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Conserved domains on  [gi|81898699|sp|Q8C3I9|]
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RecName: Full=Divergent protein kinase domain 2B; AltName: Full=Deleted in autism-related protein 1 homolog; Flags: Precursor

Protein Classification

divergent protein kinase domain-containing protein( domain architecture ID 10573880)

divergent protein kinase (DIPK) domain-containing protein similar to vertebrate divergent protein kinase domain 2A and 2B proteins

CATH:  1.10.510.10
PubMed:  21334309|16244704
SCOP:  3000066

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 213-393 7.14e-46

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


:

Pssm-ID: 463512  Cd Length: 188  Bit Score: 157.07  E-value: 7.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   213 LYTLAVNAHPIILQIFPGAEgwPMPRYLGSCGRFLVSTSTRPLQ---------EFYDASPEQAADLAYQLLRVLESLRSN 283
Cdd:pfam12260   1 LWALLQNNEPLLLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   284 DLNyFFYFTHVDAGMFGIFDNGHLFIRDASALGIIDKQEGSQAAARTGENED--IFSCLvSDCQIQLSSCDTVPEKQSLV 361
Cdd:pfam12260  79 DPG-FLYMCDVSLENFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQ 156

                         170       180       190
                  ....*....|....*....|....*....|..
gi 81898699   362 LVCQQLLPQLLQGKfPSPVQKEIDSALSLCSK 393
Cdd:pfam12260 157 KVCQKLLDYLLRGP-PSPLPEELEKLLQECAA 187
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 213-393 7.14e-46

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 157.07  E-value: 7.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   213 LYTLAVNAHPIILQIFPGAEgwPMPRYLGSCGRFLVSTSTRPLQ---------EFYDASPEQAADLAYQLLRVLESLRSN 283
Cdd:pfam12260   1 LWALLQNNEPLLLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   284 DLNyFFYFTHVDAGMFGIFDNGHLFIRDASALGIIDKQEGSQAAARTGENED--IFSCLvSDCQIQLSSCDTVPEKQSLV 361
Cdd:pfam12260  79 DPG-FLYMCDVSLENFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQ 156

                         170       180       190
                  ....*....|....*....|....*....|..
gi 81898699   362 LVCQQLLPQLLQGKfPSPVQKEIDSALSLCSK 393
Cdd:pfam12260 157 KVCQKLLDYLLRGP-PSPLPEELEKLLQECAA 187
 
Name Accession Description Interval E-value
PIP49_C pfam12260
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ...
 213-393 7.14e-46

Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.


Pssm-ID: 463512  Cd Length: 188  Bit Score: 157.07  E-value: 7.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   213 LYTLAVNAHPIILQIFPGAEgwPMPRYLGSCGRFLVSTSTRPLQ---------EFYDASPEQAADLAYQLLRVLESLRSN 283
Cdd:pfam12260   1 LWALLQNNEPLLLQIFQDRE--PFPKYLGSCGRLYVVEYVGAGPllgisrrplDWFSPPWPRRAKIALQLLELVEDLFNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81898699   284 DLNyFFYFTHVDAGMFGIFDNGHLFIRDASALGIIDKQEGSQAAARTGENED--IFSCLvSDCQIQLSSCDTVPEKQSLV 361
Cdd:pfam12260  79 DPG-FLYMCDVSLENFGVTNDGRLKLVDLDNVFPEDKLRRKISEQKCEKDEDcdFFDCL-SFCDLEKDRCSSEVVNPNLQ 156

                         170       180       190
                  ....*....|....*....|....*....|..
gi 81898699   362 LVCQQLLPQLLQGKfPSPVQKEIDSALSLCSK 393
Cdd:pfam12260 157 KVCQKLLDYLLRGP-PSPLPEELEKLLQECAA 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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