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Conserved domains on  [gi|75180644|sp|Q9LVC8|]
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RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; Flags: Precursor

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10011316)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259|GO:1904047
PubMed:  9045837|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-288 5.50e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


:

Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 340.59  E-value: 5.50e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   33 FQEVKEEEKSKLVGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRiydavysvkrra 112
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  113 LQKvdeASLEETQIYVCDINPNMLNVGKQRAAERGLRDNksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAE 192
Cdd:PRK00216  69 LAK---AVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGN--VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALRE 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  193 AYRVLKRGGRFLCLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEY 272
Cdd:PRK00216 144 MYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRY 223

                        250
                 ....*....|....*.
gi 75180644  273 ENLVGGVVAIHSAIKL 288
Cdd:PRK00216 224 RNLTGGIVALHVGYKP 239
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-288 5.50e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 340.59  E-value: 5.50e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   33 FQEVKEEEKSKLVGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRiydavysvkrra 112
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  113 LQKvdeASLEETQIYVCDINPNMLNVGKQRAAERGLRDNksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAE 192
Cdd:PRK00216  69 LAK---AVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGN--VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALRE 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  193 AYRVLKRGGRFLCLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEY 272
Cdd:PRK00216 144 MYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRY 223

                        250
                 ....*....|....*.
gi 75180644  273 ENLVGGVVAIHSAIKL 288
Cdd:PRK00216 224 RNLTGGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 45-287 6.97e-99

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 289.16  E-value: 6.97e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    45 VGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRiydavysvkrraLQKVDEASLEET 124
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIE------------LAKSAPDRGKVT 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   125 QIyvcDINPNMLNVGKQRAAERGlrdnkSLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFL 204
Cdd:TIGR01934  69 GV---DFSSEMLEVAKKKSELPL-----NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   205 CLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVVAIHS 284
Cdd:TIGR01934 141 ILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHV 220


                  ...
gi 75180644   285 AIK 287
Cdd:TIGR01934 221 GKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
45-287 1.02e-91

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 271.23  E-value: 1.02e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    45 VGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVysvkrRALQKVDeasleet 124
Cdd:pfam01209   4 VGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSA-----GSSGKVV------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   125 qiyVCDINPNMLNVGKQRAAERGLRDnksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFL 204
Cdd:pfam01209  72 ---GLDINENMLKEGEKKAKEEGKYN---IEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   205 CLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVVAIHS 284
Cdd:pfam01209 146 CLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHW 225


                  ...
gi 75180644   285 AIK 287
Cdd:pfam01209 226 GIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 49-219 8.49e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 112.39  E-value: 8.49e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  49 FTNVASSYDImndvmsgglhrlwKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVYSVkrralqkvdeasleetqiYV 128
Cdd:COG2226   1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAERGARV------------------TG 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644 129 CDINPNMLNVGKQRAAERGLRdnksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFLCLEL 208
Cdd:COG2226  50 VDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125

                       170
                ....*....|.
gi 75180644 209 SHVEIPVFKNL 219
Cdd:COG2226 126 SPPDLAELEEL 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 86-205 2.39e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 2.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  86 KHLDVAGGTGDVAFRIydavysvkrralqkvdeASLEETQIYVCDINPNMLNVGKQRAAERGlrdNKSLVWVEGDAEALS 165
Cdd:cd02440   1 RVLDLGCGTGALALAL-----------------ASGPGARVTGVDISPVALELARKAAAALL---ADNVEVLKGDAEELP 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 75180644 166 FD-DNSMDG-YTIAFGIRNVTHIEKALAEAYRVLKRGGRFLC 205
Cdd:cd02440  61 PEaDESFDViISDPPLHHLVEDLARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 33-288 5.50e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 340.59  E-value: 5.50e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   33 FQEVKEEEKSKLVGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRiydavysvkrra 112
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  113 LQKvdeASLEETQIYVCDINPNMLNVGKQRAAERGLRDNksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAE 192
Cdd:PRK00216  69 LAK---AVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGN--VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALRE 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  193 AYRVLKRGGRFLCLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEY 272
Cdd:PRK00216 144 MYRVLKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRY 223

                        250
                 ....*....|....*.
gi 75180644  273 ENLVGGVVAIHSAIKL 288
Cdd:PRK00216 224 RNLTGGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 45-287 6.97e-99

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 289.16  E-value: 6.97e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    45 VGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRiydavysvkrraLQKVDEASLEET 124
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIE------------LAKSAPDRGKVT 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   125 QIyvcDINPNMLNVGKQRAAERGlrdnkSLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFL 204
Cdd:TIGR01934  69 GV---DFSSEMLEVAKKKSELPL-----NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   205 CLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVVAIHS 284
Cdd:TIGR01934 141 ILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHV 220


                  ...
gi 75180644   285 AIK 287
Cdd:TIGR01934 221 GKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
45-287 1.02e-91

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 271.23  E-value: 1.02e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    45 VGNVFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVysvkrRALQKVDeasleet 124
Cdd:pfam01209   4 VGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSA-----GSSGKVV------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   125 qiyVCDINPNMLNVGKQRAAERGLRDnksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFL 204
Cdd:pfam01209  72 ---GLDINENMLKEGEKKAKEEGKYN---IEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   205 CLELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVVAIHS 284
Cdd:pfam01209 146 CLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHW 225


                  ...
gi 75180644   285 AIK 287
Cdd:pfam01209 226 GIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 49-219 8.49e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 112.39  E-value: 8.49e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  49 FTNVASSYDImndvmsgglhrlwKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVYSVkrralqkvdeasleetqiYV 128
Cdd:COG2226   1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAERGARV------------------TG 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644 129 CDINPNMLNVGKQRAAERGLRdnksLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFLCLEL 208
Cdd:COG2226  50 VDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125

                       170
                ....*....|.
gi 75180644 209 SHVEIPVFKNL 219
Cdd:COG2226 126 SPPDLAELEEL 136
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 48-280 2.34e-24

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 98.81  E-value: 2.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   48 VFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVYSvkrralqkvdeasleETQIY 127
Cdd:PLN02233  38 LFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKVGS---------------DGKVM 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  128 VCDINPNMLNVGKQRAAERGLRDNKSLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFLCLE 207
Cdd:PLN02233 103 GLDFSSEQLAVAASRQELKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILD 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75180644  208 LSHVEIPVFKNLYDLYSFQVIPNLGElIAGDRESYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVV 280
Cdd:PLN02233 183 FNKSTQPFTTSMQEWMIDNVVVPVAT-GYGLAKEYEYLKSSINEYLTGEELEKLALEAGFSSAKHYEISGGLM 254
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 88-201 1.13e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 78.76  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    88 LDVAGGTGDVAFRIYDAVYSvkrralqkvdeasleetQIYVCDINPNMLNVGKQRAAERGLRdnksLVWVEGDAEALSFD 167
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGA-----------------RVTGVDLSPEMLERARERAAEAGLN----VEFVQGDAEDLPFP 60

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 75180644   168 DNSMDGYTIAFGIRNVTH--IEKALAEAYRVLKRGG 201
Cdd:pfam13649  61 DGSFDLVVSSGVLHHLPDpdLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-205 9.83e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 71.16  E-value: 9.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    88 LDVAGGTGDVAFRIYDAVYsvkrralqkvdeasleetQIYVCDINPNMLNVGKQRAAERGLRdnkslvWVEGDAEALSFD 167
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA------------------RVTGVDISPEMLELAREKAPREGLT------FVVGDAEDLPFP 56

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 75180644   168 DNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFLC 205
Cdd:pfam08241  57 DNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 130-281 7.58e-13

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 65.10  E-value: 7.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  130 DINPNMLNVGKQRAAERGLRDNKSLVWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFLCLELS 209
Cdd:PLN02232   4 DFSSEQLAVAATRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILDFN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75180644  210 HVEIPVFKNLYDLYSFQVIPNLGELIAGDREsYQYLVESVRRFPPQERFASMIADAGFEKVEYENLVGGVVA 281
Cdd:PLN02232  84 KSNQSVTTFMQGWMIDNVVVPVATVYDLAKE-YEYLKYSINGYLTGEELETLALEAGFSSACHYEISGGFMG 154
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 68-204 1.27e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 63.50  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  68 HRLWKERLVGKLSPF--AGMKHLDVAGGTGDVAFRIYDAVYSVkrralqkvdeasleetqiYVCDINPNMLNVGKQRAAE 145
Cdd:COG2227   7 RDFWDRRLAALLARLlpAGGRVLDVGCGTGRLALALARRGADV------------------TGVDISPEALEIARERAAE 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 75180644 146 RGLRdnkslvWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFL 204
Cdd:COG2227  69 LNVD------FVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLL 121
PRK08317 PRK08317
hypothetical protein; Provisional
 72-207 3.24e-12

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 64.96  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   72 KERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVYSvkrralqkvdeasleETQIYVCDINPNMLNVGKQRAAERGLRdn 151
Cdd:PRK08317   8 RARTFELLAVQPGDRVLDVGCGPGNDARELARRVGP---------------EGRVVGIDRSEAMLALAKERAAGLGPN-- 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 75180644  152 ksLVWVEGDAEALSFDDNSMDgytIAFGIRNVTHIE---KALAEAYRVLKRGGRFLCLE 207
Cdd:PRK08317  71 --VEFVRGDADGLPFPDGSFD---AVRSDRVLQHLEdpaRALAEIARVLRPGGRVVVLD 124
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 86-205 2.39e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 53.97  E-value: 2.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  86 KHLDVAGGTGDVAFRIydavysvkrralqkvdeASLEETQIYVCDINPNMLNVGKQRAAERGlrdNKSLVWVEGDAEALS 165
Cdd:cd02440   1 RVLDLGCGTGALALAL-----------------ASGPGARVTGVDISPVALELARKAAAALL---ADNVEVLKGDAEELP 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 75180644 166 FD-DNSMDG-YTIAFGIRNVTHIEKALAEAYRVLKRGGRFLC 205
Cdd:cd02440  61 PEaDESFDViISDPPLHHLVEDLARFLEEARRLLKPGGVLVL 102
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-203 1.37e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 51.60  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    88 LDVAGGTGDVAFRIydavysvkrralqkvdEASLEETQIYVCDINPNMLNVGKQRAAERGLRDNKSLVWVEGDAEAL--- 164
Cdd:pfam08242   1 LEIGCGTGTLLRAL----------------LEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELdpg 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 75180644   165 SFDdnsmdgYTIAFG-IRNVTHIEKALAEAYRVLKRGGRF 203
Cdd:pfam08242  65 SFD------VVVASNvLHHLADPRAVLRNIRRLLKPGGVL 98
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
40-204 6.32e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.54  E-value: 6.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  40 EKSKLVGNVFTNVASSYD-IMNDVMSGGLHRLWKERLVGKLSPFAGMKHLDVAGGTGDVAFRIYDAVYSvkrralqkvde 118
Cdd:COG4976   2 ALDAYVEALFDQYADSYDaALVEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR----------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644 119 asleetqIYVCDINPNMLNvgkqRAAERGLRDNkslvWVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLK 198
Cdd:COG4976  71 -------LTGVDLSEEMLA----KAREKGVYDR----LLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALK 135


                ....*.
gi 75180644 199 RGGRFL 204
Cdd:COG4976 136 PGGLFI 141
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 85-202 1.80e-07

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 51.43  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   85 MKHLDVAGGTGdvaFRIYDAVYSVKRRALQKVDEAsleetqiyvcdinPNMLNVGKQRAAERGLRdnkslvWVEGDAEAL 164
Cdd:PLN02490 115 LKVVDVGGGTG---FTTLGIVKHVDAKNVTILDQS-------------PHQLAKAKQKEPLKECK------IIEGDAEDL 172

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 75180644  165 SFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGR 202
Cdd:PLN02490 173 PFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGK 210
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 83-207 4.05e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.57  E-value: 4.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644    83 AGMKHLDVAGGTGDVAFRIYDAVYsvkrralqkvdeaslEETQIYVCDINPNMLNVGKQRAAERGLrdnKSLVWVEGDAE 162
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELG---------------PNAEVVGIDISEEAIEKARENAQKLGF---DNVEFEQGDIE 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 75180644   163 AL--SFDDNSMDgYTIAFGIRN-VTHIEKALAEAYRVLKRGGRFLCLE 207
Cdd:pfam13847  65 ELpeLLEDDKFD-VVISNCVLNhIPDPDKVLQEILRVLKPGGRLIISD 111
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 73-204 2.09e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 46.85  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  73 ERLVGKLSPFAGMKHLDVAGGTGdvafriYDAVYSVKRRALQkvdeasleetqIYVCDINPNMLNVGKQRAAERGLRDNk 152
Cdd:COG2230  41 DLILRKLGLKPGMRVLDIGCGWG------GLALYLARRYGVR-----------VTGVTLSPEQLEYARERAAEAGLADR- 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 75180644 153 sLVWVEGDAEALSFDdNSMD-----GYTIAFGIRNvthIEKALAEAYRVLKRGGRFL 204
Cdd:COG2230 103 -VEVRLADYRDLPAD-GQFDaivsiGMFEHVGPEN---YPAYFAKVARLLKPGGRLL 154
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 129-202 2.55e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 43.78  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644 129 CDINPNMLNVGKQRAAERGLRDNKSLVwveGDAEALSFDDNSMDG------YTIAFGI--RNVTHI-EKALAEAYRVLKR 199
Cdd:COG1041  54 SDIDPKMVEGARENLEHYGYEDADVIR---GDARDLPLADESVDAivtdppYGRSSKIsgEELLELyEKALEEAARVLKP 130


                ...
gi 75180644 200 GGR 202
Cdd:COG1041 131 GGR 133
PRK05785 PRK05785
hypothetical protein; Provisional
 48-262 4.69e-05

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 43.52  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   48 VFTNVASSYDIMNDVMSGGLHRLWKERLVGKLSPFAG--MKHLDVAGGTGDVAfriydavysvkrRALQKVDEAsleetQ 125
Cdd:PRK05785  14 AYNKIPKAYDRANRFISFNQDVRWRAELVKTILKYCGrpKKVLDVAAGKGELS------------YHFKKVFKY-----Y 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  126 IYVCDINPNMLNVGKqraaergLRDNKslvwVEGDAEALSFDDNSMDGYTIAFGIRNVTHIEKALAEAYRVLKRGGRFlc 205
Cdd:PRK05785  77 VVALDYAENMLKMNL-------VADDK----VVGSFEALPFRDKSFDVVMSSFALHASDNIEKVIAEFTRVSRKQVGF-- 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 75180644  206 LELSHVEIPVFKNLYDLYSFQVIPNLGELIAGDRESYQYLVESVRRFPPQERFASMI 262
Cdd:PRK05785 144 IAMGKPDNVIKRKYLSFYLRYIMPYIACLAGAKCRDYKYIYYIYERLPTNSFHREIF 200
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 78-202 9.66e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 42.48  E-value: 9.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644   78 KLSPFAGMKHLDVAGGTGDVafriydavySVkrralqkvdEASL---EETQIYVCDINPNMLNVGKQRAAERGLRDNksL 154
Cdd:PRK00377  35 KLRLRKGDMILDIGCGTGSV---------TV---------EASLlvgETGKVYAVDKDEKAINLTRRNAEKFGVLNN--I 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 75180644  155 VWVEGDA-EALSFDDNSMDGYTIAFGIRNVTHIEKAlaeAYRVLKRGGR 202
Cdd:PRK00377  95 VLIKGEApEILFTINEKFDRIFIGGGSEKLKEIISA---SWEIIKKGGR 140
arsM PRK11873
arsenite methyltransferase;
130-203 1.81e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 42.24  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  130 DINPNMLNVGKQRAAERGLrDNkslvwVE---GDAEALSFDDNSMDgyTIafgIRN-----VTHIEKALAEAYRVLKRGG 201
Cdd:PRK11873 109 DMTPEMLAKARANARKAGY-TN-----VEfrlGEIEALPVADNSVD--VI---ISNcvinlSPDKERVFKEAFRVLKPGG 177


                 ..
gi 75180644  202 RF 203
Cdd:PRK11873 178 RF 179
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 88-204 2.04e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.44  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  88 LDVAGGTGDVAFRIydavysvkrralqkvdeASLEETQIYVCDINPNMLNVGKQRAAERGLrdnKSLVWVEGD-AEALSF 166
Cdd:COG0500  31 LDLGCGTGRNLLAL-----------------AARFGGRVIGIDLSPEAIALARARAAKAGL---GNVEFLVADlAELDPL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 75180644 167 DDNSMDgYTIAFGIrnVTHI-----EKALAEAYRVLKRGGRFL 204
Cdd:COG0500  91 PAESFD-LVVAFGV--LHHLppeerEALLRELARALKPGGVLL 130
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
72-202 2.05e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 39.12  E-value: 2.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  72 KERLVGKLSpfaGMKHLDVAGGTGdvafriYDAVYSVKRRAlqkvdeasleeTQIYVCDINPNMLNVGKQRAAERGLRDN 151
Cdd:COG2521 124 KVKLVGVRR---GDRVLDTCTGLG------YTAIEALKRGA-----------REVITVEKDPNVLELAELNPWSRELANE 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75180644 152 KsLVWVEGDAEAL--SFDDNSMDG--------------YTIAFgirnvthiekaLAEAYRVLKRGGR 202
Cdd:COG2521 184 R-IKIILGDASEVikTFPDESFDAiihdpprfslagelYSLEF-----------YRELYRVLKPGGR 238
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
118-204 6.65e-03

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 37.93  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75180644  118 EASLEETQIYVCDINPNMLNVGKQRAAerglRDNKSLVWVEGDAEAL--SFDDNSMDgyTIAF--------------GIR 181
Cdd:PRK06922 437 EEETEDKRIYGIDISENVIDTLKKKKQ----NEGRSWNVIKGDAINLssSFEKESVD--TIVYssilhelfsyieyeGKK 510

                         90       100
                 ....*....|....*....|....
gi 75180644  182 -NVTHIEKALAEAYRVLKRGGRFL 204
Cdd:PRK06922 511 fNHEVIKKGLQSAYEVLKPGGRII 534
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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