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Conserved domains on  [gi|74733103|sp|Q9BT92|]
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RecName: Full=Trichoplein keratin filament-binding protein; Short=Protein TCHP; AltName: Full=Mitochondrial protein with oncostatic activity; Short=Mitostatin; AltName: Full=Tumor suppressor protein

Protein Classification

trichohyalin-plectin-homology domain domain-containing protein( domain architecture ID 12159040)

trichohyalin-plectin-homology domain (TPH) domain-containing protein similar to meiosis-specific nuclear structural protein 1, trichoplein keratin filament-binding protein, and cilia- and flagella-associated proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 146-483 7.56e-22

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


:

Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.53  E-value: 7.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
Cdd:pfam13868   4 NSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
Cdd:pfam13868  84 EREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   306 KEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE---LQMLLREEAKEMWEKREAEWARERSARDRLMSEvltG 382
Cdd:pfam13868 164 KAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKERQKEREEAEKKARQRQELQQ---A 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   383 RQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Cdd:pfam13868 241 REEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERL 320

                         330       340
                  ....*....|....*....|.
gi 74733103   463 RRVEQLSDALLQQEAETMAEQ 483
Cdd:pfam13868 321 REEEAERRERIEEERQKKLKE 341
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 146-483 7.56e-22

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.53  E-value: 7.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
Cdd:pfam13868   4 NSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
Cdd:pfam13868  84 EREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   306 KEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE---LQMLLREEAKEMWEKREAEWARERSARDRLMSEvltG 382
Cdd:pfam13868 164 KAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKERQKEREEAEKKARQRQELQQ---A 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   383 RQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Cdd:pfam13868 241 REEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERL 320

                         330       340
                  ....*....|....*....|.
gi 74733103   463 RRVEQLSDALLQQEAETMAEQ 483
Cdd:pfam13868 321 REEEAERRERIEEERQKKLKE 341
PTZ00121 PTZ00121
MAEBL; Provisional
 50-488 6.44e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.79  E-value: 6.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   130 QRKLIAEQLLyehwKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERR 209
Cdd:PTZ00121 1402 EDKKKADELK----KAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKK 1477

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   210 QLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQI 289
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEEL 1557

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   290 QEElEADRRILQALLEKED---------ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE------- 353
Cdd:PTZ00121 1558 KKA-EEKKKAEEAKKAEEDknmalrkaeEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEeekkkve 1636

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   354 ---AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR---ELARREKEESE 427
Cdd:PTZ00121 1637 qlkKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKkaeELKKKEAEEKK 1716

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74733103   428 KLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
Cdd:PTZ00121 1717 KAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEK 1777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 77-453 2.32e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 2.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  77 RRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHwkknnpKLREMELD 156
Cdd:COG1196 202 LEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA------ELEELRLE 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 157 LHQKhvvnSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATK 236
Cdd:COG1196 276 LEEL----ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 237 LKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQynAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLA 316
Cdd:COG1196 352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL--RAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 317 RREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEmwEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRR 396
Cdd:COG1196 430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL--EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFL 507

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74733103 397 AQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQ 453
Cdd:COG1196 508 EGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIE 564
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 73-312 1.48e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103     73 KEEKRRSLEARREKLRQLMQEEQDLLAR---ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLY----EHWKK 145
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQEleeKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILrerlANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERmKAEEERRQLEDKLQAEALLQQME 225
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES-RLEELEEQLETLRSKVAQLELQI 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQ 475


                   ....*..
gi 74733103    306 KEDESQR 312
Cdd:TIGR02168  476 ALDAAER 482
 
Name Accession Description Interval E-value
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 146-483 7.56e-22

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 96.53  E-value: 7.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
Cdd:pfam13868   4 NSDELRELNSKLLAAKCNKERDAQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
Cdd:pfam13868  84 EREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   306 KEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE---LQMLLREEAKEMWEKREAEWARERSARDRLMSEvltG 382
Cdd:pfam13868 164 KAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERdelRAKLYQEEQERKERQKEREEAEKKARQRQELQQ---A 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   383 RQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Cdd:pfam13868 241 REEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERL 320

                         330       340
                  ....*....|....*....|.
gi 74733103   463 RRVEQLSDALLQQEAETMAEQ 483
Cdd:pfam13868 321 REEEAERRERIEEERQKKLKE 341
PTZ00121 PTZ00121
MAEBL; Provisional
 50-488 6.44e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.79  E-value: 6.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   130 QRKLIAEQLLyehwKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERR 209
Cdd:PTZ00121 1402 EDKKKADELK----KAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKK 1477

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   210 QLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQI 289
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEEL 1557

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   290 QEElEADRRILQALLEKED---------ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE------- 353
Cdd:PTZ00121 1558 KKA-EEKKKAEEAKKAEEDknmalrkaeEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEeekkkve 1636

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   354 ---AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR---ELARREKEESE 427
Cdd:PTZ00121 1637 qlkKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKkaeELKKKEAEEKK 1716

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74733103   428 KLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
Cdd:PTZ00121 1717 KAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEK 1777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 77-453 2.32e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 2.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  77 RRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHwkknnpKLREMELD 156
Cdd:COG1196 202 LEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA------ELEELRLE 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 157 LHQKhvvnSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATK 236
Cdd:COG1196 276 LEEL----ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 237 LKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQynAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLA 316
Cdd:COG1196 352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL--RAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 317 RREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEmwEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRR 396
Cdd:COG1196 430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL--EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFL 507

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74733103 397 AQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQ 453
Cdd:COG1196 508 EGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIE 564
PTZ00121 PTZ00121
MAEBL; Provisional
 71-478 2.69e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 2.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    71 KMKEEKRRSLEARR-EKLRQLMQEEQDLLARELEELRlsmNLQERRIREQHGKLKSAKE-EQRKLIAEQLLYEHWKKNNP 148
Cdd:PTZ00121 1176 KKAEAARKAEEVRKaEELRKAEDARKAEAARKAEEER---KAEEARKAEDAKKAEAVKKaEEAKKDAEEAKKAEEERNNE 1252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   149 KLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYerarREALERMKAEEERRQLEDKLQAEALLQQMEELK 228
Cdd:PTZ00121 1253 EIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEA----KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK 1328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   229 LKEVEATklKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAlleKED 308
Cdd:PTZ00121 1329 KKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKA---EED 1403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERA-REAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVltgrqqqi 387
Cdd:PTZ00121 1404 KKKADELKKAAAAKKKADEAKKKAEEKKKADEAkKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA-------- 1475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   388 qEKIEQNRRAQEESLKHREQLIRNLEEVR--ELARREKEESEKLKSARKQElEAQVAERRLQAWEADQ-QEEEEEEEARR 464
Cdd:PTZ00121 1476 -KKKAEEAKKADEAKKKAEEAKKKADEAKkaAEAKKKADEAKKAEEAKKAD-EAKKAEEAKKADEAKKaEEKKKADELKK 1553

                         410
                  ....*....|....
gi 74733103   465 VEQLSDALLQQEAE 478
Cdd:PTZ00121 1554 AEELKKAEEKKKAE 1567
PTZ00121 PTZ00121
MAEBL; Provisional
 50-451 2.44e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 2.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQ---DLLARELEELRLSMNLQERRIREQHG-KLKS 125
Cdd:PTZ00121 1398 KKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAkkaDEAKKKAEEAKKAEEAKKKAEEAKKAdEAKK 1477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   126 AKEEQRKLIAEQLLYEHWKKNNPKLREMEldlHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAE 205
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKKKADEAKKAA---EAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKA 1554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   206 EERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAfrQKAELGRFlrhqynaqlsrR 285
Cdd:PTZ00121 1555 EELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA--KKAEEAKI-----------K 1621

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   286 TQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAElqmllreeaKEMWEKREAEW 365
Cdd:PTZ00121 1622 AEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK---------KAEEDEKKAAE 1692

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   366 ARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARR-EKEESEKLKSARKQELEAQVAER 444
Cdd:PTZ00121 1693 ALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEaKKDEEEKKKIAHLKKEEEKKAEE 1772


                  ....*..
gi 74733103   445 RLQAWEA 451
Cdd:PTZ00121 1773 IRKEKEA 1779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-472 5.05e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 5.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  68 QREKMKEEKRRSLEARREKLRQLmQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQllyEHWKKNN 147
Cdd:COG1196 236 ELEAELEELEAELEELEAELEEL-EAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDI---ARLEERR 311

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 148 PKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL 227
Cdd:COG1196 312 RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA 391

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 228 KLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKE 307
Cdd:COG1196 392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 308 DESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQI 387
Cdd:COG1196 472 AALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNI 551

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 388 QEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQ 467
Cdd:COG1196 552 VVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAAR 631


                ....*
gi 74733103 468 LSDAL 472
Cdd:COG1196 632 LEAAL 636
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 169-478 3.15e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 3.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 169 QKEEKKQQEATAEQENKRYENEYERARREALErmkAEEERRQLEDKLQAEAL----LQQMEELKLKEVEATKLKKEQENL 244
Cdd:COG1196 233 KLRELEAELEELEAELEELEAELEELEAELAE---LEAELEELRLELEELELeleeAQAEEYELLAELARLEQDIARLEE 309

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 245 LKQRWELERLEEERKQMEAFRQKAELgrflrhqyNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMAD 324
Cdd:COG1196 310 RRRELEERLEELEEELAELEEELEEL--------EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL 381

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKemwEKREAEWARERSARDRLMSEVLTGRQQQIQEKieqnRRAQEESLKH 404
Cdd:COG1196 382 EELAEELLEALRAAAELAAQLEELEEAEEAL---LERLERLEEELEELEEALAELEEEEEEEEEAL----EEAAEEEAEL 454

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74733103 405 REQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
Cdd:COG1196 455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV 528
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 12-483 1.22e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  12 SQQRLNQQLARQREQEARLRQQWEQNSRyfrmsdicSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLM 91
Cdd:COG1196 296 ELARLEQDIARLEERRRELEERLEELEE--------ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  92 QEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKE 171
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 172 EKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME--ELKLKEVEATKLKKEQENLLKQ-- 247
Cdd:COG1196 448 AEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAdyEGFLEGVKAALLLAGLRGLAGAva 527

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 248 ---------------------RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQ---IQEELEADRRILQAL 303
Cdd:COG1196 528 vligveaayeaaleaalaaalQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAaalARGAIGAAVDLVASD 607

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 304 LEKEDESQRLHLARREQVMADVAWMKQAIEEQLQL-ERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEvltg 382
Cdd:COG1196 608 LREADARYYVLGDTLLGRTLVAARLEAALRRAVTLaGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE---- 683

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 383 rqqqiqekiEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Cdd:COG1196 684 ---------LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALE 754

                       490       500
                ....*....|....*....|.
gi 74733103 463 RRVEQLSDALLQQEAETMAEQ 483
Cdd:COG1196 755 ELPEPPDLEELERELERLERE 775
PTZ00121 PTZ00121
MAEBL; Provisional
 21-367 6.52e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 6.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    21 ARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSmhAYQREKMKEEKRRSLEARR-EKLRQLMQEEQDLLA 99
Cdd:PTZ00121 1462 AKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKK--AAEAKKKADEAKKAEEAKKaDEAKKAEEAKKADEA 1539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   100 RELEELRLSMNLQE----RRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEE--- 172
Cdd:PTZ00121 1540 KKAEEKKKADELKKaeelKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEeak 1619

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   173 -KKQQEATAEQENKRYEneyERARREALERMKAEEERRQLED-KLQAEALLQQMEELKLKeveATKLKKEQENLLKQRWE 250
Cdd:PTZ00121 1620 iKAEELKKAEEEKKKVE---QLKKKEAEEKKKAEELKKAEEEnKIKAAEEAKKAEEDKKK---AEEAKKAEEDEKKAAEA 1693

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   251 LERLEEERKQMEAFRQKAElgrflrhqynAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQvmADVAWMKQ 330
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEA----------EEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDE--EEKKKIAH 1761

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 74733103   331 AIEEQLQLERAREAELQMLLREEAKEMWEKREAEWAR 367
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDK 1798
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 68-378 1.63e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.84  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    68 QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQErRIREQhgKLKSAKEEQRKLIAEQLLYEHWKKNN 147
Cdd:pfam13868  35 KAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE-QIEER--EQKRQEEYEEKLQEREQMDEIVERIQ 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   148 PKLREMELDLHQKHVVNSWEMQKEEKKQQEatAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL 227
Cdd:pfam13868 112 EEDQAEAEEKLEKQRQLREEIDEFNEEQAE--WKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   228 KLKEVEATKLKKEQENLLKQRWE-LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
Cdd:pfam13868 190 RAQQEKAQDEKAERDELRAKLYQeEQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRK 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74733103   307 EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSE 378
Cdd:pfam13868 270 QAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKKLKE 341
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 48-322 4.08e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 4.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    48 SSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAK 127
Cdd:pfam17380 285 SERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELER 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   128 EEQRKLIA--------EQLLYEHWKKNNPKLREMELDLHQKhvvnsweMQKEEKKQQEATAEQENKRYENEYERARREAL 199
Cdd:pfam17380 365 IRQEEIAMeisrmrelERLQMERQQKNERVRQELEAARKVK-------ILEEERQRKIQQQKVEMEQIRAEQEEARQREV 437

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   200 ERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE--ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQ 277
Cdd:pfam17380 438 RRLEEERAREMERVRLEEQERQQQVERLRQQEEErkRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKL 517

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   278 YNAQLSRRTQQI---------------QEELEADRRILQALLEKEDESQRLHLARREQVM 322
Cdd:pfam17380 518 LEKEMEERQKAIyeeerrreaeeerrkQQEMEERRRIQEQMRKATEERSRLEAMEREREM 577
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 73-312 1.48e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103     73 KEEKRRSLEARREKLRQLMQEEQDLLAR---ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLY----EHWKK 145
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQEleeKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILrerlANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERmKAEEERRQLEDKLQAEALLQQME 225
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES-RLEELEEQLETLRSKVAQLELQI 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQ 475


                   ....*..
gi 74733103    306 KEDESQR 312
Cdd:TIGR02168  476 ALDAAER 482
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 100-443 3.13e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 3.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    100 RELEELRLSMNLQERRIREQHGKLKSAKEEQRKLiaeqllyehwKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEEL----------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    180 AEQENKRYENEYERARREALERMKAEEE---RRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEE 256
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEeelAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    257 ERKQMEAFRQKAELGRFlrhqynAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL 336
Cdd:TIGR02168  827 ESLERRIAATERRLEDL------EEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELS 900

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103    337 QLERAREAELQML--LREEAKEMWEKREAEWARERSARDRLMS------EVLTGRQQQIQEKIEQNRRAQEESLKHREQL 408
Cdd:TIGR02168  901 EELRELESKRSELrrELEELREKLAQLELRLEGLEVRIDNLQErlseeySLTLEEAEALENKIEDDEEEARRRLKRLENK 980

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 74733103    409 IRNLEEVRELARREKEESEKlksaRKQELEAQVAE 443
Cdd:TIGR02168  981 IKELGPVNLAAIEEYEELKE----RYDFLTAQKED 1011
PTZ00121 PTZ00121
MAEBL; Provisional
 144-462 3.23e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   144 KKNNPKLREMELDLHQKHVVNswEMQKEEKKQQEATAEQENKRYENEyerarREALERMKAEEERRQLEDKLQAEALLQQ 223
Cdd:PTZ00121 1070 EGLKPSYKDFDFDAKEDNRAD--EATEEAFGKAEEAKKTETGKAEEA-----RKAEEAKKKAEDARKAEEARKAEDARKA 1142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   224 MEELKLKEVEATKLKKEQENllKQRWELERLEEERKQMEAFRqKAELGRFLRHQYNAQLSRRTQQIQEeLEADRRILQAL 303
Cdd:PTZ00121 1143 EEARKAEDAKRVEIARKAED--ARKAEEARKAEDAKKAEAAR-KAEEVRKAEELRKAEDARKAEAARK-AEEERKAEEAR 1218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   304 lEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML---LREEAKEMWEKREAEWAR--ERSARDRLMSE 378
Cdd:PTZ00121 1219 -KAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAhfaRRQAAIKAEEARKADELKkaEEKKKADEAKK 1297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   379 VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESE-KLKSARKQELEAQVAERRLQAWEADQQEEE 457
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEaAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377


                  ....*
gi 74733103   458 EEEEA 462
Cdd:PTZ00121 1378 KKADA 1382
PRK12704 PRK12704
phosphodiesterase; Provisional
 122-298 8.34e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  122 KLKSAKEEqrkliAEQLLYEHWKKNNPKLREMELDlhqkhvvnswemQKEEKKQQEATAEQENKRYENEYERA------R 195
Cdd:PRK12704  32 KIKEAEEE-----AKRILEEAKKEAEAIKKEALLE------------AKEEIHKLRNEFEKELRERRNELQKLekrllqK 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  196 REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLkqrwelerleEERKQMEAFRQKAELGRFLR 275
Cdd:PRK12704  95 EENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQEL----------ERISGLTAEEAKEILLEKVE 164

                        170       180
                 ....*....|....*....|....*
gi 74733103  276 HQYNAQLSRRTQQIQEE--LEADRR 298
Cdd:PRK12704 165 EEARHEAAVLIKEIEEEakEEADKK 189
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 158-462 1.66e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   158 HQKHVVNSWEMQKEEKKQQeataeqenkryeneyERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKL 237
Cdd:pfam17380 280 HQKAVSERQQQEKFEKMEQ---------------ERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQlsRRTQQIQEELEADRRilQALLEKEDESQ-RLHLA 316
Cdd:pfam17380 345 ERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQ--QKNERVRQELEAARK--VKILEEERQRKiQQQKV 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103   317 RREQVMADVAWMKQAIEEQLQLERAREAElqmllREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRR 396
Cdd:pfam17380 421 EMEQIRAEQEEARQREVRRLEEERAREME-----RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRK 495

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74733103   397 AQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Cdd:pfam17380 496 ILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKA 561
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 169-242 1.94e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.56  E-value: 1.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74733103  169 QKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQ-QMEELKLKEVEATKLKKEQE 242
Cdd:PRK09510  78 EEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQkQAEEAAAKAAAAAKAKAEAE 152
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 280-488 2.74e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 280 AQLSRRTQQIQEELEADRRILQALLEKEDESQRLhLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWE 359
Cdd:COG4942  23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 360 KREAEWARERSA-----RDRLM------SEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEK 428
Cdd:COG4942 102 QKEELAELLRALyrlgrQPPLAlllspeDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 429 LKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
Cdd:COG4942 182 ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 68-247 8.33e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 8.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103  68 QREKMKEEKRRSLEARREKLRQLMQEEQDLLaRELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL-LYEHWKKN 146
Cdd:COG4942  24 EAEAELEQLQQEIAELEKELAALKKEEKALL-KQLAALERRIAALARRIRALEQELAALEAELAELEKEIAeLRAELEAQ 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74733103 147 NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEE 226
Cdd:COG4942 103 KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                       170       180
                ....*....|....*....|.
gi 74733103 227 LKLKEVEATKLKKEQENLLKQ 247
Cdd:COG4942 183 LEEERAALEALKAERQKLLAR 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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