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Conserved domains on  [gi|68052343|sp|Q86WK7|]
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RecName: Full=Amphoterin-induced protein 3; AltName: Full=AMIGO-3; AltName: Full=Alivin-3; Flags: Precursor

Protein Classification

LRR and IG_like domain-containing protein( domain architecture ID 11471650)

LRR and IG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-221 8.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  66 LDLSHNALQRLrPGWLAPLFQLRALHLDHNELDALGRGVFvNASGLRLLDLSSNTLRALGRHdLDGLGALEKLLLFNNRL 145
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68052343 146 VHLDEhAFHGLRALSHLYLGCNELASFSFDhLHGLsaTHLLTLDLSSNRLGHIsvPELAALPAfLKNgLYLHNNPL 221
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANL--TNLETLDLSNNQLTDL--PELGNLTN-LEE-LDLSNNQL 262
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 286-371 3.60e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 3.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343    286 EHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLRAPG----SRDGSIAvladgSLAIGNVQEQHAGLFVCLATGPrlH 360
Cdd:smart00410   2 PSVTVKEGESVTLSCEaSGSPPPEVTWYKQGGKLLAESGrfsvSRSGSTS-----TLTISNVTPEDSGTYTCAATNS--S 74

                           90
                   ....*....|.
gi 68052343    361 HNQTHEYNVSV 371
Cdd:smart00410  75 GSASSGTTLTV 85
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-221 8.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  66 LDLSHNALQRLrPGWLAPLFQLRALHLDHNELDALGRGVFvNASGLRLLDLSSNTLRALGRHdLDGLGALEKLLLFNNRL 145
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68052343 146 VHLDEhAFHGLRALSHLYLGCNELASFSFDhLHGLsaTHLLTLDLSSNRLGHIsvPELAALPAfLKNgLYLHNNPL 221
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANL--TNLETLDLSNNQLTDL--PELGNLTN-LEE-LDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343    86 QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRL 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 286-371 3.60e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 3.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343    286 EHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLRAPG----SRDGSIAvladgSLAIGNVQEQHAGLFVCLATGPrlH 360
Cdd:smart00410   2 PSVTVKEGESVTLSCEaSGSPPPEVTWYKQGGKLLAESGrfsvSRSGSTS-----TLTISNVTPEDSGTYTCAATNS--S 74

                           90
                   ....*....|.
gi 68052343    361 HNQTHEYNVSV 371
Cdd:smart00410  75 GSASSGTTLTV 85
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-221 2.05e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  45 LSCTGLG---LQDVPAELPA--ATADLDLSHNALQRLRPGWLAPL------FQLRALHLDHNELDALGRGVFVNA---SG 110
Cdd:cd00116  30 LEGNTLGeeaAKALASALRPqpSLKELCLSLNETGRIPRGLQSLLqgltkgCGLQELDLSDNALGPDGCGVLESLlrsSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343 111 LRLLDLSSNTL-RALGRHDLDGLG----ALEKLLLFNNRLVHLD----EHAFHGLRALSHLYLGCNELASFSFDHL-HGL 180
Cdd:cd00116 110 LQELKLNNNGLgDRGLRLLAKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALaEGL 189

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 68052343 181 SA-THLLTLDLSSNRLGHISVPELAALPAFLKNGLYLH--NNPL 221
Cdd:cd00116 190 KAnCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNlgDNNL 233
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 284-355 2.31e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 2.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68052343   284 PEEHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLraPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLAT 355
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEaTGSPPPTITWYKNGEPIS--SGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 281-354 2.50e-03

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 37.22  E-value: 2.50e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68052343 281 LERPEEHLYALVGRSLRLYCNT-SVPAMRIAWVSpQQELLRApgsrDGSIAVLADGSLAIGNVQEQHAGLFVCLA 354
Cdd:cd20968   2 ITRPPTNVTIIEGLKAVLPCTTmGNPKPSVSWIK-GDDLIKE----NNRIAVLESGSLRIHNVQKEDAGQYRCVA 71
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-195 5.04e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343   66 LDLSHNALQRLRPGWLAPLfqLRALHLDHNELDA---LGRGVFvnaSGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFN 142
Cdd:PLN00113 123 LNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGeipNDIGSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 68052343  143 NRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSAthLLTLDLSSNRL 195
Cdd:PLN00113 198 NQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTS--LNHLDLVYNNL 248
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-221 8.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  66 LDLSHNALQRLrPGWLAPLFQLRALHLDHNELDALGRGVFvNASGLRLLDLSSNTLRALGRHdLDGLGALEKLLLFNNRL 145
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68052343 146 VHLDEhAFHGLRALSHLYLGCNELASFSFDhLHGLsaTHLLTLDLSSNRLGHIsvPELAALPAfLKNgLYLHNNPL 221
Cdd:COG4886 195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANL--TNLETLDLSNNQLTDL--PELGNLTN-LEE-LDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-232 5.77e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 5.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  45 LSCTGLGLQDVPAELPAATA--DLDLSHNALQRLrPGWLAPLFQLRALHLDHNELDALGrGVFVNASGLRLLDLSSNTLR 122
Cdd:COG4886 141 LDLSNNQLTDLPEPLGNLTNlkSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343 123 ALGRhDLDGLGALEKLLLFNNRLVHLDEhaFHGLRALSHLYLGCNELASFSFdhlhGLSATHLLTLDLSSNRLGHISVPE 202
Cdd:COG4886 219 DLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP----LANLTNLKTLDLSNNQLTDLKLKE 291

                       170       180       190
                ....*....|....*....|....*....|
gi 68052343 203 LAALPAFLKNGLYLHNNPLPCDCRLYHLLQ 232
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLT 321
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-221 2.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 2.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  45 LSCTGLGLQDVPAELPAATA--DLDLSHNALQRLrPGWLAPLFQLRALHLDHNELDALGRGvFVNASGLRLLDLSSNTLR 122
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNlkELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343 123 ALGrhDLDGLGALEKLLLFNNRLVHLDEHAfhGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPE 202
Cdd:COG4886 242 DLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                       170
                ....*....|....*....
gi 68052343 203 LAALPAFLKNGLYLHNNPL 221
Cdd:COG4886 318 LLLTTLLLLLLLLKGLLVT 336
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343    86 QLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRL 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
135-195 5.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 5.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68052343   135 LEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLsaTHLLTLDLSSNRL 195
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL--PSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-221 6.17e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 6.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  81 LAPLFQLRALHLDHNELdalgrgvFVNASGLRLLDLSSNTLRALGrHDLDGLGALEKLLLFNNRLVHLDEhAFHGLRALS 160
Cdd:COG4886  92 LGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLK 162

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68052343 161 HLYLGCNELASFSfDHLHGLsaTHLLTLDLSSNRLGHISvPELAALPAfLKNgLYLHNNPL 221
Cdd:COG4886 163 SLDLSNNQLTDLP-EELGNL--TNLKELDLSNNQITDLP-EPLGNLTN-LEE-LDLSGNQL 217
LRR_8 pfam13855
Leucine rich repeat;
66-119 2.60e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 68052343    66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSN 119
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 286-371 3.60e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 3.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343    286 EHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLRAPG----SRDGSIAvladgSLAIGNVQEQHAGLFVCLATGPrlH 360
Cdd:smart00410   2 PSVTVKEGESVTLSCEaSGSPPPEVTWYKQGGKLLAESGrfsvSRSGSTS-----TLTISNVTPEDSGTYTCAATNS--S 74

                           90
                   ....*....|.
gi 68052343    361 HNQTHEYNVSV 371
Cdd:smart00410  75 GSASSGTTLTV 85
LRR_8 pfam13855
Leucine rich repeat;
66-97 1.08e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.08e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 68052343    66 LDLSHNALQRLRPGWLAPLFQLRALHLDHNEL 97
Cdd:pfam13855  30 LDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-221 2.05e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  45 LSCTGLG---LQDVPAELPA--ATADLDLSHNALQRLRPGWLAPL------FQLRALHLDHNELDALGRGVFVNA---SG 110
Cdd:cd00116  30 LEGNTLGeeaAKALASALRPqpSLKELCLSLNETGRIPRGLQSLLqgltkgCGLQELDLSDNALGPDGCGVLESLlrsSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343 111 LRLLDLSSNTL-RALGRHDLDGLG----ALEKLLLFNNRLVHLD----EHAFHGLRALSHLYLGCNELASFSFDHL-HGL 180
Cdd:cd00116 110 LQELKLNNNGLgDRGLRLLAKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRALaEGL 189

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 68052343 181 SA-THLLTLDLSSNRLGHISVPELAALPAFLKNGLYLH--NNPL 221
Cdd:cd00116 190 KAnCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNlgDNNL 233
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 284-355 2.31e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 2.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68052343   284 PEEHLYALVGRSLRLYCN-TSVPAMRIAWVSPQQELLraPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLAT 355
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEaTGSPPPTITWYKNGEPIS--SGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-221 2.97e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  81 LAPLFQLRALHLDHNELDALGRgvFVNASGLRLLDLSSNTLRALGrhDLDGLGALEKLLLFNNRLVHLdEHaFHGLRALS 160
Cdd:cd21340  20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVV-EG-LENLTNLE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343 161 HLYLGCNELA---SFSFD--HLHGLSAT---------------------HLLTLDLSSNRLGHIS--VPELAALPaFLKN 212
Cdd:cd21340  94 ELHIENQRLPpgeKLTFDprSLAALSNSlrvlnisgnnidsleplaplrNLEQLDASNNQISDLEelLDLLSSWP-SLRE 172


                ....*....
gi 68052343 213 gLYLHNNPL 221
Cdd:cd21340 173 -LDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-164 6.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 6.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  66 LDLSHNALQRLRPgwLAPLFQLRALHLDHNE---------LDAL-------------------GRGVFVNASGLRLLDLS 117
Cdd:cd21340  51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenLTNLeelhienqrlppgekltfdPRSLAALSNSLRVLNIS 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 68052343 118 SNTLRALgrHDLDGLGALEKLLLFNNRLVHLDE--HAFHGLRALSHLYL 164
Cdd:cd21340 129 GNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
157-221 1.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68052343   157 RALSHLYLGCNELASFSFDHLHGLSatHLLTLDLSSNRLGHISVPELAALPAfLKNgLYLHNNPL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPS-LRY-LDLSGNRL 61
IgI_2_MuSK cd20968
agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ...
 281-354 2.50e-03

agrin-responsive second immunoglobulin-like domains (Ig2) of the Muscle-specific kinase (MuSK) ectodomain; a member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin-like (Ig) domains of the Muscle-specific kinase (MuSK) ectodomain. MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409560 [Multi-domain]  Cd Length: 88  Bit Score: 37.22  E-value: 2.50e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68052343 281 LERPEEHLYALVGRSLRLYCNT-SVPAMRIAWVSpQQELLRApgsrDGSIAVLADGSLAIGNVQEQHAGLFVCLA 354
Cdd:cd20968   2 ITRPPTNVTIIEGLKAVLPCTTmGNPKPSVSWIK-GDDLIKE----NNRIAVLESGSLRIHNVQKEDAGQYRCVA 71
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-195 5.04e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343   66 LDLSHNALQRLRPGWLAPLfqLRALHLDHNELDA---LGRGVFvnaSGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFN 142
Cdd:PLN00113 123 LNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGeipNDIGSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 68052343  143 NRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSAthLLTLDLSSNRL 195
Cdd:PLN00113 198 NQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTS--LNHLDLVYNNL 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-195 9.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 9.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052343  90 LHLDHNELDALGR-GVFVNasgLRLLDLSSNTLRALGrhDLDGLGALEKLLLFNNRLVHLDEhaFHGLRALSHLYLGCNE 168
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKN---LKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                        90       100
                ....*....|....*....|....*...
gi 68052343 169 LAsfsfdHLHGL-SATHLLTLDLSSNRL 195
Cdd:cd21340  80 IS-----VVEGLeNLTNLEELHIENQRL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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