLPLDLALER 113
Cdd:PHA02876 369 NARDYCDKTPIHYAAVR 385
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 20-95 1.01e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQVM-MMGNVKVAALLLSYGAdsnceDPTTLSR----PVHDAAREGFLDTLVVL----- 89
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGA-----DPTLLDKdgktPLELAEENGFREVVQLLsrhsq 172


                 ....*...
gi 77416385   90 --HQAGAR 95
Cdd:PTZ00322 173 chFELGAN 180
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-122 4.82e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   19 EVRALLEAGASPNAPNTFGRTPIQVMMMGN----VKVAALLLSYGADSNCEDPTTLSrPVH----DAAREGFLDTLVvlh 90
Cdd:PHA03095  29 EVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPERCGFT-PLHlylyNATTLDVIKLLI--- 104

                         90       100       110
                 ....*....|....*....|....*....|....
gi 77416385   91 QAGARLDVRDAWGRLPLD--LALERGHHDVVRYL 122
Cdd:PHA03095 105 KAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLL 138
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-101 6.91e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 6.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  15 GREHEVRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPtTLSRPVHDAAREGFLDTLVVLHQAG 93
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDK-DGLTALLLAAAAGAALIVKLLLLAL 275


                ....*...
gi 77416385  94 ARLDVRDA 101
Cdd:COG0666 276 LLLAAALL 283
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 20-113 7.73e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPN-TFGRTPIQVMMMG-NVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAGARLD 97
Cdd:PHA02878 150 TKLLLSYGADINMKDrHKGNTALHYATENkDQRLTELLLSYGANVNIPDKTNNS-PLHHAVKHYNKPIVHILLENGASTD 228

                         90
                 ....*....|....*.
gi 77416385   98 VRDAWGRLPLDLALER 113
Cdd:PHA02878 229 ARDKCGNTPLHISVGY 244
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 41-131 1.41e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   41 IQVMMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVR 120
Cdd:PLN03192 530 LTVASTGNAALLEELLKAKLDPDIGDSKGRT-PLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90
                 ....*....|.
gi 77416385  121 YLrYLLSSAGN 131
Cdd:PLN03192 609 IL-YHFASISD 618
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-146 4.96e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   50 KVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVrylRYLLSSA 129
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIV---HILLENG 224

                         90
                 ....*....|....*..
gi 77416385  130 GNvsrvTDRHNFCSSTP 146
Cdd:PHA02878 225 AS----TDARDKCGNTP 237
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-63 5.22e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.36  E-value: 5.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 77416385   23 LLEAGASPNAPNTFGRTPIQ-VMMMGNVKVAALLLSYGADSN 63
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHyAAERGNAKMVNLLLSYGADVN 205
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 20-122 6.64e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 6.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQVMMM---GNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDT----LVVLHQA 92
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISkksNSYSIVEYLLDNGANVNIKNSDGEN-LLHLYLESNKIDLkilkLLIDKGV 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 77416385   93 --------------GARLDVRDAWGRLPLDLALERGHHDVVRYL 122
Cdd:PHA03100 168 dinaknrvnyllsyGVPINIKDVYGFTPLHYAVYNNNPEFVKYL 211
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-138 1.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   37 GRTPIQV-MMMGNVKVAALLLSYGADSNCEDpTTLSRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGH 115
Cdd:PHA02875 102 GMTPLHLaTILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180

                         90       100
                 ....*....|....*....|...
gi 77416385  116 HDVVrylRYLLSSAGNVSRVTDR 138
Cdd:PHA02875 181 IAIC---KMLLDSGANIDYFGKN 200
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 16-111 2.60e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   16 REHEVRALLEAGASPNAPNTFGRTP--IQVMMMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGflDTLVVLHQAG 93
Cdd:PHA02878 213 NKPIVHILLENGASTDARDKCGNTPlhISVGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE--RKLKLLLEYG 290

                         90
                 ....*....|....*...
gi 77416385   94 ARLDVRDAWGRLPLDLAL 111
Cdd:PHA02878 291 ADINSLNSYKLTPLSSAV 308
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 20-122 3.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   20 VRALLEAGASPNAPNTFGRTPIQV-MMMGNVKVAALLLSYGADSNCEDPTTLSrPVHDAAREGFLDTLVVLHQAGARLDV 98
Cdd:PHA02875 118 MKLLIARGADPDIPNTDKFSPLHLaVMMGDIKGIELLIDHKACLDIEDCCGCT-PLIIAMAKGDIAICKMLLDSGANIDY 196

                         90       100
                 ....*....|....*....|....*...
gi 77416385   99 rdaWGRLP----LDLALERGHHDVVRYL 122
Cdd:PHA02875 197 ---FGKNGcvaaLCYAIENNKIDIVRLF 221
Ank_4 pfam13637
Ankyrin repeats (many copies);
15-56 7.63e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 77416385    15 GREHEVRALLEAGASPNAPNTFGRTPIQ-VMMMGNVKVAALLL 56
Cdd:pfam13637  12 GHLELLRLLLEKGADINAVDGNGETALHfAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 16-137 3.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 36.64  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385   16 REHEVRALLEAGASP-NAPNTFGRTPIQVMMMG-----NVKVAALLLSYGAdsNCEDPTTLsrpvHDAAREGFLDTLVVL 89
Cdd:PHA02989 159 KKDVIKILLSFGVNLfEKTSLYGLTPMNIYLRNdidviSIKVIKYLIKKGV--NIETNNNG----SESVLESFLDNNKIL 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 77416385   90 HQAG----------ARLDVRDAWGRLPLDLALERGHHDVVRYLRYLLSSAGNVSRVTD 137
Cdd:PHA02989 233 SKKEfkvlnfilkyIKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGD 290
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-122 4.27e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 36.47  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77416385  19 EVRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGARLDV 98
Cdd:COG0666   3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                        90       100
                ....*....|....*....|....
gi 77416385  99 RDAWGRLPLDLALERGHHDVVRYL 122
Cdd:COG0666  83 KDDGGNTLLHAAARNGDLEIVKLL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH