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Conserved domains on  [gi|74762445|sp|Q86T29|]
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RecName: Full=Zinc finger protein 605

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016908)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-45 7.03e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 7.03e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74762445     6 ISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFL 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-572 1.19e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 168 VYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCS--ECGKAFSQKSLLTVHQRTHSGEKPHGCSEC---QKAFSRKSLLIL 242
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 243 HqrIHTGEKPYGCSECGKAFSRKSQLKR--HQITHTIEKPYS-CSECGKAFSQKLKLITHQRAHtgekpypcSHCGKAFF 319
Cdd:COG5048 113 S--SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 320 WKSQLITHQRTHTGKKPYGCGECQKaFSRNSLLIRHQRIHTGEKPYECNECGeaFIRKPQLIKHQITHTGEKNY--RCSD 397
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSssSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 398 CEEAFFKKSELIRHQKIHLGE-------KPYGCIQCGKTFFGKSQLLTHHRT--HTGE--KPYECSE--CGKAFTQKSSL 464
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 465 ISHQRTHTGEKPYECSECRKTFSEKSSL-------IHHQRTHTGEKPFEC--SECRKAFAWKPQLLRHQRIHTGEKPYEC 535
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 74762445 536 --SECGKAFVQKVQLIKHQRNHTgEKTYGCSDCAKAFFE 572
Cdd:COG5048 420 knPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRR 457
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 589-611 5.14e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.14e-04
                          10        20
                  ....*....|....*....|...
gi 74762445   589 YKCGECGKSFTRKSHLMRHQRIH 611
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-45 7.03e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 7.03e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74762445     6 ISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFL 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
7-46 3.95e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 3.95e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74762445      7 SFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFLE 46
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 3.16e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 83.75  E-value: 3.16e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 74762445   6 ISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFL 45
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-572 1.19e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 168 VYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCS--ECGKAFSQKSLLTVHQRTHSGEKPHGCSEC---QKAFSRKSLLIL 242
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 243 HqrIHTGEKPYGCSECGKAFSRKSQLKR--HQITHTIEKPYS-CSECGKAFSQKLKLITHQRAHtgekpypcSHCGKAFF 319
Cdd:COG5048 113 S--SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 320 WKSQLITHQRTHTGKKPYGCGECQKaFSRNSLLIRHQRIHTGEKPYECNECGeaFIRKPQLIKHQITHTGEKNY--RCSD 397
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSssSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 398 CEEAFFKKSELIRHQKIHLGE-------KPYGCIQCGKTFFGKSQLLTHHRT--HTGE--KPYECSE--CGKAFTQKSSL 464
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 465 ISHQRTHTGEKPYECSECRKTFSEKSSL-------IHHQRTHTGEKPFEC--SECRKAFAWKPQLLRHQRIHTGEKPYEC 535
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 74762445 536 --SECGKAFVQKVQLIKHQRNHTgEKTYGCSDCAKAFFE 572
Cdd:COG5048 420 knPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*
gi 74762445   520 LLRHQRIHTGEKPYECSECGKAFVQ 544
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 589-611 5.14e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.14e-04
                          10        20
                  ....*....|....*....|...
gi 74762445   589 YKCGECGKSFTRKSHLMRHQRIH 611
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-45 7.03e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 7.03e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74762445     6 ISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFL 45
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
7-46 3.95e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 89.96  E-value: 3.95e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74762445      7 SFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFLE 46
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 3.16e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 83.75  E-value: 3.16e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 74762445   6 ISFEDVAVDFTLEEWQLLNPTQKNLYRDVMLENYSNLVFL 45
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-572 1.19e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 168 VYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCS--ECGKAFSQKSLLTVHQRTHSGEKPHGCSEC---QKAFSRKSLLIL 242
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplSNSKASSSSLSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 243 HqrIHTGEKPYGCSECGKAFSRKSQLKR--HQITHTIEKPYS-CSECGKAFSQKLKLITHQRAHtgekpypcSHCGKAFF 319
Cdd:COG5048 113 S--SSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 320 WKSQLITHQRTHTGKKPYGCGECQKaFSRNSLLIRHQRIHTGEKPYECNECGeaFIRKPQLIKHQITHTGEKNY--RCSD 397
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSssSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 398 CEEAFFKKSELIRHQKIHLGE-------KPYGCIQCGKTFFGKSQLLTHHRT--HTGE--KPYECSE--CGKAFTQKSSL 464
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 465 ISHQRTHTGEKPYECSECRKTFSEKSSL-------IHHQRTHTGEKPFEC--SECRKAFAWKPQLLRHQRIHTGEKPYEC 535
Cdd:COG5048 340 KRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 74762445 536 --SECGKAFVQKVQLIKHQRNHTgEKTYGCSDCAKAFFE 572
Cdd:COG5048 420 knPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-612 7.49e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 7.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 223 KPHGCSECQKAFSRKSLLILHQRIHTGEKPYGCS--ECGKAFSRKSQLKRHQITHTIEKPYSCSECGKAFSQKLKLITHQ 300
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 301 RAHTGE-KPYPCSHCGKAF--FWKSQLITHQRTHTGKKPY-----GCGECQKAFSRNSLLIRHqrihtgekpyecNECGE 372
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPssRDPQLPDLLSISNLRNNPLpgnnsSSVNTPQSNSLHPPLPAN------------SLSKD 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 373 AFIRKPQLIKHQITHTGEKNYRCSDCEEAFFKKSELIRHQKIHLgEKPYGCIQCGKTFFGKSQLLTHHRTHTGEKPYECS 452
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 453 ECGKAFTQKSSLISHQRTHTGE-------KPYECSECRKTFSEKSSLIHHQRT--HTGE--KPFECSE--CRKAFAWKPQ 519
Cdd:COG5048 259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 520 LLRHQRIHTGEKPYEC--SECGKAFVQKV------QLIKHQRNHTGEKTYGCSDCAKAFFEKAQLIIHQRIHT---GERP 588
Cdd:COG5048 339 LKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfRPYN 418

                       410       420
                ....*....|....*....|....
gi 74762445 589 YKCGECGKSFTRKSHLMRHQRIHT 612
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-640 1.12e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 334 KKPYGCGECQKAFSRNSLLIRHQRIHTGEKPYECN--ECGEAFIRKPQLIKHQITHTGEKNYRCSDCE-EAFFKKSELIR 410
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 411 HQKIHLGEKPYGCIQCGKTFFGKSQLLTHHRTHTGEKPYECSECGKAFTQ----------------------KSSLISHQ 468
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 469 RTHTGEKPYECSECRKTFSEKSSLIHHQRTHTGEKPFECSECRKAFAWKPQLLRHQRIHTGEKPYECSECGKAFVQKVQL 548
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 549 IKHQRNHTGEKT-------YGCSDCAKAFFEKAQLIIHQR--IHTGE--RPYKCGE--CGKSFTRKSHLMRHQRIHTGDK 615
Cdd:COG5048 271 QSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350
                ....*....|....*....|....*....|.
gi 74762445 616 YYGCNECGTT------FNRKSQLMIHQRNHI 640
Cdd:COG5048 351 PAKEKLLNSSskfsplLNNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-355 6.97e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 195 KPYQCSECGKAFSQKSLLTVHQRT--HSGE--KPHGCSE--CQKAFSRKSLLILHQRIHTGEKPYGC--SECGKAFSRKS 266
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 267 QLKRHQITHTI-----EKPYSC--SECGKAFSQKLKLITHQRAHTGEKPY--PCSHCGKAFFWKSQLITHQRTHTgKKPY 337
Cdd:COG5048 368 NNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                       170
                ....*....|....*...
gi 74762445 338 GCGECQKAFSRNSLLIRH 355
Cdd:COG5048 447 LLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-292 1.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 143 CDCSTCRKSSNEEPWLTA--NHITHTGVYL----CME--CGRFFNKKSQLVIHQRTHTGEKPYQC--SECGKAFSQKS-- 210
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRhlRSVNHSGESLkpfsCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnn 369

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 211 ---LLTVHQRTHSGEKPHGC--SECQKAFSRKSLLILHQRIHTGEKPYGC--SECGKAFSRKSQLKRHQITHTIEKPYSC 283
Cdd:COG5048 370 eppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449


                ....*....
gi 74762445 284 SECGKAFSQ 292
Cdd:COG5048 450 SILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*
gi 74762445   520 LLRHQRIHTGEKPYECSECGKAFVQ 544
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 410-500 2.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74762445 410 RHQKIhLGEKPYGC--IQCGKTFfgKSQL-LTHHRTHtgekpyecSECGKAFTQKSSLISHQRTHTGEKPYECSECRKTF 486
Cdd:COG5189 340 RMLKV-KDGKPYKCpvEGCNKKY--KNQNgLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408

                        90
                ....*....|....
gi 74762445 487 SEKSSLIHHqRTHT 500
Cdd:COG5189 409 KNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 589-611 5.14e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.14e-04
                          10        20
                  ....*....|....*....|...
gi 74762445   589 YKCGECGKSFTRKSHLMRHQRIH 611
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 9.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.66e-04
                          10        20
                  ....*....|....*....|....*
gi 74762445   352 LIRHQRIHTGEKPYECNECGEAFIR 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*
gi 74762445   184 LVIHQRTHTGEKPYQCSECGKAFSQ 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-460 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*
gi 74762445   436 LLTHHRTHTGEKPYECSECGKAFTQ 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 74762445   463 SLISHQRTHTGEKPYECSECRKTFS 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 197-219 3.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|...
gi 74762445   197 YQCSECGKAFSQKSLLTVHQRTH 219
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-292 3.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|....*
gi 74762445   268 LKRHQITHTIEKPYSCSECGKAFSQ 292
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
579-600 3.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.82e-03
                          10        20
                  ....*....|....*....|..
gi 74762445   579 HQRIHTGERPYKCGECGKSFTR 600
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 449-471 4.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.72e-03
                          10        20
                  ....*....|....*....|...
gi 74762445   449 YECSECGKAFTQKSSLISHQRTH 471
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-515 5.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|.
gi 74762445   495 HQRTHTGEKPFECSECRKAFA 515
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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