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Conserved domains on  [gi|158519993|sp|Q9HBX8|]
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RecName: Full=Leucine-rich repeat-containing G-protein coupled receptor 6; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-834 6.40e-162

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 475.82  E-value: 6.40e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-293 1.87e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.99  E-value: 1.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  70 YLDLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANL 149
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 150 ISLVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthS 229
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 230 FEGLHNLETLDLNYNKLQEFpvAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
349-473 6.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 349 QQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADtFSQLSSLQALDLSWNAIRSIhPEAFSTLHSLVKL 427
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKEL 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 158519993 428 DLTDNQLTTLP--LAGLGGLMHLKLKGNL--ALSQAFSKdsFPKLRILEV 473
Cdd:COG4886  188 DLSNNQITDLPepLGNLTNLEELDLSGNQltDLPEPLAN--LTNLETLDL 235
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 1.55e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 158519993    34 ACPAPCHCqEDGIMlsaDCSELGLSAVPGDLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
LRR_8 super family cl38440
Leucine rich repeat;
281-364 4.76e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  281 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 158519993  361 HNQI 364
Cdd:pfam13855  58 GNRL 61
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-834 6.40e-162

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 475.82  E-value: 6.40e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-293 1.87e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.99  E-value: 1.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  70 YLDLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANL 149
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 150 ISLVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthS 229
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 230 FEGLHNLETLDLNYNKLQEFpvAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-435 2.08e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 123.42  E-value: 2.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  60 VPGDLDPLTAYLDLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaL 134
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-L 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 135 WELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAFqNLTSL 212
Cdd:PLN00113 209 GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQ---------------ELGFHNN--------- 267
Cdd:PLN00113 287 ISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQvlqlwsnkfsgeipkNLGKHNNltvldlstn 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 268 NIKA-IPEKAFMGNPLLQTIHFYDNPIQFVGRS--AFQYLPK--LHTLSLNGAMDiQEFPDLKGTTSLEILTLTRAGiRL 342
Cdd:PLN00113 367 NLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSlgACRSLRRvrLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQG-RI 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 343 lpSGMCQQLPRLRVLELSHNQIE-ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 421
Cdd:PLN00113 445 --NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSC 522

                        410
                 ....*....|....
gi 158519993 422 HSLVKLDLTDNQLT 435
Cdd:PLN00113 523 KKLVSLDLSHNQLS 536
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
349-473 6.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 349 QQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADtFSQLSSLQALDLSWNAIRSIhPEAFSTLHSLVKL 427
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKEL 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 158519993 428 DLTDNQLTTLP--LAGLGGLMHLKLKGNL--ALSQAFSKdsFPKLRILEV 473
Cdd:COG4886  188 DLSNNQITDLPepLGNLTNLEELDLSGNQltDLPEPLAN--LTNLETLDL 235
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-273 6.24e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 6.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  73 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 150
Cdd:cd21340    7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 151 SLVpErSFEGLSSLRHLWLDDNalteipvralnNLPALQAMTLALNRISHIpdyafqnLTSLVVLHLHNNRIQHLgtHSF 230
Cdd:cd21340   81 SVV-E-GLENLTNLEELHIENQ-----------RLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 158519993 231 EGLHNLETLDLNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIP 273
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
186-246 5.88e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.88e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
374-434 7.73e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 7.73e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  374 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 306-453 2.32e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 306 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 385
Cdd:cd21340    3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 386 IWEI-GADTFSQLS---------------------------SLQALDLSWNAIRSIHPeaFSTLHSLVKLDLTDNQLT-- 435
Cdd:cd21340   80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdl 157

                        170       180
                 ....*....|....*....|.
gi 158519993 436 ---TLPLAGLGGLMHLKLKGN 453
Cdd:cd21340  158 eelLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 372-445 2.56e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 2.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 372 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGL 445
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 208-473 3.22e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLG-RLQELGFHNNNIKAIPEKAFMgnPLLQT 285
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSI--PNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 286 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLE---LSH 361
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLKwiyLGY 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 362 NQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTtlpl 439
Cdd:PLN00113 222 NNLSgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS---- 297

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 158519993 440 aglGGLMHLKLK-GNLALSQAFSKD----------SFPKLRILEV 473
Cdd:PLN00113 298 ---GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPRLQVLQL 339
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 1.55e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 158519993    34 ACPAPCHCqEDGIMlsaDCSELGLSAVPGDLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
LRR_8 pfam13855
Leucine rich repeat;
281-364 4.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  281 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 158519993  361 HNQI 364
Cdd:pfam13855  58 GNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 34-64 4.81e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 4.81e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 158519993   34 ACPAPCHCQEdgimLSADCSELGLSAVPGDL 64
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDL 27
LRR smart00370
Leucine-rich repeats, outliers;
397-419 7.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 7.39e-03
                           10        20
                   ....*....|....*....|...
gi 158519993   397 LSSLQALDLSWNAIRSIHPEAFS 419
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 562-834 6.40e-162

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 475.82  E-value: 6.40e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15362   80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15362  160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15362  240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 562-834 1.72e-144

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 430.81  E-value: 1.72e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 721
Cdd:cd15138   80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15138  160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15138  238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 562-834 3.37e-94

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 299.07  E-value: 3.37e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 721
Cdd:cd15363   80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15363  159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15363  238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 562-834 4.84e-75

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 247.47  E-value: 4.84e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 641
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 721
Cdd:cd15361   80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 722 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 801
Cdd:cd15361  159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 158519993 802 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15361  238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 562-834 2.49e-38

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 144.69  E-value: 2.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVF----AGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWE 637
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWHIsskkKKKKVP----KLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 638 TGLGCRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalpl 705
Cdd:cd14980   77 RSPPCLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY----------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 706 aSVGE------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRH 774
Cdd:cd14980  146 -SINQpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIR 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 775 VAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd14980  223 LALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 562-834 7.70e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 137.35  E-value: 7.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 562 WGIRLAVWAIVLLSVLCNG---LVLLTVFAGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWET 638
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIivlLVLLTSRTKLTVP----RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 639 GLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 718
Cdd:cd15136   77 GAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 719 PYAppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASM 797
Cdd:cd15136  157 PFE--TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAA 234

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 158519993 798 LGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15136  235 FGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-293 1.87e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.99  E-value: 1.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  70 YLDLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANL 149
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 150 ISLVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthS 229
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 230 FEGLHNLETLDLNYNKLQEFpvAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-465 1.11e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 134.68  E-value: 1.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 100 NHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 179
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 180 RALNNLPALQAMTLA-LNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGtHSFEGLHNLETLDLNYNKLQEFPVAIRTLGR 258
Cdd:COG4886   82 LSLLLLGLTDLGDLTnLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 259 LQELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTR 337
Cdd:COG4886  161 LKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSG 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 338 AGIRLLPSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLSWNAIRSIHPEA 417
Cdd:COG4886  215 NQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKE 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 158519993 418 FSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 465
Cdd:COG4886  292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
121-439 2.54e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 2.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 121 LQNNQLGGIPAEALWELPSLQSLRLDANlislvpeRSFEGLSSLRHLWLDDNALTEIPVrALNNLPALQAMTLALNRISH 200
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 201 IPDyAFQNLTSLVVLHLHNNRIQHLGThSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgn 280
Cdd:COG4886  151 LPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE------ 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 281 pllqtihfydnpiqfvgrsAFQYLPKLHTLSLNGAmDIQEFPDLKgttsleiltltragirllpsgmcqQLPRLRVLELS 360
Cdd:COG4886  223 -------------------PLANLTNLETLDLSNN-QLTDLPELG------------------------NLTNLEELDLS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 361 HNQIEELPSLHRCQKLEEIGLQHNRI-----WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 435
Cdd:COG4886  259 NNQLTDLPPLANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338


                 ....
gi 158519993 436 TLPL 439
Cdd:COG4886  339 TLAL 342
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-446 2.92e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 2.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  53 SELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAE 132
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 133 aLWELPSLQSLRLDANLISLVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSL 212
Cdd:COG4886  132 -LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 213 VVLHLHNNRIQHLGThSFEGLHNLETLDLNYNKLQEFPvAIRTLGRLQELGFHNNNIKAIPEkafmgnpllqtihfydnp 292
Cdd:COG4886  208 EELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP------------------ 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 293 iqfvgrsafqylpklhtlslngamdiqefpdLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR 372
Cdd:COG4886  268 -------------------------------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 373 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 446
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-435 2.08e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 123.42  E-value: 2.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  60 VPGDLDPLTAYLDLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaL 134
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-L 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 135 WELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAFqNLTSL 212
Cdd:PLN00113 209 GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQ---------------ELGFHNN--------- 267
Cdd:PLN00113 287 ISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQvlqlwsnkfsgeipkNLGKHNNltvldlstn 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 268 NIKA-IPEKAFMGNPLLQTIHFYDNPIQFVGRS--AFQYLPK--LHTLSLNGAMDiQEFPDLKGTTSLEILTLTRAGiRL 342
Cdd:PLN00113 367 NLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSlgACRSLRRvrLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQG-RI 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 343 lpSGMCQQLPRLRVLELSHNQIE-ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 421
Cdd:PLN00113 445 --NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSC 522

                        410
                 ....*....|....
gi 158519993 422 HSLVKLDLTDNQLT 435
Cdd:PLN00113 523 KKLVSLDLSHNQLS 536
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 564-834 1.06e-25

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 107.68  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 564 IRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 643
Cdd:cd15964    3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 644 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15964   82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 724 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15964  162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 158519993 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15964  240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 564-834 9.84e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 99.16  E-value: 9.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 564 IRLAVWAIVLLSVLCNgLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 643
Cdd:cd15360    3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 644 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 724 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15360  162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 158519993 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15360  240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-453 1.65e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 104.16  E-value: 1.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGQAFSGLYSLKILMLQNNQL-GGIPAEAlweLPSLQSLRLDAN 148
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGS---IPNLETLDLSNN 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 149 LISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-------------------------HIP 202
Cdd:PLN00113 151 MLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPN-SLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIP 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 203 dYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKA-IPE-KAFMG 279
Cdd:PLN00113 230 -YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPElVIQLQ 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 280 NplLQTIHFYDNpiQFVGR--SAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIR-LLPSGMCQQlPRLR 355
Cdd:PLN00113 309 N--LEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLSTNNLTgEIPEGLCSS-GNLF 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 356 VLELSHNQIE-ELP-SLHRCQKLEEIGLQHNRI----------------WEIGADTFS--------QLSSLQALDLSWNA 409
Cdd:PLN00113 384 KLILFSNSLEgEIPkSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDISNNNLQgrinsrkwDMPSLQMLSLARNK 463

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 158519993 410 IRSIHPEAFSTlHSLVKLDLTDNQLT-TLP--LAGLGGLMHLKLKGN 453
Cdd:PLN00113 464 FFGGLPDSFGS-KRLENLDLSRNQFSgAVPrkLGSLSELMQLKLSEN 509
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 564-834 4.97e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 94.16  E-value: 4.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 564 IRLAVWAIVLLSVLCNGLVLLtVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 643
Cdd:cd15359    3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 644 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 723
Cdd:cd15359   82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 724 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Cdd:cd15359  162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 158519993 803 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15359  240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 564-834 3.68e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 88.80  E-value: 3.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 564 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 640
Cdd:cd15137    3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 641 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 715
Cdd:cd15137   79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 716 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 789
Cdd:cd15137  157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 158519993 790 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 834
Cdd:cd15137  237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
349-473 6.63e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 349 QQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADtFSQLSSLQALDLSWNAIRSIhPEAFSTLHSLVKL 427
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKEL 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 158519993 428 DLTDNQLTTLP--LAGLGGLMHLKLKGNL--ALSQAFSKdsFPKLRILEV 473
Cdd:COG4886  188 DLSNNQITDLPepLGNLTNLEELDLSGNQltDLPEPLAN--LTNLETLDL 235
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-273 6.24e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 6.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  73 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 150
Cdd:cd21340    7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 151 SLVpErSFEGLSSLRHLWLDDNalteipvralnNLPALQAMTLALNRISHIpdyafqnLTSLVVLHLHNNRIQHLgtHSF 230
Cdd:cd21340   81 SVV-E-GLENLTNLEELHIENQ-----------RLPPGEKLTFDPRSLAAL-------SNSLRVLNISGNNIDSL--EPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 158519993 231 EGLHNLETLDLNYNKLQEFP---VAIRTLGRLQELGFHNNNIKAIP 273
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-438 3.94e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.59  E-value: 3.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 161 LSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLHLHNNRIQHLGthSFEGLHNLETLD 240
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 241 LNYNKlqefpvaIRTLGRLQELgfhnnnikaipekafmgnPLLQTIHFyDNpiqfvgrsafQYLPKlhtlslngamdiqe 320
Cdd:cd21340   75 LGGNR-------ISVVEGLENL------------------TNLEELHI-EN----------QRLPP-------------- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 321 fpdlkgTTSLEILTLTRAGIRllpsgmcqqlPRLRVLELSHNQIEELPSLhrcqkleeiglqhnriweigadtfSQLSSL 400
Cdd:cd21340  105 ------GEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPL------------------------APLRNL 144

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 158519993 401 QALDLSWNAIRSIHP--EAFSTLHSLVKLDLTDNQLTTLP 438
Cdd:cd21340  145 EQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-265 2.13e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  51 DCSELGLSAVPGDLDPLTA--YLDLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgqAFSGLYSLKILMLQNNQLGG 128
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNleELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 129 IPAEAlwELPSLQSLRLDANLIS-LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQ 207
Cdd:COG4886  265 LPPLA--NLTNLKTLDLSNNQLTdLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 158519993 208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFH 265
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR_8 pfam13855
Leucine rich repeat;
186-246 5.88e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 5.88e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
374-434 7.73e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 7.73e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  374 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 306-453 2.32e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 306 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 385
Cdd:cd21340    3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 386 IWEI-GADTFSQLS---------------------------SLQALDLSWNAIRSIHPeaFSTLHSLVKLDLTDNQLT-- 435
Cdd:cd21340   80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdl 157

                        170       180
                 ....*....|....*....|.
gi 158519993 436 ---TLPLAGLGGLMHLKLKGN 453
Cdd:cd21340  158 eelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
92-150 2.64e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 2.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 158519993   92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-441 2.99e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEalwelpslqsLRLDAN 148
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN----------LGKHNN 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 149 LISLvpersfeGLSSlrhlwlddNALT-EIPVRALNNlpalqamtlalnrishipdyafQNLTSLVvlhlhnnriqhLGT 227
Cdd:PLN00113 358 LTVL-------DLST--------NNLTgEIPEGLCSS----------------------GNLFKLI-----------LFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 228 HSFEGlhnletldlnynklqEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKL 307
Cdd:PLN00113 390 NSLEG---------------EIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSL 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 308 HTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLEEIGLQHN 384
Cdd:PLN00113 455 QMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHN 533

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 158519993 385 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-TTLPLAG 441
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
210-269 3.49e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 3.49e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  210 TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-262 4.11e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 4.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  60 VPGDL---DPLTAyLDLSMNNLTELQP-------GLFHHLRF-----------------LEELRLSGNHLSHIPGQAFSG 112
Cdd:PLN00113 348 IPKNLgkhNNLTV-LDLSTNNLTGEIPeglcssgNLFKLILFsnslegeipkslgacrsLRRVRLQDNSFSGELPSEFTK 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 113 LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFeGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 192
Cdd:PLN00113 427 LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 158519993 193 LALNRIS-HIPDyAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPvaiRTLGRLQEL 262
Cdd:PLN00113 506 LSENKLSgEIPD-ELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIP---KNLGNVESL 573
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 607-834 1.66e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.27  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 607 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 682
Cdd:cd15966   45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 683 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 759
Cdd:cd15966  124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 760 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 830
Cdd:cd15966  203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                 ....
gi 158519993 831 NPHF 834
Cdd:cd15966  280 TSFF 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-368 1.88e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 119 LMLQNNQLGGIPAEalweLP-SLQSLRLDANLISLVPErSFEGlsSLRHLWLDDNALTEIPvralNNLP-ALQAMTLALN 196
Cdd:PRK15370 183 LRLKILGLTTIPAC----IPeQITTLILDNNELKSLPE-NLQG--NIKTLYANSNQLTSIP----ATLPdTIQEMELSIN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 197 RISHIPDYAFQNLTSLVVLHlhnNRIQHLGTHSFEGlhnLETLDLNYNKLQEFPVAIRTlgRLQELGFHNNNIKAIPEKA 276
Cdd:PRK15370 252 RITELPERLPSALQSLDLFH---NKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 277 FMGnplLQTIHFYDNPIQFVGRSafqYLPKLHTLSLNGAMdIQEFPDLKGTTsLEILTLTRAGIRLLPsgmcQQLP-RLR 355
Cdd:PRK15370 324 PPG---LKTLEAGENALTSLPAS---LPPELQVLDVSKNQ-ITVLPETLPPT-ITTLDVSRNALTNLP----ENLPaALQ 391

                        250
                 ....*....|...
gi 158519993 356 VLELSHNQIEELP 368
Cdd:PRK15370 392 IMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
162-222 2.33e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  162 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
70-126 3.09e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 3.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 158519993   70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 126
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-250 1.73e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  57 LSAVPGDLDPLTAYLDLSMNNLTELQPglfHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILmlqNNQLGGIPAealwE 136
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTLPA----H 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 137 LPS-LQSLRLDANLISLVPERSFEGLSSLRhlwLDDNALTEIPVRAlnnLPALQAMTLALNRISHIPDYAFQNLTSLVVL 215
Cdd:PRK15370 302 LPSgITHLNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASL---PPELQVLDVSKNQITVLPETLPPTITTLDVS 375

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 158519993 216 HlhnnriqHLGTHSFEGL-HNLETLDLNYNKLQEFP 250
Cdd:PRK15370 376 R-------NALTNLPENLpAALQIMQASRNNLVRLP 404
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 131-392 5.26e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 5.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 131 AEALWELPSLQSLRLDANLISlvpERSFEGLS-------SLRHLWLDDNALTEIPV------RALNNLPALQAMTLALNR 197
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTLG---EEAAKALAsalrpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 198 IShiPD-----YAFQNLTSLVVLHLHNNRIQHLGT-HSFEGL----HNLETLDLNYNKLqefpvairTLGRLQELGfhnn 267
Cdd:cd00116   93 LG--PDgcgvlESLLRSSSLQELKLNNNGLGDRGLrLLAKGLkdlpPALEKLVLGRNRL--------EGASCEALA---- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 268 nikaipeKAFMGNPLLQTIHFYDNPIQFVG-RSAFQYLP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL 335
Cdd:cd00116  159 -------KALRANRDLKELNLANNGIGDAGiRALAEGLKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNL 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 158519993 336 -----TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ------KLEEIGLQHNRIWEIGAD 392
Cdd:cd00116  229 gdnnlTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-411 6.91e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.03  E-value: 6.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  71 LDLSMNNLTELQPGLFHHLRFLEEL-------------RLSGNHLSHIPGQAFSGLY-----SLKILMLQNNQLGGIPAE 132
Cdd:COG5238  119 LRRIMAKTLEDSLILYLALPRRINLiqvlkdplggnavHLLGLAARLGLLAAISMAKalqnnSVETVYLGCNQIGDEGIE 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 133 ALWElpslqslRLDANlislvpersfeglSSLRHLWLDDNALTEipvralnnlpaLQAMTLAlnrishipdYAFQNLTSL 212
Cdd:COG5238  199 ELAE-------ALTQN-------------TTVTTLWLKRNPIGD-----------EGAEILA---------EALKGNKSL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 213 VVLHLHNNRIQHLGTHSF-EGL---HNLETLDLNYNKLQEfpvairtlgrlqelgfhnNNIKAIpEKAFMGNPLLQTIHF 288
Cdd:COG5238  239 TTLDLSNNQIGDEGVIALaEALknnTTVETLYLSGNQIGA------------------EGAIAL-AKALQGNTTLTSLDL 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 289 YDNPIQFVGRSAFQylpklhtlslngamdiqefPDLKGTTSLEILTLTRAGIRllPSGM------CQQLPRLRVLELSHN 362
Cdd:COG5238  300 SVNRIGDEGAIALA-------------------EGLQGNKTLHTLNLAYNGIG--AQGAialakaLQENTTLHSLDLSDN 358

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 158519993 363 QI-----EEL-PSLHRCQKLEEIGLQHNRIWEIGADTF---SQLSSLQALDLSWNAIR 411
Cdd:COG5238  359 QIgdegaIALaKYLEGNTTLRELNLGKNNIGKQGAEALidaLQTNRLHTLILDGNLIG 416
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
49-203 9.33e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 9.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  49 SADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPglfHHLRFLEELRLSGNHLSHIPGQAFSGlysLKILMLQNNQLGG 128
Cdd:PRK15370 266 SLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTS 339

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 158519993 129 IPAEAlweLPSLQSLRLDANLISLVPERSfegLSSLRHLWLDDNALTEIPvralNNLP-ALQAMTLALNRISHIPD 203
Cdd:PRK15370 340 LPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLPE 405
LRR_8 pfam13855
Leucine rich repeat;
398-454 3.85e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.85e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  398 SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGNL 454
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
352-410 4.59e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158519993  352 PRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 410
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 201-303 5.60e-08

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 52.16  E-value: 5.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  201 IPDYAFQN--LTSLVVlhlhNNRIQHLGTHSFEGLHNLETLDLNYNklqefpvaIRTLGR-------LQELGFhNNNIKA 271
Cdd:pfam13306   3 IGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCTSLKSITLPSS--------LTSIGSyafyncsLTSITI-PSSLTS 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 158519993  272 IPEKAFMGNPLLQTIHFYDNpIQFVGRSAFQY 303
Cdd:pfam13306  70 IGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN 100
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-435 6.12e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 6.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 230 FEGLHNLETLDLNYNKLQE------------FPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVG 297
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalasalrpQPSLKELCLSLNETGRIPRGLQSLLQ-GLTKGCGLQELDLSDNALGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 298 RSAFQYL---PKLHTLSLN--------GAMDIQEFPDLKgtTSLEILTLTRagiRLLPSGMCQQL-------PRLRVLEL 359
Cdd:cd00116   98 CGVLESLlrsSSLQELKLNnnglgdrgLRLLAKGLKDLP--PALEKLVLGR---NRLEGASCEALakalranRDLKELNL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 360 SHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIG----ADTFSQLSSLQALDLSWNAIRS-----IHPEAFSTLHSL 424
Cdd:cd00116  173 ANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISL 252

                        250
                 ....*....|.
gi 158519993 425 VKLDLTDNQLT 435
Cdd:cd00116  253 LTLSLSCNDIT 263
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 253-442 1.11e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 253 IRTLGRLQELGFHNNNI-----KAIPEKAfMGNPLLQTIHFYDNPIQFVGR------SAFQYLPKLHTLSLN----GAMD 317
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLgeeaaKALASAL-RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSdnalGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 318 IQEFPDLKGTTSLEILTLTRAGI-----RLLPSGMCQQLPRLRVLELSHNQIE---------ELPSLhrcQKLEEIGLQH 383
Cdd:cd00116   98 CGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgascealakALRAN---RDLKELNLAN 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 158519993 384 NRIWEIGADT----FSQLSSLQALDLSWNAIR----SIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL 442
Cdd:cd00116  175 NGIGDAGIRAlaegLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAAL 241
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 53-271 2.25e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  53 SELGLSAVPGDL--DPLTAYLDLSMNNLTELQPGLFHHLRFLE------ELRLSGNHLS-HIPG--QAFSGLYSLKILML 121
Cdd:cd00116   36 GEEAAKALASALrpQPSLKELCLSLNETGRIPRGLQSLLQGLTkgcglqELDLSDNALGpDGCGvlESLLRSSSLQELKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 122 QNNQLGG----IPAEALWEL-PSLQSLRLDANLISlvpERSFEGLSSlrhlwlddnalteipvrALNNLPALQAMTLALN 196
Cdd:cd00116  116 NNNGLGDrglrLLAKGLKDLpPALEKLVLGRNRLE---GASCEALAK-----------------ALRANRDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 197 RISH--IPDYA--FQNLTSLVVLHLHNNRIQHLG----THSFEGLHNLETLDLNYNKLQEFPVA------IRTLGRLQEL 262
Cdd:cd00116  176 GIGDagIRALAegLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAalasalLSPNISLLTL 255


                 ....*....
gi 158519993 263 GFHNNNIKA 271
Cdd:cd00116  256 SLSCNDITD 264
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 57-199 3.13e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  57 LSAVPGDLDPLTAYLDLSMNNLT----ELQPGLFHHLRFLEELRLSGNHLSH--IP--GQAFSGLYSLKILMLQNNQL-- 126
Cdd:cd00116  128 LAKGLKDLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGIGDagIRalAEGLKANCNLEVLDLNNNGLtd 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 127 --GGIPAEALWELPSLQSLRLDANLISLVPERSF-----EGLSSLRHLWLDDNALTEIPV----RALNNLPALQAMTLAL 195
Cdd:cd00116  208 egASALAETLASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRG 287


                 ....
gi 158519993 196 NRIS 199
Cdd:cd00116  288 NKFG 291
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 139-283 7.26e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 49.08  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  139 SLQSLRLDANLISlVPERSFEGLSSLRHLWLDDNaLTEIPVRALNNLPaLQAMTLAlNRISHIPDYAFQNLTSLVVLHLH 218
Cdd:pfam13306  12 SLTSITIPSSLTS-IGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 158519993  219 NNrIQHLGTHSFEGLhNLETLDLnynklqefpvairtlgrlqelgfhNNNIKAIPEKAFMGNPLL 283
Cdd:pfam13306  88 SN-LTSIGSYAFSNC-SLKSITI------------------------PSSVTTIGSYAFSNCSNL 126
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-453 8.91e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 8.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  67 LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELpslQSLRLD 146
Cdd:COG5238   10 RNIEELLSANPATTEQSELTKRATIVNLRSYHLHGGAILLARYLQSRSSITQYLRFEGQGDPGLNPVALEK---AAEAFP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 147 ANLISLVPERSfEGLSSLRhLWLDDNALTEIPV---RALN-----NLPALQAMTLALNRISHIPDYafqNLTSLVVLHLH 218
Cdd:COG5238   87 TQLLVVDWEGA-EEVSPVA-LAETATAVATPPPdlrRIMAktledSLILYLALPRRINLIQVLKDP---LGGNAVHLLGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 219 NNRIQHLGTHS---FEGLHNLETLDLNYNKLQEfpVAIRTLGrlqelgfhnnnikaipeKAFMGNPLLQTIHFYDNPIQF 295
Cdd:COG5238  162 AARLGLLAAISmakALQNNSVETVYLGCNQIGD--EGIEELA-----------------EALTQNTTVTTLWLKRNPIGD 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 296 VGRSAF----QYLPKLHTLSLN-------GAMDIQEFpdLKGTTSLEILTL-----TRAGIRLLPSGMcQQLPRLRVLEL 359
Cdd:COG5238  223 EGAEILaealKGNKSLTTLDLSnnqigdeGVIALAEA--LKNNTTVETLYLsgnqiGAEGAIALAKAL-QGNTTLTSLDL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 360 SHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIGADTFSQlsSLQALdlswnairsihpeafSTLHSLvklDLTDNQ 433
Cdd:COG5238  300 SVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIALAK--ALQEN---------------TTLHSL---DLSDNQ 359

                        410       420
                 ....*....|....*....|
gi 158519993 434 LTTlplAGLGGLMHLkLKGN 453
Cdd:COG5238  360 IGD---EGAIALAKY-LEGN 375
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 607-829 1.09e-06

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.41  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 607 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 682
Cdd:cd15965   45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEKYICIvypfRCLTP-GKCRT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 683 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 760
Cdd:cd15965  124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 158519993 761 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 829
Cdd:cd15965  204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_8 pfam13855
Leucine rich repeat;
258-314 1.85e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.85e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 158519993  258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
51-273 1.26e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  51 DCSELGLSAVPGDLDPLTAYLDLSMNNLTELqPGLFHHLRFLEelrLSGNHLSHIPGQAfSGLYSLKILmlqNNQLGGIP 130
Cdd:PRK15387 207 NVGESGLTTLPDCLPAHITTLVIPDNNLTSL-PALPPELRTLE---VSGNQLTSLPVLP-PGLLELSIF---SNPLTHLP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 131 AealweLPSlqslrldanlislvpersfeglsSLRHLWLDDNALTEIPVRAlnnlPALQAMTLALNRISHIPDYAfqnlT 210
Cdd:PRK15387 279 A-----LPS-----------------------GLCKLWIFGNQLTSLPVLP----PGLQELSVSDNQLASLPALP----S 322

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 211 SLVVLHLHNNRIQHLGTHSfEGLHNLETLDlnyNKLQEFPvairTL-GRLQELGFHNNNIKAIP 273
Cdd:PRK15387 323 ELCKLWAYNNQLTSLPTLP-SGLQELSVSD---NQLASLP----TLpSELYKLWAYNNRLTSLP 378
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-124 1.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.93e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 158519993  70 YLDLSMNNLTELQPglFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNN 124
Cdd:cd21340  124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 372-445 2.56e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 2.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158519993 372 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGL 445
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 92-212 2.63e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.46  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993   92 LEELRLSgNHLSHIPGQAFSGLYSLKILMLQNNqLGGIPAEALWELpSLQSLRLDANLISLvPERSFEGLSSLRHLWLDD 171
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSSLTSI-GEYAFSNCSNLKSITLPS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 158519993  172 NaLTEIPVRALNNLPaLQAMTLALNrISHIPDYAFQNLTSL 212
Cdd:pfam13306  89 N-LTSIGSYAFSNCS-LKSITIPSS-VTTIGSYAFSNCSNL 126
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 208-473 3.22e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ-EFPVAIRTLG-RLQELGFHNNNIKAIPEKAFMgnPLLQT 285
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSI--PNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 286 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLE---LSH 361
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLKwiyLGY 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 362 NQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTtlpl 439
Cdd:PLN00113 222 NNLSgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS---- 297

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 158519993 440 aglGGLMHLKLK-GNLALSQAFSKD----------SFPKLRILEV 473
Cdd:PLN00113 298 ---GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPRLQVLQL 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 352-384 7.44e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 7.44e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 158519993  352 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHN 384
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
333-481 1.20e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 333 LTLTRAGIRLLPSGMCQQLPRLRVLElshNQIEELPSLHRcQKLEEIGLQHNRIWEIGadtfSQL-SSLQALDLSWNAIR 411
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANS---NQLTSIPATLP-DTIQEMELSINRITELP----ERLpSALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 158519993 412 SIhPEAFStlHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNlalSQAFSKDSFP-KLRILEV-PYAYQCCP 481
Cdd:PRK15370 276 CL-PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPpGLKTLEAgENALTSLP 341
PLN03150 PLN03150
hypothetical protein; Provisional
 392-453 2.04e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 2.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 158519993 392 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 453
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRilnLNGN 500
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 570-831 7.47e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 42.66  E-value: 7.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 570 AIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 649
Cdd:cd00637    7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 650 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 729
Cdd:cd00637   79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 730 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 795
Cdd:cd00637  159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 158519993 796 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 831
Cdd:cd00637  239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 210-246 9.42e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 9.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 158519993  210 TSLVVLHLHNNRIQHLGthSFEGLHNLETLDLNYNKL 246
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-68 1.55e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.91  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 158519993    34 ACPAPCHCqEDGIMlsaDCSELGLSAVPGDLDPLT 68
Cdd:smart00013   1 ACPAPCNC-SGTAV---DCSGRGLTEVPLDLPPDT 31
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 235-466 2.23e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.17  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  235 NLETLDLNYNKLQEFPVAIRTLGRLQELGFH-NNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN 313
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRgSKNLKEIPDLSMATN--LETLKLSDCSSLVELPSSIQYLNKLEDLDMS 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  314 GAMDIQEFPDLKGTTSLEILTLTR-AGIRLLPSGMCQqlprLRVLELSHNQIEELPSLHRCQKLEEIGL---QHNRIWE- 388
Cdd:PLN03210  690 RCENLEILPTGINLKSLYRLNLSGcSRLKSFPDISTN----ISWLDLDETAIEEFPSNLRLENLDELILcemKSEKLWEr 765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  389 --IGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQLTTLPLAglgglMHLKLKGNLALSQAFSKDS 464
Cdd:PLN03210  766 vqPLTPLMTMLSpSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTG-----INLESLESLDLSGCSRLRT 840


                  ..
gi 158519993  465 FP 466
Cdd:PLN03210  841 FP 842
LRR_8 pfam13855
Leucine rich repeat;
281-364 4.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  281 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 158519993  361 HNQI 364
Cdd:pfam13855  58 GNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 34-64 4.81e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 4.81e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 158519993   34 ACPAPCHCQEdgimLSADCSELGLSAVPGDL 64
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDL 27
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-212 4.97e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  71 LDLSMNNLTElqPG---LFHHLRF---LEELRLSGNHLSHiPG-----QAFSGLYSLKILMLQNNQL---GGIP-AEALW 135
Cdd:COG5238  269 LYLSGNQIGA--EGaiaLAKALQGnttLTSLDLSVNRIGD-EGaialaEGLQGNKTLHTLNLAYNGIgaqGAIAlAKALQ 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993 136 ELPSLQSLRLDANLIS----LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNlpALQAMTLALNRIS--HIPDYAFQNL 209
Cdd:COG5238  346 ENTTLHSLDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALID--ALQTNRLHTLILDgnLIGAEAQQRL 423


                 ...
gi 158519993 210 TSL 212
Cdd:COG5238  424 EQL 426
LRR smart00370
Leucine-rich repeats, outliers;
397-419 7.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 7.39e-03
                           10        20
                   ....*....|....*....|...
gi 158519993   397 LSSLQALDLSWNAIRSIHPEAFS 419
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
397-419 7.39e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 7.39e-03
                           10        20
                   ....*....|....*....|...
gi 158519993   397 LSSLQALDLSWNAIRSIHPEAFS 419
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN03150 PLN03150
hypothetical protein; Provisional
 71-151 7.77e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 7.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158519993  71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 158519993 151 S 151
Cdd:PLN03150 503 S 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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