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Conserved domains on  [gi|296434515|sp|Q9BZE0|]
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RecName: Full=Zinc finger protein GLIS2; AltName: Full=GLI-similar 2; AltName: Full=Neuronal Krueppel-like protein

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.82e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 233 KPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                         90
                 ....*....|....*
gi 296434515 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048  110 LSSSSSNSNDNNLLS 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 233 KPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                         90
                 ....*....|....*
gi 296434515 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048  110 LSSSSSNSNDNNLLS 124
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-246 6.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.62e-06
                          10        20
                  ....*....|....*....|..
gi 296434515  225 HIRTHTNEKPHRCPTCSKSFSR 246
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-327 2.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 233 KPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                         90
                 ....*....|....*
gi 296434515 313 HIKAHGHFVSHEQQE 327
Cdd:COG5048  110 LSSSSSNSNDNNLLS 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-308 6.25e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 233 KPHRCPTCSKSFSRLENLKIHNRS--HTGE--KPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPS 308
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 259-319 1.02e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 259 GEKPYVCPYEGCNKRYSNSS-------------------DRFKHTRTHYVDKPYYCkmPGCHKRYTDPSSLRKHIKaHGH 319
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNglkyhmlhghqnqklhenpSPEKMNIFSAKDKPYRC--EVCDKRYKNLNGLKYHRK-HSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-317 5.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515  59 FLLNSKFPEKVEGRFSAAPLVDLSLSPPsglDSPNGSSSLSPERQGNGDLPPVPSASDFQPLRYL-DGVPSSFQFFLPLG 137
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYS---IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSpSSLSSSDSSSSASE 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 138 SGGALHLPASSFLTPPKDKCLSPdlPLPKQLVCRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCarhGRGFN 217
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSSS--EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLC---GKLFS 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 218 ARYKMLIHIRTHTNEKPHRCPT--CSKSFSRLENLK-----IHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVD 290
Cdd:COG5048  335 RNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF 414

                        250       260
                 ....*....|....*....|....*..
gi 296434515 291 KPYYCKMPGCHKRYTDPSSLRKHIKAH 317
Cdd:COG5048  415 RPYNCKNPPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-246 6.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 6.62e-06
                          10        20
                  ....*....|....*....|..
gi 296434515  225 HIRTHTNEKPHRCPTCSKSFSR 246
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-304 1.67e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434515 214 RGFNARYKMLIHIRTHTNEKPHRC--PTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDK 291
Cdd:COG5048   41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDN 120

                         90
                 ....*....|...
gi 296434515 292 PYYCKMPGCHKRY 304
Cdd:COG5048  121 NLLSSHSLPPSSR 133
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 235-257 6.19e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.19e-04
                          10        20
                  ....*....|....*....|...
gi 296434515  235 HRCPTCSKSFSRLENLKIHNRSH 257
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-276 8.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.57e-04
                          10        20
                  ....*....|....*....|....*...
gi 296434515  249 NLKIHNRSHTGEKPYVCPYegCNKRYSN 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
235-257 3.57e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 34.91  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|...
gi 296434515  235 HRCPTCSKSFSRLENLKIHNRSH 257
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSH 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 293-317 7.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.55e-03
                          10        20
                  ....*....|....*....|....*
gi 296434515  293 YYCkmPGCHKRYTDPSSLRKHIKAH 317
Cdd:pfam00096   1 YKC--PDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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