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Conserved domains on  [gi|75163887|sp|Q940H2|]
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RecName: Full=GCN5-related N-acetyltransferase 3, chloroplastic; Flags: Precursor

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 149-236 6.95e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 58.08  E-value: 6.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887 149 NGQLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF--------- 219
Cdd:COG1246  36 DGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFeeidkedlp 115

                        90
                ....*....|....*..
gi 75163887 220 GDDRMGSTTMMFTKSLE 236
Cdd:COG1246 116 YAKVWQRDSVVMEKDLE 132
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 149-236 6.95e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 58.08  E-value: 6.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887 149 NGQLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF--------- 219
Cdd:COG1246  36 DGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFeeidkedlp 115

                        90
                ....*....|....*..
gi 75163887 220 GDDRMGSTTMMFTKSLE 236
Cdd:COG1246 116 YAKVWQRDSVVMEKDLE 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 149-219 5.40e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.22  E-value: 5.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75163887   149 NGQLVGFGRAYSDYG--LTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERP---FFKACGF 219
Cdd:pfam00583  41 DGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAaiaLYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 149-199 2.02e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.19  E-value: 2.02e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 75163887 149 NGQLVGFGRAYSDYGL--TASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDI 199
Cdd:cd04301   7 DGEIVGFASLSPDGSGgdTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
PRK07757 PRK07757
N-acetyltransferase;
149-219 3.52e-05

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 42.49  E-value: 3.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75163887  149 NGQLVGFGrAYSDYGLT-ASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDErpFFKACGF 219
Cdd:PRK07757  49 EGEIVGCC-ALHILWEDlAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVFALTYQPE--FFEKLGF 117
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 149-236 6.95e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 58.08  E-value: 6.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887 149 NGQLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF--------- 219
Cdd:COG1246  36 DGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFeeidkedlp 115

                        90
                ....*....|....*..
gi 75163887 220 GDDRMGSTTMMFTKSLE 236
Cdd:COG1246 116 YAKVWQRDSVVMEKDLE 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 149-219 5.40e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.22  E-value: 5.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75163887   149 NGQLVGFGRAYSDYG--LTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERP---FFKACGF 219
Cdd:pfam00583  41 DGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAaiaLYEKLGF 116
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
149-235 7.75e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.48  E-value: 7.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887 149 NGQLVGFGRAY----SDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF----- 219
Cdd:COG3153  47 DGEIVGHVALSpvdiDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFrpage 126

                        90
                ....*....|....*.
gi 75163887 220 GDDRMGSTTMMFTKSL 235
Cdd:COG3153 127 LGLTLGPDEVFLAKEL 142
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 149-219 4.05e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 52.07  E-value: 4.05e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75163887   149 NGQLVGFGRAYSDYGLTASIH-DLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF 219
Cdd:pfam13508  11 DGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGF 82
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 149-199 2.02e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.19  E-value: 2.02e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 75163887 149 NGQLVGFGRAYSDYGL--TASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDI 199
Cdd:cd04301   7 DGEIVGFASLSPDGSGgdTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
149-219 8.57e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 44.60  E-value: 8.57e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75163887 149 NGQLVGFG-----RAYSDYGLTAsIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERP---FFKACGF 219
Cdd:COG1247  60 DGEVVGFAslgpfRPRPAYRGTA-EESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEAsiaLYEKLGF 137
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 154-219 9.95e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.72  E-value: 9.95e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887 154 GFGRAYSDYGL-TASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERP---FFKACGF 219
Cdd:COG0456   1 GFALLGLVDGGdEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAaiaLYEKLGF 70
PRK07757 PRK07757
N-acetyltransferase;
149-219 3.52e-05

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 42.49  E-value: 3.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75163887  149 NGQLVGFGrAYSDYGLT-ASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDErpFFKACGF 219
Cdd:PRK07757  49 EGEIVGCC-ALHILWEDlAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVFALTYQPE--FFEKLGF 117
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 123-219 5.27e-04

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 39.30  E-value: 5.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75163887  123 SEFGRQNKDDSFLGDLFQNAVPLTPSNGQLVGFGRAYSDY------GLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTS 196
Cdd:PLN02706  37 EEFEARFQELASLGDDHLICVIEDAASGRIIATGSVFVERkfirncGKVGHIEDVVVDSAARGKGLGKKIIEALTEHARS 116

                         90       100
                 ....*....|....*....|...
gi 75163887  197 RDIYDIAALCFEDERPFFKACGF 219
Cdd:PLN02706 117 AGCYKVILDCSEENKAFYEKCGY 139
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
149-219 1.14e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 37.86  E-value: 1.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75163887 149 NGQLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDIYDIAALCFEDERPFFKACGF 219
Cdd:COG2153  42 DGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGF 112
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
151-219 9.74e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 34.50  E-value: 9.74e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75163887 151 QLVGFGRAYSDYGLTASIHDLMVLPSLQRMGIGKLIVNRIVRLLTSRDiYDIAALCFEDE----RPFFKACGF 219
Cdd:COG3393   1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARG-ARTPFLYVDADnpaaRRLYERLGF 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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