|
Name |
Accession |
Description |
Interval |
E-value |
| LPLAT_DHAPAT-like |
cd07993 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ... |
201-411 |
1.55e-100 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.
Pssm-ID: 153255 [Multi-domain] Cd Length: 205 Bit Score: 309.89 E-value: 1.55e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 201 FWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRL 280
Cdd:cd07993 1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 281 DetpdgrKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRII 360
Cdd:cd07993 81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 59803040 361 EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLE 411
Cdd:cd07993 155 EEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
|
|
| PlsB |
COG2937 |
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ... |
105-656 |
1.81e-77 |
|
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 442180 [Multi-domain] Cd Length: 707 Bit Score: 265.25 E-value: 1.81e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 105 LARRLSYVLFI----QERDV------HKgmfaTNVTENVLNSSRVQEAIAEVAAELN-PDGSAQQQSKavnkvkkkakRI 173
Cdd:COG2937 92 LARKLARVLRVhfrrQRRAVigpdlkHR----RDLIERLLRSPAVRKAIEEEAKSKGiSEEKARKEAR----------RY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 174 LQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHkgQLEMVKAATETNlPLLFLPVHRSHIDYLLLTFILFCHNIKAPYI 253
Cdd:COG2937 158 LREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH-EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHI 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 254 ASGNNLNIPIFSTLIHKLGGFFIRRRLdetpdgRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLS 333
Cdd:COG2937 235 AAGINLNFWPLGPILRRGGAFFIRRSF------KGNKLYSAVFREYLAELFERGYSVEYFIEGGRSRTGRLLPPKTGMLS 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 334 VVVDTLSTNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGvIRMLRKNYGCVRVDFAQPFSLKEYLES 412
Cdd:COG2937 309 MTVQAFLRGARRPVVFVPVYIGYERVLEVGsYAKELRGGEKKKESLGGLLRA-LRKLRRRFGRVYVNFGEPISLSEYLDQ 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 413 QsqkpvsallsleqallpailpsrpsdaADEGRDTSINesrnatDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLL 492
Cdd:COG2937 388 H---------------------------VPDWRESEDL------RPEWLRPAVDKLAFEIMVRINRAAAVNPVNLVALAL 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 493 LYRHRQGIDLSTLVE--DFFV-MKEEVLARDFDLGFSGNSEDVVMHAIQLlgNCVTITHTSRNDEFFITPSTTVpsvfEL 569
Cdd:COG2937 435 LASPKRALTEAELLAqlDLYLdLLRNVPYSLSVTLPELTPEELLEHLLSL--GLIEVEKDGLGDVISIDDEQAV----LL 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 570 NFYSNGVLHVFIMEAIIACslyAVLNKRGlggptstppnlISQEQLVRKAASLCYLLSNEGTISLPcQTFYQVCHETVGK 649
Cdd:COG2937 509 TYYRNNILHLFALPALIAS---ALLANRR-----------ISRAELLELVRLLYPLLKAELFLRWD-AEFEEVLDEELDE 573
|
....*..
gi 59803040 650 FIQYGIL 656
Cdd:COG2937 574 LVRQGLL 580
|
|
| PRK04974 |
PRK04974 |
glycerol-3-phosphate 1-O-acyltransferase PlsB; |
84-661 |
1.31e-44 |
|
glycerol-3-phosphate 1-O-acyltransferase PlsB;
Pssm-ID: 235325 [Multi-domain] Cd Length: 818 Bit Score: 173.11 E-value: 1.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 84 PSLGLRNVIYINETHTRhrgwLARRLSYVL---FIQERDVHKGMFAT---NVTENVLNSSRVQEAIAEVAAELN-PDGSA 156
Cdd:PRK04974 173 PPVSLRYMADEHGTDKR----IARKLARVArvhFRRQRLAAIGPDLPhrqALFNKLLASPAIKKAIEDEAKSKKiSHEKA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 157 QQQSKavnkvkkkakRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHkgQLEMVKAATETNLPLLFLPVHRSHIDY 236
Cdd:PRK04974 249 RQNAI----------AYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH--NAERVRQLAQDGHEIVYVPCHRSHMDY 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 237 LLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRrldeTPDGRKdvLYRALLHGHIVELLRQQQFLEIFLEG 316
Cdd:PRK04974 317 LLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRR----SFKGNK--LYSTVFREYLGELFARGYSVEYFVEG 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 317 TRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARgVIRMLRkNYGC 395
Cdd:PRK04974 391 GRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGtYAKELRGAPKEKESLFQVLR-GIRKLR-NFGQ 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 396 VRVDFAQPFSLKEYLESQSQKpvsallsleqallpailpSRPS-DAADEGRDTSINESRNatdeslrrRLIANLAEHIlf 474
Cdd:PRK04974 469 GYVNFGEPIPLNDYLNQHVPE------------------WRESiDPIEEQRPAWLTPAVN--------NLANQVMVRI-- 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 475 taSKSCAIMSTHIVACLLLYRHRQGIDLSTLVE--DFF--VMKEEVLARDFDLGfSGNSEDVVMHAIQLlgNCVTITHTS 550
Cdd:PRK04974 521 --NNAAAANPVNLCALALLASRQRALDREQLIEqlDLYlqLLRNVPYSSDTTVP-EGSGEELIDHALSL--NKFEVEKDT 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 551 RNDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACslyAVLNKRGlggptstppnlISQEQLVRKAASLCYLLSNEG 630
Cdd:PRK04974 596 LGDIISLDREQAV----LMTYYRNNILHLFVLPSLIAS---IVTHNRR-----------ISRDELLRIVNALYPFLKAEL 657
|
570 580 590
....*....|....*....|....*....|.
gi 59803040 631 TISLPCQTFYQVCHETVGKFIQYGILTVAEH 661
Cdd:PRK04974 658 FLRWDEEELPEVIDQIIDELVRQGLITLDDD 688
|
|
| PTZ00374 |
PTZ00374 |
dihydroxyacetone phosphate acyltransferase; Provisional |
80-587 |
2.08e-44 |
|
dihydroxyacetone phosphate acyltransferase; Provisional
Pssm-ID: 240389 [Multi-domain] Cd Length: 1108 Bit Score: 173.52 E-value: 2.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 80 NPSIPSLGLRNVIYINETHTRHRGWLArrlsyvlfiqerDVHKGMfATNVTENVLNSSRVQEAIAEVAAElnpDGSAQQQ 159
Cdd:PTZ00374 508 TPLLTRKYFDDVVWTQRVGLTANGWRF------------AATPGL-TPESLTSILAQPSIQRLMTALAKK---EGASEKD 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 160 skavnkVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATET-NLPLLFLPVHRSHIDYLL 238
Cdd:PTZ00374 572 ------VEARAKAILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAMpRVAVVLLPLHRSYIDFII 645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 239 LTFILFCHNIKAPYIASGNN-LNIPIFSTLIHKLGGFFIRRRLdetpdgRKDVLYRALLHGHIVELLRQQQFLEIFLEGT 317
Cdd:PTZ00374 646 MTYLLAVMGLPLPHVCAGDDfLRMGPIATLMRGSGAFFMRRSF------RDDPLYAALFKEYVRHLVLRRRPLEFFIEGT 719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 318 RSRSGKTSCARAGLLSVVVDTL--STNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGViRMLRKNYG 394
Cdd:PTZ00374 720 RSRTGKTMAPKLGLLKFICDTFyeGQQELDDVLIIPVSLSYDELLETTlYAKEQLGVSKPKENPGNLLRAR-SLLKRRHG 798
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 395 CVRVDFAQPFSLKEYLESQSQKPvsallsleqallpaiLPSRPSDaadeGRDTSINESRNATDESLRR------RLIANL 468
Cdd:PTZ00374 799 KIHVHIGEPVSLRSFKDHPLQCP---------------LPFEPKG----EATTSVCKTLDTTPSIARKssitppRVLTNI 859
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 469 AEHILFTASKSCAIMSTHIVA-----------CLLLYRHRQGIdlsTLVEDFFVMKEEVLARDfdlGFSGNSEDVVMHAI 537
Cdd:PTZ00374 860 AWHLTHKLQRNTIITPTALVAavleclgptagAMPLAEVQQGM---TWLRTNIRRRGAALSDD---CANLNPETMVRKAL 933
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 59803040 538 QLLGNCVTIthTSRNDEFFITPSTTVpSVFELNFYSNGVLHVFIMEAIIA 587
Cdd:PTZ00374 934 THLQEFVEI--TDEMSEVIYVRQDVV-TRLGVNICSNQLIHVFMDEAVVA 980
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
220-355 |
1.49e-25 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 102.36 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 220 TNLPLLFLPVHRSHIDYLLLTFILFCHNiKAPYIASGNNL-NIPIFSTLIHKLGGFFIRrrldetpdgRKDVLYRALLHG 298
Cdd:pfam01553 12 RGGPAIVVANHQSYLDVLLLSLALYKRG-RPLVFVAKKELfDIPLVGWLMRLLGCIFID---------RKNRKDAAGTLE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 59803040 299 HIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnvipDILIIPVGIS 355
Cdd:pfam01553 82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAIS 131
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
224-357 |
3.75e-24 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 98.20 E-value: 3.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 224 LLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRrldetpdgRKDVLYRALLHgHIVEL 303
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDR--------SNGRKARAALR-EAVEL 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 59803040 304 LRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnvipDILIIPVGISYD 357
Cdd:smart00563 72 LKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
|
|
| GPAT_C |
pfam19277 |
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ... |
364-593 |
5.67e-13 |
|
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.
Pssm-ID: 466024 Cd Length: 370 Bit Score: 71.40 E-value: 5.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 364 YNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSqkpvsallsleqallpailpsrpsdaade 443
Cdd:pfam19277 1 YAAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREFLDEQG----------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 444 grdtsineSRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIV-ACLLLYRHRqGIDLSTLVEDFFVMKEEVLARDFD 522
Cdd:pfam19277 52 --------DRPATDAARRRLALQKLAFEVLSRINRVTPVMPTALVgTVLLTLRGR-ALTLSELIRRVEWLLDYIRARGGP 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 59803040 523 LGFSGN--SEDVVMHAIQLLGNCVTITHTSRNDE--FFITPSttvpSVFELNFYSNGVLHVFIMEAIIACSLYAV 593
Cdd:pfam19277 123 VAHFGDlrTEEVVDRALDVLGNAGLVTRVDGGPEpvYYIAPE----DHFQASFYRNMTIHLFVERAIVELALLTK 193
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
184-360 |
5.65e-12 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 65.80 E-value: 5.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 184 AMIRLTGWVLLKLFNsffWNIQIHkgQLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILfchNIKAPYIASGNNLNIPI 263
Cdd:COG0204 14 RLVRLWARLLLRLLG---VRVRVE--GLENLPADG----PVLIVANHQSWLDILLLLAAL---PRPVRFVAKKELFKIPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 264 FSTLIHKLGGFFIRRRldetpDGRKDVlyRALLHghIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnv 343
Cdd:COG0204 82 LGWLLRALGAIPVDRS-----KRRAAL--RALRQ--AVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA----- 147
|
170
....*....|....*..
gi 59803040 344 ipDILIIPVGISYDRII 360
Cdd:COG0204 148 --GVPIVPVAIDGTERA 162
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LPLAT_DHAPAT-like |
cd07993 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ... |
201-411 |
1.55e-100 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.
Pssm-ID: 153255 [Multi-domain] Cd Length: 205 Bit Score: 309.89 E-value: 1.55e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 201 FWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRL 280
Cdd:cd07993 1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 281 DetpdgrKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRII 360
Cdd:cd07993 81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 59803040 361 EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLE 411
Cdd:cd07993 155 EEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
|
|
| PlsB |
COG2937 |
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ... |
105-656 |
1.81e-77 |
|
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 442180 [Multi-domain] Cd Length: 707 Bit Score: 265.25 E-value: 1.81e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 105 LARRLSYVLFI----QERDV------HKgmfaTNVTENVLNSSRVQEAIAEVAAELN-PDGSAQQQSKavnkvkkkakRI 173
Cdd:COG2937 92 LARKLARVLRVhfrrQRRAVigpdlkHR----RDLIERLLRSPAVRKAIEEEAKSKGiSEEKARKEAR----------RY 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 174 LQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHkgQLEMVKAATETNlPLLFLPVHRSHIDYLLLTFILFCHNIKAPYI 253
Cdd:COG2937 158 LREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD--NLERLRELAKGH-EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHI 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 254 ASGNNLNIPIFSTLIHKLGGFFIRRRLdetpdgRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLS 333
Cdd:COG2937 235 AAGINLNFWPLGPILRRGGAFFIRRSF------KGNKLYSAVFREYLAELFERGYSVEYFIEGGRSRTGRLLPPKTGMLS 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 334 VVVDTLSTNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGvIRMLRKNYGCVRVDFAQPFSLKEYLES 412
Cdd:COG2937 309 MTVQAFLRGARRPVVFVPVYIGYERVLEVGsYAKELRGGEKKKESLGGLLRA-LRKLRRRFGRVYVNFGEPISLSEYLDQ 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 413 QsqkpvsallsleqallpailpsrpsdaADEGRDTSINesrnatDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLL 492
Cdd:COG2937 388 H---------------------------VPDWRESEDL------RPEWLRPAVDKLAFEIMVRINRAAAVNPVNLVALAL 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 493 LYRHRQGIDLSTLVE--DFFV-MKEEVLARDFDLGFSGNSEDVVMHAIQLlgNCVTITHTSRNDEFFITPSTTVpsvfEL 569
Cdd:COG2937 435 LASPKRALTEAELLAqlDLYLdLLRNVPYSLSVTLPELTPEELLEHLLSL--GLIEVEKDGLGDVISIDDEQAV----LL 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 570 NFYSNGVLHVFIMEAIIACslyAVLNKRGlggptstppnlISQEQLVRKAASLCYLLSNEGTISLPcQTFYQVCHETVGK 649
Cdd:COG2937 509 TYYRNNILHLFALPALIAS---ALLANRR-----------ISRAELLELVRLLYPLLKAELFLRWD-AEFEEVLDEELDE 573
|
....*..
gi 59803040 650 FIQYGIL 656
Cdd:COG2937 574 LVRQGLL 580
|
|
| PRK04974 |
PRK04974 |
glycerol-3-phosphate 1-O-acyltransferase PlsB; |
84-661 |
1.31e-44 |
|
glycerol-3-phosphate 1-O-acyltransferase PlsB;
Pssm-ID: 235325 [Multi-domain] Cd Length: 818 Bit Score: 173.11 E-value: 1.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 84 PSLGLRNVIYINETHTRhrgwLARRLSYVL---FIQERDVHKGMFAT---NVTENVLNSSRVQEAIAEVAAELN-PDGSA 156
Cdd:PRK04974 173 PPVSLRYMADEHGTDKR----IARKLARVArvhFRRQRLAAIGPDLPhrqALFNKLLASPAIKKAIEDEAKSKKiSHEKA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 157 QQQSKavnkvkkkakRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHkgQLEMVKAATETNLPLLFLPVHRSHIDY 236
Cdd:PRK04974 249 RQNAI----------AYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH--NAERVRQLAQDGHEIVYVPCHRSHMDY 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 237 LLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRrldeTPDGRKdvLYRALLHGHIVELLRQQQFLEIFLEG 316
Cdd:PRK04974 317 LLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRR----SFKGNK--LYSTVFREYLGELFARGYSVEYFVEG 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 317 TRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARgVIRMLRkNYGC 395
Cdd:PRK04974 391 GRSRTGRLLQPKTGMLAMTLQAMLRGSRRPITLVPVYIGYEHVMEVGtYAKELRGAPKEKESLFQVLR-GIRKLR-NFGQ 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 396 VRVDFAQPFSLKEYLESQSQKpvsallsleqallpailpSRPS-DAADEGRDTSINESRNatdeslrrRLIANLAEHIlf 474
Cdd:PRK04974 469 GYVNFGEPIPLNDYLNQHVPE------------------WRESiDPIEEQRPAWLTPAVN--------NLANQVMVRI-- 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 475 taSKSCAIMSTHIVACLLLYRHRQGIDLSTLVE--DFF--VMKEEVLARDFDLGfSGNSEDVVMHAIQLlgNCVTITHTS 550
Cdd:PRK04974 521 --NNAAAANPVNLCALALLASRQRALDREQLIEqlDLYlqLLRNVPYSSDTTVP-EGSGEELIDHALSL--NKFEVEKDT 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 551 RNDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACslyAVLNKRGlggptstppnlISQEQLVRKAASLCYLLSNEG 630
Cdd:PRK04974 596 LGDIISLDREQAV----LMTYYRNNILHLFVLPSLIAS---IVTHNRR-----------ISRDELLRIVNALYPFLKAEL 657
|
570 580 590
....*....|....*....|....*....|.
gi 59803040 631 TISLPCQTFYQVCHETVGKFIQYGILTVAEH 661
Cdd:PRK04974 658 FLRWDEEELPEVIDQIIDELVRQGLITLDDD 688
|
|
| PTZ00374 |
PTZ00374 |
dihydroxyacetone phosphate acyltransferase; Provisional |
80-587 |
2.08e-44 |
|
dihydroxyacetone phosphate acyltransferase; Provisional
Pssm-ID: 240389 [Multi-domain] Cd Length: 1108 Bit Score: 173.52 E-value: 2.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 80 NPSIPSLGLRNVIYINETHTRHRGWLArrlsyvlfiqerDVHKGMfATNVTENVLNSSRVQEAIAEVAAElnpDGSAQQQ 159
Cdd:PTZ00374 508 TPLLTRKYFDDVVWTQRVGLTANGWRF------------AATPGL-TPESLTSILAQPSIQRLMTALAKK---EGASEKD 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 160 skavnkVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATET-NLPLLFLPVHRSHIDYLL 238
Cdd:PTZ00374 572 ------VEARAKAILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAMpRVAVVLLPLHRSYIDFII 645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 239 LTFILFCHNIKAPYIASGNN-LNIPIFSTLIHKLGGFFIRRRLdetpdgRKDVLYRALLHGHIVELLRQQQFLEIFLEGT 317
Cdd:PTZ00374 646 MTYLLAVMGLPLPHVCAGDDfLRMGPIATLMRGSGAFFMRRSF------RDDPLYAALFKEYVRHLVLRRRPLEFFIEGT 719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 318 RSRSGKTSCARAGLLSVVVDTL--STNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGViRMLRKNYG 394
Cdd:PTZ00374 720 RSRTGKTMAPKLGLLKFICDTFyeGQQELDDVLIIPVSLSYDELLETTlYAKEQLGVSKPKENPGNLLRAR-SLLKRRHG 798
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 395 CVRVDFAQPFSLKEYLESQSQKPvsallsleqallpaiLPSRPSDaadeGRDTSINESRNATDESLRR------RLIANL 468
Cdd:PTZ00374 799 KIHVHIGEPVSLRSFKDHPLQCP---------------LPFEPKG----EATTSVCKTLDTTPSIARKssitppRVLTNI 859
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 469 AEHILFTASKSCAIMSTHIVA-----------CLLLYRHRQGIdlsTLVEDFFVMKEEVLARDfdlGFSGNSEDVVMHAI 537
Cdd:PTZ00374 860 AWHLTHKLQRNTIITPTALVAavleclgptagAMPLAEVQQGM---TWLRTNIRRRGAALSDD---CANLNPETMVRKAL 933
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 59803040 538 QLLGNCVTIthTSRNDEFFITPSTTVpSVFELNFYSNGVLHVFIMEAIIA 587
Cdd:PTZ00374 934 THLQEFVEI--TDEMSEVIYVRQDVV-TRLGVNICSNQLIHVFMDEAVVA 980
|
|
| PRK03355 |
PRK03355 |
glycerol-3-phosphate 1-O-acyltransferase; |
129-593 |
2.09e-35 |
|
glycerol-3-phosphate 1-O-acyltransferase;
Pssm-ID: 179567 [Multi-domain] Cd Length: 783 Bit Score: 144.47 E-value: 2.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 129 VTENVLNSSRVQEAIAEVAAELNPDGSAqqqskavnkVKKKAKRILQEMVATVSPAMIRLTGwVLLKLFNS-FFWNIQIH 207
Cdd:PRK03355 184 VKPEILASARFRAGLAKIAAKLGRPPGA---------TVREAGKMLDELVAGWSRVSVDLVS-VLGRLFSRgFDPEIDYD 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 208 KGQLEMVKAATEtNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPdgr 287
Cdd:PRK03355 254 EYELAALRALLE-EHPAVLLFSHRSYIDGLVVPVAMQENRLPPVHVFGGINLSFGPMGPIMRRSGMIFIRRNIGDDP--- 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 288 kdvLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIE-GHYNG 366
Cdd:PRK03355 330 ---LYKYVLREYVGYLVEKRFNLSWYIEGTRSRTGKLLPPKLGLLSYVADAYLDGRSDDVLLQPVSISFDQLHEiGEYAA 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 367 EQLGKPKKNESL-WSVarGVIRML-RKNYGCVRVDFAQPFSLKEYLeSQSQKPvsalLSLEQALLPAILPSRPSDAADEg 444
Cdd:PRK03355 407 EARGGEKTPEGLrWLY--NYIKAQgERNYGKIYVRFGEPVSMRQYL-GAPHGP----LTQDPDAKRLALQKMAFEVAWR- 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 445 rdtsINESR--NATdeslrrrliaNLAEHILFTASKSCAIMS--THIVACLLLYRHRQGIDLSTlvedffvmkeevlaRD 520
Cdd:PRK03355 479 ----INQVTpvTAT----------SLVSLLLLGTRGRALTLDelHHTLQDSLDYLERRQLPVST--------------SA 530
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 59803040 521 FDLGfsgnSEDVVMHAIQLL--GNCVTITHTSRNDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACSLYAV 593
Cdd:PRK03355 531 LRLR----DPEGVRAALDALsnGGPVTRVDSGREPVWYIAPDDHL----VAAFYRNSVIHAFLERAIVELALAAA 597
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
220-355 |
1.49e-25 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 102.36 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 220 TNLPLLFLPVHRSHIDYLLLTFILFCHNiKAPYIASGNNL-NIPIFSTLIHKLGGFFIRrrldetpdgRKDVLYRALLHG 298
Cdd:pfam01553 12 RGGPAIVVANHQSYLDVLLLSLALYKRG-RPLVFVAKKELfDIPLVGWLMRLLGCIFID---------RKNRKDAAGTLE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 59803040 299 HIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnvipDILIIPVGIS 355
Cdd:pfam01553 82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAIS 131
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
224-357 |
3.75e-24 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 98.20 E-value: 3.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 224 LLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRrldetpdgRKDVLYRALLHgHIVEL 303
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDR--------SNGRKARAALR-EAVEL 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 59803040 304 LRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnvipDILIIPVGISYD 357
Cdd:smart00563 72 LKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
|
|
| PRK11915 |
PRK11915 |
lysophospholipid acyltransferase; |
141-429 |
1.91e-17 |
|
lysophospholipid acyltransferase;
Pssm-ID: 237022 [Multi-domain] Cd Length: 621 Bit Score: 86.92 E-value: 1.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 141 EAIAEVAAEL--NPDGSAQQQSKAvnkvkkkakriLQEMVATVSPAMIRltGWvllKLFNSFF---WNIQIHKGQLEMVK 215
Cdd:PRK11915 46 ERLRALADELgrDPDSVRAEAAGY-----------LREMAASLDERAVQ--AW---RGFSRWLmraYDVLVDEDQITQLR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 216 AaTETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPdgrkdvLYRAL 295
Cdd:PRK11915 110 K-LDRKATLAFAFSHRSYLDGMLLPEVILANRLSPALTFGGANLNFFPMGAWAKRTGAIFIRRQTKDIP------VYRFV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 296 LHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIE-GHYNGEQLGKPKK 374
Cdd:PRK11915 183 LRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEvEAMTTEAYGAVKR 262
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 59803040 375 NESLwsvaRGVIRMLRKN---YGCVRVDFAQPFSLKEYLESQSQKPVSALLSLEQALL 429
Cdd:PRK11915 263 PEDL----RFLVRLARQQgerLGRAYLDFGEPLPLRKRLQELRADKSGTGSEIERIAL 316
|
|
| GPAT_C |
pfam19277 |
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ... |
364-593 |
5.67e-13 |
|
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.
Pssm-ID: 466024 Cd Length: 370 Bit Score: 71.40 E-value: 5.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 364 YNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSqkpvsallsleqallpailpsrpsdaade 443
Cdd:pfam19277 1 YAAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREFLDEQG----------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 444 grdtsineSRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIV-ACLLLYRHRqGIDLSTLVEDFFVMKEEVLARDFD 522
Cdd:pfam19277 52 --------DRPATDAARRRLALQKLAFEVLSRINRVTPVMPTALVgTVLLTLRGR-ALTLSELIRRVEWLLDYIRARGGP 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 59803040 523 LGFSGN--SEDVVMHAIQLLGNCVTITHTSRNDE--FFITPSttvpSVFELNFYSNGVLHVFIMEAIIACSLYAV 593
Cdd:pfam19277 123 VAHFGDlrTEEVVDRALDVLGNAGLVTRVDGGPEpvYYIAPE----DHFQASFYRNMTIHLFVERAIVELALLTK 193
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
184-360 |
5.65e-12 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 65.80 E-value: 5.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 184 AMIRLTGWVLLKLFNsffWNIQIHkgQLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILfchNIKAPYIASGNNLNIPI 263
Cdd:COG0204 14 RLVRLWARLLLRLLG---VRVRVE--GLENLPADG----PVLIVANHQSWLDILLLLAAL---PRPVRFVAKKELFKIPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 264 FSTLIHKLGGFFIRRRldetpDGRKDVlyRALLHghIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnv 343
Cdd:COG0204 82 LGWLLRALGAIPVDRS-----KRRAAL--RALRQ--AVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA----- 147
|
170
....*....|....*..
gi 59803040 344 ipDILIIPVGISYDRII 360
Cdd:COG0204 148 --GVPIVPVAIDGTERA 162
|
|
| LPLAT_AGPAT-like |
cd07989 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ... |
196-356 |
2.92e-10 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.
Pssm-ID: 153251 [Multi-domain] Cd Length: 184 Bit Score: 60.36 E-value: 2.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 196 LFNSFFWNIQIHKgqLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILFcHNIKapYIASGNNLNIPIFSTLIHKLGGFF 275
Cdd:cd07989 4 LLRLLGVRVRVEG--LENLPPKG----PVIIVANHQSYLDPLVLGAALP-RPIR--FVAKKELFKIPFLGWLLRLLGAIP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 276 IRRrldetpdGRKDVLYRALLhgHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlstnvipDILIIPVGIS 355
Cdd:cd07989 75 IDR-------GNGRSAREALR--EAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-------GVPIVPVAIS 138
|
.
gi 59803040 356 Y 356
Cdd:cd07989 139 G 139
|
|
| LPLAT_AAK14816-like |
cd07992 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
186-358 |
1.55e-05 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.
Pssm-ID: 153254 [Multi-domain] Cd Length: 203 Bit Score: 46.49 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 186 IRLTGWVLLKLFnsfFWNIQIHKGQLEmvkaatETNLPLLFLPVHR-SHIDYLLLTFILfchNIKAPYIASGNNLNIPIF 264
Cdd:cd07992 1 VRLLSRVILRIY---FRRITVVGRENV------PKDGPVIFLGNHPnALIDPLLLAATL---RRPVRFLAKADLFKNPLI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 265 STLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGhIVELLRQQQFLEIFLEGTrSRSG------KTSCARAGLlsvvvdT 338
Cdd:cd07992 69 GWLLESFGAIPVYRPKDLARGGIGKISNAAVFDA-VGEALKAGGAIGIFPEGG-SHDRprllplKAGAARMAL------E 140
|
170 180
....*....|....*....|
gi 59803040 339 LSTNVIPDILIIPVGISYDR 358
Cdd:cd07992 141 ALEAGQKDVKIVPVGLNYED 160
|
|
| LPLAT |
cd06551 |
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ... |
223-359 |
2.15e-05 |
|
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).
Pssm-ID: 153244 [Multi-domain] Cd Length: 187 Bit Score: 45.87 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59803040 223 PLLFLPVHRSHIDYLLLTFILFC---HNIKAPYIASGnNLNIPIFStlihKLGGFFIRRRLDEtpDGRKDVLYrallhgh 299
Cdd:cd06551 27 PVLFVSNHSSWWDGLILFLLLERglrRDVYGLMDEEL-LERYPFFT----RLGAFSVDRDSPR--SAAKSLKY------- 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 59803040 300 IVELLRQ-QQFLEIFLEGTRSRSGKtscaRAGLLSVVVDTLSTNVipDILIIPVGISYDRI 359
Cdd:cd06551 93 VARLLSKpGSVVWIFPEGTRTRRDK----RPLQFKPGVAHLAEKA--GVPIVPVALRYTFE 147
|
|
| |
