NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|81899710|sp|Q8CBH5|]
View 

RecName: Full=Major facilitator superfamily domain-containing protein 6; AltName: Full=Macrophage MHC class I receptor 2

Protein Classification

MFS transporter( domain architecture ID 13023754)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 7.50e-166

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 483.62  E-value: 7.50e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335   1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335  81 FFV----------------------------------------------------------------------------- 83

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335  84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335 107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335 174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335 221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81899710 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 7.50e-166

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 483.62  E-value: 7.50e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335   1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335  81 FFV----------------------------------------------------------------------------- 83

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335  84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335 107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335 174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335 221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81899710 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 69-607 3.89e-69

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 231.75  E-value: 3.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710    69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNL 148
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   149 GIGFVKPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltsept 228
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   229 rrpqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASS 308
Cdd:pfam12832  88 -----------------------------------------------------------SLTFWWLALLVVLFSFFWNAI 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   309 VTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLidgkgckppeyrnYQIVFIVFGVLMTMALIV 388
Cdd:pfam12832 109 LPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   389 ATQFRFrynhfnnsdgkgkeveipqverdnstesseetPTAATHSQAFNfwDLIKLLCSVQYGSVLFVAWFMGFGYGFVF 468
Cdd:pfam12832 176 PLAPPE--------------------------------MEYESKGGSKA--VFWNLLKQPEVIIFFLAAFLLGFSHGPFY 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   469 TFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQG 547
Cdd:pfam12832 222 TFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHA 301

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   548 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 607
Cdd:pfam12832 302 ISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
453-630 1.43e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.86  E-value: 1.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2814  14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 611
Cdd:COG2814  94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                       170
                ....*....|....*....
gi 81899710 612 ACLVILLLFALIQWLAVPD 630
Cdd:COG2814 169 VNAVLALLALLLLLRLLPE 187
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
77-141 2.40e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.14  E-value: 2.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81899710   77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADrfRKG-KIVLLFSLL 141
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLAD--RKGrKIMLLRSAL 92
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 71-625 7.50e-166

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 483.62  E-value: 7.50e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  71 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGI 150
Cdd:cd17335   1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 151 GFVkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrr 230
Cdd:cd17335  81 FFV----------------------------------------------------------------------------- 83

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 231 pqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASSVT 310
Cdd:cd17335  84 ---------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVP 106

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 311 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIdvlidgkgckppeYRNYQIVFIVFGVLMTMALIVAT 390
Cdd:cd17335 107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLAL 173

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 391 QFRFRYNHfnnsdgkgkeveipqverdnstesseetptaatHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 470
Cdd:cd17335 174 KFPFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF 220

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 471 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTH 550
Cdd:cd17335 221 LFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTF 300

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81899710 551 AAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 625
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 69-607 3.89e-69

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 231.75  E-value: 3.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710    69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNL 148
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   149 GIGFVKPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltsept 228
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   229 rrpqteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqevEAIFLIILVVVIIGEFFSASS 308
Cdd:pfam12832  88 -----------------------------------------------------------SLTFWWLALLVVLFSFFWNAI 108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   309 VTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLidgkgckppeyrnYQIVFIVFGVLMTMALIV 388
Cdd:pfam12832 109 LPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   389 ATQFRFrynhfnnsdgkgkeveipqverdnstesseetPTAATHSQAFNfwDLIKLLCSVQYGSVLFVAWFMGFGYGFVF 468
Cdd:pfam12832 176 PLAPPE--------------------------------MEYESKGGSKA--VFWNLLKQPEVIIFFLAAFLLGFSHGPFY 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   469 TFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQG 547
Cdd:pfam12832 222 TFLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHA 301

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   548 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 607
Cdd:pfam12832 302 ISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 72-621 4.00e-42

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 157.86  E-value: 4.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  72 SKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLgig 151
Cdd:cd17479   1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 152 fvkpatlrclpkipptahptnvshpvtvlpmnsstvaffstppklLQKRdvqlsetepnisdidlvstaltltseptrrp 231
Cdd:cd17479  78 ---------------------------------------------LYHQ------------------------------- 81

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 232 qteaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqeveaIFLIILVVVIIGEFFSASSVTI 311
Cdd:cd17479  82 ----------------------------------------------------------IFLLVLLVIIIWELLSAPLEKV 103

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 312 VDTVTLQYLGKHR--DRYGLQRMWGSLGwgLAMLSVGIGidythidVLIDGKGCKPPEYRN-YQIVFIVFGVLMTMALIV 388
Cdd:cd17479 104 ADDSLYEYLDFVDatERYGKLKVWSALG--AAFGPCGIT-------LLVDNLDCFLPPKISrILLHFYTYGGFMILTFLL 174

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 389 ATQFrfrynhfnnsdgkgkeveiPQVERDNSTESSEEtptaathSQAFNFwdlikLLCSVQ---YGSVLFVawfMGFGYG 465
Cdd:cd17479 175 SFFY-------------------PIPVPKKEEHSSKV-------VKGLRL-----LGGDGRailYALTVFL---VGFVGS 220

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 466 FVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVL 545
Cdd:cd17479 221 TVQNFLFWLMQDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELL 300

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81899710 546 QGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFA 621
Cdd:cd17479 301 HAFSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 74-625 2.99e-28

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 117.53  E-value: 2.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd06174   3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 154 KPatlrclpkipptahptnvshpvtvlpmnsstvaffstppkllqkrdvqlsetepnisdidlvstaltltseptrrpqt 233
Cdd:cd06174  82 PS------------------------------------------------------------------------------ 83

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 234 eaithpvtglilntstvtlpptgnvtrettiavvtttkslpsdqvtlvydqqeveaiFLIILVVVIIGEFFSASSVTIVD 313
Cdd:cd06174  84 ---------------------------------------------------------FWLLLLGRFLLGLGSGLIDPAVL 106

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 314 TVTLQYLGKHR--DRYGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQ 391
Cdd:cd06174 107 ALIADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSL------------------GFGWRAVFLIAAALALLAAIL 168

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 392 FRFRYNHFNNSDGKGKEVEipqverdnstesseetptaathSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFL 471
Cdd:cd06174 169 LLLVVPDPPESARAKNEEA----------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 472 YWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIE-LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVT 549
Cdd:cd06174 227 PLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81899710 550 HAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIGGVLVNYFGAAAT-FRGIGMACLVILLLFALIQW 625
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGL-----LNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 371-623 9.69e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.62  E-value: 9.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 371 YQIVFIVFGVLMTMALIVATQFRfrynhfnnsdgkgkeveipqverdnstESSEETPTAATHSQAFNFWDLIKLLCSVQY 450
Cdd:cd17325 149 YRAPFLVCAALALLALVLALLLL---------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRL 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 451 GSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVcSVLSHVseLTAYFFShKLIELIGHIRVLYIGLACNTA 525
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPaqiglLFGA-QGLASA--LSQPPAG-KLSDRIGRKPLILIGLLLSAV 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 526 RYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAAT 605
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATP 356

                       250
                ....*....|....*...
gi 81899710 606 FRGIGMACLVILLLFALI 623
Cdd:cd17325 357 FLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
453-630 1.43e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.86  E-value: 1.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2814  14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 611
Cdd:COG2814  94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                       170
                ....*....|....*....
gi 81899710 612 ACLVILLLFALIQWLAVPD 630
Cdd:COG2814 169 VNAVLALLALLLLLRLLPE 187
MFS_1 pfam07690
Major Facilitator Superfamily;
453-633 1.26e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.92  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   453 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGaaatFRGIGM 611
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFG----WRAAFL 155

                         170       180
                  ....*....|....*....|..
gi 81899710   612 ACLVILLLFALIQWLAVPDEEE 633
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 453-633 1.90e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 1.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigMA 612
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPF----LV 155

                       170       180
                ....*....|....*....|.
gi 81899710 613 CLVILLLFALIQWLAVPDEEE 633
Cdd:cd17325 156 CAALALLALVLALLLLPEPRP 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 453-652 3.04e-11

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 65.66  E-value: 3.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd17477   1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRtsaqGILQGLHlGLGRGCGAMIGGVLVNYFG-AAATFRGIGM 611
Cdd:cd17477  81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR----GRVLGLY-STVLGLGFALGPLLLALVGtAGALPFLIAA 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 81899710 612 ACLVILLLFALIQWLAVPDEEEDKTMLAERIpVPSSPVPIA 652
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPLALL 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
291-586 2.43e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.68  E-value: 2.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 291 FLIILVVVI---IGEFFSASSVTIVDTVTLQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppe 367
Cdd:COG2814 100 LLLAARFLQglgAGALFPAALALIADLVPPERRGR---ALGLLGAGLGLGPALGPLLGGLLADLF--------------- 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 368 yrNYQIVFIVFGVLMTMALIVATQFrfrynhfnnsdgkgkeveIPqverdnstesseETPTAATHSQAFNFWDLIKllcS 447
Cdd:COG2814 162 --GWRWVFLVNAVLALLALLLLLRL------------------LP------------ESRPAARARLRGSLRELLR---R 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 448 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTAR 526
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 527 YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 586
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 424-623 6.18e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 61.82  E-value: 6.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 424 EETPTAATHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvsELT 498
Cdd:cd17474 174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLL---ALG 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 499 AYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 578
Cdd:cd17474 251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 81899710 579 GLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 623
Cdd:cd17474 331 FV-RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
453-628 1.56e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.27  E-value: 1.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:COG2271  14 LLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGM 611
Cdd:COG2271  94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG-PLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                       170
                ....*....|....*..
gi 81899710 612 ACLVILLLFALIQWLAV 628
Cdd:COG2271 173 PGLLLALLRFWLLALAY 189
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 455-622 2.59e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.92  E-value: 2.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 455 FVAWFMGFGYGFVFTFLYWHLEDLNGTT-----TLFGVCSVLSHvseltayFFSHKLIELIGHIRVLYIGLACNTARYIY 529
Cdd:cd17489 201 LILFLASIAYGAISTFLPLYAAERGISNaglffTVYAIALLLSR-------PFSGKLSDRKGPKTVIIPGLLLLALGLLL 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 530 ISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGI 609
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF-FDLGIGLGGLLLGLVAELFGYRAMFLLA 352

                       170
                ....*....|...
gi 81899710 610 GMACLVILLLFAL 622
Cdd:cd17489 353 AVVVLLALVLYIF 365
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 460-619 3.29e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 59.54  E-value: 3.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 460 MGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSE-LTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 538
Cdd:cd17490 207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNaLASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 539 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 618
Cdd:cd17490 287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365


                .
gi 81899710 619 L 619
Cdd:cd17490 366 L 366
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 459-623 6.39e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.76  E-value: 6.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 459 FMGFGYGFVFTFLYwhLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 538
Cdd:cd17489   9 FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 539 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 618
Cdd:cd17489  87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165


                ....*
gi 81899710 619 LFALI 623
Cdd:cd17489 166 LVFLV 170
MFS_1 pfam07690
Major Facilitator Superfamily;
290-578 1.23e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.43  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   290 IFLIILVVVIIGeFFSASSVTIVDTVTLQYLGK-HRDR-YGLQRMWGSLGWGLAMLSVGIGIDYThidvlidgkgckppe 367
Cdd:pfam07690  85 LWLLLVLRVLQG-LGAGALFPAALALIADWFPPeERGRaLGLVSAGFGLGAALGPLLGGLLASLF--------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   368 yrNYQIVFIVFGVLMTMALIVATqfrfrynhfnnsdgkgkeveIPQVERDNSTESSEETPTAATHSqafnfwdLIKLLCS 447
Cdd:pfam07690 149 --GWRAAFLILAILSLLAAVLLL--------------------LPRPPPESKRPKPAEEARLSLIV-------AWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   448 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN---T 524
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaA 279

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 81899710   525 ARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 578
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN 333
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 453-623 1.85e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 57.24  E-value: 1.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMA 612
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL-NSGAMPLGALLAGLLADALGLSAVFLLAGAL 372

                       170
                ....*....|.
gi 81899710 613 CLVILLLFALI 623
Cdd:cd06173 373 LLLAALLLLLL 383
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 453-654 2.42e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 56.67  E-value: 2.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 532
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 533 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGlhlglGRGCGAMIGGVLVNYFGAA--ATFRGIG 610
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQA-----FGSVGGILGPLLGGILASSlgFGWRAVF 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 81899710 611 MACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATI 654
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 461-620 3.85e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 56.05  E-value: 3.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 461 GFGYGFVFTFLYWHLEDLNGT----------TTLFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17330   9 ALGFGIVFPVLPFYVREFNKLgasgyyvgllQSSYSLGQFLA------SPLWG-RLSDRYGRKPVLLLSLAGSAVSYVLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 531 SYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATF---R 607
Cdd:cd17330  82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII-SAAFGLGFILGPALGGFLSTPYGYALPFlvaA 159

                       170
                ....*....|...
gi 81899710 608 GIGMACLVILLLF 620
Cdd:cd17330 160 ALALLNLVLVLFF 172
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-153 5.17e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.65  E-value: 5.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRkGKIVLLFSLLCWVLFNLGIGFV 153
Cdd:COG2271  17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG-RRRVLAIGLLLWGLATLLFGFA 95
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
453-622 5.23e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.66  E-value: 5.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFmgfgyGFVFTFLYWHL---------EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 523
Cdd:COG2223   6 VLLLATL-----AFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWR 159

                       170
                ....*....|....*....
gi 81899710 604 ATFRGIGMACLVILLLFAL 622
Cdd:COG2223 160 NAFLILGILLLVVAVLAWL 178
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
327-623 5.57e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 5.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 327 YGLQRMWGSLGWGLAMLSVGIGIDYTHIDvlidgkgckppEYRNYQIVFIVFGVLMTMALIVAtqFRFRynhfnnsdgkg 406
Cdd:COG2211 149 SSWRFAFAGLGGLLASVLPPPLVAAFGGD-----------AALGYRLTALIFAVLGLLAFLLT--FFGT----------- 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 407 KEVEIPQVERdnstesseetptaathsqaFNFWDLIKLLCSV-QYGSVLFVAWFMGFGYGFVFT-FLYWHLEDLNGTTTL 484
Cdd:COG2211 205 KERPVPEEEK-------------------VSLKESLKALLKNrPFLLLLLAYLLFFLALALVAAlLLYYFKYVLGLSAAL 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 485 FGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI--YISYLENAWTVLPMEVLQGVTHAAIWAACISYLS 562
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81899710 563 AAVPP-ELRT--SAQGILQGLH---LGLGRGCGAMIGGVLVNYFG-------AAATFRGIGMACLVILLLFALI 623
Cdd:COG2211 346 DVVDYdEWKTgrRREGLYFGIFtfaIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLL 419
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 77-153 5.67e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 5.67e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81899710  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17489   6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-KRLLLIGLLIFALATLLYLLA 81
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 453-622 6.40e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.82  E-value: 6.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCsvlshvseLTAYFFSH--------KLIELIGHIRVLYIGLACN 523
Cdd:COG0477  18 ALALGTFLeGLDFTIVNVALPSIAADLGASSAQLGWI--------VSAYLLGRaiglllfgRLGDRYGRKRVLLIGLLLF 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG0477  90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWR 168

                       170
                ....*....|....*....
gi 81899710 604 ATFrGIGMACLVILLLFAL 622
Cdd:COG0477 169 WIF-LINAPLGLLALVLRL 186
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
69-158 1.16e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  69 LLISKVFYFFFYSAYGSLYPLLPVYYkqLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNL 148
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309

                        90
                ....*....|
gi 81899710 149 GIGFVKPATL 158
Cdd:COG2211 310 LLFFLGPGNL 319
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 459-636 1.90e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.16  E-value: 1.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 459 FMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAW 537
Cdd:cd17329  10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 538 TVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFgaaatFRGIGMACLVIL 617
Cdd:cd17329  90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL-YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLF 163

                       170
                ....*....|....*....
gi 81899710 618 LLFALIQWLAVPDEEEDKT 636
Cdd:cd17329 164 LLAALVLLFLLPETRPKRR 182
MFS_1 pfam07690
Major Facilitator Superfamily;
76-153 2.54e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 2.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710    76 YFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLLLLFA 82
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 505-621 4.41e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 52.95  E-value: 4.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 505 KLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGL 584
Cdd:cd17321  53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 81899710 585 GRGCGAMIGGVLVNYFGAAATF--------------RGIGMACLVILLLFA 621
Cdd:cd17321 132 GAALGPLLGGLLLELFGWRWIFlinvpiglvalllaRTFSGAVLAAFLLGA 182
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 453-620 5.53e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.55  E-value: 5.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYgFVFTFLYWHLEDLNGTTTLFGVCSVLSH-VSELTAYFFSHkLIELIGHIRVLYIGLACNTARYIYIS 531
Cdd:cd17370 205 YLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNlVYALAAYPAGR-LSDRIGRKKLLILGYLSLALAYLGFA 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 532 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIG----GVLVNYFGAAATFR 607
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-----FNTVVGIGWLLAsliaGYLWDLISPSAAFL 357

                       170
                ....*....|....
gi 81899710 608 -GIGMACLVILLLF 620
Cdd:cd17370 358 fSAVLALIALLLLL 371
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 453-623 6.37e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.22  E-value: 6.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACnTARYIYIS 531
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLpTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-SGILALPL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 532 YL---ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAqgilqglhLGLGRGCGAMIGGVLVNYFGAAATFRG 608
Cdd:cd17316 261 FYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--------VGLSYNLGRLGGGGAPPLIALLLASTG 332

                       170
                ....*....|....*
gi 81899710 609 IGMACLVILLLFALI 623
Cdd:cd17316 333 GTGVPALILALLAIV 347
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 63-158 1.40e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  63 VKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGM-SPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLL 141
Cdd:cd06174 199 VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL 278

                        90
                ....*....|....*..
gi 81899710 142 CWVLFNLGIGFVKPATL 158
Cdd:cd06174 279 LMALGLALLLLAPSLLL 295
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-153 1.46e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.04  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  32 REPEPPSNETPSSTETSAIPEEEIdwiekhcvKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQL-GMSPSQSGLLVGI 110
Cdd:cd17325 172 PEPRPPPNKRAVSAARLRSGLRLL--------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGA 243

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 81899710 111 RYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLA 285
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 453-624 1.49e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 1.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLF--GVCSVLSHVSELTAYFFShKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17473 202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 531 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVN-YFGAAATFRGI 609
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA-FFLGQFLSPLVLGPLVNlTGGLSGAFLIL 359

                       170
                ....*....|....*
gi 81899710 610 GMACLVILLLFALIQ 624
Cdd:cd17473 360 GVLALVLAIVLLLLR 374
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 491-622 2.03e-06

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 50.71  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 491 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYL---ENAWTVLPMEVLQGVTHAAIWAACISYLSA 563
Cdd:cd06177 242 LGQISEilfmLAIPFFLKRL----GIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSIILHGVCYDFFFVTGYIYVDK 317

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81899710 564 AVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAAT---FRGI-----GMAcLVILLLFAL 622
Cdd:cd06177 318 KAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEGtkdWQTIwlvpaIYA-LVLAILFAL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
69-158 2.96e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 2.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNL 148
Cdd:COG2223   7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLL 85

                        90
                ....*....|
gi 81899710 149 GIGFVKPATL 158
Cdd:COG2223  86 LLALAVSYWL 95
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 506-630 3.32e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 3.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 506 LIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ-GLHLG- 583
Cdd:cd17324  57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFsGLTLGl 136

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 81899710 584 -LGRgcgaMIGGVLVNYFGAAATFRGIGmaclVILLLFALIQWLAVPD 630
Cdd:cd17324 137 vLGR----PLGGLLGQLLGWRAAFLAIA----VLALLAALLLWRLLPS 176
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-158 4.37e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.48  E-value: 4.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RKGKIVLLFSLLCWVLFNLGIG 151
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLA 266


                ....*..
gi 81899710 152 FVKPATL 158
Cdd:COG2271 267 LLPSPAL 273
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 290-624 4.75e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 4.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 290 IFLIILVVVIIGE--FFSASSVTIVDTVTlqylGKHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYthidvlidgkgckpp 366
Cdd:cd17329  90 LFAIALVLTGFGGglFEPASEAMIADVTT----PENRTRaFSLLYWAINLGVAIGPLLGGLLLLY--------------- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 367 eyrNYQIVFIVFGVLMTM-ALIVATQFRFRYNHFNNSDGKGKEVEIPQVERDnstesseetptaathsQAFnfwdlikll 445
Cdd:cd17329 151 ---SFRLLFLAAAVLFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------RAF--------- 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 446 csvqygsVLFVAWFMGFGYGFVFTFLYWHL---EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLAC 522
Cdd:cd17329 203 -------LLFLLASFLISLIYFQLESTLPVyvvEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILL 275

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 523 NTARYIyISYLENAWTVLPM--------EVLqGVTHAAIWAACISylsaavPPELRTSAQGiLQGLHLGLGRGCGAMIGG 594
Cdd:cd17329 276 FAIGFA-VLAFANTLAVLILamivltlgEML-VFPAVQTLVAALA------PPDKRGSYMG-FYALAWGLGRAIGPLVGG 346

                       330       340       350
                ....*....|....*....|....*....|
gi 81899710 595 VLVNYFGAAATFRGIGMACLVILLLFALIQ 624
Cdd:cd17329 347 LLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
74-152 5.02e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 5.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSA-YGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGIGF 152
Cdd:COG2807 221 TLFFGLQSLlYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 497-623 5.66e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.50  E-value: 5.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 497 LTAYF--------FSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPE 568
Cdd:cd17504  37 LTAYLlvgavstpILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 81899710 569 LRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 623
Cdd:cd17504 116 RVPVAQGILSAT-FGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-153 5.70e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 5.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIV---LLFSLLCWVLFNLG 149
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLligLLLLALGLLLLALA 293


                ....
gi 81899710 150 IGFV 153
Cdd:COG2814 294 GSLW 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
453-623 9.88e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 9.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWF-MGFGYGFVFTFLYWHLEDLNG--------TTTLFGVCSVlshVSELTAYFFSHKLIEliGHIRVLYIGLACN 523
Cdd:COG2271 184 LLALAYFlVYFALYGFLTWLPTYLVEVRGlslaqaglLLSLPFLAGI---VGSLLGGWLSDRLGR--RRKLVLAIGLLLA 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAA 603
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATGYQ 337

                       170       180
                ....*....|....*....|
gi 81899710 604 ATFrGIGMACLVILLLFALI 623
Cdd:COG2271 338 AAF-LLLAALALLAALLALL 356
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 69-153 1.14e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.37  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFN 147
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILSGILA 257


                ....*.
gi 81899710 148 LGIGFV 153
Cdd:cd17316 258 LPLFYL 263
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 77-153 1.42e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.99  E-value: 1.42e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81899710  77 FFFYSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17329   9 FLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85
MFS_1 pfam07690
Major Facilitator Superfamily;
34-157 1.74e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710    34 PEPPSNETPSSTETSAIPEEEIDWieKHCVKVNNDLLISKVFYFFFysAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYF 113
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAW--KALLRDPVLWLLLALLLFGF--AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 81899710   114 IEFCSAPFWGVVADRFRKGKIVLLFSLLCwVLFNLGIGFVKPAT 157
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTL 289
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 84-152 2.21e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 2.21e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710  84 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNLGIGF 152
Cdd:cd17474  16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRF-GRKKVLLPGLLLFGIGGLLCGL 83
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 463-620 2.87e-05

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 46.96  E-value: 2.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 463 GYGFVFTFLYWHL---------EDLNGTTTLFGVcsvlsHVSELTAYFFSHKLIELIGHIRVLYIGLaCNTARYIYISYL 533
Cdd:cd17338   5 SFGFLLIFLAYSAlqnlqtslhENGLGSISLGIL-----YSSFAVSSFIAPLLVKLLGEKITLVLGG-LGYAIFIASNIF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 534 ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA-------ATF 606
Cdd:cd17338  79 PIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSI-FQLSQVFGNLISLALLNHSKGSsgttilfIVF 157

                       170
                ....*....|....
gi 81899710 607 RGIgMACLVILLLF 620
Cdd:cd17338 158 MAI-MLVGIILLFF 170
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 453-623 3.82e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 3.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGY-GFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAY-FFSHKLIELIGHIRVLYIGLACNTARYIYI 530
Cdd:cd17330 179 LLLVYFLIALAFaGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 531 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFrGIG 610
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPF-LLA 336

                       170
                ....*....|...
gi 81899710 611 MACLVILLLFALI 623
Cdd:cd17330 337 AGLLLIALFLLSL 349
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 77-153 8.79e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 45.72  E-value: 8.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIG 151
Cdd:cd17391   6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIGLMA 84


                ..
gi 81899710 152 FV 153
Cdd:cd17391  85 FV 86
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
74-146 9.42e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 9.42e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81899710  74 VFYFFFYSAYGSLYPLLPVYYK-QLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLF 146
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
491-622 1.38e-04

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 45.15  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710   491 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYLEN------AWTVLPMeVLQGVTHAAIWAACISY 560
Cdd:pfam03825 251 LGQISEilfmLTLPFFLKRF----GIKNVMLIGIVAWALRFAFFAYGADptpfgtALLLLSM-IVHGVAYDFFNITGYIF 325

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710   561 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR-------GIGMAcLVILLLFAL 622
Cdd:pfam03825 326 VDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtvwlvFAGMA-LVLAVLFMA 393
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 510-636 1.60e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 44.90  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 510 IGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVthAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCG 589
Cdd:cd17472  59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI-GASIGIAFAIS 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81899710 590 AMIGGVLVNYFGAAATFrgIGMACLVILLLFalIQWLAVPDEEEDKT 636
Cdd:cd17472 136 MVLGPLLAAHLGVSGLF--LITAILSLVSLL--ILLFFVPDPPKIVQ 178
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
77-141 2.40e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.14  E-value: 2.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81899710   77 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADrfRKG-KIVLLFSLL 141
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLAD--RKGrKIMLLRSAL 92
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 454-642 2.88e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.76  E-value: 2.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 454 LFVA-WFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLyigLACNTAR------ 526
Cdd:cd06173   4 LWLAqLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRallaav 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 527 --YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAA 604
Cdd:cd06173  81 laLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLGPGG 159

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 81899710 605 TFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERI 642
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 517-622 3.57e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 43.42  E-value: 3.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 517 YIGLACNTARYIYISYLENAWTV---LPMEVLQGVT--HAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAM 591
Cdd:cd17386  67 LVGLLLSSLILVLIVYFTTVPSVwwfYLSAIPLALFggFTAFLSASFAYISDISSEKKRTYRMAILEVA-LGLGGFLGSL 145

                        90       100       110
                ....*....|....*....|....*....|.
gi 81899710 592 IGGVLVNYFGAAATFrGIGMACLVILLLFAL 622
Cdd:cd17386 146 LSGHLFKALGYAWSF-SISAALLLIALLYIL 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 82-155 3.69e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 3.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81899710  82 AYGSLYPLLPVY---YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RkgKIVLLFSLLCWVLFNLGIGFVKP 155
Cdd:cd17330  11 GFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYgR--KPVLLLSLAGSAVSYVLLGLSRN 86
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 453-621 6.78e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.54  E-value: 6.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 453 VLFVAWFMGFGYGF-VFTFLYWHLEDLNGTTT--------LFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACN 523
Cdd:cd17324 202 LAYLITFLLFGGFFaLYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SPLAG-RLADRGGRRALLIALLLLA 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 524 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPpelrtSAQGILQGLHLG---LGRGCGAMIGGVLVNYF 600
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-----EARGLASSLYLAaynLGGALGAALGGLVLDHG 349

                       170       180
                ....*....|....*....|.
gi 81899710 601 GAAATFRGIGMACLVILLLFA 621
Cdd:cd17324 350 GWAGVGWVGAALLLLALLLAL 370
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 77-138 7.92e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 7.92e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81899710  77 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLF 138
Cdd:cd17370   9 LFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIL 70
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
289-623 8.06e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 8.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 289 AIFLIILV----VVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRM-WGSLGWGL-AMLSVGIGIDYTHIDVLIDgkg 362
Cdd:COG0738  86 GLLLFALApsypLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnLLHAFFSLgALLGPLLGGLLILLGLSLS--- 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 363 ckppeyrnYQIVFIVFGVLMTMALIVATQFRFRynhfnnsdgkgkeveipqverDNSTESSEETPTAATHSQAFNFWDLI 442
Cdd:COG0738 163 --------WHLPYLILAVLLLLLALLFLRSKLP---------------------EIEEEEEEAAGSAASLKSLLKNPRLL 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 443 kllcsvqygsVLFVAWFMGFG-YGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGL 520
Cdd:COG0738 214 ----------LGGLAIFLYVGaEGAIGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 521 ACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPelRTSAQGilqGLHLGLGrGCGAMIG----GVL 596
Cdd:COG0738 284 LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK--RTAAAV---SAVLIMG-IVGGAIGppliGFL 357

                       330       340
                ....*....|....*....|....*..
gi 81899710 597 VNYFGAAATFrGIGMACLVILLLFALI 623
Cdd:COG0738 358 ADAFGLRAAF-LVPLVCYLLILLLALA 383
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 71-157 1.06e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.18  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  71 ISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFrKGKIVLLFSLLCWVLFNLG 149
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLLLLALGTLL 260


                ....*...
gi 81899710 150 IGFVKPAT 157
Cdd:cd17503 261 LAFLTPDT 268
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 88-153 1.09e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.15  E-value: 1.09e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81899710  88 PLLPVYYKQLGMSPSQSGLLVGIrYFIEFC-SAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17324  20 GLLPDIARDFGVSVAQAGLLVSA-YALGYAlGALLLGPLSDRIER-RRLLLVLLLLFILGNLLAALA 84
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 69-152 1.76e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.95  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  69 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCS-APFWGVVADRF-RkgKIVLLFSLLCWVLF 146
Cdd:COG0477  16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA-YLLGRAIgLLLFGRLGDRYgR--KRVLLIGLLLFGLA 92


                ....*.
gi 81899710 147 NLGIGF 152
Cdd:COG0477  93 SLLCGL 98
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 70-142 1.84e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 41.41  E-value: 1.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81899710   70 LISKVFYFFF-YSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLC 142
Cdd:PRK05122  17 IVSIVMFTFIsYLTIGLPLAVLPGYvHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 70-146 2.39e-03

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 41.06  E-value: 2.39e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81899710  70 LISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLF 146
Cdd:cd06172   2 WKFSLFFFLFFFIWSASFSFFPIWLTQiNHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLF 79
lacY PRK09528
galactoside permease; Reviewed
 66-131 2.44e-03

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 41.03  E-value: 2.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710   66 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADR--FRK 131
Cdd:PRK09528   9 NPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDiNGLSGTDTGIIFSANSLFALLFQPLYGLISDKlgLKK 77
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
501-636 2.79e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 2.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 501 FFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLsAAVPPELRTSAQGILQGL 580
Cdd:COG0738  61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAF 139

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710 581 HlGLGRGCGAMIGGVLVNYFGAAAT---FRGIGMACLVILLLFALIQWLAVPDEEEDKT 636
Cdd:COG0738 140 F-SLGALLGPLLGGLLILLGLSLSWhlpYLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 88-141 2.81e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.67  E-value: 2.81e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 81899710  88 PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLL 141
Cdd:cd17390  17 PLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGR-RPVLLICLL 69
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
328-629 2.97e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 2.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 328 GLQRMWGSLGWGLAMLSVGigidythidVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFrfrynhfnnsdgkgk 407
Cdd:COG2223 132 GLAAGGGNLGAAVAAFLAP---------LLIAAFG--------WRNAFLILGILLLVVAVLAWLF--------------- 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 408 eveipqVERDNSTESSEETPTAATHSQAF---NFWdlikllcsvqygsVLFVAWFMGFGYGFVFTF---LYWHLE---DL 478
Cdd:COG2223 180 ------LRDPPAGAAAAAKASLRDQLEALrdpRFW-------------LLSLLYFGTFGSFIGFSSwlpPYLVDQfglSA 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 479 NGTTTLFGVCSVLSHVSELTAYFFSHKlielIGHIRVLYIGLACNTARYIYISY-LENAWTVLPMEVLQGVTHAAIWAAC 557
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDR----IGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAV 316

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81899710 558 ISYLSAAVPPELRTSAQGILqglhlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVP 629
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLV-----GAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 69-158 3.66e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 3.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  69 LLISKVFYFFFYSaygslYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKiVLLFSLLCWVLFNL 148
Cdd:cd17370 206 LLAVALFALGNFS-----FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYL 279

                        90
                ....*....|
gi 81899710 149 GIGFVKPATL 158
Cdd:cd17370 280 GFALGSSLWL 289
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 77-153 3.95e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 3.95e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710  77 FFFYSAYGSLYPL-LPVYY-KQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKGKiVLLFSLLCWVLFNLGIGFV 153
Cdd:cd17471 208 FTLLFAANSMYIIaMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR-LLLAGFLAGVLFYLGLALA 285
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 81-141 4.24e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 40.28  E-value: 4.24e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81899710  81 SAYGSLYPLLPVYYKQLGMSPSQSGL---LVGIRYFIefcSAPFWGVVADRFRKGKIVLLFSLL 141
Cdd:cd17385 215 VSLGFLDPTLSPHLRQFKLSPGQVGLmflILAGSYAI---SAPLWGWLSDKKKIPKWLMVIGSI 275
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 63-158 4.89e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 40.28  E-value: 4.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  63 VKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLC 142
Cdd:cd17332 217 LLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGK-KKAFFIGLLL 295

                        90
                ....*....|....*.
gi 81899710 143 WVLFNLGIGFVKPATL 158
Cdd:cd17332 296 AILGLLLLFFLPPGNL 311
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 477-624 5.43e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.94  E-value: 5.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 477 DLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAA 556
Cdd:cd17391 234 DASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPA 313

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81899710 557 CISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAAATFRGIGmaclvILLLFALIQ 624
Cdd:cd17391 314 INSLLAKITPKEVAGRIFGYNQSFQY-LGNVAGPLLGSAIAAHFGYRAVFVVTA-----LLVLLNAIW 375
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 84-162 7.31e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 7.31e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710  84 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFVKPATLRCLP 162
Cdd:cd17477 205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPGLPLALLV 282
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 79-154 7.43e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 7.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81899710  79 FYSAYGS--LYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCSAP-FWGVVADRFRKgKIVLLFSLLCWVLFNLGIGFVK 154
Cdd:cd17323   9 FVVTFGSsiYSPALPQIAEDFHVSEEVANLGVSL-FVLGFGLGPlIWAPLSELYGR-RPVYLVSLFIFVIFQIGCALAP 85
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 74-153 7.70e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 7.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710  74 VFYFFFYSAYGSLYPLLpVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-RkgKIVLLFSLLCWVLFNLGIGF 152
Cdd:cd17316   9 FFDAYDFFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIgR--KKALILTLLLFGLATLLIGL 85


                .
gi 81899710 153 V 153
Cdd:cd17316  86 L 86
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 466-622 8.43e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.13  E-value: 8.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 466 FVFTFLYW------------HLEDLNGTTTLFGVCsvlshvseLTAYFFSHKLIEL-IG--------HIRVLYIGLACNT 524
Cdd:cd17490   2 LIIVFLFWfsqyvyvpflspYAESLGASLSMIGII--------LGAYGISQMLLRIpLGilsdrigkRKLFIIIGLLFTV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81899710 525 ARYIYISYLENAWTVLPMEVLQGVThAAIWAACISYLSAAVPPELRTSAQGILQgLHLGLGRGCGAMIGGVLVNYFGAAA 604
Cdd:cd17490  74 LASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLIN-LVNNLGQLIAFLIGGLIAEHFGMRA 151

                       170
                ....*....|....*....
gi 81899710 605 TFR-GIGMACLVILLLFAL 622
Cdd:cd17490 152 PFLlAALAGVLGFILSLFI 170
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
76-116 8.59e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 39.11  E-value: 8.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 81899710   76 YFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 116
Cdd:PRK11128  13 YFGYFFAYGVFLPFWSVWLKGQGYTPETIGLLLGAGLVARF 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH