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Conserved domains on  [gi|1812588785|sp|Q9H074|]
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RecName: Full=Polyadenylate-binding protein-interacting protein 1; Short=PABP-interacting protein 1; Short=PAIP-1; Short=Poly(A)-binding protein-interacting protein 1

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10501351)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats

CATH:  1.25.40.180
Gene Ontology:  GO:0005515|GO:0003723
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 160-376 5.89e-43

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 150.98  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 160 EYVQDFLNHLTeqPGSFETEIEQFAETLNgcvTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTIspqsgNFR 239
Cdd:pfam02854   2 KKVKGILNKLS--PENFEKLIKELLKLIM---SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT-----DFG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 240 QLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLnalfsNPMDDNLICA 319
Cdd:pfam02854  72 IHLLNRLQEEFEKRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKEDL-----KRDLFNLECL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 320 VKLLKLTGSVLEDawkEKGKMDMEEIIQRIENVVLDA---NCSRDVKQMLLKLVELRSSN 376
Cdd:pfam02854 147 LTLLTTIGKLLEN---EKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
35-123 6.56e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  35 AGPAERARHQPPQPKAPGFLQPPPLRQPR--TTPPPGAQCEVPASP-QRPSRPGALPEQTRPLRAPPSSQDKIPQQNSES 111
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPapAAAPAAAASAPAAPPaAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                          90
                  ....*....|..
gi 1812588785 112 AMAKPQVVVAPV 123
Cdd:PRK14951  453 AQAAPETVAIPV 464
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 160-376 5.89e-43

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 150.98  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 160 EYVQDFLNHLTeqPGSFETEIEQFAETLNgcvTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTIspqsgNFR 239
Cdd:pfam02854   2 KKVKGILNKLS--PENFEKLIKELLKLIM---SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT-----DFG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 240 QLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLnalfsNPMDDNLICA 319
Cdd:pfam02854  72 IHLLNRLQEEFEKRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKEDL-----KRDLFNLECL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 320 VKLLKLTGSVLEDawkEKGKMDMEEIIQRIENVVLDA---NCSRDVKQMLLKLVELRSSN 376
Cdd:pfam02854 147 LTLLTTIGKLLEN---EKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 160-376 1.14e-37

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 136.72  E-value: 1.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  160 EYVQDFLNHLTeqPGSFETEIEQFAETLNgcvTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTispqsgNFR 239
Cdd:smart00543   2 KKVKGLINKLS--PSNFESIIKELLKLNN---SDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNP------DFG 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  240 QLLLQRCRTEYEVKdqAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILqvglrELLNALFSNPMDDNLICA 319
Cdd:smart00543  71 SLLLERLQEEFEKG--LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELL-----NDLTKLDPPRSDFSVECL 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  320 VKLLKLTGSVLEDawkEKGKMDMEEIIQRIENVVLDA---NCSRDVKQMLLKLVELRSSN 376
Cdd:smart00543 144 LSLLPTCGKDLER---EKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKNK 200
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 35-123 6.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  35 AGPAERARHQPPQPKAPGFLQPPPLRQPR--TTPPPGAQCEVPASP-QRPSRPGALPEQTRPLRAPPSSQDKIPQQNSES 111
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPapAAAPAAAASAPAAPPaAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                          90
                  ....*....|..
gi 1812588785 112 AMAKPQVVVAPV 123
Cdd:PRK14951  453 AQAAPETVAIPV 464
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 43-123 3.41e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  43 HQPP-------QPKAPGFLQPPPLRQPRTTPPPGAQCEVPAS----------PQRPSRPGALPEQTRPLRAPPSSQDKIP 105
Cdd:pfam03154 411 HPPPlqlmpqsQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGlhqvpsqspfPQHPFVPGGPPPITPPSGPPTSTSSAMP 490

                          90       100
                  ....*....|....*....|....
gi 1812588785 106 ------QQNSESAMAKPQVVVAPV 123
Cdd:pfam03154 491 giqppsSASVSSSGPVPAAVSCPL 514
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 45-118 8.37e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 41.43  E-value: 8.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812588785  45 PPQPKAPGFLQPPPlrQPRTTPPPGaqcevPASPQRPSRPGalPEQTRPLRAPPSSQDKIPQQNSESAMAKPQV 118
Cdd:NF040983  102 PPPTPPPPPPPPPP--PPPPSPPPP-----PPPSPPPSPPP--PTTTPPTRTTPSTTTPTPSMHPIQPTQLPSI 166
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 35-105 5.12e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.22  E-value: 5.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812588785  35 AGPAERARHQP---PQPKAPGFLQPPPLRQPRTTPPPgaqcEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIP 105
Cdd:NF041121   25 EGPAPTAASQPatpPPPAAPPSPPGDPPEPPAPEPAP----LPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 160-376 5.89e-43

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 150.98  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 160 EYVQDFLNHLTeqPGSFETEIEQFAETLNgcvTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTIspqsgNFR 239
Cdd:pfam02854   2 KKVKGILNKLS--PENFEKLIKELLKLIM---SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPT-----DFG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 240 QLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLnalfsNPMDDNLICA 319
Cdd:pfam02854  72 IHLLNRLQEEFEKRFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLSSLTKEDL-----KRDLFNLECL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785 320 VKLLKLTGSVLEDawkEKGKMDMEEIIQRIENVVLDA---NCSRDVKQMLLKLVELRSSN 376
Cdd:pfam02854 147 LTLLTTIGKLLEN---EKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 160-376 1.14e-37

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 136.72  E-value: 1.14e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  160 EYVQDFLNHLTeqPGSFETEIEQFAETLNgcvTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTispqsgNFR 239
Cdd:smart00543   2 KKVKGLINKLS--PSNFESIIKELLKLNN---SDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNP------DFG 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  240 QLLLQRCRTEYEVKdqAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILqvglrELLNALFSNPMDDNLICA 319
Cdd:smart00543  71 SLLLERLQEEFEKG--LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELL-----NDLTKLDPPRSDFSVECL 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  320 VKLLKLTGSVLEDawkEKGKMDMEEIIQRIENVVLDA---NCSRDVKQMLLKLVELRSSN 376
Cdd:smart00543 144 LSLLPTCGKDLER---EKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKNK 200
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 35-123 6.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  35 AGPAERARHQPPQPKAPGFLQPPPLRQPR--TTPPPGAQCEVPASP-QRPSRPGALPEQTRPLRAPPSSQDKIPQQNSES 111
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPapAAAPAAAASAPAAPPaAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                          90
                  ....*....|..
gi 1812588785 112 AMAKPQVVVAPV 123
Cdd:PRK14951  453 AQAAPETVAIPV 464
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-117 7.08e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 7.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785   37 PAER-ARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMAK 115
Cdd:PHA03247  2882 PVRRlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961


                   ..
gi 1812588785  116 PQ 117
Cdd:PHA03247  2962 PW 2963
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-133 1.98e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785   36 GPAER---ARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGAL--PEQTRPLRAPPSSQDKIPQQNSE 110
Cdd:PHA03247  2860 GDVRRrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPppPQPQPQPPPPPQPQPPPPPPPRP 2939

                           90       100
                   ....*....|....*....|...
gi 1812588785  111 SAMAKPQVVVAPVLMSKLSVNAP 133
Cdd:PHA03247  2940 QPPLAPTTDPAGAGEPSGAVPQP 2962
PHA03378 PHA03378
EBNA-3B; Provisional
 42-122 3.29e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  42 RHQPPQPkAPGFLQPPPLRQPRTTPPPGAQCEVP---ASPQRPSRPGALPEQTRPLRAPPSSQDKIPQ-QNSESAMAKPQ 117
Cdd:PHA03378  713 RAQRPAA-ATGRARPPAAAPGRARPPAAAPGRARppaAAPGRARPPAAAPGRARPPAAAPGAPTPQPPpQAPPAPQQRPR 791


                  ....*
gi 1812588785 118 VVVAP 122
Cdd:PHA03378  792 GAPTP 796
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 43-123 3.41e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  43 HQPP-------QPKAPGFLQPPPLRQPRTTPPPGAQCEVPAS----------PQRPSRPGALPEQTRPLRAPPSSQDKIP 105
Cdd:pfam03154 411 HPPPlqlmpqsQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGlhqvpsqspfPQHPFVPGGPPPITPPSGPPTSTSSAMP 490

                          90       100
                  ....*....|....*....|....
gi 1812588785 106 ------QQNSESAMAKPQVVVAPV 123
Cdd:pfam03154 491 giqppsSASVSSSGPVPAAVSCPL 514
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 44-145 5.57e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 5.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  44 QPPQPKAPGFL-------QPPPLRQPRTTPPPgaqcEVPASPQRPSRPgALPEQTRPLRAP-----PSSQDKIPQQNSES 111
Cdd:PTZ00449  608 RPKSPKLPELLdipkspkRPESPKSPKRPPPP----QRPSSPERPEGP-KIIKSPKPPKSPkppfdPKFKEKFYDDYLDA 682

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1812588785 112 AMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYT 145
Cdd:PTZ00449  683 AAKSKETKTTVVLDESFESILKETLPETPGTPFT 716
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 37-125 7.84e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785   37 PAERARHQPPQPKAPgflqPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQtrPLRAPPSSQDkiPQQnseSAMAKP 116
Cdd:PRK10263   773 APQPQYQQPQQPVAP----QPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ--PVAPQPQYQQ--PQQ---PVAPQP 841

                           90
                   ....*....|
gi 1812588785  117 Q-VVVAPVLM 125
Cdd:PRK10263   842 QdTLLHPLLM 851
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 45-118 8.37e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 41.43  E-value: 8.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812588785  45 PPQPKAPGFLQPPPlrQPRTTPPPGaqcevPASPQRPSRPGalPEQTRPLRAPPSSQDKIPQQNSESAMAKPQV 118
Cdd:NF040983  102 PPPTPPPPPPPPPP--PPPPSPPPP-----PPPSPPPSPPP--PTTTPPTRTTPSTTTPTPSMHPIQPTQLPSI 166
PRK12438 PRK12438
hypothetical protein; Provisional
 52-114 8.81e-04

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 42.16  E-value: 8.81e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1812588785  52 GFLQPPPLRQPRTTPPPGAQCEVPASPQRPsrpgalPEQTRPLRAPPSSQDKIPQQNSE--SAMA 114
Cdd:PRK12438  900 GRVATAPGGDAASAPPPGAGPPAPPQAVPP------PRTTQPPAAPPRGPDVPPAAVAElrETLA 958
PHA03378 PHA03378
EBNA-3B; Provisional
 41-117 1.22e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  41 ARHQPPqPKAPGFLQPPPLRQPRTTPPPGAQCEVP---ASPQRPSRPGALPEQTRPLRAPPSSQDkiPQQNSESAMAKPQ 117
Cdd:PHA03378  692 GTMQPP-PRAPTPMRPPAAPPGRAQRPAAATGRARppaAAPGRARPPAAAPGRARPPAAAPGRAR--PPAAAPGRARPPA 768
PHA03247 PHA03247
large tegument protein UL36; Provisional
 46-112 2.26e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.26e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1812588785   46 PQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPlRAPPSSQDKIPQQNSESA 112
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARP-RAPVDDRGDPRGPAPPSP 2616
PHA03378 PHA03378
EBNA-3B; Provisional
 37-133 2.28e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  37 PAERARHQPPQpKAPGFLQPPPLRQPRTTPP---PGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDkiPQQNSESAM 113
Cdd:PHA03378  678 PTGANTMLPIQ-WAPGTMQPPPRAPTPMRPPaapPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRAR--PPAAAPGRA 754

                          90       100
                  ....*....|....*....|
gi 1812588785 114 AKPQVVVAPVLMSKLSVNAP 133
Cdd:PHA03378  755 RPPAAAPGRARPPAAAPGAP 774
PHA03160 PHA03160
hypothetical protein; Provisional
 38-115 2.40e-03

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 40.46  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  38 AERARHQPPQPKA--------PGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNS 109
Cdd:PHA03160  405 APKNDHHLLPPLAcsqqlpmqPLHVQQAPMQAPHVAPPPMQPPHVQQPRVLPSTDGASNEAPKPSAQEPVHIDASFAQDP 484


                  ....*.
gi 1812588785 110 ESAMAK 115
Cdd:PHA03160  485 VSKIQK 490
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 45-122 3.30e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  45 PPQP----KAPGFLQPPPLRQPRTTPPPGAQCEVPASPQrPSRPGalPEQTRPLRAPPSSQDKIPQQNSE-----SAMAK 115
Cdd:pfam03154 276 PPMPhslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS-PAAPG--QSQQRIHTPPSQSQLQSQQPPREqplppAPLSM 352


                  ....*..
gi 1812588785 116 PQVVVAP 122
Cdd:pfam03154 353 PHIKPPP 359
PHA03247 PHA03247
large tegument protein UL36; Provisional
 35-139 4.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785   35 AGPAERARHQ----PPQPKAPGflQPPPLRQPRTTPPPGAqcevPASPQRPSRPGAlPEQTRPLRAPPSSQDKIPQQNSE 110
Cdd:PHA03247  2752 GGPARPARPPttagPPAPAPPA--APAAGPPRRLTRPAVA----SLSESRESLPSP-WDPADPPAAVLAPAAALPPAASP 2824

                           90       100
                   ....*....|....*....|....*....
gi 1812588785  111 SAMAKPQVVVAPVLMSKLSVNAPEFYPSG 139
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 35-105 5.12e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.22  E-value: 5.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1812588785  35 AGPAERARHQP---PQPKAPGFLQPPPLRQPRTTPPPgaqcEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIP 105
Cdd:NF041121   25 EGPAPTAASQPatpPPPAAPPSPPGDPPEPPAPEPAP----LPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-126 5.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785   37 PAERARHQPPQPKAPGFLQPPPLRQPrTTPPPGAQCEVPASPQRPSRPGALPEQTRPlrAPPSSQDKIPQQNSESAMAKP 116
Cdd:PHA03247  2714 ALVSATPLPPGPAAARQASPALPAAP-APPAVPAGPATPGGPARPARPPTTAGPPAP--APPAAPAAGPPRRLTRPAVAS 2790

                           90
                   ....*....|
gi 1812588785  117 QVVVAPVLMS 126
Cdd:PHA03247  2791 LSESRESLPS 2800
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 35-116 6.54e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812588785  35 AGPAERARhQPPQPKaPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMA 114
Cdd:PRK14950  369 AKPTAAAP-SPVRPT-PAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPKYTP 446


                  ..
gi 1812588785 115 KP 116
Cdd:PRK14950  447 PA 448
PHA03247 PHA03247
large tegument protein UL36; Provisional
 36-103 7.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 7.35e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1812588785   36 GPAERARHQ----PPQ---PKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDK 103
Cdd:PHA03247  2579 EPAVTSRARrpdaPPQsarPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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