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Conserved domains on  [gi|61248556|sp|Q99J36|]
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RecName: Full=THUMP domain-containing protein 1

Protein Classification

THUMP domain-containing protein( domain architecture ID 10185044)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 4.26e-58

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212586  Cd Length: 158  Bit Score: 185.09  E-value: 4.26e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556  45 GILITCNM-NERKCVEEAYSLLneygddmygpekfidkdqqpsgsegedddaeaalkkevgdikastekrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 61248556 202 SRNNSHMNREEVIKELAGIVGslnSENKVDLTNPEYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELVP---EIHKVDLKNPDKVILVEVIKNVCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 4.26e-58

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 185.09  E-value: 4.26e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556  45 GILITCNM-NERKCVEEAYSLLneygddmygpekfidkdqqpsgsegedddaeaalkkevgdikastekrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 61248556 202 SRNNSHMNREEVIKELAGIVGslnSENKVDLTNPEYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELVP---EIHKVDLKNPDKVILVEVIKNVCGISVVK 158
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 96-254 5.10e-18

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 79.40  E-value: 5.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556    96 EAALKKEVGDIKastekrlrrfqsVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKtrvilrMLPISGTCKAFLED 175
Cdd:pfam02926   4 EELLKKGGINVE------------VVRSGRGRILVVLKGENPEEDRELLKEALEKAPGIE------RFPVAETCEADLED 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556   176 MKKYAETFLEPWFKAPNKgTFQIVYKSRN-NSHMNREEVIKELAGIVGSLNSEnKVDLTNPEYTVVVEIIKAVCCLSVVK 254
Cdd:pfam02926  66 ILELAKEIIKDKFKKEGE-TFAVRVKRRGkNHEFTSLEINREVGKAIVEKTGL-KVDLENPDIVVHVEIIKDKAYISIDR 143
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 120-260 5.20e-16

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 74.54  E-value: 5.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 120 VESGANNVVFIRTLGiEPEKLVHHIlqdmyKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPwfKAPNKGTFQIV 199
Cdd:COG1818  33 VPTGFSGVLLVKTSL-DPYEAVEKL-----KEEPWEPRYILRVIPVDRVVKTDLEEIVEAAKELAKK--KIPEGETFAVR 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61248556 200 YKSRNNSHMNREEVIKELAGIVgslNSENKVDLTNPEYTVVVEIIKAVCCLSVVKDYVLFR 260
Cdd:COG1818 105 CEKRGKSKLSSREVIRAIGEAI---KRGAKVDLENPDWVVLVEILGDKAGISVLKPEDIFS 162
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 173-253 3.93e-12

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 61.52  E-value: 3.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556    173 LEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSH-MNREEVIKELAGIVGSLNSENKVDLTNPEYTVVVEIIKAVCCLS 251
Cdd:smart00981   2 LEDLYETALELIRWEKIFKEGKTFAVRAKRRGKNHeFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYLS 81


                   ..
gi 61248556    252 VV 253
Cdd:smart00981  82 ID 83
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 4.26e-58

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 185.09  E-value: 4.26e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556  45 GILITCNM-NERKCVEEAYSLLneygddmygpekfidkdqqpsgsegedddaeaalkkevgdikastekrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 61248556 202 SRNNSHMNREEVIKELAGIVGslnSENKVDLTNPEYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELVP---EIHKVDLKNPDKVILVEVIKNVCGISVVK 158
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 96-254 5.10e-18

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 79.40  E-value: 5.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556    96 EAALKKEVGDIKastekrlrrfqsVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKtrvilrMLPISGTCKAFLED 175
Cdd:pfam02926   4 EELLKKGGINVE------------VVRSGRGRILVVLKGENPEEDRELLKEALEKAPGIE------RFPVAETCEADLED 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556   176 MKKYAETFLEPWFKAPNKgTFQIVYKSRN-NSHMNREEVIKELAGIVGSLNSEnKVDLTNPEYTVVVEIIKAVCCLSVVK 254
Cdd:pfam02926  66 ILELAKEIIKDKFKKEGE-TFAVRVKRRGkNHEFTSLEINREVGKAIVEKTGL-KVDLENPDIVVHVEIIKDKAYISIDR 143
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 120-260 5.20e-16

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 74.54  E-value: 5.20e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 120 VESGANNVVFIRTLGiEPEKLVHHIlqdmyKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPwfKAPNKGTFQIV 199
Cdd:COG1818  33 VPTGFSGVLLVKTSL-DPYEAVEKL-----KEEPWEPRYILRVIPVDRVVKTDLEEIVEAAKELAKK--KIPEGETFAVR 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61248556 200 YKSRNNSHMNREEVIKELAGIVgslNSENKVDLTNPEYTVVVEIIKAVCCLSVVKDYVLFR 260
Cdd:COG1818 105 CEKRGKSKLSSREVIRAIGEAI---KRGAKVDLENPDWVVLVEILGDKAGISVLKPEDIFS 162
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 173-253 3.93e-12

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 61.52  E-value: 3.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556    173 LEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSH-MNREEVIKELAGIVGSLNSENKVDLTNPEYTVVVEIIKAVCCLS 251
Cdd:smart00981   2 LEDLYETALELIRWEKIFKEGKTFAVRAKRRGKNHeFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYLS 81


                   ..
gi 61248556    252 VV 253
Cdd:smart00981  82 ID 83
THUMP cd11688
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
 153-248 1.67e-08

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212583  Cd Length: 148  Bit Score: 52.88  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 153 KKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPwfKAPNKG-TFQIVYKSRNNSHMNREEVIKELAGIVGSlNSENKVD 231
Cdd:cd11688  52 VMWSRLISRIMPPLGECKADLEDLYETALEINEP--EMGNEGaKFAVRARRRNKTILNSQEIAMKVGDAIVD-AFNPEVD 128

                        90
                ....*....|....*..
gi 61248556 232 LTNPEYTVVVEIIKAVC 248
Cdd:cd11688 129 LDNPDIVVNVEVHKEIA 145
THUMP_ThiI cd11716
THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the ...
 159-243 2.92e-05

THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the formation of the modified base S(4)U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This modification acts as a signal for UV exposure, triggering a response that provides protection against its damaging effects. ThiI consists of an N-terminal THUMP domain, followed by an NFLD domain, and a C-terminal PP-loop pyrophosphatase domain. The N-terminal THUMP domain has been implicated in the recognition of the acceptor-stem region. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212585  Cd Length: 166  Bit Score: 43.97  E-value: 2.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61248556 159 ILRMLP-ISGTCKAF-----LEDMKKYAETFLEPWFKAPnkGTFQIVYKSRNNSH-MNREEVIKELAGIVGSLNSENKVD 231
Cdd:cd11716  61 RLKKVFgIVSFSPAVevekdLEDIKEAALELLKEELKKG--KTFKVRAKRADKSFpFTSMEINREVGAALLENTPDLKVD 138

                        90
                ....*....|..
gi 61248556 232 LTNPEYTVVVEI 243
Cdd:cd11716 139 LKNPDVTIRVEI 150
ThiI COG0301
Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme ...
 173-243 8.25e-04

Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]; Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440070 [Multi-domain]  Cd Length: 382  Bit Score: 40.84  E-value: 8.25e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 61248556 173 LEDMKKYAETFLEPWFKApnkGTFQIVYKSRNNSH-MNREEVIKELAGIVGSLNSENKVDLTNPEYTVVVEI 243
Cdd:COG0301  83 LEDIKEAALELAKEELKG---KTFKVRAKRAGKHFpFTSPELEREVGGALLENTPGLKVDLKNPDVTIRVEV 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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