RecName: Full=Histone-lysine N-methyltransferase SETD7; AltName: Full=Histone H3-K4 methyltransferase SETD7; Short=H3-K4-HMTase SETD7; AltName: Full=SET domain-containing protein 7; AltName: Full=SET7/9
SETD7 family SET domain-containing protein( domain architecture ID 15524553)
SETD7 family SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones
List of domain hits
Name | Accession | Description | Interval | E-value | |||
SET_SETD7 | cd10530 | SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ... |
208-337 | 1.53e-94 | |||
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth. : Pssm-ID: 380928 Cd Length: 130 Bit Score: 277.64 E-value: 1.53e-94
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COG4642 super family | cl34799 | Uncharacterized conserved protein [Function unknown]; |
19-132 | 1.48e-23 | |||
Uncharacterized conserved protein [Function unknown]; The actual alignment was detected with superfamily member COG4642: Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 98.49 E-value: 1.48e-23
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Name | Accession | Description | Interval | E-value | |||
SET_SETD7 | cd10530 | SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ... |
208-337 | 1.53e-94 | |||
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth. Pssm-ID: 380928 Cd Length: 130 Bit Score: 277.64 E-value: 1.53e-94
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
19-132 | 1.48e-23 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 98.49 E-value: 1.48e-23
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SET | COG2940 | SET domain-containing protein (function unknown) [General function prediction only]; |
210-339 | 8.89e-15 | |||
SET domain-containing protein (function unknown) [General function prediction only]; Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 70.38 E-value: 8.89e-15
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
226-342 | 1.72e-11 | |||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 60.81 E-value: 1.72e-11
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
227-336 | 8.06e-10 | |||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 55.99 E-value: 8.06e-10
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
20-131 | 1.53e-06 | |||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 50.22 E-value: 1.53e-06
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Name | Accession | Description | Interval | E-value | |||
SET_SETD7 | cd10530 | SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ... |
208-337 | 1.53e-94 | |||
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth. Pssm-ID: 380928 Cd Length: 130 Bit Score: 277.64 E-value: 1.53e-94
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
19-132 | 1.48e-23 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 98.49 E-value: 1.48e-23
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
19-112 | 3.97e-20 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 88.86 E-value: 3.97e-20
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
18-150 | 8.07e-20 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 88.09 E-value: 8.07e-20
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
19-169 | 8.38e-15 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 73.84 E-value: 8.38e-15
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SET | COG2940 | SET domain-containing protein (function unknown) [General function prediction only]; |
210-339 | 8.89e-15 | |||
SET domain-containing protein (function unknown) [General function prediction only]; Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 70.38 E-value: 8.89e-15
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YwqK | COG2849 | Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; |
35-116 | 2.88e-13 | |||
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; Pssm-ID: 442097 [Multi-domain] Cd Length: 163 Bit Score: 67.02 E-value: 2.88e-13
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YwqK | COG2849 | Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; |
33-163 | 9.73e-13 | |||
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; Pssm-ID: 442097 [Multi-domain] Cd Length: 163 Bit Score: 65.47 E-value: 9.73e-13
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
226-342 | 1.72e-11 | |||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 60.81 E-value: 1.72e-11
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
227-336 | 8.06e-10 | |||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 55.99 E-value: 8.06e-10
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
13-164 | 1.88e-09 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 58.04 E-value: 1.88e-09
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YwqK | COG2849 | Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; |
43-168 | 1.58e-08 | |||
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; Pssm-ID: 442097 [Multi-domain] Cd Length: 163 Bit Score: 53.53 E-value: 1.58e-08
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SET_EZH | cd10519 | SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ... |
214-337 | 2.74e-07 | |||
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Pssm-ID: 380917 Cd Length: 117 Bit Score: 48.78 E-value: 2.74e-07
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SET_SETD1-like | cd10518 | SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ... |
212-338 | 2.88e-07 | |||
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me). Pssm-ID: 380916 Cd Length: 150 Bit Score: 49.52 E-value: 2.88e-07
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
13-164 | 3.65e-07 | |||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 51.11 E-value: 3.65e-07
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SET | cd08161 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ... |
291-336 | 1.42e-06 | |||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site. Pssm-ID: 380914 [Multi-domain] Cd Length: 72 Bit Score: 45.32 E-value: 1.42e-06
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
20-131 | 1.53e-06 | |||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 50.22 E-value: 1.53e-06
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
19-114 | 2.38e-06 | |||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 49.45 E-value: 2.38e-06
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
31-126 | 1.88e-05 | |||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 46.75 E-value: 1.88e-05
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SET_KMT2C_2D | cd19171 | SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ... |
215-338 | 1.66e-04 | |||
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Pssm-ID: 380948 [Multi-domain] Cd Length: 153 Bit Score: 41.65 E-value: 1.66e-04
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SET_SMYD | cd20071 | SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ... |
294-342 | 2.39e-04 | |||
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 40.44 E-value: 2.39e-04
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SET_EZH2 | cd19218 | SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ... |
226-337 | 5.75e-04 | |||
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics. Pssm-ID: 380995 Cd Length: 120 Bit Score: 39.13 E-value: 5.75e-04
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SET_EZH1 | cd19217 | SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ... |
226-340 | 6.96e-04 | |||
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Pssm-ID: 380994 Cd Length: 136 Bit Score: 39.28 E-value: 6.96e-04
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SET_LegAS4-like | cd10522 | SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ... |
221-338 | 8.93e-04 | |||
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region. Pssm-ID: 380920 [Multi-domain] Cd Length: 122 Bit Score: 38.86 E-value: 8.93e-04
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SET_SpSet7-like | cd10540 | SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ... |
296-339 | 1.43e-03 | |||
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1). Pssm-ID: 380938 Cd Length: 112 Bit Score: 38.00 E-value: 1.43e-03
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SET_SETD2-like | cd10531 | SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ... |
267-338 | 1.49e-03 | |||
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins. Pssm-ID: 380929 Cd Length: 136 Bit Score: 38.39 E-value: 1.49e-03
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SET_Suv4-20-like | cd10524 | SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ... |
295-336 | 2.18e-03 | |||
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions. Pssm-ID: 380922 [Multi-domain] Cd Length: 141 Bit Score: 38.03 E-value: 2.18e-03
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SET_ASH1L | cd19174 | SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ... |
227-338 | 4.22e-03 | |||
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA). Pssm-ID: 380951 [Multi-domain] Cd Length: 141 Bit Score: 37.27 E-value: 4.22e-03
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Blast search parameters | ||||
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