NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|218512060|sp|Q92896|]

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RecName: Full=Golgi apparatus protein 1; AltName: Full=CFR-1; AltName: Full=Cysteine-rich fibroblast growth factor receptor; AltName: Full=E-selectin ligand 1; Short=ESL-1; AltName: Full=Golgi sialoglycoprotein MG-160; Flags: Precursor

Protein Classification

cysteine rich repeat-containing protein( domain architecture ID 10467185)

cysteine rich repeat-containing protein similar to human Golgi apparatus protein 1 that binds fibroblast growth factor and E-selectin, and to cysteine-rich fibroblast growth factor receptor that regulates intracellular FGF-1 and FGF-2 levels

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List of domain hits

Name

Accession

Description

Interval

E-value

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

800-856

7.73e-14

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 67.00 E-value: 7.73e-14

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   800 KCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLS 856
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

1046-1101

2.20e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.20e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060  1046 CKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKR 1101
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

291-346

2.31e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.31e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   291 CKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEES 346
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

613-667

1.45e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 60.45 E-value: 1.45e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   613 ECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTET-GQELECLQDHLDDL 667
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGkGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

915-972

6.87e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 58.52 E-value: 6.87e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   915 PKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFChgiltkaKDDSELEGQVISCLK 972
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFC-------SDVAEGKGQVLECLK 51

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

858-911

3.69e-10

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 56.60 E-value: 3.69e-10

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   858 RCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPE--ADSKTMLQCLKQNKNSE 911
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDvaEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

480-537

1.21e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 55.05 E-value: 1.21e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   480 CQQALQTLIQEtdPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEK 537
Cdd:pfam00839    3 CRQEVLRLQEE--EAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

418-473

3.75e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 53.90 E-value: 3.75e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   418 ECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCS-GLHRKGRTLHCLMKVVRGEK 473
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSdVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

983-1038

8.62e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 8.62e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   983 DCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEaaaQEQTGQVEECLKVNL 1038
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDV---AEGKGQVLECLKEHL 54

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

670-729

9.70e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 9.70e-09

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512060   670 ECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADnqiDSGDLMECLIQNKHQKD 729
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAE---GKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

215-277

3.08e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 51.20 E-value: 3.08e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512060   215 QCHQYITKMTAIIFSDYRLICGFMDDCKNDINILkCGSIrlgekdAHSQGEVVSCLEKGLVKE 277
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-CSDV------AEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

154-212

3.50e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 50.82 E-value: 3.50e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 218512060   154 DCNHLLWNYKLNLTTDPKFESVAREVCKSTIteIKECADEPVGKGYMVSCLVDHRGNIT 212
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDI--EKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

540-601

3.64e-07

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 48.12 E-value: 3.64e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218512060   540 EDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHthgwnetSEFMPQGAVFSCLYRHAY 601
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCS-------DVAEGKGQVLECLKEHLD 55

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

349-413

6.42e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.96 E-value: 6.42e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512060   349 EKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYrCnvenlpRSREARLSYLLMCLESAVHRGR 413
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-C------SDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

732-788

7.51e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

:

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.57 E-value: 7.51e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   732 EKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKK-KVDVVICLSTTVRNDT 788
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEgKGQVLECLKEHLDDLK 58

Name

Accession

Description

Interval

E-value

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

800-856

7.73e-14

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 67.00 E-value: 7.73e-14

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   800 KCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLS 856
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

1046-1101

2.20e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.20e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060  1046 CKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKR 1101
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

291-346

2.31e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.31e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   291 CKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEES 346
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

613-667

1.45e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 60.45 E-value: 1.45e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   613 ECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTET-GQELECLQDHLDDL 667
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGkGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

915-972

6.87e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 58.52 E-value: 6.87e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   915 PKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFChgiltkaKDDSELEGQVISCLK 972
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFC-------SDVAEGKGQVLECLK 51

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

858-911

3.69e-10

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 56.60 E-value: 3.69e-10

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   858 RCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPE--ADSKTMLQCLKQNKNSE 911
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDvaEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

480-537

1.21e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 55.05 E-value: 1.21e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   480 CQQALQTLIQEtdPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEK 537
Cdd:pfam00839    3 CRQEVLRLQEE--EAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

418-473

3.75e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 53.90 E-value: 3.75e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   418 ECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCS-GLHRKGRTLHCLMKVVRGEK 473
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSdVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

983-1038

8.62e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 8.62e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   983 DCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEaaaQEQTGQVEECLKVNL 1038
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDV---AEGKGQVLECLKEHL 54

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

670-729

9.70e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 9.70e-09

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512060   670 ECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADnqiDSGDLMECLIQNKHQKD 729
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAE---GKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

215-277

3.08e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 51.20 E-value: 3.08e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512060   215 QCHQYITKMTAIIFSDYRLICGFMDDCKNDINILkCGSIrlgekdAHSQGEVVSCLEKGLVKE 277
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-CSDV------AEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

154-212

3.50e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 50.82 E-value: 3.50e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 218512060   154 DCNHLLWNYKLNLTTDPKFESVAREVCKSTIteIKECADEPVGKGYMVSCLVDHRGNIT 212
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDI--EKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

540-601

3.64e-07

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 48.12 E-value: 3.64e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218512060   540 EDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHthgwnetSEFMPQGAVFSCLYRHAY 601
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCS-------DVAEGKGQVLECLKEHLD 55

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

349-413

6.42e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.96 E-value: 6.42e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512060   349 EKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYrCnvenlpRSREARLSYLLMCLESAVHRGR 413
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-C------SDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

732-788

7.51e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.57 E-value: 7.51e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   732 EKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKK-KVDVVICLSTTVRNDT 788
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEgKGQVLECLKEHLDDLK 58

Name

Accession

Description

Interval

E-value

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

800-856

7.73e-14

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 67.00 E-value: 7.73e-14

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   800 KCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLS 856
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

1046-1101

2.20e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.20e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060  1046 CKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKR 1101
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

291-346

2.31e-12

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 62.76 E-value: 2.31e-12

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   291 CKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEES 346
Cdd:pfam00839    3 CRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

613-667

1.45e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 60.45 E-value: 1.45e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   613 ECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTET-GQELECLQDHLDDL 667
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEGkGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

915-972

6.87e-11

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 58.52 E-value: 6.87e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   915 PKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFChgiltkaKDDSELEGQVISCLK 972
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFC-------SDVAEGKGQVLECLK 51

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

858-911

3.69e-10

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 56.60 E-value: 3.69e-10

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   858 RCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPE--ADSKTMLQCLKQNKNSE 911
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDvaEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

480-537

1.21e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 55.05 E-value: 1.21e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   480 CQQALQTLIQEtdPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEK 537
Cdd:pfam00839    3 CRQEVLRLQEE--EAEDYRLDPELQKACKDDIEKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

418-473

3.75e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 53.90 E-value: 3.75e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 218512060   418 ECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCS-GLHRKGRTLHCLMKVVRGEK 473
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSdVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

983-1038

8.62e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 8.62e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 218512060   983 DCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEaaaQEQTGQVEECLKVNL 1038
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDV---AEGKGQVLECLKEHL 54

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

670-729

9.70e-09

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 52.74 E-value: 9.70e-09

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512060   670 ECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADnqiDSGDLMECLIQNKHQKD 729
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAE---GKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

215-277

3.08e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 51.20 E-value: 3.08e-08

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512060   215 QCHQYITKMTAIIFSDYRLICGFMDDCKNDINILkCGSIrlgekdAHSQGEVVSCLEKGLVKE 277
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-CSDV------AEGKGQVLECLKEHLDDL 57

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

154-212

3.50e-08

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 50.82 E-value: 3.50e-08

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 218512060   154 DCNHLLWNYKLNLTTDPKFESVAREVCKSTIteIKECADEPVGKGYMVSCLVDHRGNIT 212
Cdd:pfam00839    2 ECRQEVLRLQEEEAEDYRLDPELQKACKDDI--EKFCSDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

540-601

3.64e-07

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 48.12 E-value: 3.64e-07

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218512060   540 EDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHthgwnetSEFMPQGAVFSCLYRHAY 601
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCS-------DVAEGKGQVLECLKEHLD 55

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

349-413

6.42e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.96 E-value: 6.42e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512060   349 EKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYrCnvenlpRSREARLSYLLMCLESAVHRGR 413
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKF-C------SDVAEGKGQVLECLKEHLDDLK 58

Cys_rich_FGFR

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in ...

732-788

7.51e-05

Cysteine rich repeat; This cysteine rich repeat contains four cysteines. It is found in multiple copies in a protein that binds to fibroblast growth factors. The repeat is also found in MG160 and E-selectin ligand (ESL-1).

Pssm-ID: 425899 Cd Length: 58 Bit Score: 41.57 E-value: 7.51e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 218512060   732 EKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKK-KVDVVICLSTTVRNDT 788
Cdd:pfam00839    1 PECRQEVLRLQEEEAEDYRLDPELQKACKDDIEKFCSDVAEgKGQVLECLKEHLDDLK 58

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options