NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|317373286|sp|Q9H892|]
View 

RecName: Full=Tetratricopeptide repeat protein 12; Short=TPR repeat protein 12

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-206 9.33e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 9.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 317373286 185 LALKNYSVSRECYKKILEINPK 206
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-206 9.33e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 9.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 317373286 185 LALKNYSVSRECYKKILEINPK 206
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 50-193 1.21e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.54  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286   50 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 129
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 317373286  130 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTK-------AYFHMGKANLALKNYSVS 193
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS 220
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 105-255 5.37e-09

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 58.64  E-value: 5.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373286 185 LALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDL---QEKADLQEKEAHELLDSGKNTAVT--TKNLLETLSKP 255
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLAPG-DSRFTKLIKECDEkiaEEEKDLVQPVPSDLPSSVTAPPVEeaDATPVVPPSKP 155
TPR_1 pfam00515
Tetratricopeptide repeat;
143-173 2.72e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 2.72e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 317373286  143 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 173
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 143-173 3.42e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.42e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 317373286   143 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 173
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 106-164 8.60e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 8.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373286 106 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 164
Cdd:cd15830    3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-206 9.33e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 9.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100
                 ....*....|....*....|..
gi 317373286 185 LALKNYSVSRECYKKILEINPK 206
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPD 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
106-206 6.30e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 6.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG0457   42 AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALL 121

                         90       100
                 ....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPK 206
Cdd:COG0457  122 ELGRYDEAIEAYERALELDPD 142
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
106-236 9.35e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 9.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLD 236
Cdd:COG0457  156 KLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 92-206 1.06e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  92 AKERAKRRRENkvlADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDE 171
Cdd:COG4235    6 LRQALAANPND---AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 317373286 172 KCTKAYFHMGKANLALKNYSVSRECYKKILEINPK 206
Cdd:COG4235   83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 50-193 1.21e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.54  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286   50 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 129
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 317373286  130 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTK-------AYFHMGKANLALKNYSVS 193
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 106-206 3.02e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         90       100
                 ....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPK 206
Cdd:COG3914  192 DLGRLEEAIAAYRRALELDPD 212
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 106-206 4.45e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.58  E-value: 4.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG4783   38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117

                         90       100
                 ....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPK 206
Cdd:COG4783  118 ALGRPDEAIAALEKALELDPD 138
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 105-255 5.37e-09

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 58.64  E-value: 5.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373286 185 LALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDL---QEKADLQEKEAHELLDSGKNTAVT--TKNLLETLSKP 255
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLAPG-DSRFTKLIKECDEkiaEEEKDLVQPVPSDLPSSVTAPPVEeaDATPVVPPSKP 155
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 82-205 1.15e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  82 EAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALV 161
Cdd:COG5010   30 ALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKE 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 317373286 162 DCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINP 205
Cdd:COG5010  110 YYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 106-237 2.30e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 317373286 186 ALKNYSVSRECYKKILEINPKlqtQVKGYLNQVDLQEKADlQEKEAHELLDS 237
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPD---YLPALPRLAELYEKLG-DPEEALELLRK 237
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
116-208 2.63e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 116 AFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALvDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRE 195
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|...
gi 317373286 196 CYKKILEINPKLQ 208
Cdd:COG3063   81 YLERALELDPSAL 93
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 106-206 3.78e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 3.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                         90       100
                 ....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPK 206
Cdd:COG4783   84 KAGDYDEALALLEKALKLDPE 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 94-235 6.62e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 6.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  94 ERAKRRRENKvlADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKC 173
Cdd:COG2956   66 QKLLERDPDR--AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 317373286 174 TKAYFHMGKANLALKNYSVSRECYKKILEINPKLqtqVKGYLNQVDLQEKADlQEKEAHELL 235
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDC---ARALLLLAELYLEQG-DYEEAIAAL 201
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
76-238 7.88e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.77  E-value: 7.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  76 AEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 155
Cdd:COG4785   43 DLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 156 YEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQV-KGYLNQVDL---QEKADLQEKEA 231
Cdd:COG4785  123 YDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAlWLYLAERKLdpeKALALLLEDWA 202


                 ....*..
gi 317373286 232 HELLDSG 238
Cdd:COG4785  203 TAYLLQG 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-235 2.16e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  90 KDAKERAKR-RRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:COG2956  127 EKAIEVLERlLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 317373286 169 CDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPklqtQVKGYLNQVDLQEKADlQEKEAHELL 235
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDP----SDDLLLALADLLERKE-GLEAALALL 268
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
71-206 4.68e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.45  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  71 TAMKSAEEINSEAFLASVEKDAKERAKRRRENKVL----ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYtNR 146
Cdd:COG4785    1 LYALALALLLALALAAAAASKAAILLAALLFAAVLalaiALADLALALAAAALAAAALAAERIDRALALPDLAQLYY-ER 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 147 AQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPK 206
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 105-205 3.15e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.38  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                         90       100
                 ....*....|....*....|.
gi 317373286 185 LALKNYSVSRECYKKILEINP 205
Cdd:COG3914  157 RRLGRLEEAIAALRRALELDP 177
TPR_1 pfam00515
Tetratricopeptide repeat;
143-173 2.72e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 2.72e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 317373286  143 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 173
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 143-173 3.42e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.42e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 317373286   143 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 173
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 106-236 3.55e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 185
Cdd:COG2956   42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 317373286 186 ALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDLQEKadlQEKEAHELLD 236
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLGPE-NAHAYCELAELYLEQG---DYDEAIEALE 168
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 76-236 5.63e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.52  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  76 AEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 155
Cdd:COG3914   14 AAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 156 YEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLqtqVKGYLNQVDLQEKADlQEKEAHELL 235
Cdd:COG3914   94 YEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF---AEAYLNLGEALRRLG-RLEEAIAAL 169


                 .
gi 317373286 236 D 236
Cdd:COG3914  170 R 170
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 48-205 6.84e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 46.13  E-value: 6.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286   48 MEEDQEEDEcrttlnKTMISPPQTAMKSAEEINSEAFlasvEKDAKERAKRRRENKV---LADALKEKGNEAFAEGNYET 124
Cdd:TIGR00990 280 LEDSNELDE------ETGNGQLQLGLKSPESKADESY----EEAARAFEKALDLGKLgekEAIALNLRGTFKCLKGKHLE 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286  125 AILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEIN 204
Cdd:TIGR00990 350 ALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLD 429


                  .
gi 317373286  205 P 205
Cdd:TIGR00990 430 P 430
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 115-206 1.08e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 42.29  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 115 EAFAEGNYETAILRYSEGLEKLKDMKVL---YTNRAQAYMKLEDYEKALVDCEWALKC---DEKCTKAYFHMGKANLALK 188
Cdd:COG1729    2 ALLKAGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRypdSPKAPDALLKLGLSYLELG 81

                         90
                 ....*....|....*...
gi 317373286 189 NYSVSRECYKKILEINPK 206
Cdd:COG1729   82 DYDKARATLEELIKKYPD 99
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 111-206 2.99e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 111 EKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNY 190
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90
                 ....*....|....*.
gi 317373286 191 SVSRECYKKILEINPK 206
Cdd:COG2956   93 DRAEELLEKLLELDPD 108
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 105-206 9.01e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373286 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 184
Cdd:COG5010   19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                         90       100
                 ....*....|....*....|..
gi 317373286 185 LALKNYSVSRECYKKILEINPK 206
Cdd:COG5010   99 SRSGDKDEAKEYYEKALALSPD 120
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
90-160 2.43e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 40.25  E-value: 2.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373286  90 KDAKERAKRRR--ENKV-LADALkekgneaFAEGNYETAILRYSEGLEKL--KDMKVLYtNRAQAYMKLEDYEKAL 160
Cdd:COG4700   77 RELEKALEFADtvQNRVrLADAL-------LELGRYDEAIELYEEALTGIfaDDPHILL-GLAQALFELGRYAEAL 144
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
106-168 6.39e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 6.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 317373286 106 ADALKEKGNEAFAEGNYETAIlRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:COG3063   26 ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 106-164 8.60e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 8.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373286 106 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 164
Cdd:cd15830    3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 175-206 9.82e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.42  E-value: 9.82e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 317373286  175 KAYFHMGKANLALKNYSVSRECYKKILEINPK 206
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH