|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
17-486 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 810.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 17 APRRFALPVDAENKATTFRLFSVAKPHMRAFHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFA 96
Cdd:PLN00028 8 KYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 97 RIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAGFSLATFVSTQFWMSSMFSGPVVGSANGIAAGW 176
Cdd:PLN00028 88 RLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAAGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 177 GNLGGGATQLIMPIVFSLIRNMGATKFTAWRIAFFIPGLFQTLSAFAVLLFGQDLPDGDYWAMHKSGEREKDDVGKVISN 256
Cdd:PLN00028 168 GNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTMPKDSFSKVLRY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 257 GIKNYRGWITALAYGYCFGVELTIDNIIAEYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRFGMRGRLWA 336
Cdd:PLN00028 248 GVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFGMRGRLWA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 337 WWIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFVQAACGLTFGVVPFISRRSLGVVSGMTGAGGNVGAVLTQLIFFKGS 416
Cdd:PLN00028 328 LWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQLLFFTGS 407
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 417 TYTRETGITLMGVMSIACSLPICLIYFPQWGGMFCGPsSKKVTEEDYYLAEWNDEEKEKNLHIGSQKFAE 486
Cdd:PLN00028 408 SYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGP-SKDAVEEDYYASEWTEEEKEKGLHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-440 |
2.23e-129 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 381.21 E-value: 2.23e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 47 FHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRL-ASAALTLSTAPAVY 125
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRvFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 126 FTAGIKSPIGFIMVRFFAGFSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIRnmGATKFTA 205
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIV--FDGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 206 WRIAFFIPGLFQTLSAFAVLLFGQDLPDGDYWAMHksgerekddVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIA 285
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE---------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 286 EYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDfmsrRFGMRGRLWAWWIVQTSGGVLCACLGQISS--LTVSIIV 363
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGRRRLWWLFIVMTIGAALLSLSLPTSGtnLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75264143 364 MLVFSVFVQAACGLTFGVVPFISRRSLGVVSGMTGAGGNVGAVLTQLIFFKGS--TYTRETGITLMGVMSIACSLPICL 440
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSAlmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
45-405 |
3.55e-83 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 261.47 E-value: 3.55e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 45 RAFHLSWFQFFCCFVSTFAAPPLLPV-IRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTA-P 122
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAiP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 123 AVYFTAGIKSPIGFIMVRFFAGFSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMP-IVFSLIRNMGAT 201
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpIIGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 202 KFTAWRIAF-FIPGLFQTLSAFAVLLFGQDLPdgdywaMHKSGEREKDDVGKVisNGIKNYRGWITALAYGYCFGVELTI 280
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTP------PGKPATGKLSFKEAL--KVFGNRHTWILALLYSVTFGSFLGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 281 DNIIAEYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRfgmrgRLWAWWIVQTSGGVLCACLGQIS--SLT 358
Cdd:TIGR00886 233 SSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGA-----RKLLMNFLGVAMGAFLVVLGLVSdgSLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 75264143 359 VSIIVMLVFSVFVQAACGLTFGVVPFISRRSLGVVSGMTGAGGNVGA 405
Cdd:TIGR00886 308 AFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-434 |
1.04e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 180.46 E-value: 1.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 41 KPHMRAFHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLST 120
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 121 APAVYFTAGIKSPIGFIMVRFFAGFSL-ATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmg 199
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 200 atkftAWRIAFFIPGLFQTLSAFAVLLFGQDLPDGDyWAMHKSGEREKDDVgkvisngIKNYRGWITALAYGYCFGVELT 279
Cdd:COG2223 157 -----GWRNAFLILGILLLVVAVLAWLFLRDPPAGA-AAAAKASLRDQLEA-------LRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 280 IDNIIAEYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDfmsrRFGmrGRLWAWWIVQTSGGVLCACLGQISSLTV 359
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RIG--GRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75264143 360 SIIVMLVFSVFVQAACGLTFGVVPFI-SRRSLGVVSGMTGAGGNVGAVLTQLIF--FKGSTYTRETGITLMGVMSIAC 434
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFgaLLDATGSYTAAFLVFAVLALVA 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-412 |
3.62e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.94 E-value: 3.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 41 KPHMRAFHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLST 120
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 121 APAVYFTAGIKSPIGFIMVRFFAGFSLA-TFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmg 199
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 200 atkftAWRIAFFIPGLFQTLSAFAVLlfgqdlpdgdywamhksgerekddvgkvisngiknyrgWITALAYGYCFGVELT 279
Cdd:COG2271 162 -----GWRAAFLILGLPGLLLALLRF--------------------------------------WLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 280 IDNIIAEYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRfgmrgRLWAWWIVQTSGGVLCACLGQISSLTV 359
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 75264143 360 SIIVMLVFSVFVQAACGLTFGVVP-FISRRSLGVVSGMTGAGGNVGAVLTQLIF 412
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLV 327
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
51-443 |
1.86e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 51 WFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGI 130
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 131 KSPIGFIMVRFFAGFSLA-TFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmgatkFTAWRIA 209
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-------GFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 210 FFIPGLFQTLSAFAVLLFGQDLPDGDYwamHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFF 289
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESAR---AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 290 DRFHLKLQTAGIIAASFGLANFFARPGGGIFSDFmsrrfgMRGRLWAWWIVQTSGGVLCACLGQISSLTVSIIVMLVFSV 369
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR------LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75264143 370 FVQAACGLTFGVVPFI-SRRSLGVVSGMTGAGGNVGAVLTQLIFfkGSTYTRETGITLMGVMSIACSLPICLIYF 443
Cdd:cd06174 306 GLGGLLPLSFALIAELfPPEIRGTAFGLLNTFGFLGGAIGPLLA--GFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-407 |
7.28e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.86 E-value: 7.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 55 FCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPI 134
Cdd:COG2814 20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 135 GFIMVRFFAGFSLATFVST-QFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmgatkftAWRIAFFIP 213
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAaLALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 214 GLFQTLSAFAVLLFgqdlpdgdywaMHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFFDRFH 293
Cdd:COG2814 171 AVLALLALLLLLRL-----------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 294 LKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRFGMRGRLWAwwivqtsGGVLCACLGQISSLTVSIIVMLVFSVFVQA 373
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL-------LALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*
gi 75264143 374 ACGLTFGVVP-FISRRSLGVVSGMTGAGGNVGAVL 407
Cdd:COG2814 313 LFPLLQALVAeLAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
53-407 |
4.38e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 4.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 53 QFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKS 132
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 133 PIGFIMVRFFAGFSLA-TFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIRnmgatkftaWRIAFF 211
Cdd:pfam07690 85 LWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---------WRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 212 IPGLFqTLSAFAVLLFGQDLPDgdywaMHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFFDR 291
Cdd:pfam07690 156 ILAIL-SLLAAVLLLLPRPPPE-----SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 292 FHLKLQTAGIIAASFGLANFFARPGGGIFSDfmsrRFGMRGRLWAWWIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFV 371
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305
|
330 340 350
....*....|....*....|....*....|....*..
gi 75264143 372 QAACGLTFGVVP-FISRRSLGVVSGMTGAGGNVGAVL 407
Cdd:pfam07690 306 GLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-433 |
2.69e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.82 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 62 FAAPPllpvIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRF 141
Cdd:cd17319 24 VAAPT----IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 142 FAGFSLATFVSTQFWMSSM-FSGPVVGSANGIAAGWGNLGGGatqLIMPIVFSLIRNMGatkftaWRIAFFIPGLFQTLS 220
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEwFPARERGRATGLFNSGAPLGAA---IGPPLSGWLLLLFG------WRWAFIIEGLLGLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 221 AFAVLLFgqdlpdgdYWAMhksgerekddvgkvisngiknyrgWITALAYgYCFGVELTIDNI-IAEYFFDRFHLKLQTA 299
Cdd:cd17319 171 AVLWWFY--------LRQV------------------------WGLALGY-FGINYALYGLLTwLPTYLKQARGFSLKQV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 300 GIIAASFGLANFFARPGGGIFSDFMSRrfgmRGRLWAWWIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFVQAACGLTF 379
Cdd:cd17319 218 GLLAAIPFLAGAIGMILGGRLSDRLLR----GARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 75264143 380 GVVP-FISRRSLGVVSGMTGAGGNVGAVLTQLI--FFKGSTYTRETGITLMGVMSIA 433
Cdd:cd17319 294 SLPAdLLPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAVALL 350
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-412 |
9.82e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.25 E-value: 9.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 50 SWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAG 129
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 130 IKSPIGFIMVRFFAGFSLATFV-STQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSlirNMGatkftaWRI 208
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLAL---HYG------WRA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 209 AFFIPGLFQTLSAFAVLLFGQDLPDGDYWAMHKSGEREKddvgkvISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYF 288
Cdd:cd17475 152 AFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRS------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 289 FDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDfmsRRFGMRGRLWAWWIVQTSGGVLcACLGQISSLTVSIIVMLVFS 368
Cdd:cd17475 226 HDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGRRRPVLVITAAIAAAAL-LVLSLLSPGTPLWLLVLLLI 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 75264143 369 VFVQAACG-----LTFgVVPFISRRSLGVVSGMTGAGGNVGAVLTQLIF 412
Cdd:cd17475 302 LLGLFAIGwnglyLTL-VAESAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-411 |
5.51e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.86 E-value: 5.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 41 KPHMRAFHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLST 120
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 121 APAVYFTAGIKSPIGFIMVRFFAGFSLATF-VSTQFWMSSMfsGPVVGSAN-GIAAGWGNLGGgatqLIMPIVFSLIRNM 198
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAAL--GPETAASRlNLLHAFFSLGA----LLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 199 GATkfTAWRIAFFIPGLFQTLsaFAVLLFGQDLPDgdywamHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVEL 278
Cdd:COG0738 158 GLS--LSWHLPYLILAVLLLL--LALLFLRSKLPE------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 279 TIDNIIAEYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRFGMRgrlwawwIVQTSGGVLCACLGQISSLT 358
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR-------LSALLAAVGLLLALLAPGPW 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 75264143 359 VSIIVMLVFSVFVQAACGLTFGVVP-FISRRSLGVVSGMTGAGGNVGAVLTQLI 411
Cdd:COG0738 301 LALIGLALVGLGLSLMFPTIFSLALdGLGKRTAAAVSAVLIMGIVGGAIGPPLI 354
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
53-432 |
3.83e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 53 QFFCCFVSTFAAPPLLPVIRENLNLTATDIGNA-GIASVSGAVFaRIVMGTACDLFGPR--------LASAALTLSTAPA 123
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLIlLVARLWDAIT-DPLIGALSDRTRTRwgrrrpwiLIGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 124 VYFTAGIKSPIGFIMvrFFAGFSLATFVSTQF------WMSSMFSGPVV-GSANGIAAGWGNLGGGATQLIMPIvfsLIR 196
Cdd:COG2211 98 LFTAPDLSPTGKLIY--ALVTYLLLGLAYTLVnipysaLGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPP---LVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 197 NMGATKFTAWRIAFFIPGLFQTLSAFAVLLFGQDLPdgdywamhkSGEREKDDVGKVISNGIKNyRGWITALAYGYCFGV 276
Cdd:COG2211 173 AFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP---------VPEEEKVSLKESLKALLKN-RPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 277 ELTIDNIIAEYFF-DRFHLKLQTAGIIAASFGLANFFarpgGGIFSDFMSRRFGMRgRLWAWWIVQTSGGVLCACLGQIS 355
Cdd:COG2211 243 ALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALL----GAPLWPRLAKRFGKK-KAFIIGLLLAALGLLLLFFLGPG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 356 SLTVSIIVMLVFSVFVQAACGLTFGVVP-----------------FISRRSLGVVSGMTGAGGNVGAVLTQLIFFKGSTY 418
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWAMLAdvvdydewktgrrreglYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQ 397
|
410
....*....|....
gi 75264143 419 TRETGITLMGVMSI 432
Cdd:COG2211 398 SPSALTGIRLLFFL 411
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
54-374 |
4.01e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.17 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 54 FFCCFV---STFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR----LASAALTLSTApavyF 126
Cdd:cd17324 5 ALAAFAigtTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRrlllVLLLLFILGNL----L 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 127 TAGIKSPIGFIMVRFFAGFSLATFVSTQF-WMSSMFSGPVVGSANGIAAGwGNLGGGATQLIMPIVFSlirnmgatKFTA 205
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLVLGRPLGGLLG--------QLLG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 206 WRIAFFIPGLFQTLSAFAVLLFgqdLPDgdywamHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIA 285
Cdd:cd17324 152 WRAAFLAIAVLALLAALLLWRL---LPS------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 286 EYFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDfmsrRFGMRGRLWAWWIVQTSGGVLCACLGQISSLTVSIIVML 365
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG 298
|
....*....
gi 75264143 366 VFSVFVQAA 374
Cdd:cd17324 299 LGFFAAHSA 307
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
51-429 |
5.07e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 51 WFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR--LASAALTLSTAPAVYFTA 128
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 129 gikSPIGFIMVR-FFAGFSLATFVStqfwMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmgATKFTAWR 207
Cdd:cd17333 82 ---PSIYLFVVLmFLAGLGAGILDT----GANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSL----LTSELSWS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 208 IAFFIPGLFQTLSAFAVLLFgqDLPDGDYWAMHKSGEREKDDVGKvisnGIKNYRGWITALAYGYCF-GVELTIDNIIAE 286
Cdd:cd17333 151 WAYLIIGLIYLLLAILILLT--LFPELPSARNPQQSVGAFSASAS----RLLRNPSIILGALALFLYvGAETAFSSWVPS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 287 YFFDRFHLKLQTAGIIAASFglanFFARPGGGIFSDFMSRRFGMRgrlwawwiVQTSGGVLCACLGQISSLTVSIIVMLV 366
Cdd:cd17333 225 YLVEKKHVSDGLAGYLLSGF----WVGITIGRLLGGPISRRIKPH--------TLLVLSGSGALLGLLILLLAPTLVVGL 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75264143 367 FSVF---------VQAACGLTFGVVPFISRRSLGVVSGMTGAGGNVGAVLTQLIFFKGSTYTRETGITLMGV 429
Cdd:cd17333 293 VATAllglfmaalFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
95-444 |
8.26e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.12 E-value: 8.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 95 FARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAGFSlatfvstqfwMSSMFSGPVVGSAN---- 170
Cdd:cd17355 53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGG----------GAGTLAAVAFATVAawwf 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 171 ----GIAAGWGNLGGGATQLIM-PIVFSLIRNMGatkftaWRIAFFIPGLFQTLSAFAVLLFGQDLP-DGDYWAMHKSGE 244
Cdd:cd17355 123 errrGLALGILTAGGGLGSLVFlPLGAALIEAFG------WRTALLVLALLALLVLVPVLLLLRRRPaDLALRAYDDASP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 245 REkddVGKVISNGIKNYRGWITALAYGYC-FGVELTIDNIIAeyFFDRFHLKLQTAGIIAASFGLANFFARPGGGIFSDf 323
Cdd:cd17355 197 AS---PGSTLKEALRSASFWLLALAFFLCgFAVVGLIVHLVP--YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 324 msrrfgmrgRLWAWWIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFVQAACGLT-----FGVVPFISRRSLGVVSGMTG 398
Cdd:cd17355 271 ---------RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATvpltaALAARYFGARSYGTLFGLVF 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 75264143 399 AGGNVGAVLTQLIFfkGSTYTRETGITLMGVMSIACSLPICLIYFP 444
Cdd:cd17355 342 APHQLGSALGPWLG--GLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
65-439 |
8.27e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 8.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 65 PPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAG 144
Cdd:cd17478 16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 145 FSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIRNMGATkftawriAFFIPGLFQTLSAFAV 224
Cdd:cd17478 96 IGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLL-------ILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 225 LLFGQDLPDGDYWAMHKSGEREKDDVGKVIS-NGIKNYRGWITAlaygycfgvelTIDNIIAEYFFDRFhLKLQTAGIIA 303
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGVWRALLLlLIIVFLRSWVLS-----------SLTTFLPFYLVQRG-YSLVFAGLLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 304 ASFGLANFFARPGGGIFSDFMSRRFGMrgrlwawwIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFVQAACGLTFGVVP 383
Cdd:cd17478 237 SLFLFAGAIGTLIGGPLSDRFGRRRVI--------IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 75264143 384 FISRRSLGVVSGMT-GAGGNVGAVLTQLIFFKGSTYTRETGITLMGVMSIACSLPIC 439
Cdd:cd17478 309 ELLPGNVGLASGLMmGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-228 |
1.74e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.25 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 49 LSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR--LASAALTLSTAPAVYF 126
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 127 TAGIKSPIGFIMVRFFAGFSLATFVSTQF-WMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLirnmgatkfTA 205
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA---------TG 335
|
170 180
....*....|....*....|...
gi 75264143 206 WRIAFFIPGLFQTLSAFAVLLFG 228
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
54-407 |
6.61e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.34 E-value: 6.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 54 FFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR--LASAALTLSTAPAVYFTAgiK 131
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKrlLLLGLLLLAVSTLLFAFA--T 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 132 SPIGFIMVRFFAGFSLA-TFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGgatqLIMPIVFSLIrnmgaTKFTAWRIAF 210
Cdd:cd17325 83 SYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGF----LIGPLLGGLL-----ADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 211 FIPGLFQTLSAFAVLLFGQDLPdgdywAMHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFFD 290
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPR-----PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 291 RFHLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRfgmrgrlwawwIVQTSGGVLCACLGQISSLTVSIIVMLVFSVF 370
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-----------PLILIGLLLSAVALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 75264143 371 VQAACGLTFG-----VVPFISRRSLGVVSGMTGAGGNVGAVL 407
Cdd:cd17325 298 LGLGLGLVFPatlalLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
67-412 |
8.88e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.76 E-value: 8.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 67 LLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR-LASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAGF 145
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRvFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 146 SLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGatqlIMPIVFSLIRNMgatkFTAWRIAFFIPGLFQTLSAFAVL 225
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGG----LLPPLVLFGIAE----LYSWHWVFIVPGIIAIIVSLICF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 226 LFGQDLP-------DGDYWAMHKSGEREKDDVGKVISNG-----IKNYRGWITALAYGYCFGVELTIDNIIAEYFFDRFH 293
Cdd:TIGR00881 169 LLLRDSPqscglppAEEMPNEEPDGDAEKKEEELTKKQIflqyvLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 294 LKLQTAGIIAASFGLANFFARPGGGIFSD--FMSRRFGMrgrlwawwivqtsgGVLCACLgqissLTVSIIVMLVF---S 368
Cdd:TIGR00881 249 FSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPL--------------AVFFMAL-----IIVSLLVYWLNpaaN 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 75264143 369 VFVQAACGLTFG-------------VVPFISRRSLGVVSGMTGAGGNVGAVLTQLIF 412
Cdd:TIGR00881 310 PLMDLICLFALGflvygpqmligviASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-183 |
2.11e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 17 APRRFALPVDAENKATTFRLFSVAKPHMRAFHLSWFQFFCCFVSTFAAPPLLPVI-RENLNLTATDIGNAGIASVSGAVF 95
Cdd:COG2814 179 LLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYlQEVLGLSASAAGLLLALFGLGGVL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 96 ARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAGFSL-ATFVSTQFWMSSMFSGPVVGSANGIAA 174
Cdd:COG2814 259 GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFgLLFPLLQALVAELAPPEARGRASGLYN 338
|
....*....
gi 75264143 175 GWGNLGGGA 183
Cdd:COG2814 339 SAFFLGGPL 347
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
43-412 |
2.91e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.03 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 43 HMRAFHLSWFQFFCCFVSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR-LASAALTLSTA 121
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRrFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 122 PAVYFTAGIKSPIGFIMVRFFAGFSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGatqLIMPIVFSLIRNMGat 201
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGI---LAPILAASLASYYG-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 202 kftaWRIAFFIPGLFQTLSAFAVLLFGQDLPdgdywamhksgerekddvgKVIsngiknyrgWITALAYGYCFGVELTID 281
Cdd:cd17312 156 ----WRAAFLVPGIVGLVVAIILFFFLRDSP-------------------PYV---------WVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 282 NIIAEYFFDRFHLKLQTAGIIAASFGLANFFarpgGGIFSDFMSRRFGMRGRLwawwivqtSGGVLCACLGQIS------ 355
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIA----GTILAGLLSDKLFGGRRA--------PIAVIYMLLMTLSlalfwf 271
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75264143 356 ---SLTVSIIVMLVFSVFVQAACGLTFGVVP--FISRRSLGVVSGMTGAGGNVGAVLTQLIF 412
Cdd:cd17312 272 fphNKLLSIVLLFLIGFFVGGPINLIGGAAAqdIGRKEAAGTATGFVGLFGYLGASLAGLPL 333
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
67-438 |
7.26e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.83 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 67 LLPVIRENLNLTATDIGNA-GIASVSGAVFArIVMGTACDLFGPRLASAALTLSTAPAVYFTA-GIKSPIGFIMVRFFAG 144
Cdd:cd17353 25 FNPPLSSALGWSLASVALAfTLTIVFLAISA-PFAGRLVDRGGPRKAILIGGILFGLGFILSAfAISLPLLFLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 145 FSLATfvstqfwmssMFSGPV----------VGSANGIAAGwgNLGGGATqLIMPIVFSLIRNMGATKftawriAFFIPG 214
Cdd:cd17353 104 IGAGI----------GYITPVstavkwfpdkRGLATGIVIA--GFGLGSL-IFSPLIAYLINTVGVPT------TFLILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 215 LFQTLSAFAVLLFGQDLPDGDYWAMHKS--GEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFFDRF 292
Cdd:cd17353 165 IIFLIIIVIGAFLIRDPPKGWVPPGVDPlaNNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 293 HLKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRFGMRgrlwawwIVQTSGGVLCACLgqisSLTVSIIVMLVFSVFVQ 372
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS-------IAFLIQGVAMFLL----PFIGSVAVLFVLGVALI 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75264143 373 AAC-GLTFGVVPFISR-----RSLGVVSGM----TGAGGNVGAVLTQLIFFKGSTYTRETGITLMGVMSIACSLPI 438
Cdd:cd17353 314 GFCyGGGFALFPALTAdffgtKNAGTNYGLlytaKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
107-436 |
8.65e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.85 E-value: 8.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 107 FGPRLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAG-FSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQ 185
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGlFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 186 LimpIVFSLIRNMGATKFTAWRIAFFIPGLFQTLSAFAVLLFGQDLPDGDYW--------------AMHKSGEREKDDVg 251
Cdd:cd17327 148 L---LAYGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFlteeekelaverlrANQTGKGDQKFKW- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 252 KVISNGIKNYRGWITALAYGYCFGVELTIDN----IIAEYFFDRFHLKLQTAGIiaASFGLANFfarpgggIFSDFMSRR 327
Cdd:cd17327 224 KQIKEAFKDPRTWLLFLFFFCSQITNNGISNflplILKSLGFYSLQTNLLSVPI--GALGAVSL-------LIAALLSDR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 328 FGMRGRLWAWWIVQTSGGvlCACLGQISSLTVSIIVMLVFSVFVQAACGLTFGVVPFISR--RSLGVVSGMTGAGGNVGA 405
Cdd:cd17327 295 FKKRGLFAIFACVLALVG--SIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAgyTKRATVLAIMLIFYNVGN 372
|
330 340 350
....*....|....*....|....*....|.
gi 75264143 406 VLTQLIFFKGSTYTRETGITLMGVMSIACSL 436
Cdd:cd17327 373 IVAPQIFRAGDAPRYIPGNIALLVCACVSIV 403
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-412 |
1.03e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 63 AAPPLLPVIRENLNLTATDIG-NAGIASVSGAVFArIVMGTACDLFGPR----LASAALTLSTAPAVYFTagikSPIGFI 137
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGlLTTLPLLAFGLFA-PLAPRLARRFGLErtllLALLLLAAGLLLRSLAP----SVALLL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 138 MVRFFAGFSLA-TFVSTQFWMSSMFSGpVVGSANGIAAGWGNLGGGATQLIMPIVFSLirnmgatkfTAWRIAFFIPGLF 216
Cdd:COG2807 111 AGTALIGAGIAvGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAA---------LGWRGALAVWALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 217 QTLSAFAVLLFgqdlpdgdywAMHKSGEREKDDVGKVISNGIKNYRGWITALAYGYCFGVELTIDNIIAEYFFDRfHLKL 296
Cdd:COG2807 181 ALLALLLWLPL----------LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 297 QTAGIIAASFGLANFFARPGGGIFSDFMSRRfgmrgRLWAWwivqtsGGVLCACLGQISSLTVSIIVMLVFSVFVQAACG 376
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-----RPLLL------LLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 75264143 377 LTFGVVP-FISRRS-----LGVVSGMTGAGGNVGAVLTQLIF 412
Cdd:COG2807 319 GLFPLALtLIGLRArtpaeAAALSGMAQSVGYLLAALGPLLV 360
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
265-443 |
1.13e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.48 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 265 ITALAYGYCFGV----ELTIDNIIAEYFFDRFHLKLQTA------GIIAASFGLANFFARPGGGIFSDFMSRRFGMrgrl 334
Cdd:cd17357 7 GGSFQFGYNIGVvnapQEVFKEFINDTLVDRYGLNLSDSeldllwSLIVSIFFIGGAIGSFISAFLANRFGRKNGL---- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 335 wawwIVQTSGGVLCACLGQISSLTVSIIvMLVFSVFVQA-ACGLTFGVVPF----ISRRSL-GVVSGMTGAGGNVGAVLT 408
Cdd:cd17357 83 ----LISNALLVVSSLLMFLSKSAKSPE-LLIFGRFLVGiACGLSTGFVPMylqeISPSELrGALGSLTQIGVTLGILLG 157
|
170 180 190
....*....|....*....|....*....|....*
gi 75264143 409 QLIFFKGSTYTRETGITLMGVMSIACSLPICLIYF 443
Cdd:cd17357 158 QVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPF 192
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
49-212 |
1.26e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 49 LSWFQFFCCFVSTFAAPPLLPVI-RENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPR--LASAALTLSTAPAVY 125
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktLVIGLILSGILALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 126 FTAGIKSPIGFIMVRF-FAGFSLATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATqliMPIVFSLIRNMGATKFT 204
Cdd:cd17316 261 FYLLSGSPTLLLLLLFiLSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGA---PPLIALLLASTGGTGVP 337
|
....*...
gi 75264143 205 AWRIAFFI 212
Cdd:cd17316 338 ALILALLA 345
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
59-332 |
1.73e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 59 VSTFAAPPLLPVIRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRLASAALTLSTAPAVYFTAGIKSPIGFIM 138
Cdd:cd17477 10 LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 139 VRFFAGFSLAT-FVSTQFWMSSMFSGPVVGSANGIAAgwgnLGGGATQLIMPIVFSLIRNMGATkftawriAFFIPGLFQ 217
Cdd:cd17477 90 LRFVMGIGLAGlFVVSESWLNALATNENRGRVLGLYS----TVLGLGFALGPLLLALVGTAGAL-------PFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 218 TLSAFAVLLFGQDLPDgdywamhkSGEREKDDVGKVISNGIknyrgwiTALAYGYCFGVELTIDNIIAEYFFDRFHLKLQ 297
Cdd:cd17477 159 LLALVPLLLTRRAAPE--------IEEAESISLRRLLRIAP-------LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVA 223
|
250 260 270
....*....|....*....|....*....|....*
gi 75264143 298 TAGIIAASFGLANFFARPGGGIFSDFMSRRFGMRG 332
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
87-194 |
1.93e-03 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 40.64 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 87 IASVSGAVFaRIVMGTACDLFGPR----LASAALTLSTAPAVYFTAGIKSPIG-FIMVRFFAGFSLATFVSTQFWMSSMF 161
Cdd:PRK15034 78 LPSVSGALL-RVPYSFMVPIFGGRrwtvFSTAILIIPCVWLGIAVQNPNTPFGiFIVIALLCGFAGANFASSMGNISFFF 156
|
90 100 110
....*....|....*....|....*....|...
gi 75264143 162 SGPVVGSANGIAAGWGNLGGGATQLIMPIVFSL 194
Cdd:PRK15034 157 PKAKQGSALGINGGLGNLGVSVMQLVAPLVIFV 189
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
71-226 |
4.37e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 71 IRENLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGP---RLASAALTLSTAPAVYFTAGIKSPIGFIMVRFFAGFsL 147
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGF-G 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 148 ATFVSTQFWM--SSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFslirnmgaTKFTAWRIAFFIPGLFQTLSAFAVL 225
Cdd:cd17319 285 IGAASPVFWSlpADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV--------DATGSYTAAFLFLAAVALLAALLVL 356
|
.
gi 75264143 226 L 226
Cdd:cd17319 357 L 357
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
58-440 |
4.66e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 58 FVSTFAAPPLLPVIreNLNLTATDIGNAGIASVSGAVFARIVMGTACDLFGPRlasAALTLSTAPAVYFTAGI---KSPI 134
Cdd:cd17316 16 FLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRK---KALILTLLLFGLATLLIgllPTPI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 135 GFIMVRFFAGFSL-ATFVSTQFWMSSMFSGPVVGSANGIAAGWGNLGGGATQLIMPIVFSLIrnmgaTKFTAWRIAFFIP 213
Cdd:cd17316 91 LLLVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGDWGWRILFLIG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 214 GLFqtlsAFAVLLFgqdlpdgdywamhksgerekddvgkvisngikNYRGWITALAYGYCFGVELTIDNIIAEYFFDRFH 293
Cdd:cd17316 166 ALP----ALLALLL--------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75264143 294 LKLQTAGIIAASFGLANFFARPGGGIFSDFMSRRFGMrgrlwAWWIVQTSGGVLCACLGQISSLTVSIIVMLVFSVFVQA 373
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-----VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75264143 374 ACGLTFGVVP--FISR-RSLGVvsGMTGAGGNVGAVLTQLIFFKGSTYTRETGIT-LMGVMSIACSLPICL 440
Cdd:cd17316 285 VWGALYAYLAelFPTEvRATGV--GLSYNLGRLGGGGAPPLIALLLASTGGTGVPaLILALLAIVALIVAL 353
|
|
| |
