BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75335805  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQKHLTSMV 164
Cdd:cd18310  72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 75335805   199 GLPQEILAKHLPIELVAKIEELRLKSSMPlrSLMPHHhdltstLDLEDQKIRRMR 253
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL------DDLLEKRVRRIL 47

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75335805  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQKHLTSMV 164
Cdd:cd18310  72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805    17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFL 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE-----------------ITLDDVSPEDFE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75335805    97 LLLQFLYSGQVsivphkhEPRSNcgdrgcwhthctaavdlSLDILAAARYFGVEQLALLTQKHL 160
Cdd:pfam00651  64 ALLEFMYTGKL-------ISEEN-----------------VDDLLAAADKLQIPSLVDKCEEFL 103

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 75335805   199 GLPQEILAKHLPIELVAKIEELRLKSSMPlrSLMPHHhdltstLDLEDQKIRRMR 253
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL------DDLLEKRVRRIL 47

ankyrin-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  260 DVELVKLMV-MGEGLNLDES---LALIYAVEN-CSREVVKALLELGAaDVNYPAGpTGKTALHI--AAEMVSPDMVAVLL 332
Cdd:PHA03095  62 VKDIVRLLLeAGADVNAPERcgfTPLHLYLYNaTTLDVIKLLIKAGA-DVNAKDK-VGRTPLHVylSGFNINPKVIRLLL 139

                         90       100
                 ....*....|....*....|
gi 75335805  333 DHHADPNVQTVDGITPLDIL 352
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVL 159

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75335805  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQKHLTSMV 164
Cdd:cd18310  72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-----------------IELDDVSPEAFEALLDYIYTG 63

                ....
gi 75335805 106 QVSI 109
Cdd:cd18186  64 ELEL 67

Ankyrin repeat [Signal transduction mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805 255 ALDSSDVELVKLMVmGEGLNLDE-----SLALIYAVENCSREVVKALLELGAaDVNYPaGPTGKTALHIAAEMVSPDMVA 329
Cdd:COG0666  94 AARNGDLEIVKLLL-EAGADVNArdkdgETPLHLAAYNGNLEIVKLLLEAGA-DVNAQ-DNDGNTPLHLAAANGNLEIVK 170

                        90       100
                ....*....|....*....|..
gi 75335805 330 VLLDHHADPNVQTVDGITPLDI 351
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHL 192

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805    17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFL 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE-----------------ITLDDVSPEDFE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75335805    97 LLLQFLYSGQVsivphkhEPRSNcgdrgcwhthctaavdlSLDILAAARYFGVEQLALLTQKHL 160
Cdd:pfam00651  64 ALLEFMYTGKL-------ISEEN-----------------VDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  18 NLLINGQaFSDVTFSVEGRLVHAHRCILAARSLFFRKFF----CESDPSQpgaepanqtgsgaraaavggvIPVNSVGYE 93
Cdd:cd18287  15 ALFLNEE-YSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQSE---------------------IELKDTNAE 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75335805  94 VFLLLLQFLYSGQVSIvphkheprsncgdrgcwhthCTAAVDLSLDILAAARYFGVEQLALLTQKHL 160
Cdd:cd18287  73 AFKALLKYIYTGRLTL--------------------TDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 75335805   199 GLPQEILAKHLPIELVAKIEELRLKSSMPlrSLMPHHhdltstLDLEDQKIRRMR 253
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL------DDLLEKRVRRIL 47

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPgaepanqtgsgaraaavgGVIPVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEH------------------PVIILPDVPYSELKALLDFIYTG 62

                ....
gi 75335805 106 QVSI 109
Cdd:cd18315  63 EVNV 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  15 DYLNLLINGQAfSDVTFSVEGRLVHAHRCILAARSLFFR-KFFcesdpsqpgaepanqtgsGARAAAVGGVIPVNSVGYE 93
Cdd:cd18280   4 HFGALLESEEG-ADVTFNVDGEKFRAHKLVLAARSPVFRsMLF------------------GPMREENEGEIVIEDVEPP 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75335805  94 VFLLLLQFLYSGQvsiVPHKHEPRSNcgdrgcwhTHCTAAVDLSLDILAAARYFGVEQLALLTQKHL 160
Cdd:cd18280  65 VFKALLHFIYKDE---LPDDVEPAGS--------DSSSLDTTMAQHLLAAADRYALERLRLLCESRL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  27 SDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsQPGAEPANQTgsgaraaavggVIPVNSVGYEVFLLLLQFLYSGQ 106
Cdd:cd18298  13 SDLKFRVDGKYIYVHKAILKIRCEYFRSMF------QSHWNEDDKN-----------VIEIDQYSYPVYYAFLRYLYTDQ 75

                ....*..
gi 75335805 107 VSIVPHK 113
Cdd:cd18298  76 VDLPPED 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYEVFL 96
Cdd:cd18250  12 LSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF-----------------AGELRESRADRVVLHGVSAEILG 74

                        90       100
                ....*....|....*....|
gi 75335805  97 LLLQFLYSGQVSIVPHKHEP 116
Cdd:cd18250  75 LLLDFSYTGRVTVTQDNVEA 94

Ankyrin repeats (many copies);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 75335805   296 LLELGAADVNYPAGpTGKTALHIAAEMVSPDMVAVLLDHHADPNVQTVDGITPLDI 351
Cdd:pfam13857   1 LLEHGPIDLNRLDG-EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55

Ankyrin repeats (3 copies);

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75335805   281 LIYAVENCSREVVKALLELGaADVNYPAgPTGKTALHIAAEMVSPDMVAVLLDhHADPNVQTvDGITPLDI 351
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQD-KNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHY 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  20 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdPSQPGAEpanqtgsgaraaavGGVIPVNSVGYEVFLLLL 99
Cdd:cd18351  18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL----SNKPSAE--------------NTCIEISYVKYHIFQLVM 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805 100 QFLYsgqvsivphkheprsnCGDRGCWHTHCTAAVDLsldiLAAARYFGVEQLalltQKH 159
Cdd:cd18351  80 QYLY----------------CGGTESLLIKNNEIMEL----LSAAKFFQLEAL----QRH 115

ankyrin-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  260 DVELVKLMV-MGEGLNLDES---LALIYAVEN-CSREVVKALLELGAaDVNYPAGpTGKTALHI--AAEMVSPDMVAVLL 332
Cdd:PHA03095  62 VKDIVRLLLeAGADVNAPERcgfTPLHLYLYNaTTLDVIKLLIKAGA-DVNAKDK-VGRTPLHVylSGFNINPKVIRLLL 139

                         90       100
                 ....*....|....*....|
gi 75335805  333 DHHADPNVQTVDGITPLDIL 352
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVL 159

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  22 NGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcESDPsqpgaEPANQtgsgaraaavGGVIPVNSVGYEVFLLLLQF 101
Cdd:cd18293  11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERL-SSEP-----PPAGQ----------KVVLELQGLKAHTLLKLVDF 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 75335805 102 LYSGQVSIVPHKHEprsncgdrgcwhthctaavdlslDILAAARYFGVEQLALL 155
Cdd:cd18293  75 LYTSELEVSSEEAQ-----------------------DVLAAARRLQISELESL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYE 93
Cdd:cd18256   8 LAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF-----------------AGGMSESSKDVVQIHGVEPD 70

                        90
                ....*....|....*.
gi 75335805  94 VFLLLLQFLYSGQVSI 109
Cdd:cd18256  71 IFHILLDFIYTGVVEV 86

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYEVFL 96
Cdd:cd18360   1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMF-----------------NGNYAEAKSFLVPIYGVSKDTFL 63

                ....*...
gi 75335805  97 LLLQFLYS 104
Cdd:cd18360  64 SFLEYLYT 71

Ankyrin repeat [Signal transduction mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805 243 DLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDESLALIYAVENCSREVVKALLELGAADVNYPAGPTGKTALHIAAEM 322
Cdd:COG0666  18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                        90       100
                ....*....|....*....|....*..
gi 75335805 323 VSPDMVAVLLDHHADPNVQTVDGITPL 349
Cdd:COG0666  98 GDLEIVKLLLEAGADVNARDKDGETPL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  10 KSMSLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcESDPSQPGAEPanqtgsgaraaavggvIPVNS 89
Cdd:cd18344   7 RHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMF-EHEMEERLKNP----------------IEIHD 69

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75335805  90 VGYEVFLLLLQFLYSGQvsiVPHkheprsncgdrgcWHTHCTAAvdlslDILAAARYFGVEQLALLTQKHL 160
Cdd:cd18344  70 LDPQVFKEMMGFIYTGK---APH-------------LHSHSMAC-----DVLAAADKYGLEGLKVLCEDAL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQTGSGARAaavggvipvnsvgyE 93
Cdd:cd18258   5 LKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINA--------------D 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 75335805  94 VFLLLLQFLYSGQVSIVPHKHEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFG 148
Cdd:cd18258  71 VLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCesdpsqpgaepanqtgsgaraaAVGGVIPVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18219  21 FCDVTVIVEDRKFRAHKNILSASSTYFHQLFS----------------------VAGQVVELNFIRADIFAEILNYIYSS 78

                ..
gi 75335805 106 QV 107
Cdd:cd18219  79 KI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  21 INGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESdpsqpgaepANQTGSGARAaavggvIPVNSVGYEVFLLLLQ 100
Cdd:cd18350  19 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNK---------SEQESQGSKT------IEISDIKYHIFQMLMQ 83

                ....*
gi 75335805 101 FLYSG 105
Cdd:cd18350  84 YLYYG 88

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  28 DVTFSVEGRLVHAHRCILAARSLFFRKFFCesdpsqpgaepanqtgSGARAAAvGGVIPVNSVGYEVFLLLLQFLYSGQV 107
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFT----------------SGMKEST-QSVVQLPTIPAKDLRLLISFAYSGIL 77

                .
gi 75335805 108 S 108
Cdd:cd18263  78 H 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335805  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCEsdpsqpGAEPANQTgsgaraaavggVIPVNSVGYE 93
Cdd:cd18253   6 LQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCN------DHRESREM-----------LVEINGILAE 68

                        90
                ....*....|....*.
gi 75335805  94 VFLLLLQFLYSGQVSI 109
Cdd:cd18253  69 AMDCFLQYVYTGKVKI 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 75335805   2 SNTFEESLKSMSLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 56
Cdd:cd18243   8 TSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62