RecName: Full=Meiosis-specific with OB domain-containing protein
single-stranded DNA-binding protein( domain architecture ID 13514490)
single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
RPA1_DBD_B | cd04475 | RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding ... |
167-270 | 1.14e-18 | |||||
RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). In addition to DBD-B, RPA1 contains three other OB folds: DBD-A, DBD-C, and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties, they differ functionally. Antibodies to hRPA do not cross-react with ScRPA, and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also, ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro, whereas human RPA can. : Pssm-ID: 239921 [Multi-domain] Cd Length: 101 Bit Score: 80.71 E-value: 1.14e-18
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rpa1 super family | cl36710 | replication factor-a protein 1 (rpa1); All proteins in this family for which functions are ... |
149-406 | 6.85e-10 | |||||
replication factor-a protein 1 (rpa1); All proteins in this family for which functions are known are part of a multiprotein complex made up of homologs of RPA1, RPA2 and RPA3 that bind ssDNA and function in the recognition of DNA damage for nucleotide excision repairThis family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] The actual alignment was detected with superfamily member TIGR00617: Pssm-ID: 273177 [Multi-domain] Cd Length: 608 Bit Score: 60.90 E-value: 6.85e-10
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Name | Accession | Description | Interval | E-value | |||||
RPA1_DBD_B | cd04475 | RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding ... |
167-270 | 1.14e-18 | |||||
RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). In addition to DBD-B, RPA1 contains three other OB folds: DBD-A, DBD-C, and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties, they differ functionally. Antibodies to hRPA do not cross-react with ScRPA, and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also, ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro, whereas human RPA can. Pssm-ID: 239921 [Multi-domain] Cd Length: 101 Bit Score: 80.71 E-value: 1.14e-18
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rpa1 | TIGR00617 | replication factor-a protein 1 (rpa1); All proteins in this family for which functions are ... |
149-406 | 6.85e-10 | |||||
replication factor-a protein 1 (rpa1); All proteins in this family for which functions are known are part of a multiprotein complex made up of homologs of RPA1, RPA2 and RPA3 that bind ssDNA and function in the recognition of DNA damage for nucleotide excision repairThis family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273177 [Multi-domain] Cd Length: 608 Bit Score: 60.90 E-value: 6.85e-10
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REPA_OB_2 | pfam16900 | Replication protein A OB domain; Replication protein A contains two OB domains in it's DNA ... |
164-229 | 1.82e-03 | |||||
Replication protein A OB domain; Replication protein A contains two OB domains in it's DNA binding region. This is the second of the OB domains. Pssm-ID: 465304 [Multi-domain] Cd Length: 98 Bit Score: 37.40 E-value: 1.82e-03
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Name | Accession | Description | Interval | E-value | |||||
RPA1_DBD_B | cd04475 | RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding ... |
167-270 | 1.14e-18 | |||||
RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). In addition to DBD-B, RPA1 contains three other OB folds: DBD-A, DBD-C, and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties, they differ functionally. Antibodies to hRPA do not cross-react with ScRPA, and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also, ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro, whereas human RPA can. Pssm-ID: 239921 [Multi-domain] Cd Length: 101 Bit Score: 80.71 E-value: 1.14e-18
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rpa1 | TIGR00617 | replication factor-a protein 1 (rpa1); All proteins in this family for which functions are ... |
149-406 | 6.85e-10 | |||||
replication factor-a protein 1 (rpa1); All proteins in this family for which functions are known are part of a multiprotein complex made up of homologs of RPA1, RPA2 and RPA3 that bind ssDNA and function in the recognition of DNA damage for nucleotide excision repairThis family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273177 [Multi-domain] Cd Length: 608 Bit Score: 60.90 E-value: 6.85e-10
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REPA_OB_2 | pfam16900 | Replication protein A OB domain; Replication protein A contains two OB domains in it's DNA ... |
164-229 | 1.82e-03 | |||||
Replication protein A OB domain; Replication protein A contains two OB domains in it's DNA binding region. This is the second of the OB domains. Pssm-ID: 465304 [Multi-domain] Cd Length: 98 Bit Score: 37.40 E-value: 1.82e-03
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SoSSB_OBF | cd04491 | SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus ... |
169-256 | 9.15e-03 | |||||
SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB can substitute for the basal transcription factor TBP, stimulating transcription from promoters under conditions in which TBP is limiting, and supporting transcription when TBP is absent. SSoSSB selectively melts the duplex DNA of promoter sequences. It also relieves transcriptional repression by the chromatin Alba. In addition, SSoSSB activates reverse gyrase activity, which involves DNA binding, DNA cleavage, strand passage and ligation. SSoSSB stimulates all these steps in the presence of the chromatin protein, Sul7d. SSoSSB antagonizes the inhibitory effect of Sul7d on reverse gyrase supercoiling activity. It also physically and functionally interacts with Mini-chromosome Maintenance (MCM), stimulating the DNA helicase activity of MCM. Pssm-ID: 239937 [Multi-domain] Cd Length: 82 Bit Score: 35.29 E-value: 9.15e-03
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Blast search parameters | ||||
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