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Conserved domains on  [gi|23821855|sp|Q9BYS8|]
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RecName: Full=Leucine-rich repeat-containing protein 2

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-298 6.53e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 6.53e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
Cdd:COG4886 120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 185 ELGDCENLERLDCSGNlELMELPFELSNLKQVTFVDISANKFSSVPiCVLRMSNLQWLDISSNNLTDLPqDIDRLEELQS 264
Cdd:COG4886 200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                       170       180       190
                ....*....|....*....|....*....|....
gi 23821855 265 FLLYKNKLTYlpysmLNLKKLTLLVVSGDHLVEL 298
Cdd:COG4886 277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLL 305
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-298 6.53e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 6.53e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
Cdd:COG4886 120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 185 ELGDCENLERLDCSGNlELMELPFELSNLKQVTFVDISANKFSSVPiCVLRMSNLQWLDISSNNLTDLPqDIDRLEELQS 264
Cdd:COG4886 200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                       170       180       190
                ....*....|....*....|....*....|....
gi 23821855 265 FLLYKNKLTYlpysmLNLKKLTLLVVSGDHLVEL 298
Cdd:COG4886 277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLL 305
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-320 2.87e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 2.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   90 LPKDRGKRSSAFVFELSGEHWT-ELPDSLKEQTHLREWYI-SNTLIQIIPTYIQLFQAMRILDLPKNQIS-HLPAEIGCL 166
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLaSNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGL 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  167 KNLKELNVGFNYLK-SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFS-SVPICVLRMSNLQWLDI 244
Cdd:PLN00113 236 TSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23821855  245 SSNNLT-DLPQDIDRLEELQSFLLYKNKLT-YLPYSMLNLKKLTLLVVSGDHLV-ELPTALCDSSTPLKFVsLMDNPID 320
Cdd:PLN00113 316 FSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
LRR_8 pfam13855
Leucine rich repeat;
237-295 3.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23821855   237 SNLQWLDISSNNLTDLPQDI-DRLEELQSFLLYKNKLTYL-PYSMLNLKKLTLLVVSGDHL 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 149-287 2.12e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 149 LDLPKNQISHLPaEIGCLKNLKELNVGFNYLKSIppE-LGDCENLERLDCSG-----NLELMELPFELSNL-KQVTFVDI 221
Cdd:cd21340  51 LYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV--EgLENLTNLEELHIENqrlppGEKLTFDPRSLAALsNSLRVLNI 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23821855 222 SANKFSSV-PICVLRmsNLQWLDISSNNLTDlpqdidrLEELQSFLLyknkltylpySMLNLKKLTL 287
Cdd:cd21340 128 SGNNIDSLePLAPLR--NLEQLDASNNQISD-------LEELLDLLS----------SWPSLRELDL 175
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-298 6.53e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 6.53e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 105 LSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPP 184
Cdd:COG4886 120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 185 ELGDCENLERLDCSGNlELMELPFELSNLKQVTFVDISANKFSSVPiCVLRMSNLQWLDISSNNLTDLPqDIDRLEELQS 264
Cdd:COG4886 200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                       170       180       190
                ....*....|....*....|....*....|....
gi 23821855 265 FLLYKNKLTYlpysmLNLKKLTLLVVSGDHLVEL 298
Cdd:COG4886 277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLL 305
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-319 3.06e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 3.06e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  65 KNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQ 144
Cdd:COG4886  17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 145 AMRILDLPKNQishlpaEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNlELMELPFELSNLKQVTFVDISAN 224
Cdd:COG4886  97 NLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLGNLTNLKSLDLSNN 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 225 KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPtALCd 304
Cdd:COG4886 170 QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELG- 247

                       250
                ....*....|....*
gi 23821855 305 SSTPLKFVSLMDNPI 319
Cdd:COG4886 248 NLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-323 6.68e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 111 TELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPpELGDCE 190
Cdd:COG4886 172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 191 NLERLDCSGNlELMELPfELSNLKQVTFVDISANKFSSVPICVLrmsnlqWLDISSNNLTDLPQDIDRLEELQSFLLYKN 270
Cdd:COG4886 251 NLEELDLSNN-QLTDLP-PLANLTNLKTLDLSNNQLTDLKLKEL------ELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 23821855 271 KLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQ 323
Cdd:COG4886 323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-320 2.87e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 2.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   90 LPKDRGKRSSAFVFELSGEHWT-ELPDSLKEQTHLREWYI-SNTLIQIIPTYIQLFQAMRILDLPKNQIS-HLPAEIGCL 166
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLaSNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGL 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  167 KNLKELNVGFNYLK-SIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFS-SVPICVLRMSNLQWLDI 244
Cdd:PLN00113 236 TSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23821855  245 SSNNLT-DLPQDIDRLEELQSFLLYKNKLT-YLPYSMLNLKKLTLLVVSGDHLV-ELPTALCDSSTPLKFVsLMDNPID 320
Cdd:PLN00113 316 FSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
115-319 2.54e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.18  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  115 DSLKE-QTHLRewyISNTLIQIIPTYIQlfQAMRILDLPKNQISHLPAEIGclKNLKELNVGFNYLKSIPPELGDceNLE 193
Cdd:PRK15370 174 DCLKNnKTELR---LKILGLTTIPACIP--EQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  194 RLDCSGNlELMELPFELSNLKQVtfVDISANKFSSVPICVlrMSNLQWLDISSNNLTDLPQDIDrlEELQSFLLYKNKLT 273
Cdd:PRK15370 245 EMELSIN-RITELPERLPSALQS--LDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLT 317

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 23821855  274 YLPYSM-LNLKKLtllvVSGDH-LVELPTALcdsSTPLKFVSLMDNPI 319
Cdd:PRK15370 318 ALPETLpPGLKTL----EAGENaLTSLPASL---PPELQVLDVSKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 129-299 3.02e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 3.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  129 SNTLIQIIPTYI-QLFQAMRILDLPKNQISHlPAEIGCLKNLKELNVGFNYLK-SIPPELGDCENLERLDCSGNLELMEL 206
Cdd:PLN00113 102 NNQLSGPIPDDIfTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  207 PFELSNLKQVTFVDISANKFS-SVPICVLRMSNLQW------------------------LDISSNNLT-DLPQDIDRLE 260
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWiylgynnlsgeipyeiggltslnhLDLVYNNLTgPIPSSLGNLK 260

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 23821855  261 ELQSFLLYKNKLT-YLPYSMLNLKKLTLLVVSGDHLV-ELP 299
Cdd:PLN00113 261 NLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-314 3.60e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 3.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  123 LREWyiSNTLIQIIPTYIQLFQAMRILDLPKNQIS-HLPAEIGCLKNLKELNVGFNYLKS-IPPELGDCENLERLDCSGN 200
Cdd:PLN00113 337 LQLW--SNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  201 LELMELPFELSNLKQVTFVDISANKFS-SVPICVLRMSNLQWLDISSNNLT-DLPqDIDRLEELQSFLLYKNKLT-YLPY 277
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSgAVPR 493

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 23821855  278 SMLNLKKLTLLVVSGDHLV-ELPTALcdsSTPLKFVSL 314
Cdd:PLN00113 494 KLGSLSELMQLKLSENKLSgEIPDEL---SSCKKLVSL 528
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-334 2.14e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   79 IERNTLTR-QSSLPkdrgkrSSAFVFELSGEHWTELPDSLKeqTHLREWYISNTLIQIIPTyiQLFQAMRILDLPKNQIS 157
Cdd:PRK15370 227 ANSNQLTSiPATLP------DTIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  158 HLPAEIGclKNLKELNVGFNYLKSIPPELGdcENLERLDCSGNlELMELPFELSNLKQVtfVDISANKFSSVPICVlrMS 237
Cdd:PRK15370 297 TLPAHLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGEN-ALTSLPASLPPELQV--LDVSKNQITVLPETL--PP 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  238 NLQWLDISSNNLTDLPQDIDrlEELQSFLLYKNKLTYLPYSmlnlkkltllvvsgdhlveLPTALCDSSTPLKFVsLMDN 317
Cdd:PRK15370 368 TITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPES-------------------LPHFRGEGPQPTRII-VEYN 425

                        250
                 ....*....|....*..
gi 23821855  318 PIDNAQCEDGNEIMESE 334
Cdd:PRK15370 426 PFSERTIQNMQRLMSSV 442
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
26-297 8.49e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.01  E-value: 8.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   26 AWQKK---EVERLEKSALEKIK---EEWNFVAECRRKGIPQAVYCKNGFIDTSVrlldkIERNTLTRQSSLPKDrgkrss 99
Cdd:PRK15387 175 AWRRAapaEESRGRAAVVQKMRaclNNGNAVLNVGESGLTTLPDCLPAHITTLV-----IPDNNLTSLPALPPE------ 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  100 AFVFELSGEHWTELP---DSLKEQ-------THL--------REWYISNTLIQIiPTYIQLFQAMRILDLPKNQISHLPA 161
Cdd:PRK15387 244 LRTLEVSGNQLTSLPvlpPGLLELsifsnplTHLpalpsglcKLWIFGNQLTSL-PVLPPGLQELSVSDNQLASLPALPS 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  162 EIGCL--------------KNLKELNVGFNYLKSIPPELGDCENLerldCSGNLELMELPFELSNLKQVTfvdISANKFS 227
Cdd:PRK15387 323 ELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLT 395

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  228 SVPICVlrmSNLQWLDISSNNLTDLPQdidRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVE 297
Cdd:PRK15387 396 SLPVLP---SELKELMVSGNRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 141-249 9.15e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 9.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  141 QLFQAMRI--LDLPKNQISH-LPAEIGCLKNLKELNVGFNYLKS-IPPELGDCENLERLDCSGNLELMELPFELSNLKQV 216
Cdd:PLN00113 470 DSFGSKRLenLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549

                         90       100       110
                 ....*....|....*....|....*....|....
gi 23821855  217 TFVDISANKFS-SVPICVLRMSNLQWLDISSNNL 249
Cdd:PLN00113 550 SQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
237-295 3.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23821855   237 SNLQWLDISSNNLTDLPQDI-DRLEELQSFLLYKNKLTYL-PYSMLNLKKLTLLVVSGDHL 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 149-287 2.12e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855 149 LDLPKNQISHLPaEIGCLKNLKELNVGFNYLKSIppE-LGDCENLERLDCSG-----NLELMELPFELSNL-KQVTFVDI 221
Cdd:cd21340  51 LYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV--EgLENLTNLEELHIENqrlppGEKLTFDPRSLAALsNSLRVLNI 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23821855 222 SANKFSSV-PICVLRmsNLQWLDISSNNLTDlpqdidrLEELQSFLLyknkltylpySMLNLKKLTL 287
Cdd:cd21340 128 SGNNIDSLePLAPLR--NLEQLDASNNQISD-------LEELLDLLS----------SWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
147-201 2.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 23821855   147 RILDLPKNQISHLPAEI-GCLKNLKELNVGFNYLKSIPPE-LGDCENLERLDCSGNL 201
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
131-300 3.16e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  131 TLIQIIPTYIQlfqamrILDLPKNQISHLPAeigCLKNLKELNVGFNYLKSIP--PElgdceNLERLDCSGNlELMELPF 208
Cdd:PRK15387 215 TLPDCLPAHIT------TLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLPvlPP-----GLLELSIFSN-PLTHLPA 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855  209 ELSNLKQVTfvdISANKFSSVPICVlrmSNLQWLDISSNNLTDLPQdidRLEELQSFLLYKNKLTYLPYSMLNLKKLTll 288
Cdd:PRK15387 280 LPSGLCKLW---IFGNQLTSLPVLP---PGLQELSVSDNQLASLPA---LPSELCKLWAYNNQLTSLPTLPSGLQELS-- 348

                        170
                 ....*....|..
gi 23821855  289 vVSGDHLVELPT 300
Cdd:PRK15387 349 -VSDNQLASLPT 359
LRR_8 pfam13855
Leucine rich repeat;
168-249 6.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   168 NLKELNVGFNYLKSIPPE-LGDCENLERLDCSGNLelmelpfeLSNLKQVTFVDisankfssvpicvlrMSNLQWLDISS 246
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNL--------LTTLSPGAFSG---------------LPSLRYLDLSG 58


                  ...
gi 23821855   247 NNL 249
Cdd:pfam13855  59 NRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 147-200 6.56e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.56e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 23821855 147 RILDLPKNQISHLpAEIGCLKNLKELNVGFNYLKSIP---PELGDCENLERLDCSGN 200
Cdd:cd21340 123 RVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-208 1.14e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 23821855   167 KNLKELNVGFNYLKSIPPeLGDCENLERLDCSGNLELMELPF 208
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSD 41
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 149-302 3.25e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.47  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   149 LDLPKNQISHLPAEIGCLKNLKELNV-GFNYLKSIPpELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDIS-ANKF 226
Cdd:PLN03210  616 LQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSrCENL 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   227 SSVPICV---------------LRM-----SNLQWLDISSNNLTDLPQDIdRLEELQSFLLYKNK--------------L 272
Cdd:PLN03210  695 EILPTGInlkslyrlnlsgcsrLKSfpdisTNISWLDLDETAIEEFPSNL-RLENLDELILCEMKseklwervqpltplM 773

                         170       180       190
                  ....*....|....*....|....*....|
gi 23821855   273 TYLPYSmlnLKKLTLLVVSGdhLVELPTAL 302
Cdd:PLN03210  774 TMLSPS---LTRLFLSDIPS--LVELPSSI 798
LRR_8 pfam13855
Leucine rich repeat;
219-272 7.33e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 23821855   219 VDISANKFSSV-PICVLRMSNLQWLDISSNNLTDL-PQDIDRLEELQSFLLYKNKL 272
Cdd:pfam13855   6 LDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 159-263 9.19e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 38.32  E-value: 9.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23821855   159 LPAEIGCLKNLKELNVGfnylksippelgDCENLERLDCSGNLELMElPFELSNLKQV-TFVDISANKFS---------S 228
Cdd:PLN03210  794 LPSSIQNLHKLEHLEIE------------NCINLETLPTGINLESLE-SLDLSGCSRLrTFPDISTNISDlnlsrtgieE 860

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 23821855   229 VPICVLRMSNLQWLD-ISSNNLTDLPQDIDRLEELQ 263
Cdd:PLN03210  861 VPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLKHLE 896
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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