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Conserved domains on  [gi|57013389|sp|Q8VCT4|]
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RecName: Full=Carboxylesterase 1D; AltName: Full=Carboxylesterase 3; AltName: Full=Fatty acid ethyl ester synthase; Short=FAEE synthase; AltName: Full=Triacylglycerol hydrolase; Short=TGH; Flags: Precursor

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  8453375|3163407|8280778|9704093|11099800|37582413|31545554
SCOP:  3000102|4000699

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 645.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389    22 SPPVVNTVKGKVLGKYVNLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQvlself 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   102 tnrKENIPLQFSEDCLYLNIYTPADLTKNS-RLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   181 GDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   261 KPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLgnpkesYPFLPtVIDGVVLPKAPEEILAEKSF 340
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSVPF------VPFGP-VVDGDFLPEHPEELLKSGNF 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   341 STVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKI--SENMIPVVAEKYL--GGTDDLTKKKDLFQ 416
Cdd:pfam00135 304 PKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVdlPEEISAALREEYLdwGDRDDPETSRRALV 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   417 DLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVsaMRPKAVIGDHGDEIFSVFGSPFL-KDGASEEETNLSKMVM 495
Cdd:pfam00135 384 ELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSRKMM 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 57013389   496 KFWANFARNGNPNGG-GLPHWPEY-DQKEGYLKIGASTQAAQRLKDKEVSFW 545
Cdd:pfam00135 462 TYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 645.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389    22 SPPVVNTVKGKVLGKYVNLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQvlself 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   102 tnrKENIPLQFSEDCLYLNIYTPADLTKNS-RLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   181 GDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   261 KPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLgnpkesYPFLPtVIDGVVLPKAPEEILAEKSF 340
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSVPF------VPFGP-VVDGDFLPEHPEELLKSGNF 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   341 STVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKI--SENMIPVVAEKYL--GGTDDLTKKKDLFQ 416
Cdd:pfam00135 304 PKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVdlPEEISAALREEYLdwGDRDDPETSRRALV 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   417 DLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVsaMRPKAVIGDHGDEIFSVFGSPFL-KDGASEEETNLSKMVM 495
Cdd:pfam00135 384 ELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSRKMM 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 57013389   496 KFWANFARNGNPNGG-GLPHWPEY-DQKEGYLKIGASTQAAQRLKDKEVSFW 545
Cdd:pfam00135 462 TYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 607.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  25 VVNTVKGKVLGKYVNlegftqPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLselftnr 104
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 105 kENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSA-HENVVVVTIQYRLGIWGFFSTGDE 183
Cdd:cd00312  68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 184 HSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPI 263
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 264 AGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGnpkesyPFLPtVIDGVVLPKAPEEILAEKSFSTV 343
Cdd:cd00312 227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL------PFGP-VVDGDFIPDDPEELIKEGKFAKV 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 344 PYIVGINKQEFGWIIPTLMgypLAEGKLDQKTANSLLWKSYPTL-KISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADV 422
Cdd:cd00312 300 PLIIGVTKDEGGYFAAMLL---NFDAKLIIETNDRWLELLPYLLfYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 423 VFGVPSVIVSRSHRDA-GASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANF 501
Cdd:cd00312 377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 57013389 502 ARNGNPNG-GGLPHWPEYD-QKEGYLKIGASTQAAQR 536
Cdd:cd00312 457 AKTGNPNTeGNLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
20-549 2.59e-159

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 463.98  E-value: 2.59e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  20 PSSPPVVNTVKGKVlgkyvnlEGFTQP-VAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLS 98
Cdd:COG2272   9 AAAAPVVRTEAGRV-------RGVVEGgVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  99 elftnrkeniPLQFSEDCLYLNIYTPADlTKNSRLPVMVWIHGGGLVVGGAST--YDGLALsAHENVVVVTIQYRLGIWG 176
Cdd:COG2272  82 ----------PAPGSEDCLYLNVWTPAL-AAGAKLPVMVWIHGGGFVSGSGSEplYDGAAL-ARRGVVVVTINYRLGALG 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 177 FF-----STGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSL 251
Cdd:COG2272 150 FLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGL 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 252 TAAliTTDV-KPIAGLVATLSGCKTTTSAvmvhCLRQKTEDELLETSLKlnlfkldLLGNPKESYPFLPtVIDGVVLPKA 330
Cdd:COG2272 230 SVL--TLAEaEAVGAAFAAALGVAPATLA----ALRALPAEELLAAQAA-------LAAEGPGGLPFGP-VVDGDVLPED 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 331 PEEILAEKSFSTVPYIVGINKQEFGWiiptLMGYPLAEGKLDQKTANSLLWKSYPTLKisenmiPVVAEKYLGGTDdltk 410
Cdd:COG2272 296 PLEAFAAGRAADVPLLIGTNRDEGRL----FAALLGDLGPLTAADYRAALRRRFGDDA------DEVLAAYPAASP---- 361

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 411 kKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVigdHGDEIFSVFGSPFLKD--GASEEET 488
Cdd:COG2272 362 -AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGNLDAPAltGLTPADR 437

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57013389 489 NLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEG-YLKIGASTQAAQRLKDKE-VSFWAELR 549
Cdd:COG2272 438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
PRK10162 PRK10162
acetyl esterase;
135-223 2.17e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 43.55  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  135 VMVWIHGGGLVVGGASTYDGLA--LSAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIANFGGNP 212
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 57013389  213 GSVTIFGESAG 223
Cdd:PRK10162 154 SRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 645.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389    22 SPPVVNTVKGKVLGKYVNLEGfTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQvlself 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   102 tnrKENIPLQFSEDCLYLNIYTPADLTKNS-RLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   181 GDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   261 KPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLgnpkesYPFLPtVIDGVVLPKAPEEILAEKSF 340
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSVPF------VPFGP-VVDGDFLPEHPEELLKSGNF 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   341 STVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKI--SENMIPVVAEKYL--GGTDDLTKKKDLFQ 416
Cdd:pfam00135 304 PKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVdlPEEISAALREEYLdwGDRDDPETSRRALV 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   417 DLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVsaMRPKAVIGDHGDEIFSVFGSPFL-KDGASEEETNLSKMVM 495
Cdd:pfam00135 384 ELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSRKMM 461

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 57013389   496 KFWANFARNGNPNGG-GLPHWPEY-DQKEGYLKIGASTQAAQRLKDKEVSFW 545
Cdd:pfam00135 462 TYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 607.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  25 VVNTVKGKVLGKYVNlegftqPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLselftnr 104
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 105 kENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSA-HENVVVVTIQYRLGIWGFFSTGDE 183
Cdd:cd00312  68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 184 HSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPI 263
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 264 AGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGnpkesyPFLPtVIDGVVLPKAPEEILAEKSFSTV 343
Cdd:cd00312 227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL------PFGP-VVDGDFIPDDPEELIKEGKFAKV 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 344 PYIVGINKQEFGWIIPTLMgypLAEGKLDQKTANSLLWKSYPTL-KISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADV 422
Cdd:cd00312 300 PLIIGVTKDEGGYFAAMLL---NFDAKLIIETNDRWLELLPYLLfYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 423 VFGVPSVIVSRSHRDA-GASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANF 501
Cdd:cd00312 377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 57013389 502 ARNGNPNG-GGLPHWPEYD-QKEGYLKIGASTQAAQR 536
Cdd:cd00312 457 AKTGNPNTeGNLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
20-549 2.59e-159

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 463.98  E-value: 2.59e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  20 PSSPPVVNTVKGKVlgkyvnlEGFTQP-VAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLS 98
Cdd:COG2272   9 AAAAPVVRTEAGRV-------RGVVEGgVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  99 elftnrkeniPLQFSEDCLYLNIYTPADlTKNSRLPVMVWIHGGGLVVGGAST--YDGLALsAHENVVVVTIQYRLGIWG 176
Cdd:COG2272  82 ----------PAPGSEDCLYLNVWTPAL-AAGAKLPVMVWIHGGGFVSGSGSEplYDGAAL-ARRGVVVVTINYRLGALG 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 177 FF-----STGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSL 251
Cdd:COG2272 150 FLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGL 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 252 TAAliTTDV-KPIAGLVATLSGCKTTTSAvmvhCLRQKTEDELLETSLKlnlfkldLLGNPKESYPFLPtVIDGVVLPKA 330
Cdd:COG2272 230 SVL--TLAEaEAVGAAFAAALGVAPATLA----ALRALPAEELLAAQAA-------LAAEGPGGLPFGP-VVDGDVLPED 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 331 PEEILAEKSFSTVPYIVGINKQEFGWiiptLMGYPLAEGKLDQKTANSLLWKSYPTLKisenmiPVVAEKYLGGTDdltk 410
Cdd:COG2272 296 PLEAFAAGRAADVPLLIGTNRDEGRL----FAALLGDLGPLTAADYRAALRRRFGDDA------DEVLAAYPAASP---- 361

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 411 kKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVigdHGDEIFSVFGSPFLKD--GASEEET 488
Cdd:COG2272 362 -AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGNLDAPAltGLTPADR 437

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57013389 489 NLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEG-YLKIGASTQAAQRLKDKE-VSFWAELR 549
Cdd:COG2272 438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
121-224 1.72e-20

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 89.93  E-value: 1.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 121 IYTPADLTKNsrLPVMVWIHGGGLVVGGASTYDGLA--LSAHENVVVVTIQYRLGiwgffstgDEHSrgnW-GHLDQV-A 196
Cdd:COG0657   3 VYRPAGAKGP--LPVVVYFHGGGWVSGSKDTHDPLArrLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                        90       100
                ....*....|....*....|....*...
gi 57013389 197 ALRWVQDNIANFGGNPGSVTIFGESAGG 224
Cdd:COG0657  70 ALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 136-224 2.37e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 72.24  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   136 MVWIHGGGLVVGGASTYDGLA--LSAHENVVVVTIQYRLgiwgffstGDEHSrgnW--GHLDQVAALRWVQDNIANFGGN 211
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRL--------APEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 57013389   212 PGSVTIFGESAGG 224
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
121-250 8.14e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 62.34  E-value: 8.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 121 IYTPADltkNSRLPVMVWIHGGGlvVGGASTYDGLALSAHEN-VVVVTIQYRlgiwgffstGDEHSRGNWGHL---DQVA 196
Cdd:COG1506  14 LYLPAD---GKKYPVVVYVHGGP--GSRDDSFLPLAQALASRgYAVLAPDYR---------GYGESAGDWGGDevdDVLA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 57013389 197 ALRWVqdnIANFGGNPGSVTIFGESAGGFSVSVLVLspLAKNLFHRAISESGVS 250
Cdd:COG1506  80 AIDYL---AARPYVDPDRIGIYGHSYGGYMALLAAA--RHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 119-224 2.43e-08

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 54.49  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   119 LNIYTPADLTKNsrLPVMVWIHGGGLVVG------GASTYDGLALsAHENVVVVTIQYRLgiwgffsTGDEHSRgnwghl 192
Cdd:pfam20434   1 LDIYLPKNAKGP--YPVVIWIHGGGWNSGdkeadmGFMTNTVKAL-LKAGYAVASINYRL-------STDAKFP------ 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 57013389   193 DQV----AALRWVQDNIANFGGNPGSVTIFGESAGG 224
Cdd:pfam20434  65 AQIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
COG4099 COG4099
Predicted peptidase [General function prediction only];
101-225 2.03e-05

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 46.11  E-value: 2.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 101 FTNRKENIPLQFsedclylNIYTPADLTKNSRLPVMVWIHGGG--------LVVGGASTYDGLALSAHENVVVVTIQYRL 172
Cdd:COG4099  24 FTDPSDGDTLPY-------RLYLPKGYDPGKKYPLVLFLHGAGergtdnekQLTHGAPKFINPENQAKFPAIVLAPQCPE 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 57013389 173 GIWgffstgdehsrgnWGHLDQVAAL-RWVQDNIANFGGNPGSVTIFGESAGGF 225
Cdd:COG4099  97 DDY-------------WSDTKALDAVlALLDDLIAEYRIDPDRIYLTGLSMGGY 137
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 121-230 1.09e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 44.22  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 121 IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGL-ALSAHENVVVV----TIQYRLGIWGFFSTGDEHSRGnwGHLDQV 195
Cdd:COG3509  41 LYVPAGYDGGAPLPLVVALHGCGGSAADFAAGTGLnALADREGFIVVypegTGRAPGRCWNWFDGRDQRRGR--DDVAFI 118

                        90       100       110
                ....*....|....*....|....*....|....*
gi 57013389 196 AALrwVQDNIANFGGNPGSVTIFGESAGGFSVSVL 230
Cdd:COG3509 119 AAL--VDDLAARYGIDPKRVYVTGLSAGGAMAYRL 151
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 119-262 1.80e-04

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 43.22  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   119 LNIYTPADLTKNSRLPVMVWIHGGGLVVGGA--STYDGLALSAH-ENVVVVTIQY-----RLGIWGFfstGDEHSRGNWG 190
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGWFQNGPakEGLDRLAASGEiPPVIIVGSPRggevsFYSDWDR---GLNATEGPGA 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57013389   191 H--LDQVAA--LRWVQdniANFGGNPGSVTIFGESAGGFsvSVLVLSPLAKNLFHRAISESG-VSLTAALITTDVKP 262
Cdd:pfam00756  87 YayETFLTQelPPLLD---ANFPTAPDGRALAGQSMGGL--GALYLALKYPDLFGSVSSFSPiLNPSNSMWGPEDDP 158
PRK10162 PRK10162
acetyl esterase;
135-223 2.17e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 43.55  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  135 VMVWIHGGGLVVGGASTYDGLA--LSAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIANFGGNP 212
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 57013389  213 GSVTIFGESAG 223
Cdd:PRK10162 154 SRIGFAGDSAG 164
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
155-250 2.06e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 39.91  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389   155 LALSAHENVVVVTIQYRLGiwGFFSTGDEHS-RGNWGHL---DQVAALRWVqdnIANFGGNPGSVTIFGESAGGFSVSVL 230
Cdd:pfam00326   7 AQLLADRGYVVAIANGRGS--GGYGEAFHDAgKGDLGQNefdDFIAAAEYL---IEQGYTDPDRLAIWGGSYGGYLTGAA 81

                          90       100
                  ....*....|....*....|
gi 57013389   231 VLSplAKNLFHRAISESGVS 250
Cdd:pfam00326  82 LNQ--RPDLFKAAVAHVPVV 99
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
44-248 7.71e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 38.68  E-value: 7.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389  44 TQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAV-GGQVLSELFTNRKENIPLQfsedclyLNIY 122
Cdd:COG2382  28 PPGLLVASAVVVVRVLPAAAAAARLLAPVVAAAVVVLGGPPPATDDKDVpHGTVETVTYPSKALGRTRR-------VWVY 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57013389 123 TPAD-LTKNSRLPVMVWIHGGG------LVVGGA-STYDGLALSAH-ENVVVVTIQYRLGiwgffSTGDEHSRGNWGHLD 193
Cdd:COG2382 101 LPPGyDNPGKKYPVLYLLDGGGgdeqdwFDQGRLpTILDNLIAAGKiPPMIVVMPDGGDG-----GDRGTEGPGNDAFER 175

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 57013389 194 QVAA--LRWVQDNiANFGGNPGSVTIFGESAGGFSVSVLVLS-PlakNLFHRAISESG 248
Cdd:COG2382 176 FLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGLAALYAALRhP---DLFGYVGSFSG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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