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Conserved domains on  [gi|46396816|sp|Q810B7|]
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RecName: Full=SLIT and NTRK-like protein 5; Flags: Precursor

Protein Classification

SLIT and NTRK-like protein 5( domain architecture ID 17599378)

SLIT and NTRK-like protein 5 (SLITRK5) suppresses neurite outgrowth

Gene Symbol:  SLITRK5
Gene Ontology:  GO:0005515|GO:0007409
PubMed:  14747988|11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 6.08e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 6.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  86 LLLSGNLLSRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 166 SVIePNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
433-493 1.01e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.01e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396816   433 TGLDLLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 391-563 1.52e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 391 VNCQERKIESIAELQPKPyNPKKMYLTENYITVVRRTDFLeaTGLDLLHLGNNRISMIQDraFGDLGNLRRLYLNGNRIE 470
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 471 RLspELFYGLQSLQYLFLQYNLIREIQAGTFDPvpnlqllflnnnqlqampsgvFSGLTLLR----LNLRGNSFTSLpvs 546
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                       170
                ....*....|....*..
gi 46396816 547 GVLDQLTSLIQIDLHDN 563
Cdd:cd21340 136 EPLAPLRNLEQLDASNN 152
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.23e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 1.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46396816    235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
563-599 2.96e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 2.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 46396816    563 NPWDCTCDVVGMKLWIEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 6.08e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 6.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  86 LLLSGNLLSRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 166 SVIePNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
129-189 4.93e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 4.93e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396816   129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 1.01e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.01e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396816   433 TGLDLLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 391-563 1.52e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 391 VNCQERKIESIAELQPKPyNPKKMYLTENYITVVRRTDFLeaTGLDLLHLGNNRISMIQDraFGDLGNLRRLYLNGNRIE 470
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 471 RLspELFYGLQSLQYLFLQYNLIREIQAGTFDPvpnlqllflnnnqlqampsgvFSGLTLLR----LNLRGNSFTSLpvs 546
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                       170
                ....*....|....*..
gi 46396816 547 GVLDQLTSLIQIDLHDN 563
Cdd:cd21340 136 EPLAPLRNLEQLDASNN 152
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
427-563 1.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 427 TDFLEATGLDLLHLGNNRISMIqDRAFGDLGNLRRLYLNGNRIERLSPELFyGLQSLQYLFLQYNLIREIQAGtFDPVPN 506
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTN 183

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 46396816 507 LQLLFLNNNQLQAMPSgVFSGLTLLR-LNLRGNSFTSLPVSgvLDQLTSLIQIDLHDN 563
Cdd:COG4886 184 LKELDLSNNQITDLPE-PLGNLTNLEeLDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-235 8.85e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  85 HLLLSGNLLSRLypNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLELLRDdtFLGLENLEYLQVDYNY 164
Cdd:cd21340   6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 165 ISVIEpnAFGKLHMLQVL-ILNDNLLSGLPnnlFRFVP---------LTHLDLRGNRlklLPYVGLLQHMDKVVELQLEE 234
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLPPGEK---LTFDPrslaalsnsLRVLNISGNN---IDSLEPLAPLRNLEQLDASN 151


                .
gi 46396816 235 N 235
Cdd:cd21340 152 N 152
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.23e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 1.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46396816    235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-212 1.89e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   86 LLLSGNLLSRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 46396816  166 SVIEPNAFGKLHMLQVLILNDNLLSG-LPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113 249 TGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSL 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 381-495 1.22e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 381 NLQISDLGLNvNCQERKIESIAELQPKPYNPKKMYLTENYITVVRRTDFLEA----TGLDLLHLGNNRISmiqDRAFGDL 456
Cdd:COG5238 181 SVETVYLGCN-QIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIG---DEGVIAL 256

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 46396816 457 G-------NLRRLYLNGNRIE----RLSPELFYGLQSLQYLFLQYNLIRE 495
Cdd:COG5238 257 AealknntTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGD 306
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-599 2.96e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 2.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 46396816    563 NPWDCTCDVVGMKLWIEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
456-479 5.14e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|....
gi 46396816    456 LGNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 6.08e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 6.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  86 LLLSGNLLSRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 166 SVIePNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-236 4.29e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 4.29e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  85 HLLLSGNLLSRLyPNEFVNYTGASILHLGSNVIQDIeTGAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNY 164
Cdd:COG4886 140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46396816 165 ISVIePNAFGKLHMLQVLILNDNLLSGLPNnLFRFVPLTHLDLRGNRLKLLPyvgLLQHMDKVVELQLEENP 236
Cdd:COG4886 217 LTDL-PEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
129-189 4.93e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 4.93e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396816   129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 1.01e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.01e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396816   433 TGLDLLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-215 3.33e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  85 HLLLSGNLLSRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNY 164
Cdd:COG4886 163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 46396816 165 ISVIEpnAFGKLHMLQVLILNDNLLSGLPNnLFRFVPLTHLDLRGNRLKLL 215
Cdd:COG4886 240 LTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
109-165 2.18e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.18e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46396816   109 ILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 391-563 1.52e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 391 VNCQERKIESIAELQPKPyNPKKMYLTENYITVVRRTDFLeaTGLDLLHLGNNRISMIQDraFGDLGNLRRLYLNGNRIE 470
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 471 RLspELFYGLQSLQYLFLQYNLIREIQAGTFDPvpnlqllflnnnqlqampsgvFSGLTLLR----LNLRGNSFTSLpvs 546
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                       170
                ....*....|....*..
gi 46396816 547 GVLDQLTSLIQIDLHDN 563
Cdd:cd21340 136 EPLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
154-212 1.97e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.97e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   154 NLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLLSGLPNNLFRFVP-LTHLDLRGNRL 212
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
458-540 8.38e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 8.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   458 NLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIqagtfdpvpnlqllflnnnqlqamPSGVFSGLTLLR-LNLR 536
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL------------------------SPGAFSGLPSLRyLDLS 57


                  ....
gi 46396816   537 GNSF 540
Cdd:pfam13855  58 GNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
427-563 1.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 427 TDFLEATGLDLLHLGNNRISMIqDRAFGDLGNLRRLYLNGNRIERLSPELFyGLQSLQYLFLQYNLIREIQAGtFDPVPN 506
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTN 183

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 46396816 507 LQLLFLNNNQLQAMPSgVFSGLTLLR-LNLRGNSFTSLPVSgvLDQLTSLIQIDLHDN 563
Cdd:COG4886 184 LKELDLSNNQITDLPE-PLGNLTNLEeLDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
412-469 7.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 46396816   412 KKMYLTENYITVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLGNLRRLYLNGNRI 469
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-235 8.85e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  85 HLLLSGNLLSRLypNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLELLRDdtFLGLENLEYLQVDYNY 164
Cdd:cd21340   6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 165 ISVIEpnAFGKLHMLQVL-ILNDNLLSGLPnnlFRFVP---------LTHLDLRGNRlklLPYVGLLQHMDKVVELQLEE 234
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLPPGEK---LTFDPrslaalsnsLRVLNISGNN---IDSLEPLAPLRNLEQLDASN 151


                .
gi 46396816 235 N 235
Cdd:cd21340 152 N 152
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-497 3.12e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 3.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  66 ENRGIISLSEISPPRFPIYHLLLSGNLLSRLYPNEFVNYTGASILHLGSNVIQDI-ETGAFHGLRGLRRLHLNNNKLELL 144
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLsGNEELSNLTNLESLDLSGNQLTDL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 145 rDDTFLGLENLEYLQVDYNYISVIePNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPYVglLQHM 224
Cdd:COG4886 129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 225 DKVVELQLEENpwncscelislkdwldsisysalvgdvvcetpfrlhgrdldevskqelcprklisdyemrpqtplsttg 304
Cdd:COG4886 205 TNLEELDLSGN--------------------------------------------------------------------- 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 305 ylhttpasvnsvatsssavykpplkppkgtrqpnkprvrptsrqpskdlgysnygpsiayqtkspvplecptactcnlQI 384
Cdd:COG4886 216 ------------------------------------------------------------------------------QL 217

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 385 SDLGlnvncqerkiESIAELqpkpynpkkmyltenyitvvrrtdfleaTGLDLLHLGNNRISMIqdRAFGDLGNLRRLYL 464
Cdd:COG4886 218 TDLP----------EPLANL----------------------------TNLETLDLSNNQLTDL--PELGNLTNLEELDL 257

                       410       420       430
                ....*....|....*....|....*....|...
gi 46396816 465 NGNRIERLSPELfyGLQSLQYLFLQYNLIREIQ 497
Cdd:COG4886 258 SNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-235 9.01e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 9.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  66 ENRGIISLSEISPPRFPIYHLLLSGNLLSRLYPNEFVNYTGAS-ILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELL 144
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTlLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 145 RDDTFLGLENLEYLQVDYNyisviepNAFGKLHMLQVLILNDNLLSGLPNNLFRFVPLTHLDLRGNRLKLLPYVglLQHM 224
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNL 158

                       170
                ....*....|.
gi 46396816 225 DKVVELQLEEN 235
Cdd:COG4886 159 TNLKSLDLSNN 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.23e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 1.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 46396816    235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-210 1.68e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816  85 HLLLSGNLLSRLypNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLE-----LLRDDTFLGL-ENLEYL 158
Cdd:cd21340  50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 46396816 159 QVDYNYISVIEPnaFGKLHMLQVLILNDNLLSGLpNNLFRFVP----LTHLDLRGN 210
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDL-EELLDLLSswpsLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-212 1.89e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   86 LLLSGNLLSRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 46396816  166 SVIEPNAFGKLHMLQVLILNDNLLSG-LPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113 249 TGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
416-564 5.41e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 5.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 416 LTENYITVVRRTDFLEATGLDLLHLGNNRismiqdrAFGDLGNLRRLYLNGNRIERLsPELFYGLQSLQYLFlqynlire 495
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELD-------- 142

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 496 iqagtfdpvpnlqllfLNNNQLQAMPSgVFSGLT-LLRLNLRGNSFTSLPVSgvLDQLTSLIQIDLHDNP 564
Cdd:COG4886 143 ----------------LSNNQLTDLPE-PLGNLTnLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQ 193
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-212 2.02e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   85 HLLLSGNLLSRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNY 164
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 46396816  165 ISVIEPNAFGKLHMLQVLILNDNLLSG-LPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113 320 FTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNL 368
PLN03150 PLN03150
hypothetical protein; Provisional
 128-191 3.46e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 3.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46396816  128 LRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHMLQVLILNDNLLSG 191
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
LRR_8 pfam13855
Leucine rich repeat;
179-236 5.45e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 5.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 46396816   179 LQVLILNDNLLSGLPNNLFRFVP-LTHLDLRGNRLKLLPYvGLLQHMDKVVELQLEENP 236
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 381-495 1.22e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816 381 NLQISDLGLNvNCQERKIESIAELQPKPYNPKKMYLTENYITVVRRTDFLEA----TGLDLLHLGNNRISmiqDRAFGDL 456
Cdd:COG5238 181 SVETVYLGCN-QIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIG---DEGVIAL 256

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 46396816 457 G-------NLRRLYLNGNRIE----RLSPELFYGLQSLQYLFLQYNLIRE 495
Cdd:COG5238 257 AealknntTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGD 306
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-212 1.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396816   88 LSGNLLSRLYPNEFVNYTGASILHLGSNVIQ-DIETGAFHgLRGLRRLHLNNNKLELLRDDTFlGLENLEYLQVDYNYIS 166
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFS 488

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 46396816  167 VIEPNAFGKLHMLQVLILNDNLLSG-LPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113 489 GAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQL 535
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-599 2.96e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 2.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 46396816    563 NPWDCTCDVVGMKLWIEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 458-498 3.29e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46396816   458 NLRRLYLNGNRIERLSPelFYGLQSLQYLFLQYN-LIREIQA 498
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLSD 41
LRR smart00370
Leucine-rich repeats, outliers;
456-479 5.14e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|....
gi 46396816    456 LGNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
456-479 5.14e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|....
gi 46396816    456 LGNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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