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Conserved domains on  [gi|74759547|sp|Q86Z23|]
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RecName: Full=Complement C1q-like protein 4; AltName: Full=C1q and tumor necrosis factor-related protein 11; Short=C1q/TNF-related protein 11; Flags: Precursor

Protein Classification

complement C1q domain-containing protein( domain architecture ID 10448922)

complement C1q domain-containing protein may be involved in the regulation of the inflammatory network

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
111-235 1.29e-46

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


:

Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 150.90  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74759547   111 AFYAGLRRPHEGYE--VLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLmrGGDGTSMWADLMKNGQVRASAIAQD 188
Cdd:pfam00386   1 AFSAGRTTGLTAPNeqPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHIT--TVDGKSLYVSLVKNGQEVVSFYDQP 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 74759547   189 ADQNYDYASNSVILHLDVGDEVFIKLDGGK-VHGGNTNKYSTFSGFII 235
Cdd:pfam00386  79 QKGSLDVASGSVVLELQRGDEVWLQLTGYNgLYYDGSDTDSTFSGFLL 126
 
Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
111-235 1.29e-46

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 150.90  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74759547   111 AFYAGLRRPHEGYE--VLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLmrGGDGTSMWADLMKNGQVRASAIAQD 188
Cdd:pfam00386   1 AFSAGRTTGLTAPNeqPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHIT--TVDGKSLYVSLVKNGQEVVSFYDQP 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 74759547   189 ADQNYDYASNSVILHLDVGDEVFIKLDGGK-VHGGNTNKYSTFSGFII 235
Cdd:pfam00386  79 QKGSLDVASGSVVLELQRGDEVWLQLTGYNgLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
106-238 3.13e-36

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 124.72  E-value: 3.13e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74759547    106 YVPRIAFYAGL-RRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRggdGTSMWADLMKNGQVRASA 184
Cdd:smart00110   4 AQPRSAFSVIRsNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESK---GRNVKVSLMKNGIQVMST 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 74759547    185 IAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHG-GNTNKYSTFSGFIIYPD 238
Cdd:smart00110  81 YDEYQKGLYDVASGGALLQLRQGDQVWLELPDEKNGLyAGEYVDSTFSGFLLFPD 135
 
Name Accession Description Interval E-value
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
111-235 1.29e-46

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 150.90  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74759547   111 AFYAGLRRPHEGYE--VLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLmrGGDGTSMWADLMKNGQVRASAIAQD 188
Cdd:pfam00386   1 AFSAGRTTGLTAPNeqPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHIT--TVDGKSLYVSLVKNGQEVVSFYDQP 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 74759547   189 ADQNYDYASNSVILHLDVGDEVFIKLDGGK-VHGGNTNKYSTFSGFII 235
Cdd:pfam00386  79 QKGSLDVASGSVVLELQRGDEVWLQLTGYNgLYYDGSDTDSTFSGFLL 126
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
106-238 3.13e-36

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 124.72  E-value: 3.13e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74759547    106 YVPRIAFYAGL-RRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRggdGTSMWADLMKNGQVRASA 184
Cdd:smart00110   4 AQPRSAFSVIRsNRPPPPGQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESK---GRNVKVSLMKNGIQVMST 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 74759547    185 IAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHG-GNTNKYSTFSGFIIYPD 238
Cdd:smart00110  81 YDEYQKGLYDVASGGALLQLRQGDQVWLELPDEKNGLyAGEYVDSTFSGFLLFPD 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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