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Conserved domains on  [gi|81917759|sp|Q9QZP2|]
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RecName: Full=PR domain zinc finger protein 4; AltName: Full=PR domain-containing protein 4

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-533 6.15e-93

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


:

Pssm-ID: 380966  Cd Length: 133  Bit Score: 286.67  E-value: 6.15e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 401 RARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENEC 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 81917759 481 NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIG 533
Cdd:cd19189  81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.44e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.44e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 81917759   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
628-653 5.95e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.95e-06
                          10        20
                  ....*....|....*....|....*.
gi 81917759   628 NLRTHLKIHTGQKNYRCTLCDKSFTQ 653
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
656-679 2.40e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....
gi 81917759   656 HLESHMVIHTGEKNLKCDYCDKLF 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
684-709 2.31e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 81917759   684 DLKQHVLIHTQERQIKCPKCDKLFLR 709
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-624 7.59e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|.
gi 81917759   604 HFMGHMGMKPHKCDFCSKAFS 624
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-533 6.15e-93

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 286.67  E-value: 6.15e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 401 RARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENEC 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 81917759 481 NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIG 533
Cdd:cd19189  81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.44e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.44e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 81917759   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
628-653 5.95e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.95e-06
                          10        20
                  ....*....|....*....|....*.
gi 81917759   628 NLRTHLKIHTGQKNYRCTLCDKSFTQ 653
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 422-529 6.62e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 43.09  E-value: 6.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759    422 GVWTAETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVSHV-WKIYhngvLEFCIITTDENecNWMMFVRKARNREEQ 495
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYlFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 81917759    496 NL-VAYPHDGKIYFCTSQDIPPENELLFYYSRDYA 529
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
656-679 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....
gi 81917759   656 HLESHMVIHTGEKNLKCDYCDKLF 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
684-709 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 81917759   684 DLKQHVLIHTQERQIKCPKCDKLFLR 709
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 422-524 6.82e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.12  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759   422 GVWTAETIPVRTCFG-----PLIGQQSHSMEVAEWTDKAVSHVWKIYH---NGVLEFCIITTDENECNWMMFVrkarNRE 493
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFI----NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 81917759   494 -EQNLVAY----PHDGKIYFCTSQDIPPENELLFYY 524
Cdd:pfam00856  79 cDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-624 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|.
gi 81917759   604 HFMGHMGMKPHKCDFCSKAFS 624
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
ZnF_C2H2 smart00355
zinc finger;
642-664 7.95e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 7.95e-03
                           10        20
                   ....*....|....*....|...
gi 81917759    642 YRCTLCDKSFTQKAHLESHMVIH 664
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-533 6.15e-93

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 286.67  E-value: 6.15e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 401 RARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENEC 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 81917759 481 NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIG 533
Cdd:cd19189  81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 405-530 2.54e-35

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 130.14  E-value: 2.54e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 405 SLPKQLVLRQSIVGTDV-GVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKavSHVWKIYHNGVLEFCIITTDENECNWM 483
Cdd:cd19187   2 SLPRNLTLKYSSVGREVlGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANR--KYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81917759 484 MFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQ 530
Cdd:cd19187  80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFAR 126
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 401-533 3.12e-35

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 130.16  E-value: 3.12e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 401 RARLSLPKQLVLRQsIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVaewTDKAVSHVWKIYHNGVlEFCIITTDENEC 480
Cdd:cd19194   1 RARASLPLILQIFR-FGETLGGVFAKRRIPKRTQFGPLEGPLVKKSEL---KDNKIHPLELEEDDGE-DLYFDLSDENKC 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 81917759 481 NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIG 533
Cdd:cd19194  76 NWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 400-532 2.62e-32

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 121.75  E-value: 2.62e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 400 SRARLSLPKQLVLRQSIVGTDvGVWTAETIPVRTCFGPLIGQqshsmEVAEWtDKAVSHVWKIYHNGVLEFCIITTDENE 479
Cdd:cd19199   1 SRARSSLPDNLEIRQLEDGSE-GVFALVPLVKRTQFGPFEAK-----RVARL-DGFAVFPLKVFEKDGSVVYLDTSNEDD 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 81917759 480 CNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQI 532
Cdd:cd19199  74 CNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 403-533 5.27e-31

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 118.11  E-value: 5.27e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 403 RLSLPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEwtdkaVSHVWKIYHNGVLEFCIITTDENECN 481
Cdd:cd19193   1 RLTLPPGLSIKRSsIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEAAD-----SGYSWQIYKGGKLSHYIDAKDESKSN 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 81917759 482 WMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIG 533
Cdd:cd19193  76 WMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 406-525 1.11e-30

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 115.37  E-value: 1.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 406 LPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQshsmevaewtdkavshvwkiyhngvlefciittdenecNWMM 484
Cdd:cd10534   1 LPAGLELVLSsIPEGGLGVFARRTIPAGTRFGPLEGVV--------------------------------------NWMR 42

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 81917759 485 FVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYS 525
Cdd:cd10534  43 FVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 404-535 1.96e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 96.31  E-value: 1.96e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 404 LSLPKQLVLRQSIVGTDV--GVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKavSHVWKIYHNGVLEFCIITTDENEcN 481
Cdd:cd19198   1 LDLPEGLRVLQTSFGGTPhyGVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDN--SFMWEIFEDGKLSHFIDGRGSTG-N 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 81917759 482 WMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVP 535
Cdd:cd19198  78 WMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIP 131
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.44e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.44e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 81917759   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 406-535 4.60e-23

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 95.50  E-value: 4.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 406 LPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKavSHVWKIYH-NGVLEFCIITTDENECNWM 483
Cdd:cd19196   1 LPSQVIIAQSsIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNN--NLMWEVFNeDGTVSHFIDASQENHRSWM 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 81917759 484 MFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVP 535
Cdd:cd19196  79 TFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 406-524 3.36e-21

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 89.81  E-value: 3.36e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 406 LPKQLVLRQSIV-GTDVGVWTAETIPVRTCFGPLIGQQSHSMEVaewtdKAVSHVWKIYHNGVLEFCIITTDENECNWMM 484
Cdd:cd19188   4 LPEELELKPSAVdKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQV-----KNNVYMWEIYGPKRGWMCVDASDPTKGNWLR 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 81917759 485 FVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYY 524
Cdd:cd19188  79 YVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 406-532 1.76e-19

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 84.84  E-value: 1.76e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 406 LPKQLVL-RQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAvSHVWKIY-HNGVLEFCIITTDENECNWM 483
Cdd:cd19191   1 LPDEVCLcTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVRNT-QHLWEIYdQEGTLQHFIDGGDPSKSSWM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 81917759 484 MFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQI 532
Cdd:cd19191  80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 404-523 1.34e-18

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 82.80  E-value: 1.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 404 LSLPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAewtdkavSHVWKIY-HNGVLEFCIittDENEC- 480
Cdd:cd19200   8 IPIPPDFELRESaAVGAGLGVWTKVRIEVGEKFGPFVGVQRSSVKDP-------TYAWEIVdEFGKVKFWI---DASEPg 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81917759 481 --NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFY 523
Cdd:cd19200  78 tgNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLY 122
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 385-536 4.25e-17

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 79.21  E-value: 4.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 385 PDHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQSHSMevaewtdKAVSHVWKIY 463
Cdd:cd19214  17 PYKAPIYIPDDIPI--------PSEFELRESnIPGTGLGIWTKRKIEVGEKFGPYVGEQRSNL-------KDPSYGWEVL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81917759 464 HN-GVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELL-FYYSRDYAQQIGVPE 536
Cdd:cd19214  82 DEfGNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLlFMKSEDYSHETMAPD 156
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 404-521 5.40e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 77.77  E-value: 5.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 404 LSLPKQLVLRQSI--VGTDVGVWTAETIPVRTCFGPL---IGQQSHSMEVaEWTdkavshVWKIYHNGvlEFCIITTDEN 478
Cdd:cd19201   1 LSLPGELELRKPSqdAGRSGGVWAKQPLPEGTRFGPYpgkLVKEPLDPSY-EWK------VEAQGSKG--GEGLLLLTED 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 81917759 479 ECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELL 521
Cdd:cd19201  72 SGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELI 114
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 415-529 3.11e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 70.15  E-value: 3.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 415 SIVGTDV--GVWTAETIPVRTCFGPLIGqqSHSMeVAEWTDKAVSHvwKIYHNGVLEFCIITTDENEC----NWMMFVRK 488
Cdd:cd19192  12 KSVLTDIftSVVTTTDIPAGTIFGPCVL--SFTL-GYDIADIALKT--TDKRVVPYIFRVDTGACNGSsepsDWLRLVQP 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 81917759 489 ARNREEQNLVAY-PHDGKIYFCTSQDIPPENELLFYYSRDYA 529
Cdd:cd19192  87 ARDRHEQNLEAFrKNEGQVYFRTLRRIRKGEELLVWYSDELA 128
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 427-532 3.59e-12

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 64.11  E-value: 3.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 427 ETIPVRTCFGPLIGQQSHSmevaewtDKAVS-HVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGK 505
Cdd:cd19195  26 EVIPKGHIFGPYEGQICTQ-------DKSSGfFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQ 98

                        90       100
                ....*....|....*....|....*..
gi 81917759 506 IYFCTSQDIPPENELLFYYSRDYAQQI 532
Cdd:cd19195  99 IYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 385-523 5.00e-12

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 64.90  E-value: 5.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 385 PDHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGTDVGVWTAETIPVRTCFGPLIGQQSHSM-------EVAEWTDKAV 456
Cdd:cd19213   7 PYEAPVYIPDDIPI--------PSDFELRESsIPGAGLGVWAKRKIEAGERFGPYTGVQRSTLkdtnfgwEQILNDVEVS 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81917759 457 SH---VWKIYHN-GVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFY 523
Cdd:cd19213  79 SQegcITKIVDDlGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 406-524 4.57e-11

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 60.77  E-value: 4.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 406 LPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVshVWKIYHN-GVLEFCIITTDENECNWMM 484
Cdd:cd19190   5 VPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRL--MWEVRGSkGEVLYILDASNPRHSNWLR 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 81917759 485 FVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYY 524
Cdd:cd19190  83 FVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 464-532 2.95e-09

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 55.21  E-value: 2.95e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81917759 464 HNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAY--PHDGKIYFCTSQDIPPENELLFYYSRDYAQQI 532
Cdd:cd19197  33 RRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIadLPGGQIFYRALRDIQPGEELTVWYSNSLAQWF 103
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 405-521 4.94e-07

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 49.34  E-value: 4.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759 405 SLPKQLVLRQSIV-GTDVGVWTAET-IPVRTCFGPLIGQqshsmevAEWTDKAVSHVWKIYHNGVLEFCIITtdENECNW 482
Cdd:cd10520   4 SLPPGLALGPSLAqEERLGVWCVGDaLQKGTFLGPLEEE-------LESHDLTEGGSPRQEESGQSGDVLAC--EQSSKW 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 81917759 483 MMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELL 521
Cdd:cd10520  75 MRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELL 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
628-653 5.95e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.95e-06
                          10        20
                  ....*....|....*....|....*.
gi 81917759   628 NLRTHLKIHTGQKNYRCTLCDKSFTQ 653
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 422-529 6.62e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 43.09  E-value: 6.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759    422 GVWTAETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVSHV-WKIYhngvLEFCIITTDENecNWMMFVRKARNREEQ 495
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYlFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 81917759    496 NL-VAYPHDGKIYFCTSQDIPPENELLFYYSRDYA 529
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
656-679 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....
gi 81917759   656 HLESHMVIHTGEKNLKCDYCDKLF 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 642-664 4.26e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|...
gi 81917759   642 YRCTLCDKSFTQKAHLESHMVIH 664
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
684-709 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 81917759   684 DLKQHVLIHTQERQIKCPKCDKLFLR 709
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 422-524 6.82e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.12  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81917759   422 GVWTAETIPVRTCFG-----PLIGQQSHSMEVAEWTDKAVSHVWKIYH---NGVLEFCIITTDENECNWMMFVrkarNRE 493
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFI----NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 81917759   494 -EQNLVAY----PHDGKIYFCTSQDIPPENELLFYY 524
Cdd:pfam00856  79 cDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-624 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|.
gi 81917759   604 HFMGHMGMKPHKCDFCSKAFS 624
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
ZnF_C2H2 smart00355
zinc finger;
642-664 7.95e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 7.95e-03
                           10        20
                   ....*....|....*....|...
gi 81917759    642 YRCTLCDKSFTQKAHLESHMVIH 664
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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