NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17380347|sp|Q9P2S5|]
View 

RecName: Full=WD repeat-containing protein WRAP73; AltName: Full=WD repeat-containing protein 8; AltName: Full=WD repeat-containing protein antisense to TP73 gene

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-404 7.75e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 7.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  71 GLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHlRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMA 149
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG-TVRLWDLATgKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 150 LAERRDckdYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAV--WDTcleyKILLYSLD-GRLLSTYSAYEWSlgI 226
Cdd:COG2319 179 SGSDDG---TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASgsADG----TVRLWDLAtGKLLRTLTGHSGS--V 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 227 KSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFpppragagplpSSE 305
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVN-------------------SVAF-----------SPD 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 306 SKYeIAS------VPV-SLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLEQ-LSPVR 377
Cdd:COG2319 300 GKL-LASgsddgtVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGhTGAVT 376

                       330       340
                ....*....|....*....|....*..
gi 17380347 378 AFQWDPQQPRLAICTGGSRLYLWSPAG 404
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
TolB super family cl43285
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 16-121 1.38e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0823:

Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  16 FSPDGKYLA----SCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLeqpewhcKIDEG- 90
Cdd:COG0823  38 WSPDGRRIAftsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFDIYVL-------DLDGGa 110

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17380347  91 ----SAGLVASCWSPDGRHILNTTEFHLRITVWSL 121
Cdd:COG0823 111 prrlTDGPGSPSWSPDGRRIVFSSDRGGRPDLYVV 145
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-404 7.75e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 7.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  71 GLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHlRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMA 149
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG-TVRLWDLATgKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 150 LAERRDckdYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAV--WDTcleyKILLYSLD-GRLLSTYSAYEWSlgI 226
Cdd:COG2319 179 SGSDDG---TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASgsADG----TVRLWDLAtGKLLRTLTGHSGS--V 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 227 KSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFpppragagplpSSE 305
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVN-------------------SVAF-----------SPD 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 306 SKYeIAS------VPV-SLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLEQ-LSPVR 377
Cdd:COG2319 300 GKL-LASgsddgtVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGhTGAVT 376

                       330       340
                ....*....|....*....|....*..
gi 17380347 378 AFQWDPQQPRLAICTGGSRLYLWSPAG 404
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-268 6.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  14 CKFSPDGKYLASCVqyrlvvRDvNTLQILQLYTCL---------DQIQHIEWSADSLFILCAmYKRGLVQVWSLEQPEWH 84
Cdd:cd00200  15 VAFSPDGKLLATGS------GD-GTIKVWDLETGEllrtlkghtGPVRDVAASADGTYLASG-SSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  85 CKIdEGSAGLVASC-WSPDGrHILNTTEFHLRITVWSLCTKsvsyikYPKACLQGIT-------FTRDGRYMALAerrdC 156
Cdd:cd00200  87 RTL-TGHTSYVSSVaFSPDG-RILSSSSRDKTIKVWDVETG------KCLTTLRGHTdwvnsvaFSPDGTFVASS----S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 157 KD-YVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVwdTCLEYKILLYSLD-GRLLSTYSAYEwsLGIKSVAWSPS 234
Cdd:cd00200 155 QDgTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLStGKCLGTLRGHE--NGVNSVAFSPD 230

                       250       260       270
                ....*....|....*....|....*....|....*
gi 17380347 235 SQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAIN 268
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGHTNSVT 265
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 203-258 6.07e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 6.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17380347   203 KILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMI 258
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 16-121 1.38e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  16 FSPDGKYLA----SCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLeqpewhcKIDEG- 90
Cdd:COG0823  38 WSPDGRRIAftsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFDIYVL-------DLDGGa 110

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17380347  91 ----SAGLVASCWSPDGRHILNTTEFHLRITVWSL 121
Cdd:COG0823 111 prrlTDGPGSPSWSPDGRRIVFSSDRGGRPDLYVV 145
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-249 3.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17380347    210 DGRLLSTYSAYEWSlgIKSVAWSPSSQFLAVGSYDGKVRI 249
Cdd:smart00320   1 SGELLKTLKGHTGP--VTSVAFSPDGKYLASGSDDGTIKL 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-404 7.75e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 7.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  71 GLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHlRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMA 149
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG-TVRLWDLATgKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 150 LAERRDckdYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAV--WDTcleyKILLYSLD-GRLLSTYSAYEWSlgI 226
Cdd:COG2319 179 SGSDDG---TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASgsADG----TVRLWDLAtGKLLRTLTGHSGS--V 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 227 KSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFpppragagplpSSE 305
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVN-------------------SVAF-----------SPD 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 306 SKYeIAS------VPV-SLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLEQ-LSPVR 377
Cdd:COG2319 300 GKL-LASgsddgtVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGhTGAVT 376

                       330       340
                ....*....|....*....|....*..
gi 17380347 378 AFQWDPQQPRLAICTGGSRLYLWSPAG 404
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-269 7.40e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 7.40e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  16 FSPDGKYLASCVQYRLV-VRDVNTLQILQLYTC-LDQIQHIEWSADSLFILCAMYkRGLVQVWSLEQPEWHCKIDEGSAG 93
Cdd:COG2319 128 FSPDGKTLASGSADGTVrLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGA 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  94 LVASCWSPDGRHILnTTEFHLRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMALAeRRDCKdyVSIFVCSDWQLLR 172
Cdd:COG2319 207 VRSVAFSPDGKLLA-SGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASG-SADGT--VRLWDLATGELLR 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 173 HFDTDTQDLTGIEWAPNGCVLAVwdTCLEYKILLYSLD-GRLLSTYSAYEWslGIKSVAWSPSSQFLAVGSYDGKVRILN 251
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLAtGKLLRTLTGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       250
                ....*....|....*....
gi 17380347 252 HVTWKMITEF-GHPAAIND 269
Cdd:COG2319 359 LATGELLRTLtGHTGAVTS 377
WD40 COG2319
WD40 repeat [General function prediction only];
16-249 1.83e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 1.83e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  16 FSPDGKYLASCVQYRLV-VRDVNTLQILQLYTC-LDQIQHIEWSADSLFILCAMYkRGLVQVWSLEQPEWHCKIDEGSAG 93
Cdd:COG2319 170 FSPDGKLLASGSDDGTVrLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGS 248

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  94 LVASCWSPDGRHILnTTEFHLRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMALAeRRDCKdyVSIFVCSDWQLLR 172
Cdd:COG2319 249 VRSVAFSPDGRLLA-SGSADGTVRLWDLATgELLRTLTGHSGGVNSVAFSPDGKLLASG-SDDGT--VRLWDLATGKLLR 324

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 173 HFDTDTQDLTGIEWAPNGCVLAV--WDTcleyKILLYSLD-GRLLSTYSAYEWslGIKSVAWSPSSQFLAVGSYDGKVRI 249
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASgsDDG----TVRLWDLAtGELLRTLTGHTG--AVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
70-437 1.92e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 1.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  70 RGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMA 149
Cdd:COG2319  15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 150 LAeRRDCKdyVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAV--WDtcleYKILLYSL-DGRLLSTYSAYEWslGI 226
Cdd:COG2319  95 SA-SADGT--VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASgsAD----GTVRLWDLaTGKLLRTLTGHSG--AV 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 227 KSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFpppragagplpSSE 305
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVR-------------------SVAF-----------SPD 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 306 SKYeIASVPV-------SLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLE-QLSPVR 377
Cdd:COG2319 216 GKL-LASGSAdgtvrlwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTgHSGGVN 292

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 378 AFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDH 437
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352
WD40 COG2319
WD40 repeat [General function prediction only];
71-436 2.68e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 2.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  71 GLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILnTTEFHLRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMA 149
Cdd:COG2319  58 LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATgLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 150 LAerrdCKDY-VSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTclEYKILLYSLD-GRLLSTYSAYEWSlgIK 227
Cdd:COG2319 137 SG----SADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLAtGKLLRTLTGHTGA--VR 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 228 SVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINDpkivvykeaekspqlglgcLSFpppragagplpSSES 306
Cdd:COG2319 209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtGHSGSVRS-------------------VAF-----------SPDG 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 307 KYeIASVPV-------SLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLE-QLSPVRA 378
Cdd:COG2319 259 RL-LASGSAdgtvrlwDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTgHTGAVRS 335

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17380347 379 FQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKD 436
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-268 6.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  14 CKFSPDGKYLASCVqyrlvvRDvNTLQILQLYTCL---------DQIQHIEWSADSLFILCAmYKRGLVQVWSLEQPEWH 84
Cdd:cd00200  15 VAFSPDGKLLATGS------GD-GTIKVWDLETGEllrtlkghtGPVRDVAASADGTYLASG-SSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  85 CKIdEGSAGLVASC-WSPDGrHILNTTEFHLRITVWSLCTKsvsyikYPKACLQGIT-------FTRDGRYMALAerrdC 156
Cdd:cd00200  87 RTL-TGHTSYVSSVaFSPDG-RILSSSSRDKTIKVWDVETG------KCLTTLRGHTdwvnsvaFSPDGTFVASS----S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 157 KD-YVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVwdTCLEYKILLYSLD-GRLLSTYSAYEwsLGIKSVAWSPS 234
Cdd:cd00200 155 QDgTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLStGKCLGTLRGHE--NGVNSVAFSPD 230

                       250       260       270
                ....*....|....*....|....*....|....*
gi 17380347 235 SQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAIN 268
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-401 4.86e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 4.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  89 EGSAGLVAS-CWSPDGRHIL----NTTefhlrITVWSLCTKSVSY-IKYPKACLQGITFTRDGRYMALAerrdCKDY-VS 161
Cdd:cd00200   6 KGHTGGVTCvAFSPDGKLLAtgsgDGT-----IKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG----SSDKtIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 162 IFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLA---------VWDTcleykillysLDGRLLSTYSAYEWSlgIKSVAWS 232
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSsssrdktikVWDV----------ETGKCLTTLRGHTDW--VNSVAFS 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 233 PSSQFLAVGSYDGKVRILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFPPPR----AGAGplpSSESK 307
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWDLRTGKCVATLtGHTGEVN-------------------SVAFSPDGekllSSSS---DGTIK 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 308 -YEIASvPVSLQTLKPVTDRANpkigigMLAFSPDSYFLATRNDNipNAVWVWDIQKLRLFAVLEQL-SPVRAFQWDPQQ 385
Cdd:cd00200 203 lWDLST-GKCLGTLRGHENGVN------SVAFSPDGYLLASGSED--GTIRVWDLRTGECVQTLSGHtNSVTSLAWSPDG 273

                       330
                ....*....|....*.
gi 17380347 386 PRLAICTGGSRLYLWS 401
Cdd:cd00200 274 KRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-460 2.45e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 2.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 178 TQDLTGIEWAPNGCVLA---------VWDtcLEYKILLYSLDGRllstysayewSLGIKSVAWSPSSQFLAVGSYDGKVR 248
Cdd:cd00200   9 TGGVTCVAFSPDGKLLAtgsgdgtikVWD--LETGELLRTLKGH----------TGPVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 249 ILNHVTWKMITEF-GHPAAINdpkivvykeaekspqlglgCLSFPPpragAGPLPSSESK------YEIASvPVSLQTLK 321
Cdd:cd00200  77 LWDLETGECVRTLtGHTSYVS-------------------SVAFSP----DGRILSSSSRdktikvWDVET-GKCLTTLR 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347 322 PVTDRANpkigigMLAFSPDSYFLAT-RNDNIpnaVWVWDIQKLRLFAVLEQ-LSPVRAFQWDPQQPRLAICTGGSRLYL 399
Cdd:cd00200 133 GHTDWVN------SVAFSPDGTFVASsSQDGT---IKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17380347 400 WSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCF-LETEAVVGTacrqLGGHT 460
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWdLRTGECVQT----LSGHT 261
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 203-258 6.07e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 6.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17380347   203 KILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMI 258
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 16-121 1.38e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380347  16 FSPDGKYLA----SCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLeqpewhcKIDEG- 90
Cdd:COG0823  38 WSPDGRRIAftsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFDIYVL-------DLDGGa 110

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17380347  91 ----SAGLVASCWSPDGRHILNTTEFHLRITVWSL 121
Cdd:COG0823 111 prrlTDGPGSPSWSPDGRRIVFSSDRGGRPDLYVV 145
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-249 3.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17380347    210 DGRLLSTYSAYEWSlgIKSVAWSPSSQFLAVGSYDGKVRI 249
Cdd:smart00320   1 SGELLKTLKGHTGP--VTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
211-249 1.29e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17380347   211 GRLLSTYSAYewSLGIKSVAWSPSSQFLAVGSYDGKVRI 249
Cdd:pfam00400   1 GKLLKTLEGH--TGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH