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Conserved domains on  [gi|74762454|sp|Q86VZ1|]
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RecName: Full=P2Y purinoceptor 8; Short=P2Y8

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607472)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
24-304 9.23e-169

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


:

Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 471.56  E-value: 9.23e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCFDVLKWTM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:cd15368 161 LPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 264 RLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15368 241 RLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
 
Name Accession Description Interval E-value
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
24-304 9.23e-169

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 471.56  E-value: 9.23e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCFDVLKWTM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:cd15368 161 LPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 264 RLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15368 241 RLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-293 7.34e-49

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 165.16  E-value: 7.34e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454    40 GNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCIS 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   119 VERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLkwtmLPSVAMWAVFLFTIF 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDF----PEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   199 ILLFLIPFVITVACYTATILKLLRTEEAHGRE----QRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHV 274
Cdd:pfam00001 157 VLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDK 236
                         250       260
                  ....*....|....*....|
gi 74762454   275 -YKLTLCLSCLNNCLDPFVY 293
Cdd:pfam00001 237 aLSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
26-308 4.28e-35

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 131.05  E-value: 4.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPrSPSVIFMINLSVTDLMLASVLPFQIYYHcNRHHWVFGVLLCNVVTVAFYA 105
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYVLTKTKIK-TPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHalGIITCFDVLKwtmlP 185
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDH--ETLICCMFYN----N 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  186 SVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTEEAhgrEQRRRAVGLAAVVLLAFVTCFAPNN---FVLLAHI 261
Cdd:PHA03087 195 KTMNWKLFInFEINIIGMLIPLTILLYCYSKILITLKGINKS---KKNKKAIKLVLIIVILFVIFWLPFNvsvFVYSLHI 271
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74762454  262 VSrLFYG----KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYL 308
Cdd:PHA03087 272 LH-FKSGckavKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSL 321
 
Name Accession Description Interval E-value
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
24-304 9.23e-169

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 471.56  E-value: 9.23e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCFDVLKWTM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:cd15368 161 LPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 264 RLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15368 241 RLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
26-301 1.44e-99

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 295.90  E-value: 1.44e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15162   3 LPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLp 185
Cdd:cd15162  83 NMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPEQLL- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 sVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRL 265
Cdd:cd15162 162 -VGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLIS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 74762454 266 F-YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15162 241 SsGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
24-304 3.83e-78

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 241.40  E-value: 3.83e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHaLGIITCFDVLKwtM 183
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKE-NNSTTCFEFLS--E 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFIllFLIPFVITVACYTATILKLLRTE-EAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd14982 158 WLASAAPIVLIALVVG--FLIPLLIILVCYSLIIRALRRRSkQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 263 SRLFYGK------SYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14982 236 VRLSFIAdcsarnSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
26-301 2.74e-69

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 218.48  E-value: 2.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15369   3 VPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLP 185
Cdd:cd15369  83 NMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTCHDVLNEQLLM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SvamWAVFLFTIF-ILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV-- 262
Cdd:cd15369 163 G---YYVYYFSIFsCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSKKTRALFMAVAVFCVFVICFGPTNVLLLAHYVrf 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 74762454 263 SRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15369 240 AYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQ 278
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
26-301 7.93e-65

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 206.91  E-value: 7.93e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15372   3 VPSLYTLVFLVGLPANGLALWVLATQV-KRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMlp 185
Cdd:cd15372  82 NMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDE-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGreqrrRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR- 264
Cdd:cd15372 160 QDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLRSGQRYG-----HAMKLTVLVLVSFVLCFTPSNLLLLLHYSDPt 234
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 74762454 265 LFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15372 235 LDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
24-301 8.90e-56

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 183.85  E-value: 8.90e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15370   1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15370  81 YGNMYCSILFMTCLSVQRYWVIVNPMSHSR-KKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LpSVAMWAVFLfTIFILLFLIPFVITVACYTATI--LKLLRTEEAHGReQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15370 160 L-VGDMFNYFL-SLAIGVFLFPAFLTAVAYVLMIraLKSSINDESIEK-KRKRAIKLIVTVLVMYLICFTPSNLLLVVHY 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 262 VSRLFYGKSY-YHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15370 237 FLLKNQGQSSvYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
26-304 2.40e-54

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 180.21  E-value: 2.40e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15168   3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARtdLTYPVHALGIITCFDVLKWTMLP 185
Cdd:cd15168  83 NLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILF--FATTGRKNNRTTCYDTTSPEELN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLftiFILLFLIPFVITVACYTATILKLLRT-EEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR 264
Cdd:cd15168 161 DYVIYSMVL---TGLGFLLPLLIILACYGLIVRALIRKlGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAAR 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 265 LFYGKSYYHV-------YKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15168 238 LLSGTASCATlngiyvaYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
26-298 4.53e-54

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 179.22  E-value: 4.53e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGpRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15371   3 IPAVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVlkwtmLP 185
Cdd:cd15371  82 NMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDV-----LP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILL----FLIPFVITVACYTATILKLlrteeaHGREQRRRA-VGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15371 157 ECEQNSNFQFYYFISMavfgFLIPLVITIFCYISIIRTL------NAYEHKWFWyVKITALVLIIFTICFAPSNVILIIH 230
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 74762454 261 IVSRLFY-GKSYYHVYKLTLCLSCLNNCLDPFVYYFASR 298
Cdd:cd15371 231 HFNYYYFnNDNLYSIYLIALCLGSLNSCLDPFLYFLMSK 269
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
26-300 1.45e-49

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 167.56  E-value: 1.45e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15160   3 LPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYpVHALGIITCFDvlkwtMLP 185
Cdd:cd15160  83 NIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELF-RDEPNHTLCYE-----KYP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTAtILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRL 265
Cdd:cd15160 157 MEGWQASYNYARFLVGFLIPLSLILFFYRR-VLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIEL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 266 FY------GKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15160 236 VQnglcgfEKRVFTAYQISLCLTSLNCVADPILYIFVTEDV 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-293 7.34e-49

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 165.16  E-value: 7.34e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454    40 GNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCIS 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   119 VERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLkwtmLPSVAMWAVFLFTIF 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDF----PEDLSKPVSYTLLIS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   199 ILLFLIPFVITVACYTATILKLLRTEEAHGRE----QRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHV 274
Cdd:pfam00001 157 VLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDK 236
                         250       260
                  ....*....|....*....|
gi 74762454   275 -YKLTLCLSCLNNCLDPFVY 293
Cdd:pfam00001 237 aLSVTLWLAYVNSCLNPIIY 256
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
28-301 1.90e-48

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 164.71  E-value: 1.90e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANM 107
Cdd:cd15155   5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRH-WPFGDSLCKISGTAFLTNI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlgIITCFDVLkwtmlpSV 187
Cdd:cd15155  84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNT--STTCFEGF------SK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFL--FTIFILL--FLIPFVITVACyTATILKLLRTEE--AHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15155 156 SIWKTYLskITIFIEVvgFIIPLLLNLTC-SSLVLRTLRKPAtlSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 262 VSR------LFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15155 235 LVRsqaianCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQ 280
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
24-304 3.38e-47

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 161.41  E-value: 3.38e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15161   1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypVHALGIITCFDVLKWTM 183
Cdd:cd15161  81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQT--VEVNNTTVCLQLYREKA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVamwavfLFTIfILLFLIPFVITVACYtATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNfvllahiVS 263
Cdd:cd15161 159 SRGA------LVSL-AVAFTIPFVTTVTCY-LLIIRSLRTGKREEKPLKDKAIKMIILVLTIFLICFVPYH-------IS 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 264 RLFYGKSYYHVY-------------KLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15161 224 RYIYILSHNGAGascssrrglalanRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
24-304 1.02e-46

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 160.24  E-value: 1.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFdvlkwtM 183
Cdd:cd14985  81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACI------M 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTEEA--HGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd14985 155 LYPHEAWHFGLsLELNILGFVLPLLIILTCYFHIARSLRKRYERtgKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLD 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 261 IVSRLFYGKSYY------HVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14985 235 FLAQLGAIRPCFwelfldLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
29-301 8.61e-46

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 157.81  E-value: 8.61e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPR-SPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15170   6 VYIITFLIGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLT---ALSPLARTDLTYPVHALGIITCFDV-----L 179
Cdd:cd15170  86 YISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFShcsIVYIVEYHIDSENTSVTNNSRCYDNftpeqL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KwTMLPsvamwaVFLfTIFILLFLIPFVITVACYTATIlKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNfvlLA 259
Cdd:cd15170 166 K-ILLP------VRL-ELFLVLFCIPFLITCFCYINFI-RILSSLPHISRQRKQRAIGLAVATLLNFIVCFAPYN---IS 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHVYklTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15170 234 HVVGFIQRKSPEWRMY--ALLLSTLNACLDPIIFYFSSSAVR 273
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
24-300 1.98e-45

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 156.84  E-value: 1.98e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15373   1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltALSPLARTDLTYPVHA---LGIITCFDVlk 180
Cdd:cd15373  81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVW-----VIVLACQSPVLYFVTTsdkGGNITCHDT-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 wTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHG--REQRRRAVGLAAVVLLAFVTCFAPnnfvll 258
Cdd:cd15373 154 -SSPELFDQFVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTStnSRSKKKSVKMIIIVLAVFILCFLP------ 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 259 AHIVSRLFYGKSYYHV-----------YKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15373 227 FHVTRTLYYSFRSMDLscgtlnainlaYKVTRPLASANSCLDPILYFLAGQSF 279
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
24-304 9.69e-44

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 152.51  E-value: 9.69e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHalGIITCFDVLKWTM 183
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMG--GRITCMEYPNFEK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMwaVFLFTIFIlLFLIPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15159 159 IKRLPL--ILLGACVI-GFGVPVGIILFCYSQITLKLCRTAKENPLTEKsghhKKACNVILLVLLVFVVCFSPYHLNIIQ 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 260 HIVSRLFYG------KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15159 236 FMIRKLLYQpscselKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
26-304 1.68e-43

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 151.88  E-value: 1.68e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15374   3 LPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPvhALGIITCFDVlkwTMLP 185
Cdd:cd15374  83 NLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSR--KDNITLCHDT---TRPE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ----RRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15374 158 EFDHYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQgpssKKRSLKTIIMVLTVFAICFVPFHITRTLYY 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 262 VSRLFYGKSYY-----HVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15374 238 VARLLKADCDTlniinVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
24-308 1.29e-42

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 149.29  E-value: 1.29e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHcnRHHWVFGVLLCNVVTVAF 103
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYA--ADGWVFGSFLCKLVSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYP-------VHALGIITCF 176
Cdd:cd14984  79 TINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALL---------LSLPefifsqvSEENGSSICS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 177 dvLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEeahgREQRRRAVGLAAVVLLAFVTCFAPNNFV 256
Cdd:cd14984 150 --YDYPEDTATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRAR----NHKKHRALRVIFAVVVVFFLCWLPYNIV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 257 LLAHIVSRLFYGKSYYHV-----YKLTLC--LSCLNNCLDPFVYYFASREFqlrlREYL 308
Cdd:cd14984 224 LLLDTLQLLGIISRSCELsksldYALQVTesLAFSHCCLNPVLYAFVGVKF----RKYL 278
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
28-295 7.11e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.44  E-value: 7.11e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYAN 106
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGlLVIPFSLVSLLLGR-WWFGDALCKLLGFLQSVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALsplartdLTYPVHALGIITCFDVLKWTMLPS 186
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLA-------LPPLLGWGVYDYGGYCCCCLCWPD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTATILKLLR-----------TEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNF 255
Cdd:cd00637 155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 256 VLLAHIVSRLFYgKSYYHVYKLTLCLSCLNNCLDPFVYYF 295
Cdd:cd00637 235 LLLLDVFGPDPS-PLPRILYFLALLLAYLNSAINPIIYAF 273
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
26-303 9.05e-41

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 144.92  E-value: 9.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15968   3 LPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypvhalGII----TCFDVLKW 181
Cdd:cd15968  83 NLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFART------GIIrnrtVCYDLAPP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFLftiFILLFLIPFVITVACYTATILKLLRTE---EAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15968 157 ALFPHYVPYGMAL---TVSGFLLPFSIILWCYCLVVRTLCRTLgpaEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRT 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 259 AHIVSRLFYG------KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15968 234 IYLAVRVTPGvpchvlEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
26-301 2.19e-38

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 138.28  E-value: 2.19e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15375   3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltALSPLARTDLTYPVHALGI---ITCFDvLKWT 182
Cdd:cd15375  83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVW-----VISLAEVSPMTFLITTKEKnnrTICLD-FTSS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTifILLFLIPFVITVACYTaTILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15375 157 DNLNTIWWYNWILT--VLGFLLPLVIVTLCYT-RIIYTLAKGPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRIE 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 263 SRLFY-----GKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15375 234 TRLPPvscclKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQ 277
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
29-304 2.48e-38

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 138.34  E-value: 2.48e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHalGIITCFDVLKWTmlPSVA 188
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTET--NKTKCFEPPQSN--QQLT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 189 MWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ--RRRAVGLAAVVLLAFVTCFAPNNFVLLAHI----- 261
Cdd:cd15158 162 KLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQssRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLhflsr 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 262 -----VSRLFYGKSYYhvykLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15158 242 kdstcEEVLYMQKSVV----ITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
24-300 6.41e-38

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 137.04  E-value: 6.41e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAF 103
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYL-LGYWPFGEVMCKIVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS---PLARTDltypVHALGIITCfdVLK 180
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLpviIFARTL----QEEGGTISC--NLQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WtmlPSVAMWAVFLFTI--FILLFLIPFVITVACYTATILKLLRT---EEAHGREQ---RRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd14970 154 W---PDPPDYWGRVFTIytFVLGFAVPLLVITVCYSLIIRRLRSSrnlSTSGAREKrraRRKVTRLVLVVVAVFVVCWLP 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 253 NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd14970 231 FHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENF 278
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
27-304 1.07e-37

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 136.48  E-value: 1.07e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15921   4 PTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLarTDLTYPVHALGIITCFDVlkwtMLPS 186
Cdd:cd15921  84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPL--LFAKSKQHDEGSTRCLEL----AHDA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ--RRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR 264
Cdd:cd15921 158 VDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRpsRRKACALIIISLGIFLVCFLPYHIVRTIHLITE 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 265 LFYGKSYYHVYKL------TLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15921 238 RQIKESCGYILRVrkaaviTLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
24-304 1.83e-37

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 136.04  E-value: 1.83e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTAL---SPLARTDLTYpvhalGIITCFDVlk 180
Cdd:cd16001  81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLlptLVYARTGSIN-----NRTVCYDL-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 wTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAH--GREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd16001 154 -TSPDNFGNYFPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAgvGKAARAKSIRTILLVCGLFALCFVPFHITRT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 259 AHIVSRLFYGKSYYHV------YKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd16001 233 IYLFVRVYLVQDCPLLqfvslaYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
26-304 6.73e-37

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 134.65  E-value: 6.73e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15377   3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTyPVHALGIITCFDVLKWTMLP 185
Cdd:cd15377  83 NLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGT-GVRKNKTITCYDTTSDEYLR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SvamWAVFLFTIFILLFLIPFVITVACY----TATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15377 162 S---YFIYSMCTTVAMFCVPFILILGCYglivRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 262 VSRLF--------YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15377 239 RARLDfqtpamcaFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
25-301 3.90e-36

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 132.10  E-value: 3.90e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHcnRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH--SSGWIFGEILCKAVTSIFY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTML 184
Cdd:cd15182  80 IGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCEYSSIKWKLG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 psvamwavfLFTIFILLFLIPFVITVACYTATILKLLRTEEahgrEQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR 264
Cdd:cd15182 160 ---------YYYQQNLFFLIPLGIIVYCYVRILQTLMRTRT----MRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKD 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 265 LF-----YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15182 227 LTipiceCSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
24-304 5.87e-36

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 132.01  E-value: 5.87e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYhcNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVS--VVKGWIFGTFMCKLVSLLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLkwtM 183
Cdd:cd15178  79 EANFYSGILLLACISVDRYLAIVHATRALT-QKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCYENL---G 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTeeaHGReQRRRAVGLAAVVLLAFVTCFAPNNFVLLahiV 262
Cdd:cd15178 155 NESADKWRVVLrILRHTLGFLLPLVVMLFCYGFTIKTLLQT---RSF-QKHRAMRVIFAVVLAFLLCWLPYNVTVL---I 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 263 SRLFYGKSY-------YHVYKL---TLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15178 228 DTLMRTKLItetcelrNHVDVAlyvTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
24-304 9.50e-36

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 131.37  E-value: 9.50e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15157   1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypvHALGIITCFDVLKWTM 183
Cdd:cd15157  81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTS---KYNSQTKCLDLHPSKI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILlfliPFVITVACYTATILKLL--RTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15157 158 DKLLILNYIVLVVGFIL----PFCTLSICYILIIKALLkpRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 262 VSrLFYGKSYYHVYK---LTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15157 234 MQ-WSEGQCNLRLHKavvITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
38-304 1.85e-35

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 130.68  E-value: 1.85e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  38 IPG---NLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrHHWVFGVLLCNVVTVAFYANMYSSILTM 114
Cdd:cd15153  12 IPGllaNSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQ-HTWPFGRFLCLLCFYLKYLNMYASICFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 115 TCISVERFLGVLYPLSSKRWrRRRYAVAACAGTWLLLLTALSPLARtdLTYPVHALGIITCFDVL---KWTMLPSVAMWA 191
Cdd:cd15153  91 TCISIQRCFFLLHPFKARDW-KRRYDVGISAAVWIVVGLACLPFPL--LRSKSLSNNNRSCFADLgmkKLNFGAAIAMMT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 192 VF-LFTifillFLIPFVITVACYTATILKLL-RTEEAHGREQRRRAVGLAAVVLLAFVTCFAPN--NFVLLAHIVSRLFY 267
Cdd:cd15153 168 VAeLFG-----FVIPLFIIAWCTWKTENSLRqRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYhiNFLFYLMVSESIIT 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 268 GKSYYHVYK----LTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15153 243 NCEVSQVILqfhpISLCLASLNCCLDPILYYFMTSEFQDQL 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
26-308 4.28e-35

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 131.05  E-value: 4.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPrSPSVIFMINLSVTDLMLASVLPFQIYYHcNRHHWVFGVLLCNVVTVAFYA 105
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYVLTKTKIK-TPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHalGIITCFDVLKwtmlP 185
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDH--ETLICCMFYN----N 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  186 SVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTEEAhgrEQRRRAVGLAAVVLLAFVTCFAPNN---FVLLAHI 261
Cdd:PHA03087 195 KTMNWKLFInFEINIIGMLIPLTILLYCYSKILITLKGINKS---KKNKKAIKLVLIIVILFVIFWLPFNvsvFVYSLHI 271
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74762454  262 VSrLFYG----KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYL 308
Cdd:PHA03087 272 LH-FKSGckavKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSL 321
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
29-301 5.39e-35

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 129.59  E-value: 5.39e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15156   6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRN-WPFGDLLCKISVTLFYTNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLkwtmlpSVA 188
Cdd:cd15156  85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFENF------SSK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 189 MWAVFLFTIFILL----FLIPFVITVACyTATILKLLRTEE--AHGREQRRRAVGLAAVVLLAFVTCFAPNN--FVLLAH 260
Cdd:cd15156 159 TWKTYLSKIVIFIeivgFFIPLILNVTC-STMVLKTLRRPNtlSRSKLNKKKVLKMIFVHLFIFCFCFIPYNvnLVLYSL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 261 IVSRLFYGKSYYHV----YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15156 238 VRTQTFKNCSVVAAvrtmYPITLCIAVSNCCFDPIVYYFTSETIQ 282
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
28-300 5.99e-35

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 128.99  E-value: 5.99e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHcnRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15165   5 VVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSS--KKQWPLGRTLCSFLESLYFVNM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltaLSPLARTDLTYPVH--ALGIITCFDVLkwtmlp 185
Cdd:cd15165  83 YGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIW------VFVWAGSIPIYSFHdkPTNNTRCFHGF------ 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMW-AVFLFTIFILLFLIPFVITVACYTATILKLLRTeEAHGREQRRRAVGLAAVV--LLAFVTCFAPNN------FV 256
Cdd:cd15165 151 SNKTWsKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDM-RRPEQPKVKQNKSVKIVLsnLVVFLVCFTPYHlgiflqFL 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 257 LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15165 230 VKNDIINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEF 273
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
27-297 8.17e-35

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 128.74  E-value: 8.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15365   4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYpVHALGIITCFDvlKWTMLPS 186
Cdd:cd15365  84 FYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSF-HESSSHTLCYD--KFPLEDW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFillFLIPFVITVACYTaTILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLL-----AHI 261
Cdd:cd15365 161 QARLNLFRICLG---YLLPLLIILFCYW-KIYQAVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLLirsivEPC 236
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 74762454 262 VSRLfyGKSYYHVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15365 237 DCRN--AKWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
40-301 1.19e-34

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 128.34  E-value: 1.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  40 GNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHcnRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISV 119
Cdd:cd15923  17 LNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSY--RRESAGLQKLCNFVLSLYYINMYVSIFTITAISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 120 ERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDltypvHALGIITCFDVLKWTmlpsvamWAVFLFTIFI 199
Cdd:cd15923  95 DRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLD-----SSNEKTMCFQRTKQT-------ESLKVFLLLE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 200 LL-FLIPFVITVACYTATILKLL-RTEEAHGREQRRRAVGLAAVVLLAFVTCFAPnnfVLLAHIVsRLFYGKSYYHVYKL 277
Cdd:cd15923 163 IFgFLLPLIIMTFCSARVIHTLQkRLDDVGSRSETKQCIRVIMANLIVFIVCFLP---VHVGFFV-KFIVGKSYSCDSKL 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 74762454 278 TL--------CLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15923 239 IIhfflqsafCLSDMNCCLDAFCYYFATKEFR 270
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
24-304 1.37e-34

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 128.34  E-value: 1.37e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPL--ARTDLTYPVhalGIITCfdVLKW 181
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVwvYSSLIYFPD---GTTFC--YVSL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMlPSVAMWavFLFTIFILLFLIPFVITVACYTATILKLLRT----EEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15088 156 PS-PDDLYW--FTIYHFILGFAVPLVVITVCYILILHRLARGvapgNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQ 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 258 LAHI-VSRLFYgkSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15088 233 LVNLaMNRPTL--AFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
28-301 2.97e-34

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 126.99  E-value: 2.97e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHwvfGVLLCNVVTVAFYANM 107
Cdd:cd15164   5 IIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWP---DDELCLVLQSIYFINR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDltypVHALGIitCFdvLKWTMLPSV 187
Cdd:cd15164  82 YMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIISVSLRLAWE----EQEENF--CF--GKTSTRPSK 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 amWAVFLftiFILLFLIPFVITVACYTATILKLLR--TEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV--- 262
Cdd:cd15164 154 --RTLIF---SLLGFFIPLIILSFCSIQVIRSLKKkkKTNPHEEKLIQKAIYIVSANLIVFIVCFLPLHIGLLVRFVmes 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 263 --SRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15164 229 nkASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEFQ 269
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
28-301 3.69e-34

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 127.19  E-value: 3.69e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15154   5 VGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGSIFQMNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPV--HALGIITCF----DVLKW 181
Cdd:cd15154  84 YGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCllHGEKVYRCFesfsDNDWK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAvflftifILLFLIPFVITVACYTATILKLLRTEEAHGrEQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH- 260
Cdd:cd15154 164 GLLPLVVLAE-------ILGFLLPLAAVLYCSCRIFVELCRTQEPQQ-GRRRKTVRLLLVNLVIFLICFVPYNTTLAVYg 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 261 -IVSRLFYGK-----SYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15154 236 lLRANLVEDTwnikdTLRKVLSVTVLLASTNCALDPLVYYFSTEGFR 282
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
24-304 1.15e-33

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 125.49  E-value: 1.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGpRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMK-RTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA--RTDLTYPVHALGIITCFDVLKW 181
Cdd:cd14974  80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFvfRDTVTHHNGRSCNLTCVEDYDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TmlPSVAMWAVflFTIFILLFLIPFVITVACYTATILKLLRTeeahGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd14974 160 R--RSRHKALT--VIRFLCGFLLPLLIIAICYSVIAVKLRRK----RLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLEL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 262 VSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14974 232 VAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
24-301 3.29e-33

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 124.53  E-value: 3.29e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYhcnrHHWVFGVLLCNVVTVAF 103
Cdd:cd15920   1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY----QNTAGPLSFCKIVGAFF 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTdlTYPVHALGIItCFDVLKWTM 183
Cdd:cd15920  77 YLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFE--SRNEGPCDNK-CFHFRSKGL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPS-VAMWAVFLFTIFILLFLIpfvitvaCYTATILKLLRTEEAHGREQ----RRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15920 154 TAGgINLTAVVIFYILSLLFLY-------FYAKISHKLYKVSLGNAQQQikkaSKRAIIKTFIVLAIFIVCFVPYHIVRV 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 259 AHIVSRL-----FYGKSYYHVY-KLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15920 227 PYVLAQIdvissLPWKQTLHIAnELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
24-297 8.07e-33

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 123.35  E-value: 8.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15364   1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYA--VAACAGTWLLLLTALSPLARTDLTYPVHalgiiTCFDvlkw 181
Cdd:cd15364  81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAafISFLIFIVVGLVHSPVFIMREGQTEGSH-----TCFE---- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 tMLPSVAMWAVFLFTIFILLFLIPFVITVacYT-ATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15364 152 -TLQMDTQVAGFYYARFCIGFAIPLAILI--FTnYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVR 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 261 IVSRLFYG-------KSYYHVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15364 229 AIAFSLYPngmcgfeERIYTPSVIFLCLSTVNSVADPIIYVLVS 272
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
25-301 1.80e-32

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 122.90  E-value: 1.80e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15922   2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhaLGIITCFDVLKWTML 184
Cdd:cd15922  82 THMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLF-----------------VQGLPFFFVLKTSVI 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PS------------VAMWAVFLFTIFILLFLIPFVITVACYT---ATILKlLRTEEAHGREQRRRAVGLAAVVLLAFVTC 249
Cdd:cd15922 145 DGktkclsihqselSLLYFVWNFVLLILGFLLPFGVSLTCYAllgASIAK-MNSNNARGRAMKAKSLQMIGISLVIFIIC 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74762454 250 FAPNNFVLLAHIVSRLFYGKS---YYHV---YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15922 224 FVPLHVTRTVGVVVKLFYPESctlLHKVevaYYISWVLTGVNCCLDPLLYCFASEKFR 281
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
27-301 2.13e-32

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 122.55  E-value: 2.13e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLcRRMGPR---SPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15147   4 PIVYSIIFVLGLIANCYVLWVF-ARLYPSkklNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALG--IITCFDVLKW 181
Cdd:cd15147  83 FINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVKIDSgnFTRCFEGYEK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFLFTIFILLFLIPFVITVacytaTILKLLRTEEAHGR---EQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15147 163 DNSKPVLIIHFIIIGLFFLVFLLILVCNL-----VIARTLLSQPVQGQrnaGVKRRALWMVCTVLAVFVICFVPHHVVQG 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 259 AHIVSRL---FYGKSYYH-----VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15147 238 PWTLAVLqqwRYWDCQFRqalndAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
28-304 2.83e-32

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 122.14  E-value: 2.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15152   5 VTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLN-KSWPFGKFLCMFCFYLKYVNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALsplartdLTYPVHALGIITCFDVLkWTMLPSV 187
Cdd:cd15152  84 YASIYFLVCISVRRCLYLIYPFRYND-CKRKCDVYISIAGWLVVCVGC-------LPFPLLRQSQDTNPTCC-FADLPLR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 ---AMWAVFLFTIFILL-FLIPFVITVACYTATILKLL-RTEEAHGREQRRRAVGLAAVVLLAFVTCFAPN------NFV 256
Cdd:cd15152 155 nvgLTTSVIMLTIAELTgFVTPLLIVLYCSWKTVMSLReKTPVLQDLGEKKKALKMILTCAVVFLICFAPYhisfplDFL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 257 LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15152 235 VKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
29-304 5.29e-32

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 121.39  E-value: 5.29e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPR-SPSVIFMINLSVTDLMLASVLPFQIYyHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd14983   6 VYVLTILLGLPSNLLALYAFVNRARLRlTPNVIYMINLCLSDLVFILSLPIKIV-EALSSAWTLPAVLCPLYNLAHFSTL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSP-----LARTDLTYPVHALGIITCFDVLKWT 182
Cdd:cd14983  85 YASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTLvfileTSGGTLDINTPVGNSSTCYENFTPE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVamwAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGReqRRRAVGLAAVVLLAFVTCFAPNNFvllAHIV 262
Cdd:cd14983 165 QLALL---APVRLELSLVLFFLPLAITAFCYVRCIRILVRSRLHERR--KRRAVRVAVSTLLTFVVCFGPYNI---SHVV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 263 SRLFYGKSYYHvyKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14983 237 GFVRHESVWWR--KLALLTSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
25-304 8.72e-32

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 121.01  E-value: 8.72e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTml 184
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNE-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 pSVAMWAVFLFTIFILL-FLIPFVITVACYTATILKLLRTEEAHGREQRR-RAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15191 159 -KYAQWSAGLALMKNTLgFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRRdKVLKMVAAVVLAFLICWFPFHVLTFLDAL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 263 SRLFYGKSYYHVY------KLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15191 238 ARMGVINNCWVITvidkalPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
28-304 9.10e-32

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 120.46  E-value: 9.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDL-MLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15001   4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLlLLVFCVPLKTAEYF-SPTWSLGAFLCKAVAYLQLLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITcfDVLKWTMLPS 186
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVT--VYHCQKAWPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTatilkllrteeahgREQRRRAVGLAAVVLLAFVTCFAPN---NFVLLAHIVS 263
Cdd:cd15001 161 TLYSRLYVVYLAIVIFFIPLIVMTFAYA--------------RDTRKQVIKMLISVVVLFAVCWGPLlidNLLVSFDVIS 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 264 RLFYGKSYYHVYKLTLcLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15001 227 TLHTQALKYMRIAFHL-LSYANSCINPIIYAFMSKNFRSSF 266
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
28-298 2.00e-31

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 119.89  E-value: 2.00e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANM 107
Cdd:cd14975   5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGT-WDFGLAACKGCVYVCAVSM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHAlgiitcFDVLKWTMLPSV 187
Cdd:cd14975  84 YASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVL---------LATPVIA------FRHVEETVENGM 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AM-------WAVFLFTIFILL-FLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd14975 149 CKyrhysdgQLVFHLLLETVVgFAVPFTAVVLCYSCLLRRLRRRRFR----RRRRTGRLIASVVVAFAACWLPYHVGNLL 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 260 HIVSRLFYGK----SYYHVYKL----TLCLSCLNNCLDPFVYYFASR 298
Cdd:cd14975 225 EVVSELIGGSkmagTLGKVAEAgrpiAGALAFLSSSINPLLYAFAAR 271
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
28-301 3.08e-31

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 119.48  E-value: 3.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15116   5 VIYSVVFVLGVLGNGLVIFITGFKM-KKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCF-------DVLK 180
Cdd:cd15116  84 FTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFnnfslsgDNSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAM-WAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15116 164 PEVNQLRNMrHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLA----KSSKPFKIIAAVIVTFFLCWAPYHILNLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15116 240 EMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
24-297 4.44e-31

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 119.03  E-value: 4.44e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15148   1 LPLAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALsplartdLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15148  81 YMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGF-------VPMIVLTEKNEESTKCFQYKD 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LpSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRT--EEAHGREQRR--RAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15148 154 R-KNAKGKAIFNFLIVAMFWLVFLLLILSYGKIAKKLLRIsrDKPDFPNAAKynRTARKSFFVLFIFTVCFVPYHAFRIF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 260 HIVSRL----FYGKSYYH-VYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15148 233 YITSQLqnnsCYWKEILHkTNEIMLLLSAFNSCLDPVMYFLLS 275
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
24-301 1.37e-30

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 118.09  E-value: 1.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRP-WVFGEVLCKAVPYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS---PLARTDLTYPVHALGIITCFDVL 179
Cdd:cd14993  80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLpllVVYELEEIISSEPGTITIYICTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGRE------------QRRRAVGLAAVVLLAFV 247
Cdd:cd14993 160 DW---PSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGsanstssrrilrSKKKVARMLIVVVVLFA 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 248 TCFAPNNFV---LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14993 237 LSWLPYYVLsilLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
26-304 2.87e-30

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 116.71  E-value: 2.87e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15967   3 LPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSplarTDLTYPVHALGIITCFDVLKWTMLP 185
Cdd:cd15967  83 NLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSL----PDLFFSKTNSNGTKCFDTTFNDYLE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVflfTIFILLFLIPFVITVACYTATILKLLRTEEAHgREQRRRAVGLAAVVLLAFVTCFAP----NNFVLLAHI 261
Cdd:cd15967 159 SYLTYSL---GWTVTGFVIPLLIILGCYGHVVVVLCRNNNVD-KGLKQRCLKLVIILIVLFSVCYIPyhvfRNLNLLSRI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 262 VSR----LFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15967 235 LQKqgscTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
25-300 3.74e-30

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 116.39  E-value: 3.74e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd14991   2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypVHALGIITCFDVLKWTML 184
Cdd:cd14991  82 VNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLL--TVNSNKSSCHSFSSYTKP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAvflFTIFILLFLIPFVITVACyTATILKLLRTEEAHGREQR-RRAVGLAAVVLLAFVTCFAPN-NFVLLAHIV 262
Cdd:cd14991 160 SLSIRWH---NALFLLEFFLPLGLIVFC-SVRIACNLRIRQSLGKQARvQRAIRLVFLVVIVFVLCFLPSiIAGLLALVF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 263 SRLFYGKSY---YHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd14991 236 KNLGSCRCLnsvAQLFHISLAFTYLNSALDPVIYCFSSPWF 276
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
24-301 2.13e-29

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 113.73  E-value: 2.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQI--YYHCNrhhwvfGVLLCNVVTV 101
Cdd:cd15163   1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIvmYYSAG------NCLTCSFVHI 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 -AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdltypvhaLGIITCFDVLK 180
Cdd:cd15163  75 fSYFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWL--------------------FAIVVTFSILT 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTM-LPSVAMWAVFLFTIFilLFLIPFVITVACYTATILKLLRTEEAH-GREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15163 135 TAIkFASCCLSKLFALTVF--EFFLPLLIITFFTIRIMCALSRPGLMHqSRERRMRAVQLLITVLIIFMICFTPFHVRQV 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15163 213 AVAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
28-301 3.61e-29

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 114.14  E-value: 3.61e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVL--CRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd14976   5 VVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDlTYPVHALGIITCfdVLKWTMLP 185
Cdd:cd14976  85 NMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFS-TDTWSSVNHTLC--LLRFPKNS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFL----FTIFILLFLIPFVITVACYtATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd14976 162 SVTRWYNWLgmyqLQKVVLGFFLPLGIITLSY-LLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSA 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 262 VSRL---FYGKSYY----HVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14976 241 LIKFddvPFSDAFFafqtYAFPVAICLAHSNSCLNPVLYCLVRREFR 287
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
26-293 5.15e-29

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 113.25  E-value: 5.15e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVL-CRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15376   3 LWPILGVEFLVAVLGNGLALWLFvTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS-PLARTDLTYPVHALgiITCFDVLKWTM 183
Cdd:cd15376  83 CNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSApVLSFSHLEVERHNK--TECLGTAVDSR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLfliPFVITVACYTAtILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:cd15376 161 LPTYLPYSLFLAVVGCGL---PFLLTLASYLA-IVWAVLRSPGITTLEKRKVAALVAVVVALYAVSFVPYHILRNLNLYR 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 74762454 264 RLFYGKSY-----YHVYKLTLCLSCLNNCLDPFVY 293
Cdd:cd15376 237 RLQWLKAAaslriYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
24-303 2.12e-28

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 111.89  E-value: 2.12e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15379   1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRR-RRYAVAACAGTWlllltaLSPLARTDLTYPVHALGI----ITCFDv 178
Cdd:cd15379  81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKKgKKLTWLVCGAVW------LVVIAQCLPTFVFASTGTqrnrTVCYD- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 lkwtMLPSVAMWAVFLF--TIFILLFLIPFVITVACYTATILKLLRTEEAHG-----REQRRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15379 154 ----LSPPARSTAYFPYgiTLTRTGFLLPFAARLACYCSMATILCRVVIAVAvvaapGEKRGKAARMIIVVAAVFLISFL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74762454 252 PNNFVLLAHIVSRLFYG------KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15379 230 PFHYTKTRYLQVRSWDGgpcttrQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
27-296 2.28e-28

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 111.43  E-value: 2.28e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15366   4 PTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPvHALGIITCFDvlKWTMLPS 186
Cdd:cd15366  84 IYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFR-DRYNHTFCFE--KYPMEDW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMwaVFLFTIFIlLFLIPFVITVACYtATILKLLR----TEEAHGREQRRRAVGLAAVVLLafvtCFAPNNFVLLAHIV 262
Cdd:cd15366 161 VAW--MNLYRVFV-GFLFPWVLMLFSY-RGILRAVRgnvsTEQQEKAKIKRLALSLIAIVLL----CFAPYHVLLLSRSV 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 263 SRLF------YGKSYYHVYKLTLCLSCLNNCLDPFVYYFA 296
Cdd:cd15366 233 VYLGkpcdcgFEERVFTAYHVSLALTSLNCVADPILYCLV 272
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
26-301 2.35e-28

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 111.68  E-value: 2.35e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15201   3 LPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLartdLTYPvHALGIITCFDVLKWTMLP 185
Cdd:cd15201  83 NRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYL----LTKK-HLFPRGNATQCESFNICT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLL-RTEEAHGReqRRRAVGLAAVVLLAFVTCFAPNN------FVLL 258
Cdd:cd15201 158 GTDSSSNWHEAMFLLEFFLPLAIILYCSVRIIWQLRgRQLDRHAK--IKRAVQFIMVVAIVFIICFLPSNvtriaiWILK 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15201 236 HTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFK 278
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-301 9.11e-28

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 109.86  E-value: 9.11e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  40 GNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISV 119
Cdd:cd15189  17 GNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQ 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 120 ERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdvlkwTMLPSVAMWAVF-LFTIF 198
Cdd:cd15189  97 DRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITAC------VLLYPHEAWHFAhIVLLN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 199 ILLFLIPFVITVACyTATILKLLRTEEAHGR---EQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRL--FYGKSYYH 273
Cdd:cd15189 171 IVGFLLPLLVITFC-NYNILQALRTREESTRcedRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVgvLDECFWEH 249
                       250       260       270
                ....*....|....*....|....*....|..
gi 74762454 274 VYKLTLCLSC----LNNCLDPFVYYFASREFQ 301
Cdd:cd15189 250 FIDIGLQLAVflafSNSCLNPVLYVFVGRYFR 281
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-301 1.13e-27

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 109.86  E-value: 1.13e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAF 103
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRH-WPFGSVLCRLVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPvHALGIITCfdVLKWTM 183
Cdd:cd15093  80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRE-NQDGSSAC--NMQWPE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRA----VGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15093 157 -PAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSerkvTRMVVMVVVVFVICWLPFYVLQLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15093 236 NVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFK 277
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-308 1.26e-27

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 109.45  E-value: 1.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqiyYHCN--RHHWVFGVLLCNVVTVA 102
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPF---YVSTyfLKKWYFGDVGCRLLFSL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALSPLA---RTDLTYPVHALGIITCFDVl 179
Cdd:cd14999  78 DFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAimiRLVTVEDKSGGSKRICLPT- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 kwtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRR-----AVGLAAVVLLAFVTCFAP-- 252
Cdd:cd14999 156 -----WSEESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRlpkqkVLKMIFTIVLVFWACFLPfw 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 253 NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASRefqlRLREYL 308
Cdd:cd14999 231 IWQLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTK----NYKEYL 282
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
28-304 1.45e-27

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 109.44  E-value: 1.45e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15117   5 VIYSSAFVLGTLGNGLVIWVTGFRM-TRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypVHALGIITCF----------- 176
Cdd:cd15117  84 FASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDT--RKENGCTHCYlnfdpwnetae 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 177 DVLKWTMLPSVAMWAVFLfTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRravgLAAVVLLAFVTCFAPNNFV 256
Cdd:cd15117 162 DPVLWLETVVQRLSAQVI-TRFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFR----VLTAVVAAFFLCWFPFHLV 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 257 LLAHIVSRLFYGKSYYH----VYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15117 237 SLLELVVILNQKEDLNPllilLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-304 1.91e-27

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 109.03  E-value: 1.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15114   1 VVALVLYAVVFLVGVPGNALVAWVTGFEA-KRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdVLKWTM 183
Cdd:cd15114  80 LLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVC--VVDYGG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAmWAVFLFTiFILLFLIPFVITVACYTatilKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAP---NNFVLLAH 260
Cdd:cd15114 158 STGVE-WAVAIIR-FLLGFLGPLVVIASCHG----VLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPyhvVGLIIAAS 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 261 IVSRLFYgKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15114 232 APNSRLL-ANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
26-301 2.27e-27

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 108.70  E-value: 2.27e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnrHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15173   3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAA--HEWIFGTVMCKITNGLYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSK--RWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15173  81 NLYSSMLILTCITVDRFIVIVQATKAHncHAKKMRWGKVVCTLVWVISLL---------LSLPQFIYSEVRNLSSKICSM 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 L-PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTeeahGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15173 152 VyPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHA----KGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTL 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 263 SRLFYGKSYYHVYKL-TLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15173 228 HIENTDSTNFKYAILiTEAIAYLHACLNPILYAFVGVKFR 267
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
29-301 3.58e-27

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 108.46  E-value: 3.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15970   6 IYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTL-LRHWPFGSLLCRLVLSVDAINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPvHALGIITCfdvlkwTML---P 185
Cdd:cd15970  85 TSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAP-NSDGSVAC------NMQmpeP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRA----VGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15970 158 SQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSerkiTLMVMMVVTVFVICWMPFYVVQLVSV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 262 vsrlFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15970 238 ----FVGQHDATVSQLSVILGYANSCANPILYGFLSDNFK 273
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
24-301 1.91e-26

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 106.35  E-value: 1.91e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCR--RMGPRSPSVIFMINLSVTDLM-LASVLPFQ--IYyhcNRHHWVFGVLLCNV 98
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARvkPGKRRSTTNVFILNLSIADLFfLLFCVPFQatIY---SLPEWVFGAFMCKF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLART-DLTYPVHALGIITCFD 177
Cdd:cd15098  78 VHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHqDLVHHWTASNQTFCWE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 178 VlkWTMlpsvAMW-AVFLFTIFILLFLIPFVITVACYtATILKLLRTEEAHGREQRRRAVGLAA----VVLLAFVTCFAP 252
Cdd:cd15098 158 N--WPE----KQQkPVYVVCTFVFGYLLPLLLITFCY-AKVLNHLHKKLKNMSKKSERSKKKTAqtvlVVVVVFGISWLP 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 253 NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15098 231 HHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-305 2.27e-26

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 106.77  E-value: 2.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV-IFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd15190  11 ALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRRRSAdTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFdvLKWT 182
Cdd:cd15190  91 VFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICD--MDYS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVA---MWAVFLFTIFILL-FLIPFVITVACYTA---TILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNF 255
Cdd:cd15190 169 GVVSNEsewAWIAGLGLSSTVLgFLLPFLIMLTCYFFigrTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHL 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 256 VLLAHIVSRLF-------YGKSYYHVYKLTLCLSCLNNCLDPFVYYFasreFQLRLR 305
Cdd:cd15190 249 VKTLYALMYLGilpfscgFDLFLMNAHPYATCLAYVNSCLNPFLYAF----FDPRFR 301
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
27-304 2.61e-26

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 106.21  E-value: 2.61e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQ-IYYHCNRhhWVFGVLLCNVVTVAFY 104
Cdd:cd15095   4 PLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAfLVCCVPFTaALYATPS--WVFGDFMCKFVNYMMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA-RTDL----TYPVHALgiitCFDVl 179
Cdd:cd15095  82 VTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAiYYRLeegyWYGPQTY----CREV- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 kWtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEA----------HGREQRRRAVGLAAVVLLAFVTC 249
Cdd:cd15095 157 -W---PSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDgnnqseqlseRALRQKRKVTRMVIVVVVLFAIC 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 250 FAPNNFVLLAHIVSRLFYGKSYYHVYKLT-LCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15095 233 WLPNHVLNLWQRFDPNFPETYATYALKIAaLCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
24-303 3.29e-26

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 105.60  E-value: 3.29e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15193   1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdltypvhaLGIITCF------D 177
Cdd:cd15193  81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLV----------------LGIPSLVyrnlinE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 178 VLKWTMLPSVAMWAVFLFTIFiLLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAV--VLLAFVTCFAPNNF 255
Cdd:cd15193 145 SVCVEDSSSRFFQGISLATLF-LTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSLRIVfaIVTAFVLSWLPFNT 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74762454 256 VLLAHIVSRLFYGKSYYHVY-------KLTLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15193 224 LKAVRLLLELGGGVLPCHTTvairqglTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
26-302 9.01e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 104.82  E-value: 9.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVTVAFY 104
Cdd:cd14992   3 LGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFcTPFNFTYVVS-LSWEYGHFLCKIVNYLRT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTML 184
Cdd:cd14992  82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQIPPV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLL--------RTEEAHGR-EQRRRAVGLAAVVLLAFVTCFAP-NN 254
Cdd:cd14992 162 DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWfrkvpgfsIKEVERKRlKCKRRVIKMLVCVVVLFVICWLPfHL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 255 FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQL 302
Cdd:cd14992 242 FFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
24-304 3.10e-25

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 103.23  E-value: 3.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnrHHWVFGVLLCNVVTVAF 103
Cdd:cd15180   1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV--HGWIFGTGLCKLAGAVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLL---------LLTALSPLARTDLTYPVHALGIIT 174
Cdd:cd15180  79 KINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFclllsipdfIFLEATKDPRQNKTECVHNFPQSD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 CFDVLKWTMLPsvamwavflftiFILLFLIPFVITVACYTATILKLLRTEEAhgrEQRRRAVGLAAVVLLAFVTCFAPNN 254
Cdd:cd15180 159 TYWWLALRLLY------------HIVGFLLPLAVMVYCYTSILLRLLRSSQG---FQKQRAIRVIVAVVVVFFLCWTPYN 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 255 FVLLAHIVSRLFYGK-------SYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15180 224 IALLVDTLIDLSVLDrncgtesRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
28-303 7.78e-25

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 101.77  E-value: 7.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15115   5 VVLSLTFLLGVPGNGLVIWVAGLKM-KRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPV-HALGIITCFDVLKWTMLPS 186
Cdd:cd15115  84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALL---------LCLPVfIYRTTVTDGNHTRCGYDFL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMwavfLFTIFILLFLIPFVITVACYTATILKLLRteeAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLF 266
Cdd:cd15115 155 VAI----TITRAVFGFLLPLLIIAACYSFIAFRMQR---GRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPP 227
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 74762454 267 YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15115 228 LSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
24-301 1.33e-24

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 101.37  E-value: 1.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSL--WVLCRRMgpRSPSVIFMINLSVTDLMLASVLPFQIYYHcnRHHWVFGVLLCNVVTV 101
Cdd:cd15172   1 VFVPVIYSLICVVGLIGNSLVVitYAFYKRT--KSMTDVYLLNMAIADILFVLTLPFWAVYE--AHQWIFGNFSCKLLRG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRR--YAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdVL 179
Cdd:cd15172  77 IYAINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTlaYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVC--EP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAMWAVFLFTIFILL-FLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15172 155 KYPKNSTAIMWKLLVLSLQVSLgFFIPLLVMIFCYSFIIKTLLQAQNS----QRHKAVRVVVAVVLVFLVCQVPYNIVLL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 259 AHiVSRLFYGKS------YYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15172 231 IE-AINLGEQQScssekaVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
24-301 1.38e-24

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 101.35  E-value: 1.38e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdVLKWTM 183
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVC--AFHYPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIfILLFLIPFVITVACYTATILKLLRTEEAHGREQRR-RAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15192 159 QNSTLLVGLGLMKN-LLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNdEIFKMIMAVVLFFFFCWIPHQIFTFLDVL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 263 SRLFYGKSYYHV------YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15192 238 IQLKVIQDCHIAdivdtaMPFTICIAYFNSCLNPILYGFVGKNFR 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-301 1.54e-24

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 100.72  E-value: 1.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNrHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd14967   4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALlVMPFSAVYTLL-GYWPFGPVLCRFWIALDVLC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSplartdLTYPVHALGIITCFDVLKWTMLPS 186
Cdd:cd14967  83 CTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL------PPLVGWRDETQPSVVDCECEFTPN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VamwaVFLFTIFILLFLIPFVITVACYtATILKLLRTEeahgreqrRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLF 266
Cdd:cd14967 157 K----IYVLVSSVISFFIPLLIMIVLY-ARIFRVARRE--------LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPD 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 74762454 267 YGKsyYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14967 224 CVP--PILYAVFFWLGYLNSALNPIIYALFNRDFR 256
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
27-301 2.78e-24

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 100.62  E-value: 2.78e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQ-IYYHCNrhHWVFGVLLCNVVTVAFY 104
Cdd:cd14971   4 PLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTfLLFCVPFTaTIYPLP--GWVFGDFMCKFVHYFQQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdvlkWTML 184
Cdd:cd14971  82 VSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVC-----SEAW 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEE-----AHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd14971 157 PSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVrpvlsEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14971 237 VALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
26-304 7.62e-24

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 99.10  E-value: 7.62e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRhhWVFGVLLCNVVTVAFYA 105
Cdd:cd15187   3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQ--WVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARtdLTYPVHALGIITCFDVLKwtmlP 185
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLV--FYQVASEDGRLQCIPFYP----G 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFL-FTIFILLFLIPFVITVACYtATILKLLRTEEAHgreQRRRAVGLAAVVLLAFVTCFAPNNFVLL------ 258
Cdd:cd15187 155 QGNSWKVFTnFEVNILGLLIPFSILIFCY-HNILRNLRRCHNQ---NKTKAIKLVFIVVIVFFLFWTPFNVVLFldslhs 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15187 231 LHIIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
24-301 7.78e-24

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 99.09  E-value: 7.78e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAF 103
Cdd:cd15094   1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPvhALGIITCfdVLKWTM 183
Cdd:cd15094  80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVP--DSGRYSC--TIVWPD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRA----VGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15094 156 SSAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRShrkvTRLVLTVISVYIICWLPYWAFQVH 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 260 HIVSRLFYGKSYYHVY--KLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15094 236 LIFLPPGTDMPKWEILmfLLLTVLSYANSMVNPLLYAFLSENFR 279
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-293 9.70e-24

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 99.22  E-value: 9.70e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15203   5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVsLPFTLIYTLTKN-WPFGSILCKLVPSLQGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKrwRRRRYAVAACAGTWLLLLTALSPLAR-TDLTYPVHALGIITC-FDVLKWtml 184
Cdd:cd15203  84 IFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSLPLAIfQELSDVPIEILPYCGyFCTESW--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL--------------LRTEEAHGREQRRRAVGLAAVVlLAFVTCF 250
Cdd:cd15203 159 PSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrvkkkrgkrtlsSRRRRSELRRKRRTNRLLIAMV-VVFAVCW 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 251 APNNF--VLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVY 293
Cdd:cd15203 238 LPLNLfnLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVNPLLY 282
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
29-303 1.29e-23

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 99.01  E-value: 1.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCNRhHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15195   6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTfFNMPMDAVWNYTV-EWLAGDLMCRVMMFLKQFGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVlkwTMLPSV 187
Cdd:cd15195  85 YLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFHQCVDF---GSAPTK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEA--------HGR-------EQRRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd15195 162 KQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRardtpisnRRRsrtnsleRARMRTLRMTALIVLTFIVCWGP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 253 NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15195 242 YYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
24-301 1.35e-23

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 98.49  E-value: 1.35e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQ-IYYHCNRhhWVFGVLLCNVVTVA 102
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQsTVYLMNS--WPFGDVLCKIVISI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdVLKWT 182
Cdd:cd15091  79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTEC--SLQFP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MlPSVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15091 157 D-DDYSWWDTFMkICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKdrnlRRITRLVLVVVAVFVVCWTPIHIFI 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15091 236 LVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFK 279
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
24-301 2.22e-23

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 98.00  E-value: 2.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPF-LAASAALQHWPFGSAMCRTVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlGIITCfdVLKWtm 183
Cdd:cd15973  80 GINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKG-QAVAC--NLIW-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVG----LAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15973 155 -PHPAWSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKkitrMVLMVVTVFVICWMPFYVVQLL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HivsrLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15973 234 N----LFLPRLDATVNHASLILSYANSCANPILYGFLSDNFR 271
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
24-301 2.37e-23

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 97.95  E-value: 2.37e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPF-LATQNAISYWPFGSFLCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLartdLTYPVHALGIITCfdVLKWTm 183
Cdd:cd15974  80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPV----IIFSDVQPDLNTC--NISWP- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMW-AVFLFTIFILLFLIPFVITVACYTATILKL----LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15974 153 -EPVSVWsTAFIIYTAVLGFFGPLLVICLCYLLIVIKVkssgLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNI 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15974 232 VNLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFK 274
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
26-303 2.87e-23

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 97.95  E-value: 2.87e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15380   3 LPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFdvlkwTMLP 185
Cdd:cd15380  83 NLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISACI-----LLFP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVAcYTATILKLLRTeeaHGREQRRR--------AVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15380 158 HEAWHFARRVELNIVGFLLPLAAIVF-FNFHIIASLRE---RTEESRKRcgglkdtkATRLILTLVLMFLVCWTPYHFFA 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 258 LAHIVSRLFYGKSYYHVYKLTLCLSC------LNNCLDPFVYYFASREFQLR 303
Cdd:cd15380 234 FLDFLFQVEVIQGCFWEEFIDLGLQLanffafANSCLNPVIYVFAGKLFRTK 285
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
24-304 2.94e-23

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 97.52  E-value: 2.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRrMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15924   1 QLFPVLYTVIFFAGILLNGLAMWIFFH-IPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDlTYPVHALGIITCFDVLKwtm 183
Cdd:cd15924  80 YFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILT-NQQPREKNVKKCSFLKS--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ--RRRAVGLAAVVLLA-FVTCFAPNNFVLLAH 260
Cdd:cd15924 156 -ELGLKWHEIVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSssRRKKSNVKIFIIVAvFFVCFVPYHFARIPY 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 261 IVSRL------FYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15924 235 TLSQTrdvfdcTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
24-301 3.23e-23

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 97.66  E-value: 3.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV-IFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSInLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlgiitcfDVLKWT 182
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSN-------EELCLV 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIF-----ILLFLIPFVITVACYTaTILKLLRTEEAHGREQRRRAVGLAAV--VLLAFVTCFAPNNF 255
Cdd:cd15926 154 KFPDNRGNAQFWLGLYhaqkvLLGFLIPLGIISLCYL-LLVRFITDKNITGSSTKRRSKVTKSVtiVVLSFFLCWLPNQA 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 256 VLLAHIVSRL---FYGKSYY----HVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15926 233 LTTWGILIKLnvvHFSYEYFttqvYIFPITVCLAHSNSCLNPILYCLMRREFR 285
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
24-301 4.44e-23

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 97.22  E-value: 4.44e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15971   1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPF-LAIQVALVHWPFGKAICRVVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITcfdvLKWTM 183
Cdd:cd15971  80 GINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCT----IIWPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL----LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15971 156 -ESSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVkssgIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVS 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15971 235 SVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFK 276
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
24-298 6.88e-23

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 96.46  E-value: 6.88e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15194   1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKW-- 181
Cdd:cd15194  81 SVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCL---------LGLPTLLSRELKKYEEKEYcn 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 --TMLPSVAMWAVflfTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR--RRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15194 152 edAGTPSKVIFSL---VSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKklRKSIKIVFIVVAAFVFSWMPFNLFK 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 258 LAHIVSRL---FYGKSYYHV---YKLTLCLSCLNNCLDPFVYYFASR 298
Cdd:cd15194 229 ALAIASGLqveVTCLPYTLAqlgMEVSAPLAFANSCANPFIYYFFDR 275
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
24-301 9.25e-23

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 96.05  E-value: 9.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRmGPRSPSV--IFMINLSVTDL-MLASVLPFQ--IYyhcNRHHWVFGVLLCNV 98
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRS-GQSGHNTtnLFILNLSVADLcFILFCVPFQatIY---SLEGWVFGSFLCKA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypVHALGIITCFDV 178
Cdd:cd15097  77 VHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSL--------------LFAGPYLSYYDL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 LKWTML----PSVAMW--AVFLFTIFILLFLIPFVITVACYTATILKLLRT-EEAHGREQRRRAVGLAAVVLLA----FV 247
Cdd:cd15097 143 IDYANStvcmPGWEEArrKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAvDPLEAMSESKRAKRKVTKMIIIvtalFC 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 248 TCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15097 223 LCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFR 276
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
24-301 1.52e-22

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 95.79  E-value: 1.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAF 103
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYL-METWPFGELLCKAVLSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlGIITCfdVLKWTM 183
Cdd:cd15089  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRD-GAVVC--MLQFPS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVTCFAP-NNFVLL 258
Cdd:cd15089 157 -PSWYWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKdrnlRRITRMVLVVVAAFIICWTPiHIFVIV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 259 AHIVSrlFYGKSYYHVYKLTLC--LSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15089 236 WTLVD--IDRRNPLVVAALHLCiaLGYANSSLNPVLYAFLDENFK 278
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-300 1.54e-22

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 95.83  E-value: 1.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15096   4 PVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFcVPFTATDYV-LPTWPFGDVWCKIVQYLVYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLP 185
Cdd:cd15096  83 TAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEVGT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMwavFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGR------EQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15096 163 AAQT---FFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRrsaesqRGKRRVTRLVVVVVVVFAICWLPIHIILLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 260 HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15096 240 KYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNF 280
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
26-304 3.13e-22

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 94.82  E-value: 3.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqiYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15174   3 LPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPF--WATAASSGWVFGTFLCKVVNSMYKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRR--YAVAACAGTWlllltalspLARTDLTYP------VHALGIITCFD 177
Cdd:cd15174  81 NFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVW---------LLSTILSLPeilfsqSKEEESVTTCT 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 178 VLKWTMLPSVAMWAVFLFTIfILLFLIPFVITVACYTATILKLLRTEeahgREQRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15174 152 MVYPSNESNRFKVAVLALKV-TVGFFLPFVVMVICYTLIIHTLLQAK----RFQKHKALKVIIAVVTVFVLSQLPYNSIL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHI-------VSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15174 227 LIKTinaynitITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
27-301 5.04e-22

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 94.45  E-value: 5.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15381   4 PIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTAL--SPLARTDLTYPVHalGIITCfdVLKWtml 184
Cdd:cd15381  84 LYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMStpMIVFRTVMYFPEY--NITAC--VLDY--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAmWAVFLFTIFILL-FLIPFVITVACyTATILKLLRTEEAHGREQ---RRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15381 157 PSEG-WHVALNILLNVVgFLIPLSIITFC-STQIIQVLRNNKMQKFKEiqtERKATVLVLAVLLMFFICWLPFHIFTFLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 261 IVSRL--FYGKSYYHVY----KLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15381 235 TLHKLglISGCRWEDILdigtQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
29-304 5.73e-22

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 94.17  E-value: 5.73e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVL--CRRMGPrSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15925   6 AYGLVCAIGLLGNLAVMYLLrnCARRAP-PPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLN 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVhaLGIITCfdVLKWtmlPS 186
Cdd:cd15925  85 VYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEV--CGVELC--LLKF---PS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAA-VVLLAFVTCFAPNNFVLLAHIVSR- 264
Cdd:cd15925 158 NYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVrLVVASFFLCWFPNHVVTFWGVLVKf 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 265 --LFYGKSYY----HVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15925 238 raVPWNSTFYfihtYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
24-304 6.08e-22

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 93.73  E-value: 6.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRhHWVFGVLLCNVVT--V 101
Cdd:cd15166   1 IAALVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKD-EWPFGDYFCRILGalT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMtcISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDlTYPVHALGIITCFDVLKW 181
Cdd:cd15166  80 VFYPSIALWLLAF--ISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLY-EDPDKASNFTTCLKMLDI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVamwAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ-RRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15166 157 IHLKEV---NVLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGRTSKLKPKvKEKSIRIIITLIVQVLVCFVPFHICFAFL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 261 IVSRlfYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15166 234 MLQN--GDNSYNPWAAFTTFLMNLSTCLDVILYYIVSKQFQARV 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
28-300 6.08e-22

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 94.28  E-value: 6.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVL--CRRMgpRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVTVAFY 104
Cdd:cd15390   5 IVFVVMVLVAIGGNLIVIWIVlaHKRM--RTVTNYFLVNLAVADLLISAFnTVFNFTYLLY-NDWPFGLFYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLssKRWRRRRYAVAACAGTWLLLLTA---LSPLARTDLTYPVHALGIITCFdvLKW 181
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIWLASFLLalpQLLYSTTETYYYYTGSERTVCF--IAW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR--------RRAVGLAAVVLLAFVTCFAPN 253
Cdd:cd15390 158 PDGPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRqlesvrakRKVVKMMIVVVVIFAICWLPY 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 254 N-FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15390 238 HlYFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRF 285
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
29-301 1.39e-21

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 93.14  E-value: 1.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15090   6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGNILCKIVISIDYYNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTypVHALGIITCfdvlkwTMLPSVA 188
Cdd:cd15090  85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT--KYRQGSIDC------TLTFSHP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 189 MW---AVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVTCFAPNNFVL---- 257
Cdd:cd15090 157 SWyweNLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYViika 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHIVSRLFYGKSYYhvykLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15090 237 LVTIPETTFQTVSWH----FCIALGYTNSCLNPVLYAFLDENFK 276
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
20-335 1.53e-21

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 95.08  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   20 PAIAVALPVVYSLVAAVSIPGNLFSLWVL-CRRMgpRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRhhWVFGVLLCNV 98
Cdd:PHA02638  95 PSISEYIKIFYIIIFILGLFGNAAIIMILfCKKI--KTITDIYIFNLAISDLIFVIDFPFIIYNEFDQ--WIFGDFMCKV 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS----PLARTDLTYPVH----AL 170
Cdd:PHA02638 171 ISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSpayfIFEASNIIFSAQdsneTI 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  171 GIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEeahgREQRRRAVGLAAVVLLAFVTCF 250
Cdd:PHA02638 251 SNYQCTLIEDNEKNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQLK----KSKKTKSIIIVSIIIICSLICW 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  251 APNNFVLLahiVSRLFYGKSYYHVYKLTLC--------------LSCLNNCLDPFVYYFASREFQLRLreYLGCRRVPRD 316
Cdd:PHA02638 327 IPLNIVIL---FATMYSFKGFNSIISEHICgfiklgyammlaeaISLTHCCINPLIYTLIGENFRMHL--LMIFRNIFTN 401
                        330
                 ....*....|....*....
gi 74762454  317 TldtrresLFSARTTSVRS 335
Cdd:PHA02638 402 A-------KFSFRKSSISS 413
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
24-301 5.50e-21

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 91.40  E-value: 5.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPF-LAAQNALSYWPFGSFMCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLartdLTYPVHALGIITCFdvLKWTM 183
Cdd:cd15972  80 AINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPV----VIFSGVPGGMGTCH--IAWPE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL------LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15972 154 -PAQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVrssgrrVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALN 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15972 233 IVNLVCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFK 276
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
24-304 6.80e-21

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 91.00  E-value: 6.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSpSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15969   1 IVFPVLYLIIFIGSILLNGLAVWIFFHIRNKTS-FIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlGIITCFDVLKwtm 183
Cdd:cd15969  80 YASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTED-NIHDCSKLKS--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 lPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAH--GREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15969 156 -PLGVKWHTAVSYINICIFVAVLVILIVCYISISRYIYKSSKQFisSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFT 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 262 VSRL---FYGKSY---YHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15969 235 FSQLdkiLDCTIKtilYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
27-297 9.36e-21

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 90.59  E-value: 9.36e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15367   4 PVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYEN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLL-LLTALSPLARTDLTYPVHALgiITCFDvlkwtMLP 185
Cdd:cd15367  84 IYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKeLMTCVFFFLHGEISKDKENH--SVCFE-----HYP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTAtILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV--S 263
Cdd:cd15367 157 IKAWEHNINYYRFYAGFLFPIFLLSFSYCR-ILRAVRKSHGTQKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVfeR 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 74762454 264 RLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15367 236 DCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFAS 269
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
24-304 1.08e-20

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 90.60  E-value: 1.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14988   1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLltalsplartdltypvhalGIITCFDVLKWTM 183
Cdd:cd14988  81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLS-------------------AIIPLPEVVHMQL 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFL--------------FTIFILLFLIPFVITVACYTATILKLLRteeaHGREQRRRAVGLAAVVLLAFVTC 249
Cdd:cd14988 142 LDGVEPMCLFLapfetydewalavsLLTLIIGFLIPFSIIAVFNVLTARYIRT----AGRPESRRHCLLIYAYILVFVVC 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 250 FAPNNFVLL------AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14988 218 WLPYHVTLLlltlhgSHISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
24-300 2.56e-20

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 89.41  E-value: 2.56e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRrmGPRSPSV--IFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTV 101
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVILR--APKMKTVtnVFILNLAIADDLFTLVLPINIAEHL-LQQWPFGELLCKLILS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKR--WRRRRYAVAACAGTWLLLLTALSPLARTDLTYpVHALGIITCFDVL 179
Cdd:cd15087  78 IDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVY-SNELGRKSCVLSF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTE-EAHGR---EQRRRAVGLAAVVLLAFVTCFAPNNf 255
Cdd:cd15087 157 PS---PESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRlNSNAKaldKAKKKVTLMVLVVLAVCLFCWTPFH- 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 256 vlLAHIVS--------RLFYGKSYYhvyklTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15087 233 --LSTVVAlttdlpqtPLVIGISYF-----ITSLSYANSCLNPFLYAFLDDSF 278
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
24-301 2.93e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 89.42  E-value: 2.93e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrhHWVFGVLLCNVVTVAF 103
Cdd:cd15181   1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIA--GWVFGTFLCKLVGAIH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTA------------LSPLARTDLTYpvHALG 171
Cdd:cd15181  79 KLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLslpnlvflevetSTNANRTSCSF--HQYG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 172 IitcfdvlkwtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEahgREQRRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15181 157 I------------HESNWWLTSRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSR---RLQKQKAIRVAILVTLVFCLCWL 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 252 PNNFVLLAHIVSRLFYGKSYYHVYKL-------TLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15181 222 PYNIVIFLDTLDDLKAVVKNCKLNDLldaaitvTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
24-304 4.98e-20

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 88.72  E-value: 4.98e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSvIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15339   1 VILPSFIGILCSTGLVGNILVLFTIIRSRKKTVPD-IYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltalspLARTDLTYPVHALGIITCF-DVLKWT 182
Cdd:cd15339  80 TCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVW---------AASFILVLPVWVYAKVIKFrDGLESC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIF--ILLFLIPFVITVACYTATIL----------KLLRTEEAHGREQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15339 151 AFNLTSPDDVLWYTLYqtITTFFFPLPLILICYILILCytwemyrknkKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 251 APNNFVLLAHIvSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15339 231 APYHVIQLVNL-SVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
24-301 6.76e-20

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 88.50  E-value: 6.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVcMPVALVETWAREPWLLGEFMCKLVPFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKWT 182
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALL---------TSSPVLFITEFKEEDFNDGT 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAM-----WAV-FLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ----------RRRAVGLAAVVLLAF 246
Cdd:cd14997 152 PVAVCRTpadtfWKVaYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRAdaanrhtlrsRRQVVYMLITVVVLF 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 247 VTCFAPNNFVLLAHIVS-----RLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14997 232 FVCLLPFRVVTLWIIFApdedlQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFR 291
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
24-301 8.90e-20

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 88.00  E-value: 8.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQ---IYYHcnrhHWVFGVLLCNVVT 100
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQgtdIFLG----FWPFGNALCKTVI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGI-------I 173
Cdd:cd15092  77 AIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASV---------VGVPVMVMGSaqvedeeI 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 174 TCFDVLKwtmlPSVAMW-AVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR----RRAVGLAAVVLLAFVT 248
Cdd:cd15092 148 ECLVEIP----TPQDYWdPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKdrnlRRITRLVLVVVAVFVG 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 249 CFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15092 224 CWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
28-304 1.28e-19

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 87.49  E-value: 1.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15119   5 VIYIVAFVLGVPGNAIVIWVTGFKW-KKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYpVHALGIITCF-DVLKWTMLPS 186
Cdd:cd15119  84 FASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTM-ELSINVTICFnNFHKHDGDLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTATILKllrteeahgrEQRRRAVGLA------AVVLLAFVTCFAPNNFV---- 256
Cdd:cd15119 163 VMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIK----------VKRRTLLISSkffwtiSAVIVAFFVCWTPYHIFsile 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 257 LLAHIVSRLFYgkSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15119 233 LSIHHSSYLHN--VLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
27-301 1.52e-19

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 87.14  E-value: 1.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYyhCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15177   4 PCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAA--ETLQGWIFGNAMCKLIQGLYAIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRR--RYAVAACAGTWllllTALSPLARTDLTYPV--HALGIITCFdvLKWT 182
Cdd:cd15177  82 FYSGFLFLTCISVDRYVVIVRATSAHRLRPKtlFYSVLTSLIVW----LLSILFALPQLIYSRveNRSELSSCR--MIFP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15177 156 EVVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGW----ERHRALRVIAALVVAFVLFQLPYSVVLLLDTA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 263 SRLFYGKSYYHVYK-------LTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15177 232 DLLATLELSCSQSKrkdiallVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
22-300 1.53e-19

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 86.55  E-value: 1.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  22 IAVALPVVyslVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQ--IYYHcnrHHWVFGVLLCNV 98
Cdd:cd15210   2 FAAVWGIV---FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFnLPLAasTFLH---QAWIHGETLCRV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLartdltypvhALGIITCFD- 177
Cdd:cd15210  76 FPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPL----------WLGIWGRFGl 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 178 ---VLKWTMLPSVA--MWAVFLFTIFillFLIPFVITVACYTatilkllrteeahgREQRRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd15210 146 dpkVCSCSILRDKKgrSPKTFLFVFG---FVLPCLVIIICYA--------------RREDRRLTRMMLVIFLCFLVCYLP 208
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 253 nnfVLLAHIVSRLFygkSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15210 209 ---ITLVNVFDDEV---APPVLHIIAYVLIWLSSCINPIIYVAMNRQY 250
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
24-304 2.56e-19

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 86.76  E-value: 2.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV-IFMINLSVTDLMLASVLPFQIYYHCNrhHWVFGVLLCNVVTVA 102
Cdd:cd15188   1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVPKKKKMTeVYLLNLAVSDLLFLVTLPFWAMYVAW--HWVFGSFLCKFVSTL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlGIITCFDVLKWT 182
Cdd:cd15188  79 YTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNN-GVWVCHADYGGH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLpsvaMWAVFLFTIFILL-FLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15188 158 HT----IWKLVFQFQQNLLgFLFPLLAMVFFYSRIACVLTRLRPP----GQGRALRFVAALVVVFFVLWFPYNLTLFLHS 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 262 VSRLFY------GKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15188 230 LQDLHVigncerSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
24-301 2.67e-19

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 87.16  E-value: 2.67e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVV---- 99
Cdd:cd14996   1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIAnffg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 100 TVAFYANMYSSILTMTCISVERF----------------LGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDL 163
Cdd:cd14996  81 TLVIHVSMCVSILILSWIAISRYatlmkhdsatqkqscyEKIFYGHFLKRFRQPKFARYLCIYIWGVVLCIIIPVVVYYS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 164 TYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIpfVITVACYTATILKLLRTEEAHGREQR-RRAVGLAAVV 242
Cdd:cd14996 161 VREADEDGESLCYNRQVELGAKGSQIAGLIATTFFFLFFLV--VLLSYYSFVNHLRRIQKNTCISEKDLiYRSVKRNILI 238
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 243 LLA-FVTCFAPNnfvllaHIVSRLFYG----------KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14996 239 IQAlLVVCFLPY------HIFKPVFYVlhqredcqqlNYLIETKNILTCLASARSSTDPIMYLLLDKTFK 302
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
24-304 5.81e-19

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 85.64  E-value: 5.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRrMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15150   1 VIFPLLYTVLFIVGLTMNGLAMRVFFQ-IPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWllLLTALSPLARTDLTYPVHALGiitcfDVLKWTM 183
Cdd:cd15150  80 YFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIW--ASMFALSLPNMILTNRQPTPK-----NVKKCSL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSV--AMWAVFLFTIFILLFLIPFVITVACYTATILKLLRT--EEAHGREQRRRAVGLAAVVLLA-FVTCFAPNNFVLL 258
Cdd:cd15150 153 LKSEfgLVWHEIVNYICQVIFWVNFLIVIVCYTLITKELYKSykRTRGVGKVSRKKVNVKVFIIIAvFFICFVPFHFARI 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 259 AHIVSR---LFY---GKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15150 233 PYTLSQtrdVFDctaKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
24-301 7.04e-19

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 85.21  E-value: 7.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqiYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15179   1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPF--WAVDAAANWYFGNFLCKAVHVIY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYP--VHALGIITCFDVLKW 181
Cdd:cd15179  79 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALL---------LTVPdlVFAKVSELDDRYICD 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVA--MWAV-FLFTIFILLFLIPFVITVACYTATILKLlrtEEAHGrEQRRRAVGLAAVVLLAFVTCFAPNN---- 254
Cdd:cd15179 150 RIYPEDTfeLWVVaFRFQHILVGLVLPGLVILTCYCIIISKL---SHSKG-HQKRKALKTTVILILAFFACWLPYYigis 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 255 ---FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15179 226 idtFMLLEIIKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
24-301 1.72e-18

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 84.18  E-value: 1.72e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYhCNRHHWVFGVLLCNV--VT 100
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVgYPLSFYS-NLSGRWSFGDPGCVIygFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYAnmYSSILTMTCISVERFLGVLYPLsSKRWRRRRYAVAACAGTWlllltalsplartdltypvhalgIITCFdvlk 180
Cdd:cd14969  80 VTFLG--LVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIW-----------------------LYGLF---- 129
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLP----------------SVAMWAV------FLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGR 229
Cdd:cd14969 130 WALPPlfgwssyvpegggtscSVDWYSKdpnslsYIVSLFVFCFFLPLAIIIFCYYKIYRTLrkmskraarRKNSAITKR 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74762454 230 EQR--RRAVGLAAVVLLAFVTCFAPnnFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14969 210 TKKaeKKVAKMVLVMIVAFLIAWTP--YAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFR 281
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
24-301 1.88e-18

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 84.07  E-value: 1.88e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15199   1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFdvlkwTM 183
Cdd:cd15199  81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVG---------LTIPTLLASQPKNF-----TE 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTI------FILLFLIPFVITVACyTATILKLL--RTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNnf 255
Cdd:cd15199 147 CNSFSPKDDEDFSDtwqeavFFLQFLLPFGLIVFC-TVRIIRRLkkRLRDVGKQPKLQRAMALVTSVVVVFGFCFLPC-- 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 256 vLLAHIVSRLFYGKS-------YYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15199 224 -FLARVLMLIFQNKEscnalniAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
24-304 1.91e-18

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 84.09  E-value: 1.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV---IFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVT 100
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRCQQTvpdIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLIT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlGIITCfdvlk 180
Cdd:cd15338  81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPD-GSVGC----- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAMwAVFLFTI--FILLFLIPFVITVACYTATILKLLRTE----EAHGREQRRRAVGLAAVVLLAFVTCFAPNN 254
Cdd:cd15338 155 ALLLPNPET-DTYWFTLyqFFLAFALPLVVICVVYFKILQNMASTVaplpQRSLRVRTKKVTRMAVAICLAFFICWAPFY 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 255 FVLLAHI-VSRLFYgkSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15338 234 ILQLAHLsIDRPSL--AFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
24-308 5.71e-18

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 82.57  E-value: 5.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrhHWVFGVLLCNVVTVAF 103
Cdd:cd15186   1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLIN--EWGLHNAMCKLTTAFF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIitcfdvlkwtm 183
Cdd:cd15186  79 FIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENECLGD----------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAM--WAVFLFT-IFILLFLIPFVITVACYTATILKLLRTEEahgrEQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15186 148 YPEVLQeiWPVLRNVeLNFLGFLLPLLIMSYCYFRIIQTLFSCKN----HKKARAIKLILLVVIVFFLFWTPYNVMIFLE 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 261 IVSRLFYGKSYYHVYKLTLCLSCLNN------CLDPFVYYFASREFqlrlREYL 308
Cdd:cd15186 224 TLKLYDFFPSCDMKKDLRLALSVTETiafshcCLNPLIYAFAGEKF----RRYL 273
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
21-301 6.17e-18

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 82.91  E-value: 6.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  21 AIAVALpVVYSLVAAVsipGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVT 100
Cdd:cd15120   2 LIAVAL-FVTFLVGLV---VNGLYLWVLGFKM-RRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLN 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLK 180
Cdd:cd15120  77 STLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYAL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAM--------WAVFLFTiFILLFLIPFVITVACYTATILKLlrTEEAHGREQRRRAVGLAAVVllAFVTCFAP 252
Cdd:cd15120 157 STNWESAEVqasrqwihVAMFVFR-FLLGFLLPFLIITFCYVRMALKM--KERGLARSSKPFKVMFTAVV--SFFVCWLP 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 253 nnfvllAHIVSRLFYGKSYYHVYK-----LTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15120 232 ------YHLHSGLVLTRGRPPSLTditllLTVGTTCFNTCFTPVLYLFVGENFK 279
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
25-304 6.59e-18

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 82.50  E-value: 6.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd14987   2 TLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltALSPLARTDLTYPVHALGIITCFDVLKWTML 184
Cdd:cd14987  82 INLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVW-----LLAFVASLPDTYFLKTVTSPSNNETYCRSFY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 P--SVAMWAVFLFTIFILL-FLIPFVITVACYtatiLKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd14987 157 PeeSFKEWLIGMELVSIVLgFVIPFPIIAVFY----FLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDI 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 262 VSRLFY-------GKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd14987 233 LSFLHLipfscqlENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
26-301 7.82e-18

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 82.51  E-value: 7.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSL--WVLCRRMgpRSPSVIFMINLSVTDLMLASVLPFQIYyhCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15175   3 LPAMYSVICFLGLLGNGLVIltYIYFKRL--KTMTDIYLLNLALADILFLLTLPFWAA--SAAKKWVFGEEMCKAVYCLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRR--YAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCF--DVL 179
Cdd:cd15175  79 KMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAvfISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFtnNKQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAMwavflftiFILLFLIPFVITVACYTATILKLLRTEEAhgreQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15175 159 TLSVKIQISQ--------MVLGFLVPLVVMSFCYSVIIKTLLQARNF----EKNKAIKVIIAVVVVFVVFQLPYNSVMLV 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 74762454 260 HIVSRLF-------YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15175 227 STLSSFKgnttdcdYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
29-304 8.50e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 82.74  E-value: 8.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV-IFMINLSVTDLMLASVL-PFQIYYHCNRHhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15382   6 VYSVLFLIAAVGNLTVLLILLRNRRRKRSRVnILLMHLAIADLLVTFIMmPLEIGWAATVA-WLAGDFLCRLMLFFRAFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAgtWLLLLTALSPLArtdLTYPVHALGIITCFD-VLKWTMLP 185
Cdd:cd15382  85 LYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVA--WVISFLCSIPQS---FIFHVESHPCVTWFSqCVTFNFFP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMwaVFLFTIF--ILLFLIPFVITVACYTATILK--------------------LLRTEEAHGREQRRRAVGLAAVVL 243
Cdd:cd15382 160 SHDH--ELAYNIFnmITMYALPLIIIVFCYSLILCEisrkskekkedvseksssvrLRRSSVGLLERARSRTLKMTIVIV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 244 LAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15382 238 LVFIICWTPYFIMSLWYWFDRESASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
30-304 9.61e-18

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 82.12  E-value: 9.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  30 YSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYS 109
Cdd:cd15167   7 YYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMYL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 110 SILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSplarTDLTYPVHAL---GIITCFDVLK-----W 181
Cdd:cd15167  87 SIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMV----PNMAIPIKTIeekPGVGCADFKTefgrhW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFL-FTIFILLFlipfvitvacYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15167 163 HVLTNFICMAIFLnFSAIILIS----------NFLVIRKLYRNKDSEEYRNARQALVNILLVTAGYVICFVPYHIVRIPY 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 261 ------IVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15167 233 tlsqseVITDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
26-308 1.71e-17

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 81.46  E-value: 1.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15183   3 LPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKL-KDDWIFGDAMCKFLSGFYYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS---PLARTDLTYPVHalgiiTCFDVLKWT 182
Cdd:cd15183  82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMpclYFFKSQWEFTHH-----TCSAHFPRK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 mlpSVAMWAVF-LFTIFILLFLIPFVITVACYTATILKLLRTEEahgrEQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd15183 157 ---SLIRWKRFqALKLNLLGLILPLLVMIICYTGIINILLRRPN----EKKAKAVRLIFVITLLFFLLWTPYNLAAFVSA 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 262 VSRLFYGKSYYHVYKLTLC------LSCLNNCLDPFVYYFASREFqlrlREYL 308
Cdd:cd15183 230 FQDVLFTPSCEQSQQLDLAlqvtevIAYTHCCVNPVIYVFVGERF----RKYL 278
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
26-304 2.58e-17

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 80.84  E-value: 2.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVTVAFY 104
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLnTPFTLVRFVN-STWVFGKIMCHLSRFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLssKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTML 184
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHPL--KPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFPE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLR-------TEE---AHGREQRRRAVGLAAVVLLaFVTCFAP-N 253
Cdd:cd15389 160 PSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLrnaigdvTTEqyvAQRRKKKKTIKMLMLVVLL-FAICWLPlN 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 254 NFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNncldPFVYYFASREFQLRL 304
Cdd:cd15389 239 CYHVLLSSHPIRSNSALFFAFHWLAMSSTCYN----PFIYCWLNDSFRSEL 285
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
28-300 4.61e-17

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 80.23  E-value: 4.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSV--IFMINLSVTDLMLASVLPFQIYYhCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15122   5 IFLLLAALLGLPGNGFIIWSILWKMKARGRSVtcILILNLAVADGAVLLLTPFFITF-LTRKTWPFGQAVCKAVYYLCCL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKWTML- 184
Cdd:cd15122  84 SMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALL---------LALPAFVYRHVWKDEGMNDRICe 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 ---PSVAMwAVFLFTIFILL-FLIPFVITVACYTATILKLlrtEEAHGReQRRRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15122 155 pchASRGH-AIFHYTFETLVaFVLPFGVILFSYSVILVRL---KGARFR-RRARVEKLIAAIVVAFALLWVPYHVVNLLQ 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 261 IVSRLFYGK---SYYHVYKL----TLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15122 230 VVANLAPGEvleKLGGAAKAaragATALAFFSSSVNPLLYVFAAGDL 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
26-308 5.62e-17

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 79.80  E-value: 5.62e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCnrHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15184   3 LPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAA--NEWVFGNAMCKLLTGLYHI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS------PLARTDLTYpvhalgiiTCFDVL 179
Cdd:cd15184  81 GFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLpgiiftKSQKEGSHY--------TCSPHF 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTmlpSVAMWAVFL-FTIFILLFLIPFVITVACYTATILKLLRTEEahgREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15184 153 PPS---QYQFWKNFQtLKMNILGLVLPLLVMIICYSGILKTLLRCRN---EKKRHKAVRLIFTIMIVYFLFWAPYNIVLL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 259 AHIVSRLFYGKSYYHVYKL------TLCLSCLNNCLDPFVYYFASREFqlrlREYL 308
Cdd:cd15184 227 LNTFQEFFGLNNCSSSNRLdqamqvTETLGMTHCCINPVIYAFVGEKF----RSYL 278
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
26-231 6.09e-17

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 79.93  E-value: 6.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIyYHCNRHHWVFGVLLCNVvtvafYA 105
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFI-YNSFYEGWALGPLGCQI-----YA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NM-----YSSILTMTCISVERFLGVLYPLSSKRWRRRRyAVAACAGTWLLLltalsplartdLTYPVHALGII------- 173
Cdd:cd15079  77 FLgslsgIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGK-ALLLILFIWLYA-----------LPWALLPLLFGwgryvpe 144
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74762454 174 ----TC-FDVLKWTMLPsvamwAVFLFTIFILLFLIPFVITVACYTAtILKLLRTEEAHGREQ 231
Cdd:cd15079 145 gfltSCsFDYLTRDWNT-----RSFVATIFVFAYVIPLIIIIYCYSF-IVKAVFAHEKALREQ 201
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
36-303 6.25e-17

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 79.81  E-value: 6.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  36 VSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMT 115
Cdd:cd15200  13 LGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIVFLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 116 CISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDltypvHALGIITCFDVLKWTMLPSVAMWAVFLf 195
Cdd:cd15200  93 AIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLD-----HVQSNSTCLSYDHGTDPSASDRWHRIL- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 196 tiFILLFLIPFVITVACYTATILKLLRTEEAhGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS-RLFYGKSYYHV 274
Cdd:cd15200 167 --FFLEFFLPLGIILFCIFSIILTLKQRKLA-KQAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAfKVSQCRSLDLC 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 74762454 275 YKL---TLCLSCLNNCLDPFVYYFASREFQLR 303
Cdd:cd15200 244 TQLfhgSLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
24-301 7.73e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 79.36  E-value: 7.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFcMPFTLVGQLLRN-FIFGEVMCKLIPYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdVLKWT 182
Cdd:cd15206  80 QAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKC--REVWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIfilLFLIPFVITVACYTATILKLLrteeahgrEQRRRAVGLAAVVLLAFVTCFAPnnfvLLAHIV 262
Cdd:cd15206 158 NEIAEQAWYVFLDLM---LLVIPGLVMSVAYGLISWTLL--------EAKKRVIRMLFVIVVEFFICWTP----LYVINT 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 263 SRLFYGKSYYH-----VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15206 223 WKAFDPPSAARyvsstTISLIQLLAYISSCVNPITYCFMNKRFR 266
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
24-300 1.30e-16

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 79.32  E-value: 1.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDL-MLASVLPFQIYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLlILLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWT 182
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVA-MWAVFLFTIFIlLFLIPFVITVACYTATILKL--------------LRTEEAHGREQ-RRRAVGLAAVVLLAF 246
Cdd:cd14979 161 LVVDRStFKYVFQVSTFI-FFVLPMFVISILYFRIGVKLrsmrnikkgtraqgTRNVELSLSQQaRRQVVKMLGAVVIAF 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 247 VTCFAPNNFV-LLAHIVSR--LFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd14979 240 FVCWLPFHAQrLMFSYASKedTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRF 296
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
24-300 1.78e-16

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 78.91  E-value: 1.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQIYYHCNRHHWVFGVLLCnvVTVA 102
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLlLILGLPFELYTIWQQYPWVFGEVFC--KLRA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANM--YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA-RTDLTYPVHALGI-ITCFDV 178
Cdd:cd15134  79 FLSEMssYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAiQTRIVYLEYPPTSgEALEES 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 LKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHG----------REQRRRAV--GLAAVVlLAF 246
Cdd:cd15134 159 AFCAMLNEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRgqrsvsggrrSSQSRRTVlrMLVAVV-VAF 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 247 VTCFAP---NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15134 238 FICWAPfhaQRLLTVYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKY 294
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
28-296 2.08e-16

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 78.32  E-value: 2.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANM 107
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGG-WEFGSVVCKLCHYVCGVSM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHAL-GIITCFDVLKWTML-- 184
Cdd:cd15121  84 YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFL---------LSLPMPFYrTVLKKNINMKLCIPyh 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTaTILKLLRTEeahgREQRRRAVG-LAAVVLLAFVTCFAPNNFV------- 256
Cdd:cd15121 155 PSVGHEAFQYLFETITGFLLPFTAIVTCYS-TIGRRLRSA----RFRRKRRTNrLVVLIIATFALFWLPYHVVnliqvag 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 257 LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFA 296
Cdd:cd15121 230 ALQNQAGNASVLKAAKLARPNVTALAFLSSSVNPVLYAFA 269
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
26-304 2.12e-16

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 78.35  E-value: 2.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSpSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15149   3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNKS-FIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWllLLTALSPLARTDLT-YPVHALGIITCFDV-----L 179
Cdd:cd15149  82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVW--MLMAVLSVPNIILTnQSFHEANYTKCARLkselgI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAMWAVFlFTIFILLflipfVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15149 160 QWHKASNYICVSIF-WVVFLLL-----IIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIP 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 260 HIVSRLfyGKSY--------YHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15149 234 YTLSQT--GADYscqsktilYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
24-304 2.57e-16

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 78.32  E-value: 2.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLC--RRMgpRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVT 100
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFknQRM--RTVTNYFIVNLAVADIMITLFnTPFTFVRAVN-NTWIFGLFMCHFSN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKrwRRRRYAVAACAGTWLLLLTALSPLA-RTDLTYPVHALGIITCFDVL 179
Cdd:cd15202  78 FAQYCSVHVSAYTLTAIAVDRYQAIMHPLKPR--ISKTKAKFIIAVIWTLALAFALPHAiCSKLETFKYSEDIVRSLCLE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAmWAVFLFTIFILLFLIPFVITVACYTATILKL--------LRTEEAHG-REQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15202 156 DWPERADLF-WKYYDLALFILQYFLPLLVISFAYARVGIKLwasnmpgdATTERYFAlRRKKKKVIKMLMVVVVLFALCW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74762454 251 APNN-FVLLAHIVSRLFYgKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15202 235 LPFNiYVLLLSSKPDYLI-KTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
24-304 2.58e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 78.31  E-value: 2.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15118   1 VATICLHGIVSTLGIVENLLILWVVGFRL-RRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKW-- 181
Cdd:cd15118  80 FLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFALFsp 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 ---TMLPSVAMWAV-FLFTIFILLFLIPFVITVACYTATILKLlrteEAHGREQRRRAVGLAAVVLLAFVTCFAPNN-FV 256
Cdd:cd15118 160 spdNNHPICKQRQEgLAISKLLLAFLIPLVIIAVSYAVVSLII----RHRCRRRPGRFVRLVVSVVVSFALCWAPYHiFS 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 257 LL---AHIVSRLFygKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15118 236 IIevmAHNQHSLR--PLVIQGLPFATTLAFLNSVLNPVLYVFSCPDFCNKI 284
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
30-293 4.60e-16

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 77.47  E-value: 4.60e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  30 YSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-LMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDmLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLsskrwrRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHA----LGIITC----FDVLK 180
Cdd:cd15394  87 VSVFTLTAIAVDRYYVTVYPL------RRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVefkgLDFSICeefwFGQEK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAMWavflftifILLFLIPFVITVACYTATILKLLR---------TEEAHGREQRRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15394 161 QRLAYACSTL--------LITYVLPLLAISLSYLRISVKLRNrvvpgsmtqSQAEWDRARRRKTFRLLVVVVVAFAICWL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 252 PNNFVLLAHIVSRLFYGKSYYHVYKLtLC--LSCLNNCLDPFVY 293
Cdd:cd15394 233 PLHIFNVIRDIDIDLIDKQYFNLIQL-LChwLAMSSACYNPFLY 275
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
24-301 4.84e-16

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 77.53  E-value: 4.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15928   1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRR---------YAVAACAGTWLLLLTALSPLARTDLTYPVHalgiit 174
Cdd:cd15928  81 ETCTYASILHITALSVERYLAICHPLRAKVLVTRGrvklliaviWAVAIVSAGPALVLVGVEHIQGQQTPRGFE------ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 CFDVLKWTMLPSVAMWAVFLFtifillFLIPFVITVACYTATILKL------LRTEEAHGREQ-RRRAVGLAAVVLLAFV 247
Cdd:cd15928 155 CTVVNVSSGLLSVMLWVSTSF------FFVPMVCLSLLYGLIGRALwdrrqrSRTAGASRRDNnHRQTVRMLAVIVLAFV 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74762454 248 TCFAPnnfvllaHIVSRLFYGKSY---YHVYK-------LTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15928 229 LCWLP-------FHVGRVIFNHSRastKHLHYvsqyfnlVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
26-148 5.01e-16

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 77.45  E-value: 5.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSL--WVLCRRMGprSPSVIFMINLSVTDLMLASVLPFQIYYHcNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15378   3 LPTMYSIEFVLGFIGNTIVIlgYIFCLKNW--KSSNIYLFNLSVSDLAFLCTLPMLVYSY-SNGQWLFGDFLCKSNRYLL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15378  80 HANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIW 124
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
24-252 7.12e-16

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 76.99  E-value: 7.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVtvAF 103
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMY--GF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMY--SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKW 181
Cdd:cd15083  79 SGGLFgiMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFDYLSR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSvamwaVFLFTIFILLFLIPFVITVACYTATILKLLRTEEA-------------HGREQRRRA-VGLAAVVL---L 244
Cdd:cd15083 159 DDANR-----SYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAmkemakrfskselSSPKARRQAeVKTAKIALllvL 233

                ....*...
gi 74762454 245 AFVTCFAP 252
Cdd:cd15083 234 LFCLAWTP 241
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
24-304 8.70e-16

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 76.74  E-value: 8.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRrMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15151   1 VVFPVLYTVLFLVGLILNSVAAWIFFH-IPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALG--IITCFDVLKW 181
Cdd:cd15151  80 YITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFL---------LSVPNMILSnkPATPISVKKC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVA--MWAVFLFTIFILLFLIPFVITVACYTATILKLLRT---EEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFV 256
Cdd:cd15151 151 ASLKSPLglKWHEVVNYICQFIFWGVFALMVLFYTIISKKVYESykkSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFV 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 257 LLAHIVSRLFYGKS------YYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15151 231 RVPYTLSQTGKITDcqlqnlLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
26-304 9.65e-16

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 76.41  E-value: 9.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYhCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15185   3 LPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHY-VRWNNWVFGHGMCKLLSGFYYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWllllTALSPLARTDLTY--PVHALGIITCFDVLKWTM 183
Cdd:cd15185  82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITW----GLAVLAALPEFIFyeTQELFEEFLCSPLYPEDT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILlfLIPFVITVACYTATILKLLRTEEahgrEQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:cd15185 158 EDSWKRFHALRMNIFGL--ALPLLIMVICYTGIIKTLLRCPS----KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQ 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 264 RLFYG------KSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15185 232 SIFFEtdcersKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
28-300 2.52e-15

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 75.35  E-value: 2.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLC--RRMgpRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15207   5 VSYSLIFLLCVVGNVLVCLVVAknPRM--RTVTNYFILNLAVSDLLVGVFcMPFTLVDNI-LTGWPFGDVMCKLSPLVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRryAVAACAGTWLLLLTALSPLA--RTDLTYPVH-ALGIITCfdVLKW 181
Cdd:cd15207  82 VSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQ--AFVIIVAIWVLALAIMIPQAlvLEVKEYQFFrGQTVHIC--VEFW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 tmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGR-----------EQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15207 158 ---PSDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGsasreaqaavsKKKVRVIKMLIVVVVLFALSW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 251 APNNFVLLAHIVSRLFYGKS---YYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15207 235 LPLHTVTMLDDFGNLSPNQRevlYVYIYPIAHWLAYFNSCVNPIVYGYFNRNF 287
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-252 3.78e-15

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 75.01  E-value: 3.78e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQI-YYHCNRHHWVFGVLLCNVVTV 101
Cdd:cd15204   1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFcLPFEMdYYVVRQRSWTHGDVLCAVVNY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPlsskRWRRRRYAVAAC--AGTWLLLLTALSPLARTDLTYPVHALGIITCFDVl 179
Cdd:cd15204  81 LRTVSLYVSTNALLVIAIDRYLVIVHP----LKPRMKRRTACVviALVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQI- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 kWTMLPSVAMWAVFLFtIFILLFLIPFVITVACYTATILKLLR------TEEAHGREQ--RRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15204 156 -WPVDQQAYYKAYYLF-LFVLEFVLPVLIMTLCYLRIVRKVWFrrvpgqQTEQIRRRLrrRRRKVRLLVVILTAFVLCWA 233

                .
gi 74762454 252 P 252
Cdd:cd15204 234 P 234
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
29-254 6.33e-15

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 74.28  E-value: 6.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPR-SPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15169   6 LYVAAFALGFPLNVLAIRGATAHARLRlTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTD-----LTYPVHALGIIT-------C 175
Cdd:cd15169  86 YAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEapggwLDHSNTSLGINTpvngspvC 165
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 176 FDVlkWTmlPSVAMWAVFLFTifILLFLIPFVITVACYTATILKLLRTEEAHGReqRRRAVGLAAVVLLAFVTCFAPNN 254
Cdd:cd15169 166 LEA--WD--PASAGPARFSLS--LLLFFLPLAITAFCYVGCLRALARSGLTHRR--KLRAAWVAGGALLTLLLCVGPYN 236
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
24-301 7.58e-15

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 74.05  E-value: 7.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFcIPFTLLQNISSN-WLGGAFMCKMVPFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS---PLARTDLTY-PVHALGIITCFDv 178
Cdd:cd15205  80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSpmlFVQQLEVKYdFLYEKRHVCCLE- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 lKWTMLPSVAMWAVFlftIFILLFLIPFVITVACYTATILKLL---------------RTEEAHGREQRRRAVGLAAVVL 243
Cdd:cd15205 159 -RWYSPTQQKIYTTF---ILVILFLLPLTTMLFLYSRIGYELWikkrvgdasvlqtihGIEMSKISRKKKRAVKMMVTVV 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 244 LAFVTCFAPNNFVLLAHIVSRL---FYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15205 235 LLFAVCWAPFHVVHMMIEYSNLenkYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
32-308 8.71e-15

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 73.44  E-value: 8.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMLASVLPFQIY-YHCNRHHWVFGV-LLCNVVTVAFYAnmyS 109
Cdd:cd14973   9 LLSLCGLVGNGLVLWLLGFRI-KRNPFSVYILNLAAADFLFLSCQAIQSLeDLLGGSLPGFALcRLLATLMFFSYT---V 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 110 SILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCfdvlKWTMLPSVAM 189
Cdd:cd14973  85 GLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWA-------------LSLLLSVLESYFC----GFLFWKFNES 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 190 WAVFLFTIFILLFLIPFVITVACYTATILKLLRteeahgREQRRRAVGLAAVVL---LAFVTCFAPNNFvllAHIVSRLF 266
Cdd:cd14973 148 ACRTFNFLSALLFLLLFLVMCVSSLTLLIRVQC------SSQRRPPTRLYVVILltvLVFLLCGLPLGI---YWFLLLWF 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 267 YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYL 308
Cdd:cd14973 219 SNYLFHTFHPISDLLSCVNSSANPIIYFFVGSLRGRRLREPL 260
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
28-300 8.96e-15

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 73.82  E-value: 8.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRR-MgpRSPSVIFMINLSVTDLM-LASVLPFQI--YYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14978   5 YVLPVICIFGIIGNILNLVVLTRKsM--RSSTNVYLAALAVSDILvLLSALPLFLlpYIADYSSSFLSYFYAYFLPYIYP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANM--YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPlartdlTYPVHALGIITCFDVLKW 181
Cdd:cd14978  83 LANTfqTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLP------RFFEYEVVECENCNNNSY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAM-------WAVFLFTIFILLFLIPFVITVACYTATILKLLRTEE-------------AHGREQRRRAVGLAAV 241
Cdd:cd14978 157 YYVIPTLLrqnetylLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKrrrllrrrrrllsRSQRRERRTTIMLIAV 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 242 VLLaFVTCFAPNNFV-LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd14978 237 VIV-FLICNLPAGILnILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKF 295
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-295 1.01e-14

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 73.56  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA--SVLPFQIYYHCNRhhWVFGVLLCNVVTVAFYAN 106
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAffTVLTQIIWEATGE--WVAGDVLCRIVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSS--KRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHAlgiitCfdvlkWTML 184
Cdd:cd14986  84 LFASTYILVSMSLDRYQAIVKPMSSlkPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVHQ-----C-----WSSF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQ------------------------RRRAVGLAA 240
Cdd:cd14986 154 YTPWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPiaptamscrsvscvssrvslisraKIKTIKMTL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74762454 241 VVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLscLNNCLDPFVYYF 295
Cdd:cd14986 234 VIILAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLAS--LNSALNPLIYGF 286
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
28-300 3.49e-14

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 72.01  E-value: 3.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLC--RRMgpRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15392   5 LMYSTIFVLAVGGNGLVCYIVVsyPRM--RTVTNYFIVNLALSDILMAVFcVPFSFIALLILQYWPFGEFMCPVVNYLQA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLssKRWRRRRYAVAACAGTWLLLLTALSPLArtdLTYPVHALGIITCFDVLKWTML 184
Cdd:cd15392  83 VSVFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIA---ITSRLFEDSNASCGQYICTESW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLL--RT--EEAHGREQR-----RRAVGLAAVVLLAFVTCFAPNNF 255
Cdd:cd15392 158 PSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWakRTpgEAENNRDQRmaeskRKLVKMMITVVAIFALCWLPLNI 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 256 VLLA-HIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15392 238 LNLVgDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKF 283
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
24-307 4.16e-14

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 71.67  E-value: 4.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQiYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd15393   1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFsIPFQ-FQAALLQRWVLPRFMCPFCPFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSkRWRRRRYAVAACaGTWLLLLTALSPLARTDLTY--PVHALGIITCFDVLK 180
Cdd:cd15393  80 QVLSVNVSVFTLTVIAVDRYRAVIHPLKA-RCSKKSAKIIIL-IIWILALLVALPVALALRVEelTDKTNNGVKPFCLPV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WtmlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGREQRRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15393 158 G---PSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIwgtkapgnaQDVRDDEILKNKKKVIKMLIIVVALFALCWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 252 PNNFVLLAHIVSRLFygKSYYHVYKLTLC---LSCLNNCLDPFVYYFASREFQlrlREY 307
Cdd:cd15393 235 PLQTYNLLNEIKPEI--NKYKYINIIWFCshwLAMSNSCYNPFIYGLYNEKFK---REF 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
30-304 5.44e-14

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 71.39  E-value: 5.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  30 YSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVTVAFYANMY 108
Cdd:cd15391   7 YQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFcMPFTFTQIML-GHWVFPAPMCPIVLYVQLVSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSK-RWRRRRYAVAACAGTWLLLLTALSPLARTDLtYPVHALGIITCFDVlkWtmlPSV 187
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSRhTKSRTKCIIASIWAISFSLSSVQLFAGRTQR-YGQYSEGRVLCGES--W---PGP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAV-FLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15391 160 DTSRSaYTVFVMLLTYIIPLLILTSTYGYVGFRLwnrtapgnaDKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFN 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 258 LAHIVSRLFYGKSYY---HVYKLTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15391 240 LVQDFSTVFRNMPQHttrLIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-301 6.32e-14

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 71.37  E-value: 6.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15132   1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSP------LARTDLTYPVHALGIITCFD 177
Cdd:cd15132  81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPflflvgVEQDNNIHPDDFSRECKHTP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 178 VLKWTMLPSVAMW---AVFLFTIFILLFLIPFvitVACYTATILKLLRTEEAHGREQ-RRRAVGLAAVVLLAFVTCFAP- 252
Cdd:cd15132 161 YAVSSGLLGIMIWvttTYFFLPMLCLSFLYGF---IGRKLWKSKNDLRGPNAAARERsHRQTVRILAVVVLAFIICWLPf 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 253 --NNFVLLAHIVSRLFYGKSYYHVYKLTLCLscLNNCLDPFVYYFASREFQ 301
Cdd:cd15132 238 hiGRILFANTEDYRTMMFSQYFNIVAMQLFY--LSASINPILYNLISRKYR 286
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
24-301 1.16e-13

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 70.41  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVsMPFYIPYTL-TGKWPFGKVFCKAWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITcFDVLKWT 182
Cdd:cd15048  80 DYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWI-------------LAFLLYGPAIIG-WDLWTGY 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 --------MLPSVAMWAvFLFTIFILLFLIPFVITVACYTATILKLLR-------------------------TEEAHGR 229
Cdd:cd15048 146 sivptgdcEVEFFDHFY-FTFITSVLEFFIPFISVSFFNLLIYLNIRKrsrrrplrsvpilpasqnpsrarsqREQVKLR 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74762454 230 EQRRRAVGLaAVVLLAFVTCFAPnnFVLLAHIVSrlFYGKSYYH--VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15048 225 RDRKAAKSL-AILVLVFLICWAP--YTILTIIRS--FCSGSCVDsyLYEFTFWLLWTNSAINPFLYAACHPRFR 293
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
25-249 1.18e-13

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 70.38  E-value: 1.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVL-PFQIyYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAI-ISAFAHRWLFGDIGCVFYGFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAgTWLLLLTALSPLARTDLTYPVHALGIITCFDvlkWTM 183
Cdd:cd15074  81 FLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVA-IWLYALFWAVAPLVGWGSYGPEPFGTSCSID---WTG 156
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLL---RTEEAHGREQRRRAVGLAAVVLLAFVTC 249
Cdd:cd15074 157 ASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKssrKRVAGFDSRSKRQHKIERKVTKVAVLIC 225
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
29-258 1.59e-13

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 70.13  E-value: 1.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-LMLASVLPFqIYYHCNRHHWVFGVLLCNVVtvAFYANM 107
Cdd:cd15336   6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDfLMSLTQSPI-FFVNSLHKRWIFGEKGCELY--AFCGAL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 Y--SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTmlP 185
Cdd:cd15336  83 FgiTSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDYMTFT--P 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLftiFILLFLIPFVITVACYTATILKLLRT------------EEAHGREQRRRA----VGLAAVVLLAFVTC 249
Cdd:cd15336 161 SVRAYTMLL---FCFVFFIPLGIIIYCYLFIFLAIRSTgrevqklgsqdrKEKAKQYQRMKNewkmAKIAFVVILLFVLS 237

                ....*....
gi 74762454 250 FAPNNFVLL 258
Cdd:cd15336 238 WSPYACVAL 246
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
60-304 2.01e-13

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 69.47  E-value: 2.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  60 IFMINLSVTDLMLASVLPFQIYYHCNRHHWVfgVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRY 139
Cdd:cd14989  37 LYFVNLAVADLILVADSLIEVFNLNEKYYDI--AVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQH 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 140 AVAACAGTWLLLLTALSPLarTDLTYPVHALGIITCF-DVLKWTMLPsvamwavflftiFILLFLIPFVITVACYTATIL 218
Cdd:cd14989 115 ARLSCGLIWMASISATLLP--FTAVQAQHTGEVHFCFaDVREIQWLE------------VTLGFIIPFSIIGLCYSLIVR 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 219 KLLRTEEAHG-REQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSR-----LFYGKSYYHVYKLTLCLSCL----NNCL 288
Cdd:cd14989 181 VLVRAQKHRRlRPRRQKALRMILVVVLVFFICWLPENVFISIQLLQGtqepsESYDESFRHNHPLTGHIVNLaafsNSCL 260
                       250
                ....*....|....*.
gi 74762454 289 DPFVYYFASREFQLRL 304
Cdd:cd14989 261 NPLIYSFLGETFRDKL 276
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-302 2.87e-13

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 69.15  E-value: 2.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  36 VSIPGN-LFSLWVLCRRMgPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVAFYANMYSSILT 113
Cdd:cd15326  13 FAIVGNiLVILSVVCNRH-LRIPTNYFIVNLAIADLLLSFtVLPFSATLEI-LGYWVFGRIFCDIWAAVDVLCCTASILS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 114 MTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhalgIITCFDVLKWTMLPS-----VA 188
Cdd:cd15326  91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLST-------------------VISIGPLLGWKEPAPpddkvCE 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 189 MWAVFLFTIFILL--FLIPFVITVACYTATILKLLRteeaHGREqrRRAVGLAAVVLLAFVTCFAPnnFVLLAHIVSRLF 266
Cdd:cd15326 152 ITEEPFYALFSSLgsFYIPLIVILVMYCRVYIVALK----FSRE--KKAAKTLGIVVGMFILCWLP--FFIALPLGSLFS 223
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 74762454 267 YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQL 302
Cdd:cd15326 224 HLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKR 259
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-301 6.10e-13

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 68.24  E-value: 6.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWV--LCRRMgpRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15012   4 ILYTLVFCCCFFGNLLVILVvtSHRRM--RTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKR---WRRRRYAVAACAGTWLLLLTALSPLARTdLTYPVHALGIITCFDVLKWT 182
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKQlltAARLRVTIVTVWLTSAVYNTPYFVFSQT-VEILVTQDGQEEEICVLDRE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLpSVAMWAVFlftIFILLFLIPFVITVACYTATILKLLRteeAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15012 161 MF-NSKLYDTI---NFIVWYLIPLLIMTVLYSKISIVLWK---SSSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYW 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 263 SRLFYGKSYYH--VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15012 234 SEPYRCDSNWNalLTPLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
26-301 8.68e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 67.85  E-value: 8.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGN--LFSLWVLCRRMgpRSPSVIFMINLSVTDLMLASVLPFqiYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15176   3 LPVFYTIALVVGLAGNslVVAIYAYYKKL--KTKTDVYILNLAVADLLLLFTLPF--WAADAVNGWVLGTAMCKITSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVaaCAGTWLLLLTalsplartdLTYPVHALGII-------TCF 176
Cdd:cd15176  79 TMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIV--CLCVWLLAIL---------LSIPDLVFSTVrensdryRCL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 177 DVLKWTMLPSVAmwAVFLFTIFILLFLIPFVITVACYTATILKLLRTEeahgREQRRRAVG-LAAVVLLAFVTCFaPNNF 255
Cdd:cd15176 148 PVFPPSLVTSAK--ATIQILEVLLGFVLPFLVMVFCYSRVARALSRTP----NVKKSRALKvLLAVVGVFIVTQL-PYNV 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 256 VLLAHIVSRLF-------YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15176 221 VKFYRAIDVIYllitdcsMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
25-300 1.69e-12

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 66.61  E-value: 1.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSiVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPvhalGIITCFDVLKWTM 183
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSAL---------ISFP----AIAWWRAVDPGPS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMW---AVFLFTIFILLFLIPFVITVACYTatilkllRTEEAHGREQrrRAVGLAAVVLLAFVTCFAPnNFV---L 257
Cdd:cd15067 148 PPNQCLFtddSGYLIFSSCVSFYIPLVVMLFTYY-------RIYRAAAKEQ--KAAKTLGIVMGVFILCWLP-FFVtniL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 258 LAHIVSRLFYGKSYyhVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15067 218 IGFCPSNCVSNPDI--LFPLVTWLGYINSGMNPIIYACSSRDF 258
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
24-301 1.88e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 66.91  E-value: 1.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDL--MLASVlPFQ--IYYHcnrHHWVFGVLLCNVV 99
Cdd:cd15927   1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLllLLTCV-PFTstIYTL---DSWPFGEFLCKLS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 100 TVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALG-----IIT 174
Cdd:cd15927  77 EFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDnqtiqICY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 CFDVLKWTMLPSVAMWAVFLftifiLLFLIPFVITVACYTATILKLLRT-------EEAHGREQRRRAVGLAAVVL---L 244
Cdd:cd15927 157 PYPQELGPNYPKIMVLLRFL-----VYYLIPLLIIGVFYVLMARHLIRStrnigsgQNQAAQRQIEARKKVAKTVLafvV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74762454 245 AFVTCFAPNN-FVLLAHIVSrlfYGKSYY----HVYKLT-LCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15927 232 LFAVCWLPRHvFMLWFHFAP---NGLVDYnafwHVLKIVgFCLSFINSCVNPVALYLLSGSFR 291
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-293 3.34e-12

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 66.04  E-value: 3.34e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd16002   5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLsSKRWRRRRYAVAACAgTWLLLLTALSPLARTDLTYPVHalGIITCFdvLKWTMLPSV 187
Cdd:cd16002  85 FASIYSMTAIALDRYMAIIHPL-QPRLSATATKVVICV-IWVLAFLLAFPQGYYSDTEEMP--GRVVCY--VEWPEHEER 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTE---EAHGR-----EQRRRAVGLAAVVLLAFVTCFAPNN-FVLL 258
Cdd:cd16002 159 KYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEipgDSSDRyheqvSAKRKVVKMMIVVVCTFAICWLPYHiYFLL 238
                       250       260       270
                ....*....|....*....|....*....|....*
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVY 293
Cdd:cd16002 239 QYFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
24-300 9.84e-12

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 64.66  E-value: 9.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYEL-RGEWPLGPVFCNIYISL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPlartdltyPVHaLGIITCFDVLKWT 182
Cdd:cd15051  80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFL--------PIH-LGWNTPDGRVQNG 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPS---VAMWAVFLFTIFILLFLIPFVITVACYTaTILKLLRTE-----------------EAHGREQRRRAVGLAAvV 242
Cdd:cd15051 151 DTPNqcrFELNPPYVLLVAIGTFYLPLLIMCGVYL-RIFRIAREQakrinaltpastansskSAATAREHKATVTLAA-V 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74762454 243 LLAFVTCFAPnNFVLLAhiVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15051 229 LGAFIICWFP-YFTYFT--YRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDF 283
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
24-301 1.01e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 64.53  E-value: 1.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGN-LFSLWVLCRRMgPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTV 101
Cdd:cd15325   1 IVLGVILGGFILFGVLGNiLVILSVACHRH-LQTVTHYFIVNLAVADLLLTStVLPFSAIFEI-LGYWAFGRVFCNIWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALS-------PLARTDLTypvhalgiit 174
Cdd:cd15325  79 VDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIgplfgwkEPAPEDET---------- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 cfdVLKWTMLPSVAMWAVFLFtifillFLIPFVITVACYTATILKLLRteeaHGREqrRRAVGLAAVVLLAFVTCFAPnn 254
Cdd:cd15325 149 ---ICQITEEPGYALFSALGS------FYLPLAIILVMYCRVYVVALK----FSRE--KKAAKTLGIVVGCFVLCWLP-- 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 255 FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15325 212 FFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFK 258
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
28-300 1.23e-11

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 64.29  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAIlVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhALGIITCFdVLKWT--ML 184
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSA----------------AIACPLLF-GLNNVpyRD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 PSVAMWAVFLFTIF--ILLFLIPFVITVACYTATILKLLRteeahgreqRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIV 262
Cdd:cd15053 148 PEECRFYNPDFIIYssISSFYIPCIVMLLLYYRIFRALRR---------EKKATKTLAIVLGVFLFCWLPFFTLNILNAI 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 263 SRLFYGKSY---YHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15053 219 CPKLQNQSChvgPALFSLTTWLGYVNSFLNPIIYTIFNIEF 259
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 1.31e-11

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 64.57  E-value: 1.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd16003   5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALgiitCFdvLKWTMLPSV 187
Cdd:cd16003  85 FASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTL----CF--VAWPGGPDQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMwaVFLFTIFILLFLIPFVITVACYTATILKLLRTE-------EAHGR-EQRRRAVGLAAVVLLAFVTCFAPNN-FVLL 258
Cdd:cd16003 159 HF--TYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEipgdtsdKYHEQlRAKRKVVKMMIIVVLTFAICWLPYHiYFIV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 259 AHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd16003 237 TGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
28-300 1.41e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 64.18  E-value: 1.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA--SVLPFQIyyhcnrhhWVFGV------LLCNVV 99
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlfNVLPQLI--------WDITYrfyggdLLCRLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 100 TVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAAcAGTWLLLLTALSPLArTDLTYPVHALGIITCFDVL 179
Cdd:cd15196  77 KYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMV-AIAWVLSLLLSIPQL-FIFSYQEVGSGVYDCWATF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 --KWTMLPSVAMwavflftIFILLFLIPFVITVACYTATILKLLRTeeahgreqRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15196 155 epPWGLRAYITW-------FTVAVFVVPLIILAFCYGRICYVVWRA--------KIKTVKLTLVVVACYIVCWTPFFVVQ 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 258 LAHivsrLFYGKSYYH--VYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15196 220 MWA----AWDPTAPIEgpAFVIIMLLASLNSCTNPWIYLAFSGNL 260
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
24-304 1.67e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 64.31  E-value: 1.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVsipGNLFSLWVLCRRMGPRSPSV-IFMINLSVTDLMLA-SVLPFQIYYHCNRHhWVFGVLLCNVVTV 101
Cdd:cd15383   4 VAVTFVLFVLSAC---SNLAVLWSATRNRRRKLSHVrILILHLAAADLLVTfVVMPLDAAWNVTVQ-WYAGDLACRLLMF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAV--AACAGTWLLLLTALSPLARTDLTYPVHalgIITCFdvl 179
Cdd:cd15383  80 LKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMlcAAWGLSALLALPQLFLFHTVTATPPVN---FTQCA--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 kwTMLPSVAMW---AVFLFTiFILLFLIPFVITVACYTATILKLLR---------TEEAHGREQ-------RRRAVGLAA 240
Cdd:cd15383 154 --THGSFPAHWqetLYNMFT-FFCLFLLPLLIMIFCYTRILLEISRrmkekkdsaKNEVALRSSsdnipkaRMRTLKMTI 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74762454 241 VVLLAFVTCFAPNNFV---------LLAHIVSrlfygKSYYHVYKLtlcLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15383 231 VIVSSFIVCWTPYYLLglwywfspeMLEQTVP-----ESLSHILFL---FGLLNACLDPLIYGLFTISFRRGL 295
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
26-301 1.67e-11

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 64.11  E-value: 1.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15357   3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTD----LTYPVHAL--GIITCfdv 178
Cdd:cd15357  83 TVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHgiklQYFPNGTLipDSATC--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 lkwTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL-----LRTEEAHGREQR--RRAVG-LAAVVLLAFVTCF 250
Cdd:cd15357 160 ---TVVKPLWIYNLIIQITSLLFYVLPMGVISVLYYLMGLKLrgdksLEADEMNVNIQRpsRKSVTkMLFVLVLVFAICW 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 251 APNNfvllahiVSRLFYG------KSYYHVYKLTLCLS----CLNNCLDPFVYYFASREFQ 301
Cdd:cd15357 237 APFH-------VDRLFFSfvvewtEPLANVFNLIHVVSgvffYLSSAVNPIIYNLLSRRFR 290
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
61-252 3.16e-11

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 63.10  E-value: 3.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  61 FMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRY 139
Cdd:cd15052  38 FLMSLAIADLLVGLlVMPLSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTT 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 140 AVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKWT--MLPSVAmwavflFTIF--ILLFLIPFVITVACYTA 215
Cdd:cd15052 118 VFLKIAIVWLISIG---------ISSPIPVLGIIDTTNVLNNGtcVLFNPN------FVIYgsIVAFFIPLLIMVVTYAL 182
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 74762454 216 TIlKLLRTEeahgreqrRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd15052 183 TI-RLLSNE--------QKASKVLGIVFAVFVICWCP 210
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
28-302 3.92e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 62.97  E-value: 3.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15978   5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKD-FIFGSAVCKTATYFMGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALsplartdLTYPVHA-LGIITCFDVLKWTM-- 183
Cdd:cd15978  84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIM-------LPYPIYSnLVPFTRINNSTGNMcr 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 --LPSVAM---WAVFLftiFILLFLIPFVITVACYTATILKLLRTEEAhgREQRRRAVGLAAVVLLAFVTCFAPNNFVLL 258
Cdd:cd15978 157 llWPNDVTqqsWYIFL---LLILFLIPGIVMMTAYGLISLELYRGIKF--LMAKKRVIRMLIVIVILFFLCWTPIFSANA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 74762454 259 AHIVSRLFYGKSYYHV-YKLTLCLSCLNNCLDPFVYYFASREFQL 302
Cdd:cd15978 232 WRAFDTRSADRLLSGApISFIHLLSYTSACVNPIIYCFMNKRFRM 276
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
28-301 4.56e-11

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 62.52  E-value: 4.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCnRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15979   5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAvFCMPFTLIPNL-MGTFIFGEVICKAVAYLMGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVH-ALGIITCFDVLKWTMLP 185
Cdd:cd15979  84 VSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPvGDRPRGHQCRHAWPSAQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIfilLFLIPFVITVACYtatilKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPnnfvLLAHIVSRL 265
Cdd:cd15979 164 VRQAWYVLLLLI---LFFIPGVVMIVAY-----GLISRELYRGLLAKKRVIRMLVVIVAMFFLCWLP----IFSANTWRA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 266 FYGKSYYHVY-----KLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15979 232 FDPLSAHRALsgapiSFIHLLSYTSACVNPLVYCFMNRRFR 272
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
24-301 5.29e-11

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 62.12  E-value: 5.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFS-LWVLCRRmGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCnRHHWVFGVLLCNVVTV 101
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLViLSVACNR-HLRTPTHYFIVNLAVADLLLsFTVLPFSATLEV-LGYWAFGRIFCDVWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhalgIITCFDVLKW 181
Cdd:cd15062  79 VDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSL-------------------VISIGPLLGW 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 T--MLPSVAMWAVFLFTIFILL-----FLIPFVITVACYTatilKLLRTEEAHGREqrRRAVGLAAVVLLAFVTCFAPNN 254
Cdd:cd15062 140 KepAPADEQACGVNEEPGYVLFsslgsFYLPLAIILVMYC----RVYVVAFKFSRE--KKAAKTLGIVVGAFVLCWFPFF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 255 FVL-LAHIVSRLfygKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15062 214 VVLpLGSLFSTL---KPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
28-301 1.58e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 61.12  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAn 106
Cdd:cd14968   5 VLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPLAILISLGLPTNFHGCLFMACLVLVLTQ- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 mySSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA----RTDLTYPVHALGIITC-FDvlkw 181
Cdd:cd14968  84 --SSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMfgwnNGAPLESGCGEGGIQClFE---- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 tmlpSVAMWAVFLFTIFILLFLIPFVITVACYTAtILKLLRTEEAHGREQ------------RRRAVGLAAVVLLAFVTC 249
Cdd:cd14968 158 ----EVIPMDYMVYFNFFACVLVPLLIMLVIYLR-IFRVIRKQLRQIESLlrsrrsrstlqkEVKAAKSLAIILFLFALC 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 250 FAPnnfvllAHIVS--RLFYGKSYYH--VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd14968 233 WLP------LHIINciTLFCPECKVPkiLTYIAILLSHANSAVNPIVYAYRIRKFR 282
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
24-301 2.31e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 60.42  E-value: 2.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAvLVMPLSAVYEL-TGRWILGQVLCDIWISL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhalgIITCFDVLKW- 181
Cdd:cd15064  80 DVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSI-------------------CISLPPLFGWr 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 ---TMLPSVAMWAV-FLFTIF--ILLFLIPFVITVACYTatilkllRTEEAHGREqrRRAVGLAAVVLLAFVTCFAPnnF 255
Cdd:cd15064 141 tpdSEDPSECLISQdIGYTIFstFGAFYIPLLLMLILYW-------KIYRAAARE--RKAAKTLGIILGAFIVCWLP--F 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 256 VLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15064 210 FLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
28-293 2.38e-10

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 60.53  E-value: 2.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYhCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFcIPSEAIW-AYTVAWLAGNTMCKLVKYLQVFG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAacAGTWLLLltalsplartdltyPVHALGIITCFDVLKWTMLPS 186
Cdd:cd15384  84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMV--TVAWILS--------------PIFSIPQAVIFHVERGPFVED 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 ----------VAMWAVFLFT--IFILLFLIPFVITVACYTATILKLLRTEE----------AHGREQRR-------RAVG 237
Cdd:cd15384 148 fhqcvtygfyTAEWQEQLYNmlSLVFMFPIPLVIMVTCYVLIFITLSKSSRdfqgleiytrNRGPNRQRlfhkakvKSLR 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 238 LAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSclNNCLDPFVY 293
Cdd:cd15384 228 MSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMS--NSCVNPLIY 281
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
24-301 2.43e-10

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 60.31  E-value: 2.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFS-LWVLCRRMgPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCnRHHWVFGVLLCNVVTV 101
Cdd:cd15327   1 VGVGVFLAIFILMAIVGNILViLSVACNRH-LQTVTNYFIVNLAIADLLLsTTVLPFSATLEV-LGFWAFGRVFCDIWAA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdltypvhalgIITCFDVLKW 181
Cdd:cd15327  79 VDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSM-------------------VISIGPLLGW 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLP-------SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRteeaHGREqrRRAVGLAAVVLLAFVTCFAPNN 254
Cdd:cd15327 140 KEPPppdesicSITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALK----FSRE--KKAAKTLAIVVGVFILCWFPFF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 74762454 255 FVL-LAHIVSRLfygKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15327 214 FVLpLGSFFPAL---KPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFK 258
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
24-300 3.28e-10

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 60.20  E-value: 3.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNrHHWVFGVLLCNVVTVA 102
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVlVMPFGAIELVN-NRWIYGETFCLVRTSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAAcAGTWLLLLTALSPlarTDLTYPVHaLGIITCFDVLKWT 182
Cdd:cd15056  80 DVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVML-GGCWVIPTFISFL---PIMQGWNH-IGIEDLIAFNCAS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIF--ILLFLIPFVITVACY-----TAT-----ILKLLR-----TEEAHGREQRRRAVGLAA----V 241
Cdd:cd15056 155 GSTSCVFMVNKPFAIIcsTVAFYIPALLMVLAYyriyvAAReqahqIRSLQRagssnHEADQHRNSRMRTETKAAktlgI 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 242 VLLAFVTCFAPnnfVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15056 235 IMGCFCVCWAP---FFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSF 290
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-301 5.11e-10

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 59.71  E-value: 5.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQIYYHCNRHhWVFGVLLCNVVTVAF 103
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLvIIICLPATLLVDVTET-WFFGQVLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRryAVAACAGTWLLLLTALSPLART-DLTYPVHALGIITCFDVLK-- 180
Cdd:cd15208  81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKR--ARVSILIIWIVSLLIMIPQAIVmECSRVVPLANKTILLTVCDer 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAMWAVFlftIFILLFLIPFVITVACYTATILKLLR----------------------TEEAHGREQRRRAVGL 238
Cdd:cd15208 159 WSDSIYQKVYHIC---FFLVTYLLPLCLMILAYFQIFRKLWCrqipgtssvvqrkwnkprksavAAEEKQLRSRRKTAKM 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 239 AAVVLLAFVTCFAPnnfvllAHIVSRLFYGKSYYH-----VYKLTLC---LSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15208 236 LIVVVIMFAICYLP------VHLLNILRYVFGLFTvdretIYAWFLFshwLVYANSAINPIIYNFMSGKFR 300
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
25-302 5.57e-10

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 59.74  E-value: 5.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM-LASVLPFQIYYHCNRhHWVFGVLLCNVVTVAF 103
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLlLLLCVPLNAYNLLTK-DWLFGDVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA--RTDLTYPVHALGIIT-Cfdvlk 180
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAvlSTVARESSLDNSSLTvC----- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 wTMLPSVAMWAVF----LFTIFILLFLIPFVITVACYTATILKLLRTEEAHGR------EQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd14977 156 -IMKPSTPFAETYpkarSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRgtkkhmKQRRQLAKTVLCLVLVFAFCW 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 251 APNNfvlLAHIVsRLFYGKSYYHVYKLTL--------CLSCLNNCLDPFVYYFASREFQL 302
Cdd:cd14977 235 LPEH---ISNIL-RATLYNEVLIDTRSTLdildligqFLSFFNSCVNPIALYLLSEPFRR 290
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
28-300 6.20e-10

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 59.53  E-value: 6.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSViFMINLSVTDLMLASVLPFQIyyHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVIAVLIVKRFMFVVDV-YLFNIAMSDLMLVFSFPFII--HNDLNEWIFGEFMCKLVLGVYFVGF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  108 YSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTalsplartdLTYPVHALGIITCFDVLKWTML--- 184
Cdd:PHA02834 110 FSNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVI---------LSMPAMVLYYVDNTDNLKQCIFndy 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  185 -PSVAMWAVFLFTIFILLFLIPFVITVACYTatilKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVS 263
Cdd:PHA02834 180 hENFSWSAFFNFEINIFGIVIPLIILIYCYS----KILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQ 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 74762454  264 RL-FYGKSYYHVYKLTLC------LSCLNNCLDPFVYYFASREF 300
Cdd:PHA02834 256 SVgLIDIGCYHFKKIVYSidiaelISFVHCCVNPIIYAFVGKNF 299
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
30-311 9.50e-10

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 58.81  E-value: 9.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  30 YSLVAAVSIPGNLFSLWVLC------RRMgpRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15307   3 WALLALVLVLGTAAGNILVClaiaweRRL--QNVTNYFLMSLAITDLMVAVlVMPLGILTLV-KGHFPLSSEHCLTWICL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdvlkwt 182
Cdd:cd15307  80 DVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTC------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSvamwAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQR--RRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15307 153 QIPD----PVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRleQKATKVLGVVFFTFVILWSPFFVLNLLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 261 IVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCR 311
Cdd:cd15307 229 TVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
27-300 9.98e-10

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 58.58  E-value: 9.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVI--FMINLSVTD-LMLASVLPFQIYYHCnRHHWVFGVLLCNVVTVAF 103
Cdd:cd15002   3 PILLGVICLLGFAGNLMVIGILLNNARKGKPSLIdsLILNLSAADlLLLLFSVPFRAAAYS-KGSWPLGWFVCKTADWFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRR-YAVAACAGTWLLLLTALSPLARTdLTYPVHALGIITCFDVlkwt 182
Cdd:cd15002  82 HACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRiTAVVASIWVPACLLPLPQWLFRT-VKQSEGVYLCILCIPP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 mlPSVAMWAVFLFTIFILLFLIPFVITVACYTATI--LKLLRTEEAHGREQRRR---AVGLAAVVlLAFVTCFAPnNFVL 257
Cdd:cd15002 157 --LAHEFMSAFVKLYPLFVFCLPLTFALFYFWRAYgqCQRRGTKTQNLRNQIRSrklTHMLLSVV-LAFTILWLP-EWVA 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHIVSRLFYGKSYYHVYK-LTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15002 233 WLWLIHIKSSGSSPPQLFNvLAQLLAFSISSVNPIIFLLMSEEF 276
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
24-293 1.16e-09

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 58.68  E-value: 1.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLcLPFTLVYTL-LDEWKFGAVLCHLVPYA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACagTWLLLLTALSPLA---RTDLTYPVHALGIITCFDvl 179
Cdd:cd15399  80 QALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGL--TWAASALLASPLAifrEYSVIEISPDFKIQACSE-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMlPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLR-----TEEAHGREQRRRAVGLAAVVLLAFVTCFAP-N 253
Cdd:cd15399 156 KWPN-GTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNhvspgGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPfH 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 254 NFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVY 293
Cdd:cd15399 235 AFQLASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLY 274
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
24-300 1.49e-09

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 58.17  E-value: 1.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM--LASVLPFQIYYHCNRHHWVFGVLLCNVVTV 101
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMvlVAAGLPNEIESLLGPDSWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCfdvlKW 181
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVV----RC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFLFTIFILLFLIPFVITVACYtATILKLLRTeeahgreQRRRAVGLAAVVLLAFVTCFAPNNFVllahI 261
Cdd:cd14995 157 GYKVSRHYYLPIYLADFVLFYVIPLLLAIVLY-GLIGRILFS-------SRKQVTKMLAVVVVLFALLWMPYRTL----V 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 74762454 262 VSRLFYGKSYYHVYKLTLCLSC--LNNCLDPFVYYFASREF 300
Cdd:cd14995 225 VYNSFASPPYLDLWFLLFCRTCiyLNSAINPILYNLMSQKF 265
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
32-308 1.81e-09

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 57.80  E-value: 1.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLML---ASVLPFQIYYHCNRHHWVFGVLLCN-VVTVAFYANM 107
Cdd:cd15110   9 IICLLGLVGNGIVLWFLGFRI-RRNPFTVYILHLAIADFTFllcIFILSIMYIGPFNFSHSRDYVAMLIfIILFLFGYNT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YssILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVLKWTMLPSV 187
Cdd:cd15110  88 G--LYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWA-------------LSVLMTSLEYLMCIDEGFHVRNECR 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMwavfLFTIFILLFLIpfVITVACYTATILKLlrteEAHGREQRRRAVGLAAVVLLAFVtcfapnnFVLLAHIVSRLFY 267
Cdd:cd15110 153 AV----LIFIGILTFLV--FTPLMLISSLILFI----KVRCNSQRRHPGKLYIIIMLTVI-------FFLIFAMPMRVLL 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 268 GKSYYHVYKL------TLCLSCLNNCLDPFVYYFASREFQLRLREYL 308
Cdd:cd15110 216 LLNYLHHSSFlfsnpvPFLLSTVNSSINPIVYFLVGSLRRKRIKKSL 262
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
36-270 2.41e-09

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 57.59  E-value: 2.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  36 VSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMT 115
Cdd:cd15131  13 VGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNIT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 116 CISVERFLGVLYPLSSKRWRRRR---------YAVAACAGTWLLLLTALSPLARTDltyPVHALGIITCFDVLKWTMLps 186
Cdd:cd15131  93 ALSVERYFAICFPLRAKVVVTKRrvklvilvlWAVSFLSAGPIFVLVGVEHENGTN---PIDTNECKATEYAVRSGLL-- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 vamwAVFLFTIFILLFLIPFVITVAcYTATILKLLRTEE-------AHGREQRRRAVGLAAVVLLAFVTCFAPnnFVLLA 259
Cdd:cd15131 168 ----TIMVWVSSVFFFLPVFCLTVL-YSLIGRKLWRRRRenigpnaSHRDKNNRQTVKMLAVVVFAFVLCWLP--FHVGR 240
                       250
                ....*....|.
gi 74762454 260 HIVSRLFYGKS 270
Cdd:cd15131 241 YLFSKSFEAGS 251
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
28-252 2.49e-09

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 57.86  E-value: 2.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15358   5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLELYEMWSNYPFLLGAGGCYFKTLLFETV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPS 186
Cdd:cd15358  85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPCRGPVPDSATCMLVKP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWAVFLFTIFILLFLIPFVITVACYTATIL-----KLLRTEEAHGRE---------------QRRRAVGLAAVVLLAF 246
Cdd:cd15358 165 RWMYNLIIQITTLLFFFLPMGTISVLYLLIGLqlkreKMLLVLEAKGSKagdsyqhrriqqekrRRRQVTKMLFVLVVVF 244

                ....*.
gi 74762454 247 VTCFAP 252
Cdd:cd15358 245 GICWAP 250
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
28-297 2.90e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 57.05  E-value: 2.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd14964   3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKwtmlpSV 187
Cdd:cd14964  83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICT-----TI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTifilLFLIPFVITVACYTATILKLLRTEEAHGREQRR------RAVGLAAVVLLAFVTCFAPNNFVLLAHI 261
Cdd:cd14964 158 YLTWGFLLV----SFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLntdknlKATKSLLILVITFLLCWLPFSIVFILHA 233
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 74762454 262 VSRLFYGKSYyhVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd14964 234 LVAAGQGLNL--LSILANLLAVLASTLNPFIYCLGN 267
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-148 6.52e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 56.38  E-value: 6.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15133   5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFETV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15133  85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVW 126
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
55-300 9.70e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 55.35  E-value: 9.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  55 RSPSVIFMINLSVTDLMLA-SVLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPL--SS 131
Cdd:cd15329  32 RTPSNYLIVSLAVSDLLVAlLVMPLAIIYELSGY-WPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLtyAV 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 132 KRWRRRRYAVAACAgtWLLLltalsplartdltypvhalGIITCFDVLKWTMLPSV----AMWAVFLFTIF--ILLFLIP 205
Cdd:cd15329 111 KRTPKRMALMIAIV--WLLS-------------------ALISIPPLFGWKNKVNDpgvcQVSQDFGYQIYatFGAFYIP 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 206 FVITVACYtATILKLLRTEeahgreqrRRAVGLAAVVLLAFVTCFAPnnFVLLAHIVSRLFYGKSYY---HVYKLTLCLS 282
Cdd:cd15329 170 LIVMLVLY-YKIYRAAKSE--------RKAIKTLGIIMGAFTLCWLP--FFILALLRPFLKPIKCSCiplWLSRLFLWLG 238
                       250
                ....*....|....*...
gi 74762454 283 CLNNCLDPFVYYFASREF 300
Cdd:cd15329 239 YANSFLNPIIYAKFNREF 256
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
24-293 1.44e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 55.33  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVsipGNLFSLWVLCRRMGPRSPSVI--FMINLSVTDLM-LASVLPFQIYYHCNRHHWVFGVLLCNVVT 100
Cdd:cd14981   4 PAPPALMFVFGVL---GNLLALIVLARSSKSHKWSVFyrLVAGLAITDLLgILLTSPVVLAVYASNFEWDGGQPLCDYFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPlartdltyPVHALGIIT------ 174
Cdd:cd14981  81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASL--------PLLGLGSYVlqypgt 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 -CFdvlkWTMLPSVAMWAVFLFTIFILLFLIPFViTVACYTATILKLLRTEEAHGREQRRRA------------VGLAAV 241
Cdd:cd14981 153 wCF----LDFYSKNTGDAAYAYLYSILGLLILLV-TLLCNLLVIITLLRMRRRKKRHRRSRRsarrqkrneiqmVVLLLA 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 242 VLLAFVTCFAPnnfvLLAHIVSRLFYGKSYYHVYKL-TLCLSCLNNCLDPFVY 293
Cdd:cd14981 228 ITVVFSVCWLP----LMIRVLINATGDSEKNGKTDLlAVRMASWNQILDPWVY 276
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
24-148 1.53e-08

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 55.18  E-value: 1.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRrMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNrHHWVFGVLLCNVVTVAF 103
Cdd:cd14994   2 YSLIFLYSVVLIGGVIGVILMSFLLVK-MNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYAS-KTWKFGMPLCKMVSAMI 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd14994  80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVW 124
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
24-301 2.48e-08

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 54.57  E-value: 2.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIF---MINLSVTDLMLASV-LPFQIYYHCNRHH-WVFGVLLCNV 98
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLaMPVELYNFIWVHHpWAFGDAGCRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLART--------DLTYPvhal 170
Cdd:cd15130  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTmglqnesdDGTHP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 171 GIITCfdvlkwTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTeeahgreqRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15130 157 GGLVC------TPIVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQA--------LRRGVLVLRAVVIAFVVCW 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 251 APNN-----FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15130 223 LPYHvrrlmFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
24-301 3.09e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 53.97  E-value: 3.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCNrHHWVFGVLLCNVVTVA 102
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLE-SKWILGRPVCLFWLSM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltalsplartdltypvhALGIITCFDVLKWT 182
Cdd:cd15050  80 DYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAW--------------------LLSFLWVIPILGWH 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVA------------MWAVFLFTIF--ILLFLIPFVITVaCYTATILKLLRTEeahgreqrRRAVGLAAVVLLAFVT 248
Cdd:cd15050 140 HFARGGervvledkcetdFHDVTWFKVLtaILNFYIPSLLML-WFYAKIFKAVNRE--------RKAAKQLGFIMAAFIL 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 249 CFAPnNFVLLahIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15050 211 CWIP-YFILF--MVIAFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFK 260
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
25-301 4.51e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 53.77  E-value: 4.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCnRHHWVFGVLLCNVVTVAF 103
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLlTCVPVDATRYI-ADTWLFGRIGCKLLSFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd15123  81 LTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRT-------EEAHGREQ---RRRAVGLAAVVLLAFVTCFAPN 253
Cdd:cd15123 161 VSEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKStfnmpaeEHSHARKQiesRKRVAKTVLVLVALFAFCWLPN 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 254 NFVLLAH-IVSRLFYGKSYYH----VYKLTLCLSclNNCLDPFVYYFASREFQ 301
Cdd:cd15123 241 HILYLYRsFTYHTSVDSSAFHliatIFSRVLAFS--NSCVNPFALYWLSKSFR 291
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
24-301 4.53e-08

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 53.67  E-value: 4.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15395   1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMcLPFTFVYTL-MDHWVFGEAMCKLNSMV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPlssKRWR-RRRYAVAACAGTWLLLLTALS----PLARTDLTYPVHAL------G 171
Cdd:cd15395  80 QCISITVSIFSLVLIAIERHQLIINP---RGWRpNNRHAYVGIAVIWVLAVLTSLpfliFQVLTDEPFKNVNVsldaykG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 172 IITCFDvlkwtMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGREQRRRAVGLAAVV 242
Cdd:cd15395 157 KYVCLD-----QFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLkrrnnmmdkMRDNKYRSSETKRINIMLISIV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 243 lLAFVTCFAP-NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15395 232 -VAFAVCWLPlNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 5.23e-08

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 53.69  E-value: 5.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLC--RRMgpRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd16004   5 IAYSLIVLVAVTGNATVIWIILahRRM--RTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVaaCAGTWllllTALSPLARTDLTYPVHALGIITCFDVLKWTMLP 185
Cdd:cd16004  83 AMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVV--IAGIW----LVALALAFPQCFYSTVTMDQGRTKCIVAWPGDS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRT----EEAHGREQR-----RRAVGLAAVVLLAFVTCFAPNNF- 255
Cdd:cd16004 157 GGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSavpgHQAHGAYHRqlqakKKFVKTMVVVVVTFAICWLPYHLy 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 256 VLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd16004 237 FILGSFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
24-301 5.47e-08

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 53.30  E-value: 5.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYyHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLnMPFALV-TIITTRWIFGDAFCRVSAMF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTwLLLLTALSPLARTDLTYPVHALGIitcfdVLKWT 182
Cdd:cd15404  80 FWLFVMEGVAILLIISIDRFLIIVQKQDKLNPYRAKVLIAVSWAV-SFCVAFPLAVGSPDLQIPSRAPQC-----VFGYT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIFillFLIPFVITVACYTAtILKLLRTeeahgreQRRRAVGLAAVVLLAFVTCFAP-NNFVLLAHI 261
Cdd:cd15404 154 TNPGYQAYVILIMLIF---FFIPFMVMLYSFMG-ILNTVRS-------FKTRAFTTILILFIVFTVCWAPfTTYSLVATF 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 262 VSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15404 223 NSHFYHKHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-301 5.69e-08

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 53.42  E-value: 5.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML----ASVLPFQIYYHcnrhHWVFGVLLCNVVTV 101
Cdd:cd15125   3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLlvtcVPVDASRYFYE----EWMFGTVGCKLIPV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKW 181
Cdd:cd15125  79 IQLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 ----TMLPSVAMwavflFTIFILLFLIPFVITVACYTATILKLLRTEE-------AHGREQRRRAVGLAAVVLLaFVTCF 250
Cdd:cd15125 159 pqtdEMHPKIHS-----VLIFLVYFLIPLAIISIYYYHIAKTLIKSAHnipgeysEHSKRQMETRKRLAKIVLV-FVGLF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 251 A----PNNFVLLAHIVSRLFYGKSYYH--VYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15125 233 AfcwfPNHVLYMYRSFNYNEIDSSLGHmiVTLVARVLSFCNSCVNPFALYLLSESFR 289
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-297 5.88e-08

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 53.65  E-value: 5.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA--SVLPFQIYYHCNRhhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVAlfQVLPQLIWEITYR--FQGPDLLCRAVKYLQVLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRwRRRRYAVAACAGTWLLLLTALSPLART-DLTYPVHALGIITCfdvlkwtmlp 185
Cdd:cd15386  84 MFASTYMLIMMTVDRYIAVCHPLRTLQ-QPSRQAYLMIGATWLLSCILSLPQVFIfSLREVDQGSGVLDC---------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 svamWAVFLFT---------IFILLFLIPFVITVACY---TATILKLLRTEEAHGREQRR-------------------- 233
Cdd:cd15386 153 ----WADFGFPwgakayitwTTLSIFVLPVAILIVCYsliCYEICKNLKGKTQTSRSEGGgwrtqgmpsrvssvrtisra 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 234 --RAVGLAAVVLLAFVTCFAPnnfvllahivsrlFYGKSYYHV--------------YKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15386 229 kiRTVKMTFVIVLAYIACWAP-------------FFSVQMWSVwdenapdedssdfaFTITMLLASLSSCCNPWIYMFFS 295
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
26-301 6.00e-08

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 53.59  E-value: 6.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15397   3 LVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVcLPFTVVYTL-MDYWIFGEVLCKMTPFIQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYavAACAGTWLLLLTALS-PLARTDLT-YPVHALGIITCFDVLKWT 182
Cdd:cd15397  82 MSVTVSILSLVLIALERHQLIINPTGWKPSVSQAY--LAVVVIWMLACFISLpFLAFHILTdEPYKNLSHFFAPLADKAV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAV-FLFTIFILLF--LIPFVITVACYTATILKLL-------RTEEAHGR-EQRRRAVGLAAVVLLAFVTCFA 251
Cdd:cd15397 160 CTESWPSEHHkLAYTTWLLLFqyCLPLLFILVCYLRIYLRLRrrkdmleRRGEYNRRaGHSKRINVMLVSLVAAFALCWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 252 P-NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15397 240 PlNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
28-301 6.23e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 53.05  E-value: 6.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15310   5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATlVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPL----SSKRWRRRRYAVAACAgTWLLLLTalsplartdLTYPVhALGIITCFDvlkwt 182
Cdd:cd15310  85 CTASILNLCAISIDRYTAVVMPVhyqhGTGQSSCRRVSLMITA-VWVLAFA---------VSCPL-LFGFNTTGD----- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 mlPSVAMWAVFLFTIF--ILLFLIPFVITVACYTATILKLLRteeahgreqRRRAVGLAAVVLLAFVTCFAPnnfVLLAH 260
Cdd:cd15310 149 --PTVCSISNPDFVIYssVVSFYLPFGVTLLVYVRIYVVLLR---------EKKATQMLAIVLGAFIVCWLP---FFLTH 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 261 IVSRlfYGKSYY---HVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15310 215 ILNT--HCQACHvppELYSATTWLGYVNSALNPVIYTTFNIEFR 256
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
24-300 8.59e-08

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 52.75  E-value: 8.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVcMPFAAVTIITGR-WIFGDIFCRISAML 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRrryAVAACAGTWLLLLTALS--PLARTDLTYPVHALgiiTCfdVLK 180
Cdd:cd15213  80 YWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHR---AKILIAVSWVLSFCVSFppLVGWGKYEFPPRAP---QC--VLG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLPSVAMWAVFLFTIfilLFLIPFVITVACYTAtILKLLRTEEAhgreqrrRAVGLAAVVLLAFVTCFAPNNFVLLAH 260
Cdd:cd15213 152 YTESPADRIYVVLLLVA---VFFIPFLIMLYSYFC-ILNTVRSFKT-------RAFTTILILFIGFSVCWLPYTVYSLLS 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 261 IVSRlfYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15213 221 VFSR--YSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKF 258
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
25-307 1.12e-07

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 52.47  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAsVLPFQIYYHCNRHH-WVFGVLLCNVVTVAF 103
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVA-IYPYPLILHAIFHNgWTLGQLHCQASGFIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTAlsplartdlTYPVHALGIITcFDVLKWTM 183
Cdd:cd15209  81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLA---------VLPNFFIGSLQ-YDPRIYSC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRR-------RAVGLAAVVLLAFVTCFAPNNFV 256
Cdd:cd15209 151 TFAQTVSTVYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPklkpadvRNFLTMFVVFVLFAVCWAPLNFI 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 257 LLA----------HIVSRLFYGkSYYHVYkltlclscLNNCLDPFVYYFASREFQlrlREY 307
Cdd:cd15209 231 GLAvainpkemapKIPEWLFVA-SYFMAY--------FNSCLNAIIYGLLNQNFR---KEY 279
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-300 1.14e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 52.36  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGN-LFSLWVLCRRmGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHcNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15061   2 LISFLILAIIFTIFGNlLVILAVATTR-RLRTITNCYIVSLATADLLVGvLVLPLAIIRQ-LLGYWPLGSHLCDFWISLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdltypvhALGIITCFDVLKW-- 181
Cdd:cd15061  80 VLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWV-------------------ISLLITSPPLVGPsw 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 ---TMLPSVAMWAVFLFTIF--ILLFLIPFVITVACYtATILKLLRTEeahgreqrRRAVGLAAVVLLAFVTCFAPnnFV 256
Cdd:cd15061 141 hgrRGLGSCYYTYDKGYRIYssMGSFFLPLLLMLFVY-LRIFRVIAKE--------RKTAKTLAIVVGCFIVCWLP--FF 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 257 LLaHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF 300
Cdd:cd15061 210 IM-YLIEPFCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDF 252
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
26-301 1.29e-07

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 52.07  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSP-SVIFMINLSVTDLMLASV-LPFQIYyHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd15219   2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQvPGIFLLNLSFCNLLLTVLnMPFTLL-GVVRNRQPFGDGFCQAVGFLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLltalsplartdLTYPVHALGI---------IT 174
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHS-----------LTFSLVALFLswlgysslyAS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 CfdVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYtatiLKLLRTeeahgrEQRRRAVGLAAVVLLAFVTCFAPnn 254
Cdd:cd15219 150 C--TLHLPREEERRRFAVFTAFFHAFTFLLSLLVLCVTY----LKVLKV------RRRQRATKKISIFIGTFVLCFAP-- 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 255 fvllaHIVSRLFYGKSYYHVYK----LTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15219 216 -----YVITRLVELLPFVTINRywgiVSKCLTYSKAASDPFVYSLLRQQYR 261
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
31-252 1.33e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 52.32  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  31 SLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIY-YHCNRHHWVFGVLLCNVVTVAFYANMYS 109
Cdd:cd15337   8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKtISSFNKKWIWGKVACELYGFAGGIFGFM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 110 SILTMTCISVERFLGVLYPL--SSKRWRRRRYAVAACAGTWLLLLTALsplartdltyPVHALG-------IITC-FDVL 179
Cdd:cd15337  88 SITTLAAISIDRYLVIAKPLeaMKKMTFKRAFIMIIIIWLWSLLWSIP----------PFFGWGryvpegfQTSCtFDYL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMlPSVAmwavFLFTIFILLFLIPFVITVACYTATIL-------KLLRTEEAHGREQRR----------RAVGLAAVV 242
Cdd:cd15337 158 SRDL-NNRL----FILGLFIFGFLCPLLIIIFCYVNIIRavrnhekEMTQTAKSGMGKDTEkndarkkaeiRIAKVAIIL 232
                       250
                ....*....|
gi 74762454 243 LLAFVTCFAP 252
Cdd:cd15337 233 ISLFLLSWTP 242
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
40-270 2.08e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 51.48  E-value: 2.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  40 GNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHhWVFGVLLCNVVTVAFYANMYSSILTMTCIS 118
Cdd:cd15214  16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVlVLPFVVTSSIRRE-WIFGVVWCNFSALLYLLISSASMLTLGAIA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 119 VERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltalsplartdltypVHALgiITC-----------FDVLKWTMLPSV 187
Cdd:cd15214  95 IDRYYAVLYPMVYPMKITGNRAVLALVYIW------------------LHSL--IGClpplfgwssleFDRFKWMCVAAW 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTIFILLFLIPFVITVACYtATILKLLRTEEAhgreqrrRAVGLAAVVLLAFVTCFAPNNFVllahIVSRLFY 267
Cdd:cd15214 155 HKEAGYTAFWQVWCALLPFVVMLVCY-GFIFRVARANQC-------KAFITILVVLGAFVTTWGPYMVV----ISTEALW 222

                ...
gi 74762454 268 GKS 270
Cdd:cd15214 223 GKN 225
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
35-297 2.21e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 51.66  E-value: 2.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  35 AVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM--LASVLPFQIYYHCNRhhWVFGVLLCNVVTVAFYANMYSSIL 112
Cdd:cd15197  12 VFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCvgLINVLTDIIWRITVE--WRAGDFACKVIRYLQVVVTYASTY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 113 TMTCISVERFLGVLYPLS-SKRWRRRRYAVAacaGTWLLLLT----ALSPLARTDLTYpvhalGIITCfdvlkWTMLPSV 187
Cdd:cd15197  90 VLVALSIDRYDAICHPMNfSQSGRQARVLIC---VAWILSALfsipMLIIFEKTGLSN-----GEVQC-----WILWPEP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGREQRR------------RAVGLAAVVLLAF 246
Cdd:cd15197 157 WYWKVYMTIVAFLVFFIPATIISICYIIIVRTIwkkskiqvtINKAGLHDGSSRRsssrgiiprakiKTIKMTFVIVTVF 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 74762454 247 VTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15197 237 IICWSPYFVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFS 287
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
5-312 3.65e-07

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 51.74  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454    5 NSTGPDNATLQMLRNPAIAVALpvvysLVAAVSIPGNLFSLW--VLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYy 82
Cdd:PHA03235  19 NDTCVPTEGLSAARTTETFINL-----LIISVGGPLNLIVLVtqLLANRVHGFSTPTLYMTNLYLANLLTVFVLPFIML- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454   83 hCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLgVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA--R 160
Cdd:PHA03235  93 -SNQGLLSGSVAGCKFASLLYYASCTVGFATVALIAADRYR-VIHQRTRARSSAYRSTYKILGLTWFASLICSGPAPvyT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  161 TDLTY---PVHALGIITCFDVLKWTMLPSVamwavfLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVG 237
Cdd:PHA03235 171 TVVAHddvDPEAPGYETCVIYFRADQVKTV------LSTFKVLLTLVWGIAPVVMMTWFYTFFYRTLKRASYKKRSRTLT 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  238 LAAVVLLAFVTCFAP-------NNFVLL------AHIVSRlfygKSYYHVYKLTLCLSCLnncLDPFVYYFASREFQLRL 304
Cdd:PHA03235 245 FVCILLLSFLCLQTPfvaimifDSYATLiwpsdcEHINLR----DAVSTLSRLVPNLHCL---LNPILYAFLGNDFLKRF 317

                 ....*...
gi 74762454  305 REylgCRR 312
Cdd:PHA03235 318 RQ---CFR 322
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
24-148 3.85e-07

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 50.90  E-value: 3.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVA 102
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLEsMPFYTVYVLNGDYWPLGWVLCDLWLSV 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITW 126
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
26-301 6.59e-07

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 50.29  E-value: 6.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-------LMLASV-LPFQIYYHCNRHHWVFGVLlCN 97
Cdd:cd15964   3 LRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADfcmgiylLLIASVdLHTRSEYYNHAIDWQTGPG-CN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  98 vvTVAFYANMYS--SILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYpvHALGIITC 175
Cdd:cd15964  82 --TAGFFTVFASelSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSY--AKVSICLP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 176 FDvlkwTMLPSVAMWAVFLFTIFIllflIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVtCFAPNNF 255
Cdd:cd15964 158 MD----TETPLAQAYIVFVLMLNI----IAFVIICACYIKIYITVRNPQYKSGDKDTKIAKRMAVLIFTDFI-CMAPISF 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 256 VLLAHIVSRLFYGKSYYHVykLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15964 229 YALSAILNKPLITVSNSKI--LLVLFYPLNSCANPFLYAIFTKAFR 272
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
26-301 6.84e-07

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 50.22  E-value: 6.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVVTVAFY 104
Cdd:cd15396   3 LIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMcIPFTAVYTL-MDHWIFGETMCKLTSFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTML 184
Cdd:cd15396  82 VSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTDEPFRNLSSHSDFYKDKVVCI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 185 ---PSVAMWAVFLFTIFILLFLIPFVITVACYTATILKL---------LRTEEAHGREQRRRAVGLAAVVlLAFVTCFAP 252
Cdd:cd15396 162 eawPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLkkrnskidrMRENESRLSENKRINTMLISIV-VTFAACWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 253 -NNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15396 241 lNIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
32-304 1.22e-06

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 49.55  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIF-MINLSVTDLML-------ASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLMgiylliiAIADQYYRGRYAQYSEEWLRSPPCLLACFLV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRyAVAACAGTWllllTALSPLARTDLTYPVHALGIITCFDVLKWTM 183
Cdd:cd14980  89 SLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKS-AKIILILGW----LFSIIFAAIPILYSINQPGDNRLYGYSSICM 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 -----LPSVAMWAVflftIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVT---CFAPNNF 255
Cdd:cd14980 164 psnvsNPYYRGWLI----AYLLLTFIAWIIICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALILITdliCWLPYYI 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 256 VLLAhivSRLFYGKSYYHVYKLTLCLSC-LNNCLDPFVYYFASREFQLRL 304
Cdd:cd14980 240 VIFS---GLLTSTEIDIHVLQFIAILALpLNSAINPYLYTLTTPTFKRDF 286
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
24-301 1.67e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 49.08  E-value: 1.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRS--PSVIF-MINLSVTDLM-LASVLPFQIYYHCNRHH-WVFGVLLCNV 98
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQHlqSTVHYhLASLALSDLLiLLLAMPVELYNFIWVHHpWAFGDAACRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSK----RWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHalGIIT 174
Cdd:cd15355  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKslmsRSRTKKFISAIWLASALLAIPMLFTMGEQNRSGTHP--GGLI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 175 CFDVLKWTMLPSVAMWAVFLFTIF----------------ILLFLIPFVITVACYTATILKLLRTEEAHGREQR-RRAVG 237
Cdd:cd15355 159 CTPIVDTSTLKVVIQVNAFLSFLFpmlvisvlntlianqlTVMVNQAEQENQVCTIGGQRTVLSVSMEPGRVQSlRHGVL 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 238 LAAVVLLAFVTCFAPNN-----FVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15355 239 VLRAVVIAFVVCWLPYHvrrlmFCYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFR 307
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
24-301 2.01e-06

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 48.74  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-LMLASVLPFQIYYHCNrHHWVFGVLLCNVVTVA 102
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDlLLLVTCAPVDASRYLA-DEWLFGRVGCKLIPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGI----ITCFDV 178
Cdd:cd15124  80 QLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTnktfVSCAPY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 LKWTML-PSVAMWAVFLftifiLLFLIPFVITVACYTATILKLLRTE-------EAHGREQ---RRRAVGLAAVVLLAFV 247
Cdd:cd15124 160 PHSNELhPKIHSMASFL-----IFYVIPLSIISVYYYFIAKNLIRSAynlpvegNVHVRRQiesRKRLAKTVLVFVGLFA 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 248 TCFAPNNFVLLAHIVSRLFYGKSYYHvYKLTLC---LSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15124 235 FCWLPNHIIYLYRSYHYSEVDTSMLH-FVSSICariLAFTNSCVNPFALYLLSKSFR 290
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
24-301 2.13e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 48.75  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAsVLPFQIYYHCNRHH-WVFGVLLCNVVTVA 102
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVA-VYPYPLILLAIFHNgWTLGNIHCQISGFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSplartdltyPVHALGIITcFDVLKWT 182
Cdd:cd15401  80 MGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIV---------PNFFVGSLQ-YDPRIYS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEE--AHGREQRRRAVGLAA-----VVLLAFVTCFAPNNF 255
Cdd:cd15401 150 CTFAQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHrvRQDSKQKLKANDIRNfltmfVVFVLFAVCWGPLNF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 256 VLLA----------HIVSRLFYgKSYYHVYkltlclscLNNCLDPFVYYFASREFQ 301
Cdd:cd15401 230 IGLAvainplkvapKIPEWLFV-LSYFMAY--------FNSCLNAVIYGVLNQNFR 276
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
30-216 3.03e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.19  E-value: 3.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  30 YSLVAAV-SIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCnRHHWVFGVLLCNVvtvafYA-- 105
Cdd:cd15073   6 YLIVAGIiSTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIgYPFSAASDL-HGSWKFGYAGCQW-----YAfl 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMY---SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGtWLLLLTALSPLARTDLTYPVHALGiITCfdVLKWT 182
Cdd:cd15073  80 NIFfgmASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLA-WTNAFFWAAMPLVGWASYALDPTG-ATC--TINWR 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 74762454 183 MlpSVAMWAVFLFTIFILLFLIPFVITVACYTAT 216
Cdd:cd15073 156 K--NDSSFVSYTMSVIVVNFIVPLAVMFYCYYNV 187
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
29-148 4.40e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 47.73  E-value: 4.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNrHHWVFGVLLCNVvTVAFYAnM 107
Cdd:cd15065   5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALlVMTFAVVNDLL-GYWLFGETFCNI-WISFDV-M 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 74762454 108 YS--SILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15065  82 CStaSILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVW 124
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
23-307 9.05e-06

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 46.82  E-value: 9.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  23 AVALPVVYSLVaaVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAsVLPFQIYYHCNRHH-WVFGVLLCNVVTV 101
Cdd:cd15402   2 ALACILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVA-IYPYPLVLTSIFHNgWNLGYLHCQISGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLART-DLTYPVHalgIITCfdvlk 180
Cdd:cd15402  79 LMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVgSLQYDPR---IYSC----- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 wTMLPSVAmwAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRR-------RAVGLAAVVLLAFVTCFAPN 253
Cdd:cd15402 151 -TFAQSVS--SAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPklkphdfRNFVTMFVVFVLFAVCWAPL 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74762454 254 NFVLLA------HIVSRL---FYGKSYYHVYkltlclscLNNCLDPFVYYFASREFQlrlREY 307
Cdd:cd15402 228 NFIGLAvavdpeTIVPRIpewLFVASYYMAY--------FNSCLNAIIYGLLNQNFR---REY 279
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
33-252 9.99e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 46.42  E-value: 9.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  33 VAAVSIPGNLFSL-WVLCRRMGPRSPSvIFMINLSVTDLM-------LASV-LPFQIYYHCNRHHWVFGVLlCNVVTVAF 103
Cdd:cd15137  10 VGIIALLGNLFVLiWRLKYKEENKVHS-FLIKNLAIADFLmgvylliIASVdLYYRGVYIKHDEEWRSSWL-CTFAGFLA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRyAVAACAGTWLLLLTALSP-----------LARTDLTYPVHalgi 172
Cdd:cd15137  88 TLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRR-AIIVLACIWLIGLLLAVLpllpwdyfgnfYGRSGVCLPLH---- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 173 ITCFDVLKWtmLPSVAmwavflftIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRR----AVGLAAVVLLAFVt 248
Cdd:cd15137 163 ITDERPAGW--EYSVF--------VFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRdmavAKRFFLIVLTDFL- 231

                ....
gi 74762454 249 CFAP 252
Cdd:cd15137 232 CWIP 235
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
24-301 1.37e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 46.33  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLC--RRMGPRSPSVI-FMINLSVTDLM-LASVLPFQIYYHC-NRHHWVFGVLLCNV 98
Cdd:cd15135   1 ITLTLLYSLILVAGILGNSATIKVTQvlQKKGYLQKSVTdHMVSLACSDLLvLLLGMPVELYSAIwDPFATPSGNIACKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPV-----HALGII 173
Cdd:cd15135  81 YNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVWLTSALVALPLLFAMGTEDPLeafpsYRGTRH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 174 TCFDVL--KWTMLPSVAMWAVF---LFTIFILLFLIPFVITVACYT-------------------ATILKLLRTEEAHGR 229
Cdd:cd15135 161 HCQDQKsnLTICTSLSSKWTVFqasIFSAFVLYLLVLASVAFMCRRmmralmgskkgavavkgpgGSVQLLRKHESAEGK 240
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 230 EQRRRAVGLAAVVLLAFVTCFAPNNF-VLLAHIVSRLFYGKSYYHVYKLTL----CLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15135 241 TARKQTILFLGLIVGTLAVCWMPNQIrRIMAAAKPKDDWTRSYFRAYIILLpiadTFFYLSSVLNPLLYNLSSQQFR 317
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
32-295 2.00e-05

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 45.47  E-value: 2.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTD---LMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMy 108
Cdd:cd15107   9 IIALVGLAGNAIVLWLLGFHM-HRNAFSVYILNLAGADflfLCTQIVFSLEIVLQFHSIDIHIPLFLLTVTMFAYLAGL- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 109 sSILTMtcISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCfDVLKWTMLPSVA 188
Cdd:cd15107  87 -SMITA--ISIERCLSVMWPIWYHCQRPRHTSAVICTLLWV-------------LSLLLSLLEGKGC-GFLFSTYDYYWC 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 189 MWAVFLFTIF-ILLFLIPFVITVACYTATILKLLRTEEAhgreqrRRAVGLAAVVLLaFVTCFAPNNFVLLAHIVSRLFY 267
Cdd:cd15107 150 WTLDLITTAWlIVLFVVLSGSSLALLVRIFCGSHRIPVT------RLYVTIALTVLV-FLIFGLPFGIYWFLLKWIEEFY 222
                       250       260
                ....*....|....*....|....*...
gi 74762454 268 GKSYYHVYKLTLCLSCLNNCLDPFVYYF 295
Cdd:cd15107 223 IVPCCGFYEVILFLSCVNSCANPIIYFL 250
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
28-298 2.29e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 45.22  E-value: 2.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15215   4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVlVMPWVIATSVPLF-WPLDSHLCTALVVLMHLF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLS--SKRWRRRRYAVAACagTWLLLLTALsplartdlTYPVHALGIITcFDV------ 178
Cdd:cd15215  83 AFAGVNTIVVVSVDRYLAIIHPLSypTKMTPRRGYLLIYG--TWIVSVLQS--------TPPLYGWGQAA-FDErnalcs 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 LKWTMLPSVAMWAVFLFtifillFLIPFVITVACYTATIlkllrteEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVll 258
Cdd:cd15215 152 VIWGSSYSYTILSVVSS------FVLPVIIMLACYSMVF-------RAARRCYHCKAAKVIFIIIFSYVLSMGPYSFL-- 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 259 aHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASR 298
Cdd:cd15215 217 -SVLAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHK 255
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
31-145 2.33e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.53  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  31 SLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVtvAFYANM-- 107
Cdd:cd15005   8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVI--AFLAVLfc 85
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74762454 108 YSSILTMTCISVERFLGVLYPlsskRWRRRRYAVAACA 145
Cdd:cd15005  86 FHSAFTLFCIAVTRYMAIAHH----RFYAKRMTFWTCL 119
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
32-148 2.35e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 45.61  E-value: 2.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCNRHHWVFGVLL--CNVVTVAfyanmY 108
Cdd:cd15071   9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIIINIGPQTEFYSCLMvaCPVLILT-----Q 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 74762454 109 SSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15071  84 SSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCW 123
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
24-301 5.08e-05

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 44.43  E-value: 5.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNrHHWVFGVLLCNVVTVA 102
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAIsIPLYIPYTLT-NRWDFGRGLCVFWLVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSK-RWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITC--FDVL 179
Cdd:cd15295  80 DYLLCTASVYNIVLISYDRYQSVSNAVSYRnQQTATLRIVTQMVAVWV-------------LAFLVHGPAILVSdsWKTE 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAMWAVFLFTIFILLFLIPfVITVACYTATILKLLrteeaHGREQRRRAVGLAAVVLLAFVTCFAPnnFVLLA 259
Cdd:cd15295 147 DGECEPEFFSNWYILAITSVLEFLVP-VILVAYFNTQIYWSL-----WKRLRDRKLAKSLAIILGTFAICWAP--YSLFT 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74762454 260 HIvsRLFYGKSYYHV-YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15295 219 II--RAACEKHRGSPwYNFAFWLQWFNSFINPFLYPLCHKRFR 259
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
32-301 5.22e-05

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 44.34  E-value: 5.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSI 111
Cdd:cd15000   8 PVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 112 LTMTCISVERFLGVLYPlSSKRWRRRRYAVAACAgTWLLLLTalsplartdLTYPvhaLGIITCFDVLKWTML------P 185
Cdd:cd15000  88 LALCAVSYDRLTAIVLP-SEARLTKRGAKIVIVI-TWIVGLL---------LALP---LAIYRSYRERQWKNFletycaE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKL-------LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAP------ 252
Cdd:cd15000 154 NTQVLPIYWHVIITVLVWLPLGIMLICYSAIFWKLdkyerrvLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPftalif 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74762454 253 ---------NNFVLLAHIVSRLFYGKSYyhvykltlcLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15000 234 yryklvpndNTQNSVSGSFHILWFASKY---------LMFLNAAVNPLIYGFTNENFR 282
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
56-301 6.23e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 44.08  E-value: 6.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  56 SPSVIFMINLSVTDLML-ASVLPFQIY---YHCnrhhWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLS- 130
Cdd:cd15055  33 TPTNLLLLSLAVADFLVgLLVMPFSMIrsiETC----WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLy 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 131 SKRWRRRRYAVAACAGtWLLLLTALSPLARTDLTYPvHALGIITCFDVLkwtmlpSVAMWAVFLFTIFILLFLIPFVITV 210
Cdd:cd15055 109 PTKITIRRVKICICLC-WFVSALYSSVLLYDNLNQP-GLIRYNSCYGEC------VVVVNFIWGVVDLVLTFILPCTVMI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 211 ACYTATIL------KLLRTEEAHGREQRRRAVGL------AA----VVLLAFVTCFAPNNFVLLAHivsrlFYGKSYYHV 274
Cdd:cd15055 181 VLYMRIFVvarsqaRAIRSHTAQVSLEGSSKKVSkkserkAAktlgIVVGVFLLCWLPYYIVSLVD-----PYISTPSSV 255
                       250       260
                ....*....|....*....|....*..
gi 74762454 275 YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15055 256 FDVLIWLGYFNSCLNPLIYALFYPWFR 282
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
24-293 8.88e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 43.63  E-value: 8.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLML-ASVLPFQIYYHCNrHHWVFGVLLCNVVTVA 102
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVgGFCIPLYIPYVLT-GRWKFGRGLCKLWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWR-RRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVLKW 181
Cdd:cd15296  80 DYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKgMTRQAVLKMVLVWV-------------LAFLLYGPAIISWEYIAGG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMWAVFLFTIFILL------FLIPFvITVACYTATILKLLRTEEAHGREQRRRAVGLaAVVLLAFVTCFAPNNF 255
Cdd:cd15296 147 SIIPEGECYAEFFYNWYFLMtastleFFTPF-ISVTYFNLSIYLNIQKRRFRLSRDKKVAKSL-AIIVCVFGLCWAPYTL 224
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 74762454 256 VLlahIVSRLFYGKSYYHV-YKLTLCLSCLNNCLDPFVY 293
Cdd:cd15296 225 LM---IIRAACHGHCVPDYwYETSFWLLWVNSAINPVLY 260
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
28-309 1.03e-04

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 43.59  E-value: 1.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAV---SIPGNLFSLWVL-CRRMgpRSPSVIFMINLSVTDLM----LASVLPFQIYYHCNRHHWVFgvllcNVV 99
Cdd:cd15108   2 VLSALVMFTcvcGMAGNGLVVWLLsCRGR--RTPFCVYVLHLAVADLLfllcMASTLSLETSPLVITHDLAY-----EVV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 100 TVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVL 179
Cdd:cd15108  75 RRVKYFAYTASLSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWA-------------LSLLMNVLASFFCSEFW 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVAMWAVflFTIFILLFLIPfvITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLaFVTCFAP---NNFV 256
Cdd:cd15108 142 HPDEWQCFKVDMV--FSFLIMGIFTP--VMALSSLILFVRVRRSSRQWRRRPTRLYVVVLASVLV-FLACALPlgiYWFL 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74762454 257 L----LAHIVSRLfygksYYHVYKLTLCLSCLNNcldPFVYYFASREFQLRLREYLG 309
Cdd:cd15108 217 LywldLPQEVKTL-----FSCLSRLSSSVSSSAN---PVIYFLVGSRGSRRLREPLG 265
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-301 1.36e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 42.86  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  27 PVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM--LASVLPFQIYYHCNRHHWV----FGVLLCNVVT 100
Cdd:cd15103   4 PEVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLvsVSNALETIVIILLNNGYLVprdsFEQHIDNVID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSplarTDLTYPVHALGIItCFDVLK 180
Cdd:cd15103  84 SMICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI----LFIIYSDSVPVII-CLISMF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WTMLpsvamwaVFLFTIFILLFLIpfvitvAC-YTATILKLLRTEEAHGREQRRRAVGLAaVVLLAFVTCFAPnnFVLla 259
Cdd:cd15103 159 FAML-------VLMASLYVHMFLL------ARsHVKKIAALPGQRSTRQRANMKGAVTLT-ILLGVFIFCWAP--FFL-- 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 260 HIVSRLF-----YGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15103 221 HLTLMIScpsnpYCACYMSHFNVYLILIMCNSVIDPLIYAFRSQELR 267
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
28-148 1.39e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.87  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLW-VLCRRMgPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAaVLCSRK-LRTVTNLFIVSLACADLLVGTlVLPFSAVNEV-LDVWIFGHTWCQIWLAVDVW 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15063  83 MCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVW 125
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
24-252 1.39e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 43.10  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNV---V 99
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLlIMPFSLVNEL-MGYWYFGSVWCEIwlaL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 100 TVAFYAnmySSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVL 179
Cdd:cd15059  80 DVLFCT---ASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWI-------------ISAVISLPPLFGWKDEQ 143
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74762454 180 KWTM-LP----SVAMWAVFLFTifILLFLIPFVITVACYtATILKLLRTEEahgreqrRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd15059 144 PWHGaEPqcelSDDPGYVLFSS--IGSFYIPLLIMIIVY-ARIYRAAKRKE-------RRFTLVLGVVMGAFVLCWLP 211
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
24-148 1.55e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 42.80  E-value: 1.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIfVLPLNVAYFL-LGKWLFGIHLCQMWLTC 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15060  80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVW 125
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
37-132 1.56e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 42.94  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  37 SIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRH--HWVFGVLLCNVVTVAFYANMYSSILT 113
Cdd:cd15006  13 SLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVcVPFDIVLSASPHccWWIYTLLFCKVIKFLHKVFCSVTVLS 92
                        90
                ....*....|....*....
gi 74762454 114 MTCISVERFLGVLYPLSSK 132
Cdd:cd15006  93 FAAIALDRYYSVLYPLERK 111
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
21-301 1.58e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 43.00  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  21 AIAVALPVVyslVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIY----YHCNRHHWVFgvLL 95
Cdd:cd15069   1 ATYVALELI---IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGlFAIPFAITislgFCTDFHSCLF--LA 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  96 CNVVTVAfyanmYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTA---------LSPLARTDLTYP 166
Cdd:cd15069  76 CFVLVLT-----QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIgltpflgwnKAMSATNNSTNP 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 167 V-HALGIITCF-DVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTE-EAHGREQRRRAVGLA---A 240
Cdd:cd15069 151 AdHGTNHSCCLiSCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTElMDHSRTTLQREIHAAkslA 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74762454 241 VVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15069 231 IIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
29-148 1.60e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 42.75  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCNrHHWVFGVLLCNV---VTVAFY 104
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVAlCAMTFNASVEIT-GRWMFGYFMCDVwnsLDVYFS 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 74762454 105 AnmySSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15066  84 T---ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVW 124
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
38-148 1.75e-04

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 42.52  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  38 IPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTC 116
Cdd:cd15308  15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALlVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                        90       100       110
                ....*....|....*....|....*....|..
gi 74762454 117 ISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15308  95 ISVDRFIAVSVPLNYNRRQGSVRQLLLISATW 126
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-229 1.84e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.83  E-value: 1.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15212   6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSRPGWLFGDRLCLANGFFNACFG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRryAVAACAGTWLLLLTALS---PLARTDLTYpvHALGIITCFDVLKWTML 184
Cdd:cd15212  86 IVSTLTMTLISFDRYYAIVRQPQGKIGRRR--ALQLLAAAWLTALGFSLpwyLLASAPEYY--EKLGFYHCLYVLHSGPS 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 74762454 185 PsvaMWAVFLFTIFILLFLIPFVITVACYTaTILKLLRTEEAHGR 229
Cdd:cd15212 162 R---LGAAYSSVLIVLCYLLPFALMCFCHY-NICKTVRLSESRVR 202
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
26-304 2.18e-04

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 42.51  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFqiYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15171   3 VPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPF--WAHAAWHGGSLGNPTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVLYPLSSKRWRRRR-YAVAACAGTWLLLLT-----ALSPLARTDLTYPVHALGiitcfdvl 179
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVApCGIIASVLAWLTAFLvtlpeFVFYKPQMDSQKSKCAFS-------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 180 KWTMLPSVA-MWAVFL-FTIFILLFLIPFVITVACYtatiLKLLRTEEAhgREQRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd15171 153 RPHFLPAEEtFWKYFLtLKMNIVVLVFPLLVFIICC----VQLRKTQRF--RERQRDLSKLVFAIMVVFLLMWAPYNIAL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 74762454 258 LAHIVSRLFY---GKSYYHVYK---LTLCLSCLNNCLDPFVYYFASREFQLRL 304
Cdd:cd15171 227 FLSAFKEHFSlrdCKSSYHLDAsvqVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
26-295 2.51e-04

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 42.43  E-value: 2.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLMlasVLPFQIYYHCNR-----HHWVFGVLLCNVVT 100
Cdd:cd15106   3 LTFLTCIISLVGLTGNAVVLWLLGFRM-RRNAFSVYILNLAAADFL---FLCCHIIDSLLRlinifHIISIPKILTNVMT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 101 VAFYANMYssilTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWlllltalsplartdltypvhALGIItcFDVLK 180
Cdd:cd15106  79 FPYFAGLS----MLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLW--------------------ALSLL--LSILE 132
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 181 WtmlpsvaMWAVFLFTI----------FILLFLIPFVITVACYTATILkLLRTEEAHGREQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15106 133 W-------KFCGFLFSGadshwcqtfdFITTAWLIFLFVVLCGSSLAL-LVRILCGSRKMPLTRLYVTILLTVLVFLLCG 204
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 251 APNN--FVLLAHIVSRLFYgkSYYHVYKLTLCLSCLNNCLDPFVYYF 295
Cdd:cd15106 205 LPFGiqWFLLLWIHIDLEV--LFCHVYLVSVVLSCLNSSANPIIYFF 249
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
24-301 2.65e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 42.26  E-value: 2.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAF 103
Cdd:cd17790   1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVLKWTM 183
Cdd:cd17790  81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWL-------------ISFVLWAPAILFWQYLVGERT 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFL------FTIFILLFLIPFVITVACYTATILKLLRteeahgreqRRRAVGLAAVVLLAFVTCFAPNNFVL 257
Cdd:cd17790 148 VLAGQCYIQFLsqpiitFGTAIAAFYLPVTIMIILYWRIYRETIK---------EKKAARTLSAILLAFILTWTPYNIMV 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 74762454 258 LAHIVSRLFYGKSyyhVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd17790 219 LVSTFCKDCVPKT---LWELGYWLCYVNSTVNPMCYALCNKSFR 259
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
32-311 3.35e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 41.86  E-value: 3.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSI 111
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 112 LTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdltypvhalgiitcFDVLKWTmlPSVAMWA 191
Cdd:cd15299  92 MNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWV--------------------------ISFVLWA--PAILFWQ 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 192 VFL----------FTIFILLFLIPFVITVACY--TATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLA 259
Cdd:cd15299 144 YFVgkrtvppdecFIQFLSEPIITFGTAIAAFylPVTIMTILYWRIYKETIKEKKAAQTLSAILLAFIITWTPYNIMVLV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 260 HIVSRLFYGKSYYHvykLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCR 311
Cdd:cd15299 224 NTFCDSCIPKTYWN---LGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
29-145 4.66e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 41.68  E-value: 4.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA--SVLPFQIYYHCNRhhWVFGVLLCNVVTVAFYAN 106
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAffQVLPQLVWDITDR--FRGPDVLCRLVKYLQVVG 83
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACA 145
Cdd:cd15388  84 MFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCV 122
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 6.55e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 40.99  E-value: 6.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVL----CRRMGPRspsvIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd15976   5 VVSCLVFVLGIIGNSTLLRIIyknkCMRNGPN----ILIASLALGDLLHIIIdIPINVYKLLAED-WPFGVEMCKLVPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVlyplssKRWRRRRyavAACAGTWLLLLTALSPLARTDLTYP-VHALGIITC---FDV 178
Cdd:cd15976  80 QKASVGITVLSLCALSIDRYRAV------ASWSRIK---GIGVPKWTAVEIVLIWVVSIILAVPeAIGFDMITMdykGEL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 179 LKWTMLPSVAMWAVFLFT-------IFILLFLIPFVITVACYTATILKLLRTEEAHG------REQRRRAVGLAAVVLLA 245
Cdd:cd15976 151 LRICLLHPIQKTAFMQFYktakdwwLFSFYFCLPLACTAVFYTLMTCEMLRKKNGMQialndhLKQRREVAKTVFCLVLV 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74762454 246 FVTCFAPnnfVLLAHIVSRLFYGK---------SYYHVYK-LTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15976 231 FALCWLP---LHLSRILKLTIYDEkdpnrcellSFFLVLDyIGINMASLNSCINPIALYLVSKRFK 293
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-297 6.56e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 40.96  E-value: 6.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA--SVLP---FQIYYHCNRHHWvfgvlLCNVVTVAF 103
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAffQVLPqlcWDITYRFYGPDF-----LCRIVKHLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSS-KRWRRRRYAVAACAgtWLLLLTalsplartdLTYPVHalGIITCFDVLKWT 182
Cdd:cd15385  81 VLGMFASTYMLVMMTADRYIAICHPLKTlQQPTKRSYLMIGSA--WALSFI---------LSTPQY--FIFSLSEIENGS 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVamWAVFLFT---------IFILLFLIPFVITVACYTA---TILKLLRTEEAHGREQRR----------------- 233
Cdd:cd15385 148 GVYDC--WANFIVPwgikayitwITISIFVVPVIILLTCYGFicyNIWRNIKCKTRRGLSDNAlknillavcvssvktis 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74762454 234 ----RAVGLAAVVLLAFVTCFAPNNFV-LLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFAS 297
Cdd:cd15385 226 rakiRTVKMTFVIVLAYIVCWAPFFTIqMWSVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
28-301 6.83e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 40.79  E-value: 6.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15309   5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATlVMPWVVYLEV-VGEWRFSRIHCDIFVTLDVMM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYP-LSSKRWRRRRYAVAACAGTWLLLLTALsplarTDLTYPVHALGIITCFdvlkwtmlp 185
Cdd:cd15309  84 CTASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAIS-----CPLLFGLNNTDQNECI--------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 186 sVAMWAVFLFTIfILLFLIPFVITVACYTATILKLlrteeahgrEQRRRAVGLAAVVLLAFVTCFAPnnfVLLAHIVSRL 265
Cdd:cd15309 150 -IANPAFVVYSS-IVSFYVPFIVTLLVYVQIYIVL---------QKEKKATQMLAIVLGVFIICWLP---FFITHILNMH 215
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 74762454 266 FYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15309 216 CDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFR 251
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
32-148 9.02e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 40.56  E-value: 9.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSI 111
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74762454 112 LTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
29-308 1.06e-03

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 40.28  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  29 VYSLVAAVSIPGNLFSLWVLCRRMgPRSPSVIFMINLSVTDLM-LASVLPFQIYyHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15109   6 IFLLLCLCGLVGNGLVLWFFGFSI-KRNPFSIYFLHLASADVGyLFSKAVFSIL-NTGGFLGTFADYIRSVSRILGLCTF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALsplartdltypvhalGIITCFDVLKWTMLPSV 187
Cdd:cd15109  84 LTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVT---------------CIHNYFCVFLGREAPGA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 188 AMWAVFLFTIFILLFLIPFVITVACytatiLKLLRTEEAHGReQRRRAVGLAAVVlLAFVTCFAPNNFVL-LAHIVSRLF 266
Cdd:cd15109 149 ACRHMDIFLGILLFLLFCPLMVLPC-----LALILHVECRAR-RRQRSAKLNHVI-LAMVSVFLVSSIYLgIDWFLFWVF 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 74762454 267 YGKSYYHVYKLTLCLsCLNNCLDPFVYYFASREFQLRLREYL 308
Cdd:cd15109 222 QIPAPFPEYVTDLCI-CINSSAKPIVYFLAGRDKSQRLWEPL 262
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
24-301 1.16e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 40.31  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVA 102
Cdd:cd15323   1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATlVMPFSLANEL-MGYWYFGQVWCNIYLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWT 182
Cdd:cd15323  80 DVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYPQCKLNDETWY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVamwavflftifILLFLIPFVITVACYtatiLKLLRTEEAhgREQRRRAVglAAVVLLAFVTCFAPnnfvllahiv 262
Cdd:cd15323 160 ILSSC-----------IGSFFAPCLIMILVY----IRIYRVAKA--REKRFTFV--LAVVMGVFVVCWFP---------- 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 74762454 263 srLFYGKSYYHV-----------YKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15323 211 --FFFSYSLYGIcreacevpeplFKFFFWIGYCNSSLNPVIYTIFNQDFR 258
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
26-301 1.39e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 39.85  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-------LMLASV-LPFQIYYHCNRHHWVFGvllCN 97
Cdd:cd15359   3 LRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADfcmglylLLIASVdSQTKSQYYNHAIDWQTG---SG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  98 VVTVAFYANMYS--SILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWllllTALSPLARTDLTYPVHALGIITC 175
Cdd:cd15359  80 CSTAGFFTVFASelSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGW----VFSLLIAVLPLVGVSNYMKVSIC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 176 FDVLKWTMLPSVamwavflFTIFIL-LFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFvTCFAPNN 254
Cdd:cd15359 156 LPMDIETLLSQA-------YILLILvLNVIAFLVICACYIKIYLAVQNPELVAKNKDTKIAKRMAILIFTDF-TCMAPIS 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 255 FVLLAHIVSRLFYGKSYYHVykLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15359 228 FFAISAAFKVPLITVTNSKI--LLVLFYPINSCANPFLYAIFTKAFR 272
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
24-301 1.50e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 39.81  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASV-LPFQIYYHCNRHhWVFGVLLCNVVTVA 102
Cdd:cd15301   1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVIsMPLFTVYTALGY-WPLGYEVCDTWLAI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 103 FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLtalsplartdLTYPVHalgIITCFDVLKWT 182
Cdd:cd15301  80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISL----------LLWPPW---IYSWPYIEGKR 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 183 MLPSVAMWAVFLFT-IFILL------FLIPFVITVACYTatilKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNN- 254
Cdd:cd15301 147 TVPAGTCYIQFLETnPYVTFgtalaaFYVPVTIMCILYW----RIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNv 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 74762454 255 FVLLAHIVSRLFYGKSYYHVYKLTLCLscLNNCLDPFVYYFASREFQ 301
Cdd:cd15301 223 LVLIKAFFPCSDTIPTELWDFSYYLCY--INSTINPLCYALCNAAFR 267
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
25-137 1.87e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 39.43  E-value: 1.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIYYHCNrHHWVFGVLLCNVVTVAF 103
Cdd:cd15008   1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSvASAPFVLLQFTS-GRWTLGSAMCKLVRYFQ 79
                        90       100       110
                ....*....|....*....|....*....|....
gi 74762454 104 YANMYSSILTMTCISVERFLGVLYPLSSKRWRRR 137
Cdd:cd15008  80 YLTPGVQIYVLLSICVDRFYTIVYPLSFKVSREK 113
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
24-295 2.13e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 39.18  E-value: 2.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLM--LASVLPFQIYYHCNrhHWVFGVLLCNVVTV 101
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIigVFSMNLYTLYTVIG--YWPLGPVVCDLWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 AFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLllltalsplartdLTYPVHALGIITCFDVLKW 181
Cdd:cd15297  79 LDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWV-------------LSFILWAPAILFWQFIVGG 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 182 TMLPSVAMW------AVFLFTIFILLFLIPFVITVACYtatilklLRTEEAHGREQRRRAVGLAavVLLAFVTCFAPNNF 255
Cdd:cd15297 146 RTVPEGECYiqffsnAAVTFGTAIAAFYLPVIIMTVLY-------WQISRASSREKKVTRTILA--ILLAFIITWTPYNV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 74762454 256 VLLAHivsrlfygksyyhvyklTLCLSCLNNCLDPFVYYF 295
Cdd:cd15297 217 MVLIN-----------------TFCASCIPNTVWTIGYWL 239
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
28-145 2.51e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.55  E-value: 2.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNL-FSLWVLCRRMGPRSPsVIFMINLSVTDLMLASV-LPFQIYYHCNRHHWVFGVLLCNVVTVAFYA 105
Cdd:cd15217   5 VLLGLIICVSLAGNLiVSLLVLKDRALHKAP-YYFLLDLCLADTIRSAVcFPFVLVSIRNGSAWTYSVLSCKIVAFMAVL 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 74762454 106 NMYSSILTMTCISVERFLGVlyplSSKRWRRRRYAVAACA 145
Cdd:cd15217  84 FCFHAAFMLFCISVTRYMAI----AHHRFYSKRMTFWTCI 119
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
24-143 2.68e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 39.08  E-value: 2.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  24 VALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIF---MINLSVTDLMLASV-LPFQIYYHCNRHH-WVFGVLLCNV 98
Cdd:cd15356   1 VLFTAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLIsVPIELYNFVWFHYpWVFGDLVCRG 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 74762454  99 VTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRW---RRRRYAVAA 143
Cdd:cd15356  81 YYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLlskRRTKWLLAL 128
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
26-252 2.73e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 39.01  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLmLASVLPFQIYYHCNRHHWVF-GVLLCNVVTVAFY 104
Cdd:cd15082  16 LAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADF-LVSLTGGTISFLTNARGYFFlGVWACVLEGFAVT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 105 ANMYSSILTMTCISVERFLGVLYPLSSKRWRRRrYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIiTCFDvlKWTml 184
Cdd:cd15082  95 FFGIVALWSLAVLAFERFFVICRPLGNIRLQGK-HAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGT-TCEP--NWY-- 168
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74762454 185 pSVAMW-AVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHG-----REQRRRAVGLAAVVLLAFVTCFAP 252
Cdd:cd15082 169 -SGNMHdHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGrlgnaRKPERQVTRMVVVMIVAFMVCWTP 241
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
28-301 3.39e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 38.70  E-value: 3.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCnRHHWVFGVLLCNVVTVAFYAN 106
Cdd:cd15324   5 LVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATlVIPFSLANEV-MGYWYFGSTWCAFYLALDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTalsplartdLTYPVHalgIITCFDvlKWTMLPS 186
Cdd:cd15324  84 CTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAV---------ISFPPL---LMTKHD--EWECLLN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 187 VAMWavFLFTIFILLFLIPFVITVACYtatiLKLLRTeeAHGREQRRRAVglAAVVLLAFVTCFAPNNFVLLAHIVSRLF 266
Cdd:cd15324 150 DETW--YILSSCTVSFFAPGLIMILVY----CKIYRV--AKMREKRFTFV--LAVVMGVFVLCWFPFFFTYSLHAVCRKR 219
                       250       260       270
                ....*....|....*....|....*....|....*
gi 74762454 267 YGKSyYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15324 220 CGIP-DALFNLFFWIGYCNSSVNPIIYTIFNRDFR 253
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
32-301 8.06e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 37.50  E-value: 8.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  32 LVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSI 111
Cdd:cd15077   9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 112 LTMTCISVERFLGVLYPLSSKRWrRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALgiiTCFDVLKWTMLPSVAMWA 191
Cdd:cd15077  89 WSLAVVAFERFLVICKPLGNFTF-RGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGL---QCSCGPDWYTTNNKWNNE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 192 VFLFTIFILLFLIPFVITVACYTATILKL-----LRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRlf 266
Cdd:cd15077 165 SYVMFLFCFCFGVPLSIIVFSYGRLLLTLravakQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNR-- 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 74762454 267 yGKSY-YHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15077 243 -GEPFdLRLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
28-132 8.97e-03

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 37.56  E-value: 8.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANM 107
Cdd:cd15980   5 ASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISV 84
                        90       100
                ....*....|....*....|....*
gi 74762454 108 YSSILTMTCISVERFLGVLYPLSSK 132
Cdd:cd15980  85 SASVFTLVAIAVDRFRCIVYPFKQK 109
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
37-148 9.69e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 37.41  E-value: 9.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  37 SIPGN-LFSLWVLCRRMGPRSPSVIFMINLSVTDLMLA-SVLPFQIyyhCNR--HHWVFGVLlCNVvTVAF-YANMYSSI 111
Cdd:cd15057  14 TLLGNaLVIAAVLRFRHLRSKVTNYFIVSLAVSDLLVAiLVMPWAA---VNEvaGYWPFGSF-CDV-WVSFdIMCSTASI 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74762454 112 LTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTW 148
Cdd:cd15057  89 LNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAW 125
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
25-299 9.77e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 9.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  25 ALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVlpfqiyyhcnrhhWVFGVLLCNVVTV--- 101
Cdd:cd15102   2 ATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAA-------------YLANILLSGARTLrls 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 102 ---------AFYANMYSSILTMTCISVERFLGVLYP-LSSKRWRRRRYAVAACAgtWLLLLTALSPlartdltyPVHALG 171
Cdd:cd15102  69 paqwflregSMFVALSASVFSLLAIAIERHLTMAKMkPYGASKTSRVLLLIGAC--WLISLLLGGL--------PILGWN 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 172 IITCFDVLKwTMLPSVA-MWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCF 250
Cdd:cd15102 139 CLGALDACS-TVLPLYSkHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACW 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 74762454 251 APNNFVLLAHIVSR-----LFYGKSYYhvykltLCLSCLNNCLDPFVYYFASRE 299
Cdd:cd15102 218 GPLFILLLLDVACPvktcpILYKADWF------LALAVLNSALNPIIYTLRSRE 265
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
28-301 9.80e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 37.45  E-value: 9.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454  28 VVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLAS-VLPFQIYYHCNRHHWVFGVLLCNVVTVAFyan 106
Cdd:cd15070   5 SIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVlVIPLAIVVSLGVTIHFYSCLFMSCLLVVF--- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 107 MYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLA---RTDLTYPVHALGIITCfdvlkwtM 183
Cdd:cd15070  82 THASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMfgwNRKPSLESVNTTPLQC-------Q 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762454 184 LPSVAMWAVFLFTIFILLFLIPFVITVACYtATILKLLRTEEAHG-----------REQRRRAVGLaAVVLLAFVTCFAP 252
Cdd:cd15070 155 FTSVMRMDYMVYFSFFTWILIPLVIMCALY-VDIFYIIRNKLSQNatgfretgafyGREFKTAKSL-ALVLFLFAVCWLP 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 74762454 253 ---NNFVLlahivsrLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
Cdd:cd15070 233 lsiINCVV-------YFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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