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Conserved domains on  [gi|75165506|sp|Q94F30|]
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RecName: Full=Ubiquitin-like-specific protease ESD4; AltName: Full=Protein EARLY IN SHORT DAYS 4; Short=AtESD4

Protein Classification

C48 family peptidase( domain architecture ID 10011026)

C48 family peptidase such as ubiquitin-like-specific protease ESD4 catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins; it cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
 1-489 0e+00

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


:

Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 824.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506    1 MGAVAINRKRSDESFNfinqqstNPLRNSPYFQASKKRRFSFAMSEDSGKPASSNPTISRISRYPDAKAPLRREIHAPSR 80
Cdd:PLN03189   1 MGALTSNHKRSDECFN-------NPLSNSPDFHISKKPRFSMAQTPDSGNQHSSNSTASRISRYPEVKSPLRREVHAPCR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   81 gILRYGKAKSNDYCEKD-------ANFFVRKYDDAKRSALEALRFVNKGKDFVDLGDEVEKEEVVSDDSSVQAIEVIDCD 153
Cdd:PLN03189  74 -ILKFGRDKSTDSSEKKqglgnvmGNFLSRKYDMAKRSALDALRYYRKDKEVVDVGDELGKVEMISDDSSIEEVEAVEMD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  154 DD--EEKKNLQPSFSSGVTDVKKGENFRVEDTSMMLDSLSLDRDVDnDASSLEAYRKLMQSAEKRNSKLEALGFEIVLNE 231
Cdd:PLN03189 153 VDevEEKAEMGNGLSSDVKIVTKNGNLRVEDTSKMLDSLVLNRPET-DVLSVEAYRKLLQSAERRNSKLKDLGFEIELNE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  232 KKLSLLRQSRPKTVEKRVEVPREPFIPLTEDEEAEVYRAFSGRNRRKVLATHENSNIDITGEVLQCLTPSAWLNDEVINV 311
Cdd:PLN03189 232 KRLSSLRQSRPKPKEPVEEVPREPFIPLTREEETEVKRAFSANNRRKVLVTHENSNIDITGEILRCLKPGAWLNDEVINL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  312 YLELLKERETREPKKYLKCHYFNTFFYKKLVSD-SGYNFKAVRRWTTQRKLGYALIDCDMIFVPIHRGVHWTLAVINNRE 390
Cdd:PLN03189 312 YLELLKEREAREPKKFLKCHFFNTFFYKKLVSGkSGYDYKAVRRWTTQKKLGYHLIDCDKIFVPIHQEIHWTLAVINKKD 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  391 SKLLYLDSLNGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCGMFMLKYIDFFSRGLGLCFSQE 470
Cdd:PLN03189 392 QKFQYLDSLKGRDPKILDALAKYYVDEVKDKSEKDIDVSSWEQEFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQE 471

                        490
                 ....*....|....*....
gi 75165506  471 HMPYFRLRTAKEILRLRAD 489
Cdd:PLN03189 472 HMPYFRLRTAKEILRLKAD 490
 
Name Accession Description Interval E-value
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
 1-489 0e+00

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 824.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506    1 MGAVAINRKRSDESFNfinqqstNPLRNSPYFQASKKRRFSFAMSEDSGKPASSNPTISRISRYPDAKAPLRREIHAPSR 80
Cdd:PLN03189   1 MGALTSNHKRSDECFN-------NPLSNSPDFHISKKPRFSMAQTPDSGNQHSSNSTASRISRYPEVKSPLRREVHAPCR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   81 gILRYGKAKSNDYCEKD-------ANFFVRKYDDAKRSALEALRFVNKGKDFVDLGDEVEKEEVVSDDSSVQAIEVIDCD 153
Cdd:PLN03189  74 -ILKFGRDKSTDSSEKKqglgnvmGNFLSRKYDMAKRSALDALRYYRKDKEVVDVGDELGKVEMISDDSSIEEVEAVEMD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  154 DD--EEKKNLQPSFSSGVTDVKKGENFRVEDTSMMLDSLSLDRDVDnDASSLEAYRKLMQSAEKRNSKLEALGFEIVLNE 231
Cdd:PLN03189 153 VDevEEKAEMGNGLSSDVKIVTKNGNLRVEDTSKMLDSLVLNRPET-DVLSVEAYRKLLQSAERRNSKLKDLGFEIELNE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  232 KKLSLLRQSRPKTVEKRVEVPREPFIPLTEDEEAEVYRAFSGRNRRKVLATHENSNIDITGEVLQCLTPSAWLNDEVINV 311
Cdd:PLN03189 232 KRLSSLRQSRPKPKEPVEEVPREPFIPLTREEETEVKRAFSANNRRKVLVTHENSNIDITGEILRCLKPGAWLNDEVINL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  312 YLELLKERETREPKKYLKCHYFNTFFYKKLVSD-SGYNFKAVRRWTTQRKLGYALIDCDMIFVPIHRGVHWTLAVINNRE 390
Cdd:PLN03189 312 YLELLKEREAREPKKFLKCHFFNTFFYKKLVSGkSGYDYKAVRRWTTQKKLGYHLIDCDKIFVPIHQEIHWTLAVINKKD 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  391 SKLLYLDSLNGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCGMFMLKYIDFFSRGLGLCFSQE 470
Cdd:PLN03189 392 QKFQYLDSLKGRDPKILDALAKYYVDEVKDKSEKDIDVSSWEQEFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQE 471

                        490
                 ....*....|....*....
gi 75165506  471 HMPYFRLRTAKEILRLRAD 489
Cdd:PLN03189 472 HMPYFRLRTAKEILRLKAD 490
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
 303-483 2.46e-47

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 162.63  E-value: 2.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   303 WLNDEVINVYLELLKERETREPKKYLKCHYFNTFFYKKLVSDSGY-------NFKAVRRWTtqRKLGYALIDCDMIFVPI 375
Cdd:pfam02902   2 WLNDTVIDFYLKLLAHRLESEDYKNERVHFLNSFFYSKLTSKVSFkwgkkkdFYNGVRRWT--RKNKKWLFDVDIIYIPI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   376 HR-GVHWTLAVINNRESKLLYLDSL-----NGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCG 449
Cdd:pfam02902  80 NWdGKHWVLLIINLPKKTITILDSLislhtDKEYIRPINAMLPYLMSEALKKEQDDPDLTPFEIKRLTKVPQQPNSGDCG 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 75165506   450 MFMLKYIDFFSRGLGLCFSQE-HMPYFRLRTAKEI 483
Cdd:pfam02902 160 PYVLKFIELLAEGVPFEFLTEkDVDRFRKKLAVDI 194
 
Name Accession Description Interval E-value
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
 1-489 0e+00

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 824.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506    1 MGAVAINRKRSDESFNfinqqstNPLRNSPYFQASKKRRFSFAMSEDSGKPASSNPTISRISRYPDAKAPLRREIHAPSR 80
Cdd:PLN03189   1 MGALTSNHKRSDECFN-------NPLSNSPDFHISKKPRFSMAQTPDSGNQHSSNSTASRISRYPEVKSPLRREVHAPCR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   81 gILRYGKAKSNDYCEKD-------ANFFVRKYDDAKRSALEALRFVNKGKDFVDLGDEVEKEEVVSDDSSVQAIEVIDCD 153
Cdd:PLN03189  74 -ILKFGRDKSTDSSEKKqglgnvmGNFLSRKYDMAKRSALDALRYYRKDKEVVDVGDELGKVEMISDDSSIEEVEAVEMD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  154 DD--EEKKNLQPSFSSGVTDVKKGENFRVEDTSMMLDSLSLDRDVDnDASSLEAYRKLMQSAEKRNSKLEALGFEIVLNE 231
Cdd:PLN03189 153 VDevEEKAEMGNGLSSDVKIVTKNGNLRVEDTSKMLDSLVLNRPET-DVLSVEAYRKLLQSAERRNSKLKDLGFEIELNE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  232 KKLSLLRQSRPKTVEKRVEVPREPFIPLTEDEEAEVYRAFSGRNRRKVLATHENSNIDITGEVLQCLTPSAWLNDEVINV 311
Cdd:PLN03189 232 KRLSSLRQSRPKPKEPVEEVPREPFIPLTREEETEVKRAFSANNRRKVLVTHENSNIDITGEILRCLKPGAWLNDEVINL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  312 YLELLKERETREPKKYLKCHYFNTFFYKKLVSD-SGYNFKAVRRWTTQRKLGYALIDCDMIFVPIHRGVHWTLAVINNRE 390
Cdd:PLN03189 312 YLELLKEREAREPKKFLKCHFFNTFFYKKLVSGkSGYDYKAVRRWTTQKKLGYHLIDCDKIFVPIHQEIHWTLAVINKKD 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506  391 SKLLYLDSLNGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCGMFMLKYIDFFSRGLGLCFSQE 470
Cdd:PLN03189 392 QKFQYLDSLKGRDPKILDALAKYYVDEVKDKSEKDIDVSSWEQEFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQE 471

                        490
                 ....*....|....*....
gi 75165506  471 HMPYFRLRTAKEILRLRAD 489
Cdd:PLN03189 472 HMPYFRLRTAKEILRLKAD 490
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
 303-483 2.46e-47

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 162.63  E-value: 2.46e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   303 WLNDEVINVYLELLKERETREPKKYLKCHYFNTFFYKKLVSDSGY-------NFKAVRRWTtqRKLGYALIDCDMIFVPI 375
Cdd:pfam02902   2 WLNDTVIDFYLKLLAHRLESEDYKNERVHFLNSFFYSKLTSKVSFkwgkkkdFYNGVRRWT--RKNKKWLFDVDIIYIPI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75165506   376 HR-GVHWTLAVINNRESKLLYLDSL-----NGVDPMILNALAKYMGDEANEKSGKKIDANSWDMEFVEDLPQQKNGYDCG 449
Cdd:pfam02902  80 NWdGKHWVLLIINLPKKTITILDSLislhtDKEYIRPINAMLPYLMSEALKKEQDDPDLTPFEIKRLTKVPQQPNSGDCG 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 75165506   450 MFMLKYIDFFSRGLGLCFSQE-HMPYFRLRTAKEI 483
Cdd:pfam02902 160 PYVLKFIELLAEGVPFEFLTEkDVDRFRKKLAVDI 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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