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Conserved domains on  [gi|32171365|sp|Q8NFK1|]
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RecName: Full=Gap junction gamma-3 protein; AltName: Full=Connexin-30.2; Short=Cx30.2; AltName: Full=Connexin-31.3; Short=Cx31.3; AltName: Full=Gap junction epsilon-1 protein

Protein Classification

gap junction protein( domain architecture ID 11981343)

gap junction protein form gap-junctions between cells and contains four transmembrane (TM) regions; one gap junction consists of a cluster of closely packed pairs of TM channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
2-215 3.41e-106

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 307.12  E-value: 3.41e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365     2 CGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAFHPLSPLRFWVFQV 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365    82 ILVAVPSALYMGFTLYHVIWHWELsgKGKEEETLIQGREGNTDVPGAG-----SLRLLWAYVAQLGARLVLEGAALGLQY 156
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKR--REKEEEEMEEELYEEEGKKEAEpkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQY 158
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32171365   157 HLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGL 215
Cdd:pfam00029 159 YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
2-215 3.41e-106

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 307.12  E-value: 3.41e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365     2 CGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAFHPLSPLRFWVFQV 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365    82 ILVAVPSALYMGFTLYHVIWHWELsgKGKEEETLIQGREGNTDVPGAG-----SLRLLWAYVAQLGARLVLEGAALGLQY 156
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKR--REKEEEEMEEELYEEEGKKEAEpkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQY 158
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32171365   157 HLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGL 215
Cdd:pfam00029 159 YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
147-213 5.17e-28

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 102.57  E-value: 5.17e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32171365    147 LEGAALGLQYHLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLL 213
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
2-215 3.41e-106

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 307.12  E-value: 3.41e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365     2 CGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAFHPLSPLRFWVFQV 81
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171365    82 ILVAVPSALYMGFTLYHVIWHWELsgKGKEEETLIQGREGNTDVPGAG-----SLRLLWAYVAQLGARLVLEGAALGLQY 156
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKR--REKEEEEMEEELYEEEGKKEAEpkvhiRGGLLWTYVLSLLFRIVLEVGFLVGQY 158
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32171365   157 HLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGL 215
Cdd:pfam00029 159 YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
147-213 5.17e-28

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 102.57  E-value: 5.17e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32171365    147 LEGAALGLQYHLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLL 213
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
CNX smart00037
Connexin homologues; Connexin channels participate in the regulation of signaling between ...
43-75 3.23e-13

Connexin homologues; Connexin channels participate in the regulation of signaling between developing and differentiated cell types.


Pssm-ID: 128352  Cd Length: 34  Bit Score: 62.47  E-value: 3.23e-13
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32171365     43 VYGDEQSEFVCHTQQPGCKAACFDAFHPLSPLR 75
Cdd:smart00037   2 VWGDEQSDFVCNTQQPGCENVCYDQAFPISHVR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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