RecName: Full=Histone H2A type 2-B; AltName: Full=H2A-clustered histone 21
histone H2A( domain architecture ID 11487859)
histone H2A is a core component of the nucleosome which plays a central role in DNA double strand break (DSB) repair
List of domain hits
Name | Accession | Description | Interval | E-value | |||
PTZ00017 | PTZ00017 | histone H2A; Provisional |
1-130 | 1.20e-70 | |||
histone H2A; Provisional : Pssm-ID: 185399 Cd Length: 134 Bit Score: 207.68 E-value: 1.20e-70
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Name | Accession | Description | Interval | E-value | |||
PTZ00017 | PTZ00017 | histone H2A; Provisional |
1-130 | 1.20e-70 | |||
histone H2A; Provisional Pssm-ID: 185399 Cd Length: 134 Bit Score: 207.68 E-value: 1.20e-70
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H2A | smart00414 | Histone 2A; |
17-122 | 5.14e-69 | |||
Histone 2A; Pssm-ID: 197711 Cd Length: 106 Bit Score: 202.56 E-value: 5.14e-69
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HFD_H2A | cd00074 | histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ... |
16-104 | 7.43e-58 | |||
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Pssm-ID: 467020 Cd Length: 89 Bit Score: 173.87 E-value: 7.43e-58
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HTA1 | COG5262 | Histone H2A [Chromatin structure and dynamics]; |
3-122 | 6.79e-54 | |||
Histone H2A [Chromatin structure and dynamics]; Pssm-ID: 227587 [Multi-domain] Cd Length: 132 Bit Score: 165.42 E-value: 6.79e-54
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Histone_H2A_C | pfam16211 | C-terminus of histone H2A; |
92-125 | 1.27e-17 | |||
C-terminus of histone H2A; Pssm-ID: 465070 Cd Length: 35 Bit Score: 70.25 E-value: 1.27e-17
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Name | Accession | Description | Interval | E-value | |||
PTZ00017 | PTZ00017 | histone H2A; Provisional |
1-130 | 1.20e-70 | |||
histone H2A; Provisional Pssm-ID: 185399 Cd Length: 134 Bit Score: 207.68 E-value: 1.20e-70
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H2A | smart00414 | Histone 2A; |
17-122 | 5.14e-69 | |||
Histone 2A; Pssm-ID: 197711 Cd Length: 106 Bit Score: 202.56 E-value: 5.14e-69
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PLN00157 | PLN00157 | histone H2A; Provisional |
1-126 | 6.36e-67 | |||
histone H2A; Provisional Pssm-ID: 177758 Cd Length: 132 Bit Score: 198.54 E-value: 6.36e-67
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PLN00156 | PLN00156 | histone H2AX; Provisional |
1-125 | 2.07e-58 | |||
histone H2AX; Provisional Pssm-ID: 215080 Cd Length: 139 Bit Score: 177.08 E-value: 2.07e-58
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HFD_H2A | cd00074 | histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ... |
16-104 | 7.43e-58 | |||
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Pssm-ID: 467020 Cd Length: 89 Bit Score: 173.87 E-value: 7.43e-58
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HTA1 | COG5262 | Histone H2A [Chromatin structure and dynamics]; |
3-122 | 6.79e-54 | |||
Histone H2A [Chromatin structure and dynamics]; Pssm-ID: 227587 [Multi-domain] Cd Length: 132 Bit Score: 165.42 E-value: 6.79e-54
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PLN00153 | PLN00153 | histone H2A; Provisional |
1-125 | 1.86e-53 | |||
histone H2A; Provisional Pssm-ID: 165721 [Multi-domain] Cd Length: 129 Bit Score: 164.12 E-value: 1.86e-53
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PLN00154 | PLN00154 | histone H2A; Provisional |
1-122 | 6.32e-40 | |||
histone H2A; Provisional Pssm-ID: 177756 Cd Length: 136 Bit Score: 130.06 E-value: 6.32e-40
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PTZ00252 | PTZ00252 | histone H2A; Provisional |
10-128 | 1.88e-33 | |||
histone H2A; Provisional Pssm-ID: 240330 Cd Length: 134 Bit Score: 113.52 E-value: 1.88e-33
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HFD_SOS1_rpt2 | cd22915 | second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; ... |
26-99 | 3.28e-20 | |||
second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; SOS-1 is a guanine nucleotide exchange factor for Ras that binds to GRB2. It promotes the exchange of Ras-bound GDP by GTP. It is a catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac, by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. SOS-1 contains tandem histone folds at the N-terminal region. The model corresponds to the second repeat. Pssm-ID: 467040 Cd Length: 75 Bit Score: 78.05 E-value: 3.28e-20
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PLN00155 | PLN00155 | histone H2A; Provisional |
1-59 | 1.81e-19 | |||
histone H2A; Provisional Pssm-ID: 165723 Cd Length: 58 Bit Score: 75.90 E-value: 1.81e-19
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Histone_H2A_C | pfam16211 | C-terminus of histone H2A; |
92-125 | 1.27e-17 | |||
C-terminus of histone H2A; Pssm-ID: 465070 Cd Length: 35 Bit Score: 70.25 E-value: 1.27e-17
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Histone | pfam00125 | Core histone H2A/H2B/H3/H4; |
5-89 | 6.73e-15 | |||
Core histone H2A/H2B/H3/H4; Pssm-ID: 459682 [Multi-domain] Cd Length: 126 Bit Score: 65.92 E-value: 6.73e-15
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HFD_ABTB2-like | cd22913 | histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ... |
17-98 | 1.51e-13 | |||
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function. Pssm-ID: 467038 Cd Length: 105 Bit Score: 61.93 E-value: 1.51e-13
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BUR6 | COG5247 | Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]; |
25-106 | 2.85e-07 | |||
Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]; Pssm-ID: 227572 Cd Length: 113 Bit Score: 45.72 E-value: 2.85e-07
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HFD_DRAP1 | cd22906 | histone-fold domain found in Dr1-associated protein 1 (DRAP1) and similar proteins; DRAP1, ... |
26-97 | 2.52e-05 | |||
histone-fold domain found in Dr1-associated protein 1 (DRAP1) and similar proteins; DRAP1, also called Dr1-associated corepressor or negative cofactor 2-alpha (NC2-alpha), acts as a corepressor for Dr1 (down-regulator of transcription 1)-mediated repression of transcription. It forms a heterodimer with Dr1. The association of the Dr1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. DRAP1 can bind to DNA on its own. It also binds TATA-binding protein-associated factor 172 (BTAF1). Pssm-ID: 467031 [Multi-domain] Cd Length: 75 Bit Score: 39.81 E-value: 2.52e-05
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HFD_archaea_histone-like | cd22909 | histone-fold domain mainly found in archaeal histone-fold proteins, histone-like transcription ... |
26-89 | 2.41e-04 | |||
histone-fold domain mainly found in archaeal histone-fold proteins, histone-like transcription regulators and similar proteins; The family includes many archaeal histone-fold proteins and histone-like transcription regulators, which may bind and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. They can increase the resistance of DNA to thermal denaturation. Pssm-ID: 467034 Cd Length: 64 Bit Score: 36.75 E-value: 2.41e-04
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HHT1 | COG2036 | Archaeal histone H3/H4 [Chromatin structure and dynamics]; |
26-77 | 2.85e-04 | |||
Archaeal histone H3/H4 [Chromatin structure and dynamics]; Pssm-ID: 441639 Cd Length: 67 Bit Score: 36.73 E-value: 2.85e-04
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HFD_SF | cd00076 | histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ... |
26-89 | 3.06e-04 | |||
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10. Pssm-ID: 467021 Cd Length: 63 Bit Score: 36.43 E-value: 3.06e-04
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CBFD_NFYB_HMF | pfam00808 | Histone-like transcription factor (CBF/NF-Y) and archaeal histone; This family includes ... |
26-88 | 5.60e-04 | |||
Histone-like transcription factor (CBF/NF-Y) and archaeal histone; This family includes archaebacterial histones and histone like transcription factors from eukaryotes. Pssm-ID: 395650 Cd Length: 65 Bit Score: 36.05 E-value: 5.60e-04
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HFD_Dpb3-like | cd23645 | histone-fold domain found in Schizosaccharomyces pombe DNA polymerase epsilon subunit C (Dpb3) ... |
24-97 | 4.29e-03 | |||
histone-fold domain found in Schizosaccharomyces pombe DNA polymerase epsilon subunit C (Dpb3) and similar proteins; Schizosaccharomyces pombe Dpb3 is an accessory component of the DNA polymerase epsilon (DNA polymerase II) that is a heterotetramer consisting of cdc20/Pol2, Dpb2, Dpb3, and Dpb4, and participates in chromosomal DNA replication. Dpb3 is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. The Dpb3-Dpb4 dimer associates with histone deacetylases, chromatin remodelers, and histones and plays a crucial role in the inheritance of histone hypoacetylation and H3K9 methylation in heterochromatin. The Dpb3-Dpb4 dimer is also required for the recruitment of sir2 to heterochromatin. Pssm-ID: 467059 [Multi-domain] Cd Length: 78 Bit Score: 33.74 E-value: 4.29e-03
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Blast search parameters | ||||
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